Host-Microbe Co-Evolution in Human Health: The Microbiome-Pathobiont Continuum
Feb 18–21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Bana Jabri, Caetano Reis e Sousa, and Philippe J. Sansonetti
In Person
On Demand
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Feb 18–21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Bana Jabri, Caetano Reis e Sousa, and Philippe J. Sansonetti
Bana Jabri
Caetano Reis e Sousa
Philippe J. Sansonetti
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMerchandise Options
Registration Options
Tuesday, February 18, 2025
Fundraising
Booking Function
Registration
4:00–8:00 PM
Van Horne Foyer
Welcome Mixer
6:00–8:00 PM
Van Horne Foyer
Wednesday, February 19, 2025
Breakfast
7:00–8:00 AM
President's Hall
Welcome and Keynote Address (Joint)
8:00–9:00 AM
Van Horne A
* Suzanne Devkota, Cedars-Sinai Medical Center
Session Chair
Session Chair
* Bana Jabri, University of Chicago
Session Chair
Session Chair
Dan R. Littman, HHMI/New York University School of Medicine
Commensals and Pathobionts in the Gut
Commensals and Pathobionts in the Gut
Coffee Break
9:00–9:30 AM
Van Horne Foyer
Viruses Within Us
9:30–11:15 AM
Van Horne B
* George Kassiotis, The Francis Crick Institute
Endogenous Retroelements and Immunity
Endogenous Retroelements and Immunity
Luis Barreiro, University of Chicago
Exploring Evolutionary Immunogenomics: Lessons from our Ancestors and Past Pandemics
Exploring Evolutionary Immunogenomics: Lessons from our Ancestors and Past Pandemics
Vivien Béziat, Institut Imagine
Human Genetic Determinants of Immunity to Muco-Cutaneous Papillomavirus
Human Genetic Determinants of Immunity to Muco-Cutaneous Papillomavirus
Danielle E Campbell, Washington University in Saint Louis School of Medicine
Short Talk: Single-Cell Viral Tagging Identifies Novel Human Gut Bacteriophages and Bacterial Hosts Associated with Inflammatory Bowel Diseasea
Short Talk: Single-Cell Viral Tagging Identifies Novel Human Gut Bacteriophages and Bacterial Hosts Associated with Inflammatory Bowel Diseasea
Poster Setup
11:15–1:00 PM
Van Horne C
On Own for Lunch
11:15–3:00 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:00 PM
Van Horne B
Kevin Bonham, Tufts Medical Center
Co-Development of Gut Microbial Metabolism and Visual Neural Circuitry Over Human Infancy
Co-Development of Gut Microbial Metabolism and Visual Neural Circuitry Over Human Infancy
Michael G Constantinides, Scripps Research
MAIT Cell Responses to Intracellular and Extracellular Pathogens Are Mediated by Distinct Antigen-Presenting Cells
MAIT Cell Responses to Intracellular and Extracellular Pathogens Are Mediated by Distinct Antigen-Presenting Cells
Maude Jans, VIB-UGent
Colibactin-Driven Colon Cancer Requires Adhesin-Mediated Epithelial Binding
Colibactin-Driven Colon Cancer Requires Adhesin-Mediated Epithelial Binding
* Jeannette Messer, Cleveland Clinic
A Direct Antimicrobial Function of HMGB1 That Determines Bacterial Virulence In The Gut
A Direct Antimicrobial Function of HMGB1 That Determines Bacterial Virulence In The Gut
Patrick Schimmel, Med Uni Graz
Mechanisms of FMT Efficacy in IBD Beyond Strain Engraftment
Mechanisms of FMT Efficacy in IBD Beyond Strain Engraftment
