Joint with: Systems and Engineering Immunology: Advancing Immunological Insights in Health and Disease
Innate Immunity Across the Molecular, Cellular, Tissue and Therapeutic
Apr 09–12, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Kate L. Jeffrey, Ramnik Xavier and Xu Zhou
In Person
On Demand
Apr 09–12, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Kate L. Jeffrey, Ramnik Xavier and Xu Zhou
Available Formats:
Supported by the Directors' Fund
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMerchandise Options
Registration Options
Booking Function
Fundraising
Tuesday, April 9, 2024
Arrival and Registration
4:00–8:00 PM
Van Horne Foyer
Welcome Mixer
6:00–8:00 PM
Van Horne Foyer
Wednesday, April 10, 2024
Breakfast
7:00–8:00 AM
President's Hall
Welcome and Keynote Address
8:00–9:00 AM
Van Horne A
Ramnik Xavier, Massachusetts General Hospital
Variants Linked to Functional Phenotypes and Causal Mechanisms in Relevant Cell Types
Variants Linked to Functional Phenotypes and Causal Mechanisms in Relevant Cell Types
Sensing of Microbial Friends and Enemies
9:00–11:15 AM
Van Horne A
Marco Colonna, Washington University School of Medicine
Activating and Inhibitory Innate Immune Receptors in Neurodegeneration
Activating and Inhibitory Innate Immune Receptors in Neurodegeneration
Virginia Pascual, Cornell University
Talk Title to be Announced
Talk Title to be Announced
Nandan S Gokhale, University of Washington
Short Talk: Short Talk: Cellular RNA Interacts with MAVS to Promote Antiviral Signaling
Short Talk: Short Talk: Cellular RNA Interacts with MAVS to Promote Antiviral Signaling
Diep H. Nguyen, MIT/Whitehead Institute
Short Talk: Short Talk: Spatial Gradients of Pathogen-sensing Capability Confer a Tiered Tissue Self-Defense System
Short Talk: Short Talk: Spatial Gradients of Pathogen-sensing Capability Confer a Tiered Tissue Self-Defense System
Coffee Break
9:30–9:50 AM
Van Horne Foyer
Poster Setup
11:15–1:00 PM
Van Horne C
On Own for Lunch
11:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Workshop 1: Inflammasomes in Sickness and in Health
2:30–4:30 PM
Van Horne A
Daniel Okin, Massachusetts General Hospital
Tissue Stiffness is a Fundamental Regulator of NLRP3 Inflammasome Activities
Tissue Stiffness is a Fundamental Regulator of NLRP3 Inflammasome Activities
Pritisha Rozario, Nanyang Technological University
Mechanistic Basis for Potassium Efflux Driven Activation of the Human NLRP1 Inflammasome
Mechanistic Basis for Potassium Efflux Driven Activation of the Human NLRP1 Inflammasome
Ben A. Croker, University of California San Diego
GSDME Promotes PAD4 Activation and DNA Externalization from Apoptotic Neutrophils
GSDME Promotes PAD4 Activation and DNA Externalization from Apoptotic Neutrophils
Maria Luisa Gil Marques, Massachusetts General Hospital. Harvard Medical School
Interaction Between NLRP11, CASP4, and LPS in the Context of the Innate Immune Response to Bacterial Pathogens
Interaction Between NLRP11, CASP4, and LPS in the Context of the Innate Immune Response to Bacterial Pathogens
Charles L. Evavold, Harvard University
Sterol-izing Immunity: Cholesterol Control of Mammalian Gasdermins
Sterol-izing Immunity: Cholesterol Control of Mammalian Gasdermins
Simone Caielli, Weill Cornell Medical College - Drukier Institute For Children's Health
An Unconventional Mechanism of IL-1b Secretion that Requires Type I IFN in SLE Monocytes
An Unconventional Mechanism of IL-1b Secretion that Requires Type I IFN in SLE Monocytes
Tsan Sam Xiao, Case Western Reserve University
S-palmitoylation of Gasdermins Regulate Their Function in Membrane Pore Formation and Pyroptotic Cell Death
S-palmitoylation of Gasdermins Regulate Their Function in Membrane Pore Formation and Pyroptotic Cell Death
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Innate Immunity 2.0: Epigenetics
5:00–7:00 PM
Van Horne A
Kate L. Jeffrey, Moderna and Harvard Medical School
Chromatin Readers and Inflammation
Chromatin Readers and Inflammation
Steven Z. Josefowicz, Weill Cornell Medical College
Signaling to Chromatin for Rapid Innate Immunity
Signaling to Chromatin for Rapid Innate Immunity
Liraz Galia, UTSW Medical center
Talk Title to be Announced
Talk Title to be Announced
Theresa Alenghat, Cincinnati Children’s Hospital
Epigenetic Regulation of the Host-microbiota Relationship
Epigenetic Regulation of the Host-microbiota Relationship
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Poster Session 1
7:30–10:00 PM
Van Horne C
Thursday, April 11, 2024
Breakfast
7:00–8:00 AM
President's Hall
Innate Immunity in 3D
8:00–11:00 AM
Van Horne A
Xu Zhou, Boston Children's Hospital
Environmental Control of Inflammatory Response
Environmental Control of Inflammatory Response
Miguel Soares, Instituto Gulbenkian de Ciência
Tissue Tolerance to Infection
Tissue Tolerance to Infection
Andrés Hidalgo, Yale School of Medicine
Neutrophil Dynamic Behavior
Neutrophil Dynamic Behavior
Sacha Lebon, Weizmann Institute of Science
Short Talk: Short Talk: Dissecting a Novel Stem-Cell Defense Mechanism in Early Epithelial-Specific Responses to an Enteric Bacterial Pathogen
Short Talk: Short Talk: Dissecting a Novel Stem-Cell Defense Mechanism in Early Epithelial-Specific Responses to an Enteric Bacterial Pathogen
Alexandra Wells, University of Texas Southwestern Medical Center
Short Talk: Short Talk: Characterization of Interferon-Induced Gene Expression in the Mouse Lung and Liver
Short Talk: Short Talk: Characterization of Interferon-Induced Gene Expression in the Mouse Lung and Liver
Elizabeth F Rowland, University of Illinois at Urbana-Champaign
Short Talk: Short Talk: High Resolution 3D Spatial-Temporal Mapping of Influenza A Virus Infection and Innate Immune Signaling in Whole Lung Organs Reveals the Early Spatial Interplay of Viral Spread and Host