Imaging Biomolecules Across Scales: From Atoms to Tissues
Mar 23–26, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Elizabeth Villa, Bridget Carragher, and Ilaria Testa
In Person
On Demand
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Mar 23–26, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Elizabeth Villa, Bridget Carragher, and Ilaria Testa
Elizabeth Villa
Bridget Carragher
Ilaria Testa
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandFundraising
Sunday, March 23, 2025
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Longs Peak Foyer
Welcome Mixer
6:00–8:00 PM
Longs Peak Foyer
Monday, March 24, 2025
Breakfast
7:00–8:00 AM
Shavano/Torreys Peaks
Welcome and Keynote Address (Joint)
8:00–9:00 AM
Longs Peak/Grays Peak
* Elizabeth Villa, University of California, San Diego
Session Chair
Session Chair
* Mohammed AlQuraishi, Columbia University
Session Chair
Session Chair
Wolfgang P. Baumeister, Max Planck Institute of Biochemistry
Cryo-Electron Tomography or the Power of Seeing the Whole Picture
Cryo-Electron Tomography or the Power of Seeing the Whole Picture
Machine Learning for Protein Structure (Joint)
9:00–11:30 AM
Longs Peak/Grays Peak
* Julia Rogers, Columbia University
Session Chair
Session Chair
Hannah Wayment-Steele, University of Wisconsin-Madison
Have Protein Language Models Learned Dynamics
Have Protein Language Models Learned Dynamics
Sergey Ovchinnikov, MIT
Hacking AlphaFold to Do New Things
Hacking AlphaFold to Do New Things
* Mohammed AlQuraishi, Columbia University
Understanding How AlphaFold Learns
Understanding How AlphaFold Learns
Fabian C Spoendlin, University of Oxford
Short Talk: Predicting the Conformational Flexibility of Antibody and T-cell Receptor CDRs
Short Talk: Predicting the Conformational Flexibility of Antibody and T-cell Receptor CDRs
Katrina Black, UCSF
Short Talk: Improving Cryo-EM of Vesicle-Embedded Membrane Proteins: A Machine Learning Pipeline for Lipid Bilayer Subtraction
Short Talk: Improving Cryo-EM of Vesicle-Embedded Membrane Proteins: A Machine Learning Pipeline for Lipid Bilayer Subtraction
Coffee Break
9:30–9:50 AM
Longs Peak Foyer
Poster Setup
11:30–1:00 PM
Shavano/Torreys Peaks
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
Shavano/Torreys Peaks
Symposia Spotlight 1: Orthogonal Technologies
3:00–4:30 PM
Longs Peak
* Bridget Carragher, Chan Zuckerberg Imaging Institute
Session Chair
Session Chair
Aneesh Deshmukh, University of Southern California
3D Cell Mapping of Insulin Secretory Granule Maturation using Soft X-ray Tomography
3D Cell Mapping of Insulin Secretory Granule Maturation using Soft X-ray Tomography
Margot Riggi, MPI for Biochemistry
Bringing it All Together: 3D Animation for Integrative Modeling of Complex Molecular Mechanisms
Bringing it All Together: 3D Animation for Integrative Modeling of Complex Molecular Mechanisms
Christopher J Ackerson, Colorado State University
Cloneable Inorganic Nanoparticles
Cloneable Inorganic Nanoparticles
Yujia Zhang, Oregon Health Science University
Multiplexed Super-resolution Imaging of Cells and Clinical Tissue Sections from Nanometer to Millimeter Scales
Multiplexed Super-resolution Imaging of Cells and Clinical Tissue Sections from Nanometer to Millimeter Scales
Zhuowen (Kevin) Zhao, Chan Zuckerberg Imaging Institute
The Machine Learning Challenge for CryoET Annotation: A report on the Winning Models
The Machine Learning Challenge for CryoET Annotation: A report on the Winning Models
Josh Hutchings, Chan Zuckerberg Imaging Institute
Structural Analysis of Lysosomal Proteins via Cryo-Electron Tomography of Affinity-Captured Organelles
Structural Analysis of Lysosomal Proteins via Cryo-Electron Tomography of Affinity-Captured Organelles
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Structure Determination of Challenging Complexes in vitro and in situ
5:00–6:45 PM
Longs Peak
Lori A Passmore, MRC Laboratory of Molecular Biology
Imaging DNA Repair Proteins, One Molecule at a Time
