Feb 17–20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers:
Ashley Webb, Morgan Levine, and Dario Riccardo Valenzano

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Scientific Organizers: Ashley Webb, Morgan Levine, and Dario Riccardo Valenzano
Ashley Webb
Morgan Levine
Dario Riccardo Valenzano
***Meeting program subject to change.
Available Formats: = In Person = On DemandMonday, February 17, 2025
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Tuesday, February 18, 2025
Session Chair
Quantifying and Targeting Aging
Session Chair
Mechanisms of Chromatin Regulation in Aging
Targeting Chronic Inflammation in the Brain
DNA Repair Mechanisms in Aging and Longevity
Short Talk: Cohesin-Mediated 3d Contacts Tune Enhancer-Promoter Regulation
*Session Chair, Senior Editor
Senior Editor
Associate Editor
Senior Editor
Session Chair
Session Chair
Effects of Advancing Age on Dysregulation of Ocular Immune Homeostasis
Age-Dependent Dysregulation of Hypothalamic Circuits Contributes to Thermoregulatory Decline and Water Homeostasis Deficits in Aged Mice
Maintenance of Somatic Tert Levels as An Antiaging Strategy
Midkine as a Key Driver of Both Aging and Mammary Tumorigenesis
Virus-Induced Senescence: A Driver of Post-Acute Neurotropic Infection Syndrome
Responsiveness of Dnam Aging Biomarkers Across 51 Longevity Interventional Studies In Humans
Investigating Small Molecule Autophagy Activator Aa-20: From Lipophagy In Mammals To Longevity In C. Elegans
Engineering Multiscale Health
In silico Design of Rejuvenating Interventions
Short Talk: MethylGPT: A Foundation Model for the Dna Methylome
Short Talk: Machine Learning-Based Dimensional Reduction Of Multiparameter Cellular Morphometrics Defines Senescence Across Age
Short Talk: Untangling Cellular States Of Rejuvenation And Cell Identity In Induced Pluripotency
Short Talk: CpGPT: A Foundation Model For Dna Methylation
Wednesday, February 19, 2025
Host-Microbiome Interactions in Aging
Organelle and Metabolic Homeostasis
Circadian Clock Communication During Homeostasis and Ageing
Interactions Between the Gut Microbiome and Host Frailty
Short Talk: A Metabolic Atlas of Mouse Aging
Short Talk: A Gero-Neuroprotector That Restores Mitochondrial Function To Extend Lifespan
Associate Professor & Attending Physician
Principal Scientist
Associate Professor
Session Chair
Harnessing Cell State Transitions for Cognitive Rejuvenation
Mechanisms Underlying Neural Stem Cell Quiescence
Metabolic and Signaling Mechanisms of Stem Cell Homeostasis
Short Talk: Telomere Biology in Aging and Disease
Thursday, February 20, 2025
Nuclear Reprogramming to Ameliorate Aging
Epigenetic Mechanisms of Immune Aging and Rejuvenation
Improving Healthy Aging Through Cellular Reprogramming
In vivo Functional Rejuvenation by a Partial Reprogramming-based Approach
Short Talk: Uncovering the Mechanisms of Exceptional Longevity Through Ipsc-Based Modeling of Resiliency
Short Talk: ACC-seq Reveals Chromatin Condensate-Mediated Gene Regulation and its Role in Functional Decline
Session Chair
PRC2 Ageindex: A Universal Biomarker Of Aging And Rejuvenation
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
Exploring Metabolic Dynamics in Quiescent Versus Activated Neural Stem Cells
Vertebrate Organ Aging Impacted by Sexual Interaction
In Vivo Partial Reprogramming of Cardiomyocytes to a Molecularly Rejuvenated State Ameliorates Cardiac Failure
Senomorphic Effect of Partial Reprogramming
Cross-Generational Mechanisms of Longevity
Targeting Conserved Mechanisms of Aging
Enhancing Healthspan Through Targeted Therapeutics
Transcriptional Mechanisms of Brain Aging
Friday, February 21, 2025
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