Jan 22–25, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Morgan Maeder, Benjamin P. Kleinstiver, and Kiran Musunuru

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Scientific Organizers: Morgan Maeder, Benjamin P. Kleinstiver, and Kiran Musunuru
Morgan Maeder
Benjamin P. Kleinstiver
Kiran Musunuru
***Meeting program subject to change.
Available Formats: = In Person = On DemandBooking Function
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Monday, January 22, 2024
Tuesday, January 23, 2024
Delivering the Future of CRISPR-directed Genome Editing
Progress of CRISPR Clinical Programs
In Vivo Base and Prime Editing of Pathogenic Mutations in Mice and Non-Human Primates
Nucleic Acid Delivery Systems for RNA Therapy and Genome Editing
Short Talk: Short Talk: In Utero Gene Editing for a Metabolic Liver Disease in Mice and Nonhuman Primates
Short Talk: Short Talk: CRISPR Engineering and Phenotyping of a Large Isogenic Set of Neurodegeneration-Related Mutations in Human iPSC Models
Base Editing and Prime Editing to Introduce and Correct Pathogenic Variants Causing Pseudoxanthoma Elasticum
Development of a Customized Base Editor as a Treatment for a Severe Pediatric Vascular Disease
Base Editing Rescue of Spinal Muscular Atrophy in Cells and in Mice
Innovations in Mitochondrial Gene Therapy: mtZFNs and Beyond
Epigenetic Control of a Cardiac Gene Regulatory Element Modulates Therapeutically Relevant Phenotypes
Edit DNA Methylation in vivo
Engineered CRISPR Enzymes to Improve Genome Editing
Targeted DNA Integration in Mammalian Cells Using CRISPR-Associated Transposases
Short Talk: Short Talk: Epigenome Editing as a Tool for Basic Discovery and Therapeutic Intervention
Short Talk: Short Talk: Discovery of a Unified RNA-guided Mechanism for Programmable Genome Manipulation
Structure and Engineering of the RNA-Guided Cas7-11-Csx29 Nuclease-Protease Complex
Wednesday, January 24, 2024
Repair Mechanisms if Double Strand Breaks
Highthroughput Profiling of Gene Edited Cells
The Mechanisms of Base Editing
Short Talk: Short Talk: Directed Evolution of PhiC31 and Bxb1 Integrases to Integrate Large DNA Sequences in Mammalian Cells with Twin Prime Editing
Short Talk: Short Talk: Custom PAM-reprogrammed CRISPR-Cas Enzymes via Machine Learning
Short Talk: Short Talk: Population-scale GUIDE-seq-2 Profiling Reveals Human Genetic Variation Frequently Affects Cellular Off-target Genome Editing Activity
Short Talk: Short Talk: Generating Ultra-long Deletions using Paired Prime Editing
Professor
Group Leader
VP, Head of Research
Principal Investigator
Senior Investigator
Therapeutic Development of Epigenetic Editors
Therapeutic Development of Prime Editing
Harnessing the Power of Epi Editing for Clinical Benefit
Short Talk: Short Talk: In Vivo Correction of Human Phenylketonuria Variants Via Prime Editing and Base Editing
Short Talk: Short Talk: Epitope Edited Hematopoietic Stem Cells to Enable Immune-Based In Vivo Selection Of Genome-Engineered Cells
Thursday, January 25, 2024
Mammalian Retrovirus-Like Protein PEG10 Based Delivery Systems for mRNA Delivery and Genome Engineering
Lipid Nanoparticles for mRNA Delivery: The Exquisite Effects of Chemistry on Biological Function
Selective Organ Targeting (SORT) Lipid Nanoparticles (LNPs) for Tissue-Specific Gene Editing
Short Talk: Short Talk: Engineered Neuron Targeting CRISPR RNPs for Improved Genome Editing in the Brain
Short Talk: Short Talk: Development of Immune Modulating Ionizable Lipids and Their Lipid Nanoparticle Formulation for mRNA Vaccines and Therapeutics
Characterization and Design of Large Serine Recombinases Using Domain Swaps
Combinatorial Domain Screening for the Discovery of Stage-specific Epigenetic Interactions
Emergence of RNA-guided Transcription Factors via Domestication of Transposon-encoded Nucleases
Retargetable Fusogens Enable Delivery of Gene Editing Payloads with High Cell-specificity via Direct Coupling of Receptor Binding to Fusion
Engineering CasX to Create a Gene Editor with Potent Activity in Non-human Primates
Randomizing the Human Genome by Engineering Recombination between Repeat Elements
Engineering SpCas9 Towards Compatibility with Fully Chemically Modified sgRNA
High-Throughput Precision Genome Editing Screens to Study Variants of Uncertain Significance in Their Genomic Context
Therapeutic Gene Editing for Cardiovascular and Metabolic Diseases: From the Leading Cause of Death to N-of-1 Disorders
CRISPR and Base Edited Therapeutic T Cells
Developing in vivo Therapeutics with Ultracompact CRISPR Systems
Short Talk: Short Talk: In Vivo HSC Gene Editing for Correction of Sickle Cell Mutation using RNA Gene Writers
Friday, January 26, 2024
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