Imaging DNA Repair Proteins, One Molecule at a Time
Dimitry Tegunov, Genentech
Enabling High-Resolution Structure Determination In Situ
Enabling High-Resolution Structure Determination In Situ
Eshan Mehrotra, University of California, San Francisco
Short Talk: Cryo-ET Reveals Novel Assemblies in Olfactory Cilia
Short Talk: Cryo-ET Reveals Novel Assemblies in Olfactory Cilia
Sheena Vasquez, Stanford University
Short Talk: Towards Structurally Characterizing Nitrosomonas Europaea Enzymes in vivo for Wastewater Nitrogen Refinement
Short Talk: Towards Structurally Characterizing Nitrosomonas Europaea Enzymes in vivo for Wastewater Nitrogen Refinement
* Andres E Leschziner, UC San Diego
Regulation of LRRK2: Identifying Vulnerabilities for Parkinson’s Disease Therapeutics
Regulation of LRRK2: Identifying Vulnerabilities for Parkinson’s Disease Therapeutics
Social Hour with Lite Bites
7:00–8:00 PM
Shavano/Torreys Peaks
Women in Science Networking Session
7:05–8:00 PM
Crestone Foyer
Elizabeth Kellogg, St. Jude Children's Research Hospital
Session Chair
Session Chair
Elizabeth Villa, University of California, San Diego
Session Chair
Session Chair
Bridget Carragher, Chan Zuckerberg Imaging Institute
Session Chair
Session Chair
Suliana Manley, École Polytechnique Fédérale de Lausanne
Session Chair
Session Chair
Poster Session 1
7:30–10:00 PM
Shavano/Torreys Peaks
Tuesday, March 25, 2025
Breakfast
7:00–8:00 AM
Shavano/Torreys Peaks
CryoET/EM and Machine Learning (Joint)
8:00–11:00 AM
Longs Peak/Grays Peak
* Allison Doerr, Springer Nature
Session Chair
Session Chair
Bridget Carragher, Chan Zuckerberg Imaging Institute
Tools and Technologies for Accelerating cryoET
Tools and Technologies for Accelerating cryoET
* Bronwyn A Lucas, University of California Berkeley
Single Molecule Localization and Structure Probing in Cells
Single Molecule Localization and Structure Probing in Cells
Elizabeth Villa, University of California, San Diego
Discovering New Biology with Cryo-ET
Discovering New Biology with Cryo-ET
Elizabeth Kellogg, St. Jude Children's Research Hospital
Structural Insights into CRISPR-Based Genome Editing
Structural Insights into CRISPR-Based Genome Editing
Yuriy Chaban, Diamond Light Source ltd.
Short Talk: Automated Filtering of Particle Images in Single Particle CryoEM
Short Talk: Automated Filtering of Particle Images in Single Particle CryoEM
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Longs Peak/Grays Peak
Poster Setup
11:00–1:00 PM
Shavano/Torreys Peaks
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Shavano/Torreys Peaks
Career Roundtable (Joint)
3:00–4:30 PM
Grays Peak
Kate L. White, University of Southern California
Assistant Professor
Assistant Professor
Christina Y Ivashchenko, Novo Nordisk
Director of Scientific Projects
Director of Scientific Projects
John E Mahoney, Cystic Fibrosis Foundation
Head of Stem Cell Biology
Head of Stem Cell Biology
Ernesto Andrianantoandro, Cell Press
Scientific Editor, Cell Systems
Scientific Editor, Cell Systems
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
The Big Picture: Capturing Events with Large-Volume EM and CLEM
5:00–6:45 PM
Longs Peak
Virginie Hamel, University of Geneva
Unveiling the Architecture of the Cell by Combining cryoET and Ultrastructure Expansion Microscopy
Unveiling the Architecture of the Cell by Combining cryoET and Ultrastructure Expansion Microscopy
Adam Frost, Altos Labs
Predictions and Probes of Membrane Structure
Predictions and Probes of Membrane Structure
* Kate L. White, University of Southern California
Soft X-Ray Tomography: Unraveling the Mysteries of Cellular Biochemistry
Soft X-Ray Tomography: Unraveling the Mysteries of Cellular Biochemistry
Ami U Thakrar, Massachusetts Institute of Technology
Short Talk: Time-resolved High-pressure Freezing for Dynamic, Nanoscale Imaging
Short Talk: Time-resolved High-pressure Freezing for Dynamic, Nanoscale Imaging
Social Hour with Lite Bites
7:00–8:00 PM
Shavano/Torreys Peaks
