Joint with: MASH Pathogenesis and Therapeutic Approaches
Obesity and Adipose Tissue
Feb 23–26, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Paul Cohen, Ruth J Loos, Claudio J Villanueva and Christian Wolfrum
In Person
On Demand
Feb 23–26, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Paul Cohen, Ruth J Loos, Claudio J Villanueva and Christian Wolfrum
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMerchandise Options
Registration Options
Sunday, February 23, 2025
Fundraising
Booking Function
Registration
4:00–8:00 PM
Van Horne Foyer
Welcome Mixer
6:00–8:00 PM
Van Horne Foyer
Monday, February 24, 2025
Breakfast
7:00–8:00 AM
President's Hall
Welcome and Keynote Session (Joint)
8:00–9:30 AM
Van Horne A/B
* Paul Cohen, Rockefeller University
Session Chair
Session Chair
* Elizabeth K Speliotes, University of Michigan
Session Chair
Session Chair
Jeffrey M. Friedman, Rockefeller University
Obesity Causes and Treatment: The End of the Beginning
Obesity Causes and Treatment: The End of the Beginning
Anna Mae Diehl, Duke University
Morphogens, Metabolism and MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
Morphogens, Metabolism and MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
Coffee Break
9:30–9:50 AM
Van Horne Foyer
Award Recipient Acknowledgement
9:50–9:55 AM
Van Horne A/B
Genetic Insights into Body Fat Distribution and NAFLD (Joint)
9:55–11:30 AM
Van Horne A/B
* Lucile Dollet, University of Copenhagen
Session Chair
Session Chair
Elizabeth K Speliotes, University of Michigan
Human Genetic Insights into NAFLD
Human Genetic Insights into NAFLD
* Ruth J Loos, University of Copenhagen
Genetics of Obesity and Body Fat Distribution
Genetics of Obesity and Body Fat Distribution
Karen L. Mohlke, University of North Carolina at Chapel Hill
Genetics and Genomics of Obesity-Associated Diseases
Genetics and Genomics of Obesity-Associated Diseases
Poster Setup
11:30–1:00 PM
Van Horne C
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Health Equity Forum (Joint)
2:30–4:30 PM
Van Horne A
* Joeva Barrow, Cornell University
Session Chair
Session Chair
* Keren I Hilgendorf, University of Utah
Lean Adipocytes Secrete an Oxylipin That Protects Against Obesity-Accelerated Breast Cancer
Lean Adipocytes Secrete an Oxylipin That Protects Against Obesity-Accelerated Breast Cancer
Lisa Lazarevski, University of Tübingen
Unraveling the Impact of White Adipose Tissue on Breast Cancer Metabolism And Therapy Resistance Using a Breast Cancer-On-Chip Model
Unraveling the Impact of White Adipose Tissue on Breast Cancer Metabolism And Therapy Resistance Using a Breast Cancer-On-Chip Model
Clarissa Strieder-Barboza, Texas Tech University
Single-Nuclei Analysis Reveals Depot- And Disease-Specific Cell Types In Adipose Tissue Of Women With Gestational Diabetes
Single-Nuclei Analysis Reveals Depot- And Disease-Specific Cell Types In Adipose Tissue Of Women With Gestational Diabetes
Jennifer Below, Vanderbilt University Medical Center
Unmasking Early Cardiometabolic Risk In A High Risk Population
Unmasking Early Cardiometabolic Risk In A High Risk Population
Elizabeth C Heintz, Pennington Biomedical Research Center
Deletion of Hepatocyte NRF2 Accelerates MASH Progression Through Similar Mechanisms in Male and Female Mice
Deletion of Hepatocyte NRF2 Accelerates MASH Progression Through Similar Mechanisms in Male and Female Mice
Marijana Vujkovic, Philadelphia VA Medical Center / University of Pennsylvania
Genetic Variants Influence Chronic Liver Disease Progression through Distinct Pathways
Genetic Variants Influence Chronic Liver Disease Progression through Distinct Pathways
Donna Conlon, University of Pennsylvania
The Role of FOG2S657G in Metabolic Dysfunction-Associated Steatohepatitis
The Role of FOG2S657G in Metabolic Dysfunction-Associated Steatohepatitis
Jashdeep Bhattacharjee, University of Southern California
The Role of MALRD1 on MASH Pathogenesis
The Role of MALRD1 on MASH Pathogenesis
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Molecular and Cellular Biology of Adipocytes
5:00–7:00 PM
Van Horne A
* Andrea Galmozzi, UW Madison SMPH
Session Chair
Session Chair
Christian Wolfrum, ETH Zürich
Subtypes of Adipocytes in Mice and Humans
Subtypes of Adipocytes in Mice and Humans
Bruce M. Spiegelman, Dana-Farber Cancer Institute
Thermogenic Pathways in Adipocytes
Thermogenic Pathways in Adipocytes
Silvia Corvera, University of Massachusetts Medical School
Mechanistic Insights from Human Adipocytes
Mechanistic Insights from Human Adipocytes
