Obesity Causes and Consequences
Feb 04–07, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers:
Giles S.H. Yeo, Karine Clément, and Murielle M. Véniant-Ellison
In Person
On Demand
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Feb 04–07, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Giles S.H. Yeo, Karine Clément, and Murielle M. Véniant-Ellison
Giles S.H. Yeo
Karine Clément
Murielle M. Véniant-Ellison
Available Formats:
Supported by the Directors' Fund
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandBooking Function
Fundraising
Merchandise Options
Registration Options
Sunday, February 4, 2024
Arrival and Registration
4:00–8:00 PM
British Columbia Foyer
Welcome Mixer
6:00–8:00 PM
British Columbia Foyer
Monday, February 5, 2024
Breakfast
7:00–8:00 AM
Pacific Ballroom, Vancouver Island Room
Welcome and Keynote Session (Joint)
8:00–9:30 AM
Columbia Ballroom
* Giles S.H. Yeo, University of Cambridge
Session Chair
Session Chair
* Ewan Pearson, University of Dundee
Session Chair
Session Chair
Stephen O'Rahilly, University of Cambridge
Leveraging Genetics to Understand Metabolic Disease
Leveraging Genetics to Understand Metabolic Disease
Jose C. Florez, Massachusetts General Hospital
Optimizing Precision Medicine Across Diverse Ethnicities
Optimizing Precision Medicine Across Diverse Ethnicities
Coffee Break
9:30–9:50 AM
British Columbia Foyer
Genetics of Obesity (Joint)
9:50–11:15 AM
Columbia Ballroom
* Andrea M. Haqq, University of Alberta
Session Chair
Session Chair
Kaja Wasik, Variant Bio
Metabolic Disease in the Context of Genetic Diversity
Metabolic Disease in the Context of Genetic Diversity
Peter R. Shepherd, University of Auckland
Population Specific Precision Medicine for Metabolic Disease
Population Specific Precision Medicine for Metabolic Disease
Kathrin Landgraf, Center for Pediatric Research, Hospital for Children and Adolescents, Medical Faculty, University of Leipzig
Short Talk: Short Talk: Ectopic ASIP Expression as a Monogenic cause of Childhood Obesity through Possible Interaction with the MC4R Pathway
Short Talk: Short Talk: Ectopic ASIP Expression as a Monogenic cause of Childhood Obesity through Possible Interaction with the MC4R Pathway
Yana Hrytsenko, Beth Israel Deaconess Medical Center, Harvard Medical School
Short Talk: Short Talk: Obstructive Sleep Apnea is Associated with Increased Genetic Risk of Incident Diabetes Mellitus: the Hispanic Community Health Study/Study of Latinos
Short Talk: Short Talk: Obstructive Sleep Apnea is Associated with Increased Genetic Risk of Incident Diabetes Mellitus: the Hispanic Community Health Study/Study of Latinos
Poster Setup
11:15–1:00 PM
Pacific Ballroom, Vancouver Island Room
On Own for Lunch
11:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Pacific Ballroom, Vancouver Island Room
Workshop 1
2:30–4:30 PM
Columbia Ballroom
* Antje Körner, Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) at Helmholtz Munich and Leipzig University
Session Chair
Session Chair
Rifa T Haque, Monash University
The Intestinal MC4R Promotes Weight Loss by Reducing Caloric Intake and Increasing Energy Expenditure
The Intestinal MC4R Promotes Weight Loss by Reducing Caloric Intake and Increasing Energy Expenditure
Chen Liu, University of Texas Southwestern Medical Center
Orthopedia Regulates Mc4r Transcription and Human Obesity Risk
Orthopedia Regulates Mc4r Transcription and Human Obesity Risk
Warren T Yacawych, University of Michigan
Different Roles in Food Intake Regulation for Distinct Populations of Dorsal Vagal Complex Glp1r Neurons
