Unraveling Vascular Layers to Understand Human Disease

Mar 17–19, 2024 | Buck Institute for Research on Aging, Novato, CA, United States
Scientific Organizers: Rachel J. Roth Flach and Stephanie Wengert Watts

  In Person
  On Demand
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Mar 17–19, 2024 | Buck Institute for Research on Aging, Novato, CA, United States

Scientific Organizers: Rachel J. Roth Flach and Stephanie Wengert Watts

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, March 17, 2024
Arrival and Registration  
4:00–8:00 PM
 Courtyard by Marriott Marin Room
Welcome Mixer  
6:00–8:00 PM
 Courtyard by Marriott Marin Room
Monday, March 18, 2024
Breakfast  
8:00–9:00 AM
 Atrium
Poster Setup  
8:30–9:00 AM
 Atrium
Welcome and Keynote Address  
9:00–10:00 AM
 Drexler Auditorium
William C. Sessa, Pfizer
Advances in Vascular Biology and Application to Therapeutic Development
Poster Viewing  
9:00–7:00 PM
 Atrium
Vascular Metabolism  
10:00–12:00 PM
 Drexler Auditorium
Zoltan Arany, University of Pennsylvania
Endothelial Metabolism in Health and Disease
Tara L. Haas, York University
Metabolic Signaling and the Regulation of Skeletal Muscle Angiogenesis
Eugene Chen, University of Michigan Medical Center
Adipose Tissue and Smooth Muscle Cell Cross-Talk in Atherosclerosis and Hypertension
Aaron J. Trask, Research Institute at Nationwide Children's Hospital
Short Talk: Short Talk: Spatial Transcriptomic Profiling of the Type 2 Diabetic Coronary Microcirculation Cell Types Varied by Regions of the Heart
Coffee Break  
10:30–10:50 AM
 Atrium
Lunch  
12:00–1:00 PM
 Atrium
Poster Session 1  
12:30–2:30 PM
 Drexler Auditorium
Workshop  
2:30–4:30 PM
 Drexler Auditorium
Hisamichi Naito, Kanazawa University
Angiogenesis of Vasa Vasorum Precede the Onset of Aortic Dissection
Shashi Kant, Brigham Women's Hospital
PGC1α and Its Downstream Effectors of TERT-HMOX1 Signaling Regulate the Endothelial Response to Fluid Shear Stress
Erika Boerman, University of Missouri
NLRP3 Inflammasome Activation and Fibrosis Contribute to Perivascular Adipose Tissue Dysfunction in Inflammatory Bowel Disease
Youyang Zhao, Northwestern University-Lurie Children's Hospital of Chicago
Endothelium-targeted Nanoparticle Delivery of CRISPR/Cas9 Plasmid DNA Causes Robust Genome Editing of Endothelial HIF-2a in Adult Rats
Ana Paula Davel, University of Campinas (UNICAMP)
TUDCA Treatment Restores Anticontractile Function of Perivascular Adipose Tissue (PVAT) in Post-weaning Protein-restricted Mice
Fiene Daniel, University Hospital Halle (Saale)
Vascular Aging and Remodeling: The Role of miR-127-3p in Vascular Smooth Muscle Cells
Alexandra R. Lucas, Arizona State University
Virus-derived Serpin Targets Systemic Vascular Inflammation Improving Outcomes and Survival in Murine Models of SARS-CoV-2 and Ulcerative Colitis
Valentina Lo Sardo, University of Wisconsin-Madison
Stem Cell-based Functional Genomics Unravel Coronary Artery Disease Mechanisms Acting in the Vascular Wall
Coffee Available  
4:30–5:00 PM
 Atrium
Vascular Informatics  
5:00–7:00 PM
 Drexler Auditorium
Vivian de Waard, Amsterdam UMC
Shades of Vascular Smooth Muscle Cells, Revealed by Informatics
Elena Aikawa, Harvard Medical School, Brigham and Women’s Hospital
Multi-Omics in the Vasculature: Learning Layer by Layer
Nicholas Chavkin, University of Virginia
Single Cell Analysis in Vascular Biology
Wenduo Gu, Stanford University
Short Talk: Short Talk: Discrete Population of Rare SMC Progenitors Gives Rise Exclusively to the Fibrous Cap
Saivageethi Nuthikattu, University of California Davis
Short Talk: Short Talk: Single Nuclei Transcriptomics in Diabetic Mice Reveals Altered Brain Hippocampal Endothelial Cell Function, Permeability, and Behavior
On Own for Dinner  
7:00–8:00 PM
Tuesday, March 19, 2024
Breakfast  
8:00–9:00 AM
 Atrium
Poster Setup  
8:30–9:00 AM
 Atrium
Vascular Crosstalk and Mechanics  
9:00–12:00 PM
 Drexler Auditorium
Cynthia St. Hilaire, University of Pittsburgh
Calcification of the Vasculature: Mechanisms Driving Mineralization
Manu O. Platt, National Institutes of Health
Vascular Remodeling by Proteases in Sickle Cell Disease
Jennifer Pluznick, Johns Hopkins University School of Medicine
Does the Microbiome Influence Function of ALL Vascular Layers?
Sara Roccabianca, Michigan State University
Arterial Stiffness when Considering PVAT as a Vascular Layer
Gisele Bomfim, University of South Carolina
Short Talk: Short Talk: Is there a Difference in the Immune Function of Endothelial Cells among Different Vascular Beds
Ramani Ramchandran, Medical College of Wisconsin
Short Talk: Short Talk: Basolateral Brain Endothelial Cilia Location Suggests an Atypical Role in Promoting Vascular Stability
Poster Viewing  
9:00–6:00 PM
 Atrium
Coffee Break  
10:00–10:20 AM
 Atrium
Lunch  
12:00–1:00 PM
 Atrium
Poster Session 2  
12:30–2:30 PM
 Atrium
Career Roundtable  
2:30–3:30 PM
 Atrium
Rachel J. Roth Flach, Pfizer Inc.
Executive Director - Head of Cardiorenal Biology
Manu O. Platt, National Institutes of Health
Director, Center for Biomedical Engineering Technology Acceleration, NIBIB
Coffee Available  
3:30–4:00 PM
 Atrium
Therapeutic Development in Vascular Biology  
4:00–5:45 PM
 Drexler Auditorium
Robert Menzies, AstraZeneca
Prioritising Molecular Mechanisms in the Vasculature to Deliver Therapeutic Success
Xiaojun Wang, Eli Lilly and Company
Discovery and Development of Long-Acting Relaxin to Treat Underlying Causes of Cardiorenal Diseases
William Jackson, Stanford University
Short Talk: Short Talk: Epigenetic and Phenotypic Modulation of Adventitial Fibroblasts in Atherosclerosis by Coronary Artery Risk Gene TCF21
Jesus Maria Gomez Salinero, Weill Medical College of Cornell University
Short Talk: Short Talk: Development of a Vascularization Platform for Endothelial Cell Adaptability and Therapeutic Screening
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
5:45–6:00 PM
 Drexler Auditorium
On Own for Dinner  
6:00–7:00 PM
Wednesday, March 20, 2024
Departure  
7:00–11:59 PM

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