Andrew Patterson, University of Pennsylvania
A Phylogenetic Approach to Quantification of Human Endogenous Retrovirus RNA Expression
A Phylogenetic Approach to Quantification of Human Endogenous Retrovirus RNA Expression
Coffee Available
4:00–4:30 PM
Van Horne Foyer
Microbes Within Us
5:00–7:00 PM
Van Horne B
Salomé LeibundGut-Landmann, University of Zürich
Living with Commensal Fungi
Living with Commensal Fungi
Sophie Helaine, Harvard Medical School
Persisters Curing Infection
Persisters Curing Infection
* Emma Slack, ETH Zurich
Mechanisms the Host uses to Control the Gut Microbiota
Mechanisms the Host uses to Control the Gut Microbiota
Mohammad Arifuzzaman, Weill Cornell Medicine
Short Talk: Co-Evolution With Gut Microbiota: Host Metabolism Balances Microbial Regulation Of Bile Acid Signaling
Short Talk: Co-Evolution With Gut Microbiota: Host Metabolism Balances Microbial Regulation Of Bile Acid Signaling
Reinhard Hinterleitner, University of Pittsburgh
Short Talk: Type-2 Immune-Mediated Adaptations in Epithelial Cells in Response to Commensal Protists and Helminth Infection
Short Talk: Type-2 Immune-Mediated Adaptations in Epithelial Cells in Response to Commensal Protists and Helminth Infection
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Poster Session 1
7:30–10:00 PM
Van Horne C
Thursday, February 20, 2025
Breakfast
7:00–8:00 AM
President's Hall
What is a Pathobiont? Microbial Adaptations and Host Damage (Joint)
8:00–11:00 AM
Van Horne A
Peter J Turnbaugh, University of California, San Francisco
Harnessing the Gut Microbiome to Counteract and Predict Cancer Chemotherapy Toxicity
Harnessing the Gut Microbiome to Counteract and Predict Cancer Chemotherapy Toxicity
Purna C Kashyap, Mayo Clinic
Time to Turn the Spotlight on the Small Intestinal Microbiome
Time to Turn the Spotlight on the Small Intestinal Microbiome
* Russell E Vance, University of California, Berkeley
Mechanisms of mucosal immunity against the intracellular gut pathogen Shigella flexneri
Mechanisms of mucosal immunity against the intracellular gut pathogen Shigella flexneri
Iliyan D Iliev, Weill-Cornell Medical College
Fungal Commensalism and the Co-evolution of Type 2 Immunity
Fungal Commensalism and the Co-evolution of Type 2 Immunity
Darryl A Abbott, University of Pittsburgh
Short Talk: Maternal Immunoglobulin a Regulates the Development of the Neonatal Microbiota and Intestinal Microbiota-Specific CD4+ T Cell Responses
Short Talk: Maternal Immunoglobulin a Regulates the Development of the Neonatal Microbiota and Intestinal Microbiota-Specific CD4+ T Cell Responses
Darian T Carroll, Vanderbilt University Medical Center
Short Talk: Regulation of Enterocyte Lipid Metabolism by the Microbiota-derived Metabolite, Phenyllactic Acid
Short Talk: Regulation of Enterocyte Lipid Metabolism by the Microbiota-derived Metabolite, Phenyllactic Acid
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Van Horne A
Poster Setup
11:00–1:00 PM
Van Horne C
On Own for Lunch
11:00–2:45 PM
Career Roundtable (Joint)
1:00–2:30 PM
Van Horne B
Ashlee M Earl, Broad Institute
Director, Bacterial Genomics
Director, Bacterial Genomics