Different Roles in Food Intake Regulation for Distinct Populations of Dorsal Vagal Complex Glp1r Neurons
Claudia Anett Doege, Columbia University
Functional Genomics of Human Metabolic Disease at Single Cell Resolution
Functional Genomics of Human Metabolic Disease at Single Cell Resolution
Misbah Rashid, National Institute of Diabates, Digestive, and Kidney Diseases, National Institutes of Health
Presence of Beta-Arrestin-2 is Required for Melanocortin 4 Receptor-Mediated Metabolic Effects
Presence of Beta-Arrestin-2 is Required for Melanocortin 4 Receptor-Mediated Metabolic Effects
Jeevotham Senthil Kumar, Oklahoma State University
CTRP6-Mediated Suppression of Macrophage M2 Phenotype: Implications for Obesity-Associated Inflammation
CTRP6-Mediated Suppression of Macrophage M2 Phenotype: Implications for Obesity-Associated Inflammation
Hannah Swick, McGill / RI-MUHC
Glial Support of Neurovascular Function in Obesity
Glial Support of Neurovascular Function in Obesity
Coffee Available
4:30–5:00 PM
British Columbia Foyer
Response to Environment
5:00–7:00 PM
Columbia Ballroom
* Thomas Alexander Lutz, University of Zürich
Session Chair
Session Chair
Harriet Schellekens, University College Cork
Microbiota and Stress
Microbiota and Stress
Kevin D. Hall, NIDDK, National Institutes of Health
Ultra-Processed Foods and Obesity
Ultra-Processed Foods and Obesity
Anna Krook, Karolinska Institutet
Intertissue Communication Following an Exercise Bout in Type 2 Diabetes
Intertissue Communication Following an Exercise Bout in Type 2 Diabetes
Simon Krogh Bredum, Novo Nordisk A/S
Short Talk: Short Talk: Exploring Body Composition and Energy Expenditure Changes After Diet Restriction and Pharmacologically Induced Weight loss in a Göttingen Minipig Model of Obesity
Short Talk: Short Talk: Exploring Body Composition and Energy Expenditure Changes After Diet Restriction and Pharmacologically Induced Weight loss in a Göttingen Minipig Model of Obesity
Francois Briand, Physiogenex
Short Talk: Short Talk: Semaglutide and Lanifibranor Differentially Alter MASH and Liver Fibrosis in Diet-induced Obese Hamsters With or Without Free Access to Alcohol
Short Talk: Short Talk: Semaglutide and Lanifibranor Differentially Alter MASH and Liver Fibrosis in Diet-induced Obese Hamsters With or Without Free Access to Alcohol
Social Hour with Lite Bites
7:00–8:00 PM
Pacific Ballroom, Vancouver Island Room
Poster Session 1
7:30–10:00 PM
Pacific Ballroom, Vancouver Island Room
Tuesday, February 6, 2024
Breakfast
7:00–8:00 AM
Pacific Ballroom, Vancouver Island Room
Hypothalamic Dysfunction
8:00–11:30 AM
Columbia Ballroom
* Kevin L. Grove, Novo Nordisk
Session Chair
Session Chair
Giles S.H. Yeo, University of Cambridge
Mapping the Feeding Circuitry of the Human Hypothalamus
Mapping the Feeding Circuitry of the Human Hypothalamus
Sabrina Diano, Columbia University
Hypothalmic Nutrient Sensing
Hypothalmic Nutrient Sensing
Lora K. Heisler, Rowett Institute, University of Aberdeen
Hypothalamic Mechanisms of Obesity
Hypothalamic Mechanisms of Obesity
Martin G. Myers, Jr., University of Michigan
Hindbrain Circuits that Control Feeding
Hindbrain Circuits that Control Feeding
Michael A. Cowley, Monash University
Targeting Hypothalamic Weight-Loss Circuits
Targeting Hypothalamic Weight-Loss Circuits
Allison Duensing, University of Michigan
Short Talk: Short Talk: Glp1r-expressing LepRb Neurons of the Dorsomedial Hypothalamic Nucleus Inhibit AgRP Neurons and Suppress Body Weight