John Griffin, Pfizer, Inc
Short Talk: Inhibition of Activin Type 2 Receptor Signaling Blocks ACVR1C Signaling and Increases Adipose Lipolysis
Short Talk: Inhibition of Activin Type 2 Receptor Signaling Blocks ACVR1C Signaling and Increases Adipose Lipolysis
Shannon M Reilly, Weill Medical College of Cornell University
Short Talk: Fatty Acids Promote Uncoupled Respiration Via the Atp/Adp Carrier in White Adipocytes
Short Talk: Fatty Acids Promote Uncoupled Respiration Via the Atp/Adp Carrier in White Adipocytes
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Poster Session 1
7:30–10:00 PM
Van Horne C
Tuesday, February 25, 2025
Breakfast
7:00–8:00 AM
President's Hall
Adipose Tissue Homeostasis
8:00–11:00 AM
Van Horne A
* Mascha Koenen, Rockefeller University
Session Chair
Session Chair
Rana K Gupta, Duke University School of Medicine
Establishing memory in adipose tissue influences future metabolic outcomes in obesity
Establishing memory in adipose tissue influences future metabolic outcomes in obesity
Patrick Seale, University of Pennsylvania
Adipocyte Progenitor Cells and Adipose Tissue Remodeling
Adipocyte Progenitor Cells and Adipose Tissue Remodeling
Lawrence Kazak, McGill University
An Activation Mechanism of Ucp1-Independent Thermogenesis
An Activation Mechanism of Ucp1-Independent Thermogenesis
Yun-Hee Lee, Seoul National University
Adipose Tissue Remodeling in Health and Disease
Adipose Tissue Remodeling in Health and Disease
Vissarion Efthymiou, ETH Zurich
Short Talk: Single-Nucleus Analysis Of Human White Adipose Tissue Reveals Adipocyte Subsets With Distinct Metabolic Profiles And Tshz3 As A Novel Adipogenesis Regulator
Short Talk: Single-Nucleus Analysis Of Human White Adipose Tissue Reveals Adipocyte Subsets With Distinct Metabolic Profiles And Tshz3 As A Novel Adipogenesis Regulator
Margo Emont, University of Chicago
Short Talk: Single Nuclear RNA-Sequencing Reveals Weight Loss-Induced Pathways for Adipose Tissue Remodeling
Short Talk: Single Nuclear RNA-Sequencing Reveals Weight Loss-Induced Pathways for Adipose Tissue Remodeling
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Poster Setup
11:00–1:00 PM
Van Horne C
On Own for Lunch
11:00–3:15 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Career Roundtable (Joint)
1:30–3:00 PM
Van Horne B
Ricardo J. Samms, Eli Lilly and Company
Senior Director
Senior Director
Alexander Pfeifer, University of Bonn
Professor
Professor
Marie Guerraty, University of Pennsylvania
Assistant Professor
Assistant Professor
Henry H. Ruiz, New York Institute of Technology
Assistant Professor
Assistant Professor
Catherine Charneski, Science Translational Medicine
Senior Editor
Senior Editor
Meet the Editors (Joint)
3:15–4:30 PM
Van Horne B
Deniz Senyilmaz Tiebe, EMBO Press
*Session Chair, Senior Scientific Editor
*Session Chair, Senior Scientific Editor
Yevgeniya Nusinovich, AAAS/Science
Senior Editor
Senior Editor
Revati Sumukh Dewal, Nature Metabolism
Associate Editor
Associate Editor
Mari-Carmen Fernández-Agüera, Cell Metabolism, Cell Press
Scientific Editor
Scientific Editor
Rachel Sager, Med, Cell Press
Associate Scientific Editor
Associate Scientific Editor
George Caputa, Nature
Senior Editor
Senior Editor
Tatyana Kuznetsova, Cell Reports Medicine
Senior Scientific Editor
Senior Scientific Editor
Catherine Charneski, Science Translational Medicine
Senior Editor
Senior Editor
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Role of Adipose Tissue in Organismal Metabolism
5:00–7:00 PM
Van Horne A
* Erwei Li, Harvard Medical School
Session Chair
Session Chair
Claudio J Villanueva, University of California, Los Angeles
Adipose-Liver Crosstalk
Adipose-Liver Crosstalk
Alexander Pfeifer, University of Bonn
Metabolites that Ignite Brown Fat
Metabolites that Ignite Brown Fat
Michael P Czech, University of Massachusetts Chan Medical School
Adipose Dysfunction in Obesity and Associated Diseases
Adipose Dysfunction in Obesity and Associated Diseases
Shingo Kajimura, Harvard Medical School, Beth Israel Deaconess Medical Center
Role of Thermogenesis in Whole-Body Metabolism
Role of Thermogenesis in Whole-Body Metabolism
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Poster Session 2
7:30–10:00 PM
Van Horne C
Wednesday, February 26, 2025
Breakfast
7:00–8:00 AM
President's Hall
The Biology of Therapeutics for Obesity and NAFLD (Joint)
8:00–11:00 AM
Van Horne A/B
* Matthew Lynes, MaineHealth
Session Chair
Session Chair
* Luca Lotta, Regeneron Pharmaceuticals Inc.