Trevor Lawley, Microbiotica/Wellcome Sanger Institute
Founder & CSO/Group Leader
Founder & CSO/Group Leader
Marin Vulic, Seres Therapeutics
Senior Principal Scientist
Senior Principal Scientist
Alex Rodriguez-Palacios, Case Western Reserve University School of Medicine
Assistant Professor
Assistant Professor
Jessica Langer, Helmsley Charitable Trust
Program Officer
Program Officer
Poster Viewing
1:00–10:00 PM
Van Horne C
Panel Discussion 1: Toward Molecular Mechanisms in Microbiome Research: Insights from Genetic Systems and Co-Evolved Pathways (Joint)
2:45–4:30 PM
Van Horne A
Ramnik Xavier, Massachusetts General Hospital
Panel Co-Leader
Panel Co-Leader
Ami S. Bhatt, Stanford University
Panel Co-Leader
Panel Co-Leader
Suzanne Devkota, Cedars-Sinai Medical Center
Michael A. Fischbach, Stanford University
Andrew L Goodman, Yale School of Medicine
George Kassiotis, The Francis Crick Institute
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Jessica Langer, Helmsley Trust Introduction
5:00–5:05 PM
Van Horne A
Host Colonization and Co-Evolution of Host-Microbial Interactions (Joint)
5:05–7:00 PM
Van Horne A
Maria Manuel Dias da Mota, GIMM- Gulbenkian Institute For Molecular Medicine
Inter-Kingdom Interactions Shaping Malaria Infections
Inter-Kingdom Interactions Shaping Malaria Infections
Andrew L Goodman, Yale School of Medicine
Bacterial Diversity and Host Response to Medications
Bacterial Diversity and Host Response to Medications
* Melanie Blokesch, École Polytechnique Fédérale de Lausanne
When Microbes Turn Hosts: Phage Defense Evolution in Pandemic Vibrio cholerae
When Microbes Turn Hosts: Phage Defense Evolution in Pandemic Vibrio cholerae
Clarissa Campbell, The Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM)
Short Talk: Bacterial Quorum Sensing Molecules Produced Via HdtS Homologs Affect Host T Cell Immunity In The Mammalian Gut
Short Talk: Bacterial Quorum Sensing Molecules Produced Via HdtS Homologs Affect Host T Cell Immunity In The Mammalian Gut
Gregory P Donaldson, UCLA
Short Talk: Gut Microbiota Induce an Immunoglobulin A-DMBT1 Feedback Loop to Tune Epithelial Cycling and Tumor Risk
Short Talk: Gut Microbiota Induce an Immunoglobulin A-DMBT1 Feedback Loop to Tune Epithelial Cycling and Tumor Risk
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Poster Session 2
7:30–10:00 PM
Van Horne C
Friday, February 21, 2025
Breakfast
7:00–8:00 AM
President's Hall
Role of Gut Microbiota in Disease
8:00–11:00 AM
Van Horne B
Michael A. Fischbach, Stanford University
Discovery and Engineering of the Antibody Response to a Prominent Skin Commensal
Discovery and Engineering of the Antibody Response to a Prominent Skin Commensal
Pascale Vonaesch, University of Lausanne
The Gut Ecosystem in Childhood Undernutrition
The Gut Ecosystem in Childhood Undernutrition
* Bana Jabri, University of Chicago
Intestinal Barrier, Commensals and Immunopathology
Intestinal Barrier, Commensals and Immunopathology
Arushana A Maknojia, Baylor College of Medicine
Short Talk: Gut-bone marrow crosstalk: How microbiota-derived signals regulate steady-state hematopoiesis?
Short Talk: Gut-bone marrow crosstalk: How microbiota-derived signals regulate steady-state hematopoiesis?