Short Talk: Short Talk: Glp1r-expressing LepRb Neurons of the Dorsomedial Hypothalamic Nucleus Inhibit AgRP Neurons and Suppress Body Weight
Addison Nicole Webster, University of Virginia
Short Talk: Short Talk: Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety
Short Talk: Short Talk: Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety
Coffee Break
9:00–9:20 AM
British Columbia Foyer
Poster Setup
11:00–1:00 PM
Pacific Ballroom, Vancouver Island Room
On Own for Lunch
11:00–5:00 PM
Health Equity Forum (Joint)
11:30–12:00 PM
Columbia Ballroom
Kaja Wasik, Variant Bio
Panelist
Panelist
Peter R. Shepherd, University of Auckland
Panelist
Panelist
Moneeza Siddiqui, Queen Mary University of London
Panelist
Panelist
Shivani Misra, Imperial College London
Panelist
Panelist
Moffat Nyirenda, London School of Hygiene and Tropical Medicine
Panelist
Panelist
Poster Viewing
1:00–10:00 PM
Pacific Ballroom, Vancouver Island Room
Workshop 2
2:30–4:30 PM
Columbia Ballroom
* Siegfried Ussar, Helmholtz Zentrum Muenchen GmbH
Session Chair
Session Chair
Christelle Le Foll, University of Zurich
Astrocyte Lipid Metabolism: How it Shapes your Appetite and Energy Balance
Astrocyte Lipid Metabolism: How it Shapes your Appetite and Energy Balance
Mary N. Teruel, Weill Cornell Medicine
Disrupted Circadian Glucocorticoid Rhythms and High Fat Diet Drive Obesity through Distinct Mechanisms
Disrupted Circadian Glucocorticoid Rhythms and High Fat Diet Drive Obesity through Distinct Mechanisms
John A. Tadross, University of Cambridge
HYPOMAP: A Spatio-cellular Atlas of the Human Hypothalamus
HYPOMAP: A Spatio-cellular Atlas of the Human Hypothalamus
Martijn van de Bunt, Cytoki Pharma
Novel Lipidated Interleukin-22 Reduces Body Weight, Lowers Plasma Glucose, and Improves Cardio-Metabolic Risk Factors in Mice
Novel Lipidated Interleukin-22 Reduces Body Weight, Lowers Plasma Glucose, and Improves Cardio-Metabolic Risk Factors in Mice
María Moreno López, INSERM
Unlocking Metabolic Benefits Effects of Sodium-Glucose-Co-Transporter-4 (SGLT4) Inhibition: From Mouse Studies to Clinical Translation
Unlocking Metabolic Benefits Effects of Sodium-Glucose-Co-Transporter-4 (SGLT4) Inhibition: From Mouse Studies to Clinical Translation
Klara Piletic, Kennedy Institute of Rheumatology, University of Oxford
Adipocyte Autophagy in the Control of Obese Adipose Tissue Inflammation and Remodelling
Adipocyte Autophagy in the Control of Obese Adipose Tissue Inflammation and Remodelling
Joon Ho Moon, Seoul National University
Dissecting Adipose Tissue at Single-Cell Resolution During Metabolic Disease Development
Dissecting Adipose Tissue at Single-Cell Resolution During Metabolic Disease Development
Rea P. Anunciado-Koza, Maine Medical Center Research Institute
Disruption of Mesoderm Specific Transcript (Mest) in Female Mice Alters Spontaneous Physical Activity and Protects Against Diet-induced Obesity
Disruption of Mesoderm Specific Transcript (Mest) in Female Mice Alters Spontaneous Physical Activity and Protects Against Diet-induced Obesity
Coffee Available
4:30–5:00 PM
British Columbia Foyer
Obesity Co-Morbidities
5:00–7:00 PM
Columbia Ballroom
* Karine Clément, INSERM / Sorbonne Universite
Session Chair
Session Chair
Amalia Gastaldelli, Institute of Clinical Physiology
Cardiometabolic Risk, Insulin Resistance and Obesity
Cardiometabolic Risk, Insulin Resistance and Obesity
Philipp E. Scherer, University of Texas Southwestern Medical Center
Why does Obesity Cause Diabetes?
Why does Obesity Cause Diabetes?