Poster Session 2
7:30–10:00 PM
Shavano/Torreys Peaks
Wednesday, March 26, 2025
Breakfast
7:00–8:00 AM
Shavano/Torreys Peaks
Light Microscopy Comes to Structure
8:00–11:15 AM
Longs Peak
Eric Mulhall, The Scripps Research Institute
Linking the Structure, Mechanics, and Function of PIEZO Ion Channels with Fluorescence Nanoscopy
Linking the Structure, Mechanics, and Function of PIEZO Ion Channels with Fluorescence Nanoscopy
* Ilaria Testa, KTH Royal Institute of Technology
From Cells to STARSS: Monitoring the Life of Proteins at the Nanoscale
From Cells to STARSS: Monitoring the Life of Proteins at the Nanoscale
Joerg Bewersdorf, Yale University
All-Optical Super-Resolution Imaging of Molecules in Their Nanoscale Cellular Context
All-Optical Super-Resolution Imaging of Molecules in Their Nanoscale Cellular Context
Francisco Balzarotti, Research Institute for Molecular Pathology
Accessing the Nanoscale with Light Microscopy
Accessing the Nanoscale with Light Microscopy
Peter Dahlberg, Stanford University
Correlating Cryogenic Light and Electron Microscopy at the Nanoscale
Correlating Cryogenic Light and Electron Microscopy at the Nanoscale
Andres Jaschke, Heidelberg University
Short Talk: Illuminating RNA in Living Mammalian Cells: NIR Aptamer Advances for Super-Resolved Imaging
Short Talk: Illuminating RNA in Living Mammalian Cells: NIR Aptamer Advances for Super-Resolved Imaging
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Technological Breakthroughs
3:00–4:30 PM
Longs Peak
Philipp S Erdmann, Human Technopole
SOLIST: Unlocking Molecular Landscapes Across Scales
SOLIST: Unlocking Molecular Landscapes Across Scales
Daphne-Eleni Archonta, Harvard University
VIS-À-VIS: Visualization and Vitrification after Stimulation
VIS-À-VIS: Visualization and Vitrification after Stimulation
* Shawn Zheng, CZ Imaging Institute
High throughput Real-time Reconstruction of Fully Rorrected and Contrast Enhanced cryoET Tomograms
High throughput Real-time Reconstruction of Fully Rorrected and Contrast Enhanced cryoET Tomograms
Léa Lecomte, EMBL - Grenoble
EasyGrid: A Versatile Platform for Automated Cryo-EM Sample Preparation and Control
EasyGrid: A Versatile Platform for Automated Cryo-EM Sample Preparation and Control
Kexin Zhang, UMass Chan Medical School
Improved Cryo-EM Reconstruction of Sub-50 kDa Complexes using 2DTM
Improved Cryo-EM Reconstruction of Sub-50 kDa Complexes using 2DTM
Lindsey Young, University of California, San Diego
Expanding the ToolKit for Cellular Tomography: Delivery into Live Cells of a cryo-CLEM Nanogold Tag for Structural Cell Biology
Expanding the ToolKit for Cellular Tomography: Delivery into Live Cells of a cryo-CLEM Nanogold Tag for Structural Cell Biology
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Bringing Molecules to Life with Live Cell Imaging at High Resolution
5:00–6:15 PM
Longs Peak
* Peter Dahlberg, Stanford University
Session Chair
Session Chair
Suliana Manley, École Polytechnique Fédérale de Lausanne
Mitochondrial Dynamic and Structural States Underpinning Homeostasis
Mitochondrial Dynamic and Structural States Underpinning Homeostasis
Ralf Jungmann, Max Planck Institute of Biochemistry
DNA-PAINTs, SOMAmers and Ultra-Resolution Fluorescence Localizomics of DNA, RNA and Protein Interactions
DNA-PAINTs, SOMAmers and Ultra-Resolution Fluorescence Localizomics of DNA, RNA and Protein Interactions
Thomas A Hensel, Max Planck Institute for Multidisciplinary Natural Sciences
Short Talk: Co-Localization and Dynamics of Multiple Fluorescent Labels at the Molecular Scale
Short Talk: Co-Localization and Dynamics of Multiple Fluorescent Labels at the Molecular Scale
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:15–6:30 PM
Longs Peak
Social Hour with Lite Bites
7:00–8:00 PM
Shavano/Torreys Peaks
Entertainment
8:00–9:00 PM
Longs Peak
Cash Bar
8:00–9:00 PM
Shavano/Torreys Peaks
Thursday, March 27, 2025
Departure
12:00–11:59 PM
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