CIEDB, GPR75, INHBE in Obesity and NAFLD
CIEDB, GPR75, INHBE in Obesity and NAFLD
Rebecca A. Taub, Madrigal Pharmaceuticals
Thyroid Agonist Biology and Human Effects
Thyroid Agonist Biology and Human Effects
Ricardo J. Samms, Eli Lilly and Company
Dual Agonist Biology and Human Effects
Dual Agonist Biology and Human Effects
Jacqueline Beaudry, University of Toronto
Short Talk: Clearance of Postprandial Lipid Levels into Adipose Tissue with the Help of Glucose-Dependent Insulinotropic Peptide
Short Talk: Clearance of Postprandial Lipid Levels into Adipose Tissue with the Help of Glucose-Dependent Insulinotropic Peptide
Carla Hovarth, ETH Zürich
Short Talk: Adipose Tissue as A First Responder: Early Effects of Survodutide on Systemic Insulin Sensitivity
Short Talk: Adipose Tissue as A First Responder: Early Effects of Survodutide on Systemic Insulin Sensitivity
Joanne Hsieh, Gordian Biotechnology
Short Talk: Interrogating The Directionality And Mechanisms Of Genetic Associations As Part Of High-Throughput In Vivo Pooled Screening To Discover Novel Therapies For MASH
Short Talk: Interrogating The Directionality And Mechanisms Of Genetic Associations As Part Of High-Throughput In Vivo Pooled Screening To Discover Novel Therapies For MASH
Prabhu Ponnandy, University of Michigan
Short Talk: CRISPR Whole Genome Knock-Out Screen Identifies Potential New Targets For Treatment of MASLD.
Short Talk: CRISPR Whole Genome Knock-Out Screen Identifies Potential New Targets For Treatment of MASLD.
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Poster Setup
11:00–1:00 PM
Van Horne C
On Own for Lunch
11:00–2:30 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Symposia Spotlight: Emerging Mechanisms
2:30–4:30 PM
Van Horne A
* David M Merrick, University of Pennsylvania
Session Chair
Session Chair
Rebecca L McIntyre, University of Copenhagen
Thermogenic and Dietary Control Of Adipose Plasticity Through A Cassette Of Repressive Metabolite GPCRs
Thermogenic and Dietary Control Of Adipose Plasticity Through A Cassette Of Repressive Metabolite GPCRs
Dylan Duerre, University of Wisconsin
BCAA Catabolism Regulates Brown Adipose Tissue Thermogenesis Via Heme Biosynthesis
BCAA Catabolism Regulates Brown Adipose Tissue Thermogenesis Via Heme Biosynthesis
Ethan C Fein, University of Pennsylvania
The Innate Thermogenic Capacity of Brown Adipose Tissue Develops Independently of Sympathetic Signaling
The Innate Thermogenic Capacity of Brown Adipose Tissue Develops Independently of Sympathetic Signaling
Kaja Plucinska, The Rockefeller University
Circulating Signature of Acute Cold Exposure and Brown Fat Activation in Humans
Circulating Signature of Acute Cold Exposure and Brown Fat Activation in Humans
Daniele Neri, Columbia University Irving Medical Center
Selective, Acute Stimulation of Vasculature-Projecting Sympathetic Neurons in Brown Adipose Tissue Improves Glycemic Profile in Mice
Selective, Acute Stimulation of Vasculature-Projecting Sympathetic Neurons in Brown Adipose Tissue Improves Glycemic Profile in Mice
Ankit Sharma, University of Pittsburgh School of Medicine
Defining the Role of Igf2 In Regulating Adipocyte Progenitor Proliferation and Adipogenesis
Defining the Role of Igf2 In Regulating Adipocyte Progenitor Proliferation and Adipogenesis
Ryan P Ceddia, Vanderbilt University Medical Center
Negative Regulators of Natriuretic Peptides as Targets to Promote Adipocyte Browning
Negative Regulators of Natriuretic Peptides as Targets to Promote Adipocyte Browning
Nathalie Chami, Icahn School of Medicine at Mount Sinai
Genetic Loci Associated with Higher Adiposity and Reduced Cardiometabolic Risk Point to Distinct Subtypes and Diverse Mechanisms
Genetic Loci Associated with Higher Adiposity and Reduced Cardiometabolic Risk Point to Distinct Subtypes and Diverse Mechanisms
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Population Biology in Obesity and Related Diseases
5:00–6:45 PM
Van Horne A
* Kartik Rajagopalan, UT Southwestern Medical Center
Session Chair
Session Chair
Paul Cohen, Rockefeller University
Brown Fat in Human Health and Disease
Brown Fat in Human Health and Disease
Camilla C Schéele, University of Copenhagen
Identifying Novel Neuropeptides from Human Brown and White Adipocytes
Identifying Novel Neuropeptides from Human Brown and White Adipocytes
Matthias Blüher, University of Leipzig
Identification of Human Obesity Subphenotypes by Adipose Tissue Signatures
Identification of Human Obesity Subphenotypes by Adipose Tissue Signatures
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Van Horne A
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Poster Session 3
7:30–10:00 PM
Van Horne C
Thursday, February 27, 2025
Departure
12:00–11:59 PM
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