Fanny Matheis, New York University School of Medicine
Short Talk: Rewilding of Laboratory Mice Defines a “Microbiometer,” Reveals Major Loss of Bacterial Density and Fungal Invasion, and Improves Pathogen Resistance-Associated Innate Immunity
Short Talk: Rewilding of Laboratory Mice Defines a “Microbiometer,” Reveals Major Loss of Bacterial Density and Fungal Invasion, and Improves Pathogen Resistance-Associated Innate Immunity
Kali M. Pruss, Washington University School of Medicine, St. Louis
Short Talk: Effects Of Intergenerational Transmission of Small Intestinal Bacteria Cultured From Stunted Bangladeshi Children With Enteropathy
Short Talk: Effects Of Intergenerational Transmission of Small Intestinal Bacteria Cultured From Stunted Bangladeshi Children With Enteropathy
Wataru Ebina, NYU Langone Health
Short Talk: Enteric Murine Norovirus Infection Enhances Immune Checkpoint Inhibitor Treatment Of Distal Tumor
Short Talk: Enteric Murine Norovirus Infection Enhances Immune Checkpoint Inhibitor Treatment Of Distal Tumor
Coffee Break
9:00–9:20 AM
Van Horne Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Interface of Nutrition, Microbiome and Disease
2:30–4:15 PM
Van Horne B
Hyunji Park, POSTECH
Gut Microbial Production of Imidazole Propionate Drives Parkinson’s Pathologies
Gut Microbial Production of Imidazole Propionate Drives Parkinson’s Pathologies
* Sean Spencer, Stanford University
Capsule-Based Sampling of the Human Small Intestine Enables Rational Design of Therapeutic Bacterial Consortia for Precision Modulation of Small Intestinal Microbiota
Capsule-Based Sampling of the Human Small Intestine Enables Rational Design of Therapeutic Bacterial Consortia for Precision Modulation of Small Intestinal Microbiota
Hallie Avalos, Vanderbilt
Salmonella Typhimurium Relies on Vitamin C Utilization for Expansion During Intestinal Inflammation
Salmonella Typhimurium Relies on Vitamin C Utilization for Expansion During Intestinal Inflammation
Marie A Crane, Washington University School of Medicine
Comparative Genomics Analyses of the Microbial Targets of Microbiota-Directed Foods Yield Insights into Structure-Function Relationships
Comparative Genomics Analyses of the Microbial Targets of Microbiota-Directed Foods Yield Insights into Structure-Function Relationships
Hyoung-Soo Cho, Harvard Medical School
Colonization with Fusobacterium Remodels the Intestinal Epithelium of the Host
Colonization with Fusobacterium Remodels the Intestinal Epithelium of the Host
Elaine Kouame, UCSF
Antigen-Presenting Cells Recognizing Cell Death Modulate Immunity to Dietary Antigens During Viral Infections
Antigen-Presenting Cells Recognizing Cell Death Modulate Immunity to Dietary Antigens During Viral Infections
Meghan Chafee, Seres Therapeutics, Inc.
Pharmacokinetic (PK) and Pharmacodynamic (PD) Results From A Phase 1b Study of SER-155, An Investigational, Oral, Live Biotherapeutic Evaluated In Adults Undergoing Allogeneic Stem Cell Transplant (allo-HCT)
Pharmacokinetic (PK) and Pharmacodynamic (PD) Results From A Phase 1b Study of SER-155, An Investigational, Oral, Live Biotherapeutic Evaluated In Adults Undergoing Allogeneic Stem Cell Transplant (allo-HCT)
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Therapeutic Lessons from Bugs
5:00–6:30 PM
Van Horne B
Ramnik Xavier, Massachusetts General Hospital
Learning Mucosal Immunity from Gut Bugs
Learning Mucosal Immunity from Gut Bugs
* Caetano Reis e Sousa, Francis Crick Institute
Micronutrients, the Microbiome and Cancer Immunity
Micronutrients, the Microbiome and Cancer Immunity
Marlies Meisel, University of Pittsburgh
Metabolism, Microbiota and Cancer Immunity
Metabolism, Microbiota and Cancer Immunity
Closing Keynote Address
6:30–7:15 PM
Van Horne B
* Caetano Reis e Sousa, Francis Crick Institute
Session Chair
Session Chair
Wendy S Garrett, Harvard School of Public Health
Interplay Between the Gastrointestinal Immune System and the Gut Microbiota in Health and Disease
Interplay Between the Gastrointestinal Immune System and the Gut Microbiota in Health and Disease
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:15–7:30 PM
Van Horne B
Social Hour with Lite Bites
7:15–8:15 PM
President's Hall
Entertainment
8:15–9:15 PM
Van Horne A
Saturday, February 22, 2025
Departure
12:00–11:59 PM
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