Sam Lockhart, Wellcome–MRC Institute of Metabolic Science, University of Cambridge
Short Talk: Short Talk: Damaging Mutations in LXRalpha Uncouple Lipogenesis from Hepatotoxicity and Implicate Hepatic Cholesterol Sensing in Human Liver Health
Short Talk: Short Talk: Damaging Mutations in LXRalpha Uncouple Lipogenesis from Hepatotoxicity and Implicate Hepatic Cholesterol Sensing in Human Liver Health
Reiner Jumpertz von Schwartzenberg, Helmholtz Center Munich
Short Talk: Short Talk: Mechanisms of Prediabetes Remission in People without Weight Loss and with Weight Gain
Short Talk: Short Talk: Mechanisms of Prediabetes Remission in People without Weight Loss and with Weight Gain
Meenakshi Gupta, National Institute of Health
Short Talk: Short Talk: G Proteins Gsa and Gq/11 in the Paraventricular Nucleus of the Hypothalamus (PVN) Mediate Distinct Cardiovascular and Metabolic Responses to Melanocortins
Short Talk: Short Talk: G Proteins Gsa and Gq/11 in the Paraventricular Nucleus of the Hypothalamus (PVN) Mediate Distinct Cardiovascular and Metabolic Responses to Melanocortins
CK Wong, LTRI
Short Talk: Short Talk: Body Weight-independent Anti-inflammatory Effects of GLP-1R Agonists via the Neuronal GLP-1R
Short Talk: Short Talk: Body Weight-independent Anti-inflammatory Effects of GLP-1R Agonists via the Neuronal GLP-1R
Social Hour with Lite Bites
7:00–8:00 PM
Pacific Ballroom, Vancouver Island Room
Poster Session 2
7:30–10:00 PM
Pacific Ballroom, Vancouver Island Room
Wednesday, February 7, 2024
Breakfast
7:00–8:00 AM
Pacific Ballroom, Vancouver Island Room
Precision Obesity Management (Joint)
8:00–11:00 AM
Columbia Ballroom
* Abd A Tahrani, Novo Nordisk
Session Chair
Session Chair
Karine Clément, INSERM / Sorbonne Universite
Precision Obesity Medicine in Practice
Precision Obesity Medicine in Practice
Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute
The GLP1/GIP System in Obesity Management
The GLP1/GIP System in Obesity Management
Moneeza Siddiqui, Queen Mary University of London
Insights From Genetic and Observational Studies in South Asian Populations
Insights From Genetic and Observational Studies in South Asian Populations
Sarah Berry, King's College London
Personalized Nutrition in Obesity Management
Personalized Nutrition in Obesity Management
Jordan B. Wean, University of Michigan
Short Talk: Short Talk: GABAergic GIPR-expressing Neurons are Required for the Body Weight Reduction caused by Dual Incretin Agonists
Short Talk: Short Talk: GABAergic GIPR-expressing Neurons are Required for the Body Weight Reduction caused by Dual Incretin Agonists
Coffee Break
9:00–9:20 AM
British Columbia Foyer
On Own for Lunch
11:00–5:00 PM
Career Roundtable (Joint)
3:00–4:30 PM
British Ballroom
Jose C. Florez, Massachusetts General Hospital
Physician-in-Chief, Chair, and Professor
Physician-in-Chief, Chair, and Professor
Leslie J. Baier, National Institutes of Health
Section Chief: Diabetes Molecular Genetics Section
Section Chief: Diabetes Molecular Genetics Section
Kyle Kai-How Farh, Illumina
VP & Distinguished Scientist
VP & Distinguished Scientist
Sarah Berry, King's College London
Reader & Associate Professor
Reader & Associate Professor
Coffee Available
4:30–5:00 PM
British Columbia Foyer
Obesity Co-Morbidities and New Therapeutic Avenues
5:00–6:45 PM
Columbia Ballroom
* Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School
Session Chair
Session Chair
Katherine R. Tuttle, University of Washington
Kidney Disease and Obesity
Kidney Disease and Obesity
Murielle M. Véniant-Ellison, Amgen Inc.
Targeting GLP-1/GIPR in a Novel Bispecific Mechanism to Advance a Longer-acting Therapy for Weight Loss: Maridebart Cafraglutide (AMG 133)
Targeting GLP-1/GIPR in a Novel Bispecific Mechanism to Advance a Longer-acting Therapy for Weight Loss: Maridebart Cafraglutide (AMG 133)
Inderjeet Singh, Helmholtz Zentrum Munich
Short Talk: Short Talk: Nrac Regulates Fatty Acid Import in Adipocytes via Regulating CD36 Localization
Short Talk: Short Talk: Nrac Regulates Fatty Acid Import in Adipocytes via Regulating CD36 Localization
Frederike Sass, University of Copenhagen
Short Talk: Short Talk: Dual Energy Expenditure and Appetite Control by Insulin-Sensitizing NK2R Agonism
Short Talk: Short Talk: Dual Energy Expenditure and Appetite Control by Insulin-Sensitizing NK2R Agonism
Patrick Swan, Ulster University
Short Talk: Short Talk: Alpha-melanocyte Stimulatory Hormone (α-MSH): A Novel Mediator of Skeletal Muscle Glucose Uptake in Humans
Short Talk: Short Talk: Alpha-melanocyte Stimulatory Hormone (α-MSH): A Novel Mediator of Skeletal Muscle Glucose Uptake in Humans
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Columbia Ballroom
Social Hour with Lite Bites
7:00–8:00 PM
Pacific Ballroom, Vancouver Island Room
Cash Bar
8:00–9:00 PM
Pacific Ballroom, Vancouver Island Room
Thursday, February 8, 2024
Departure
7:00–11:59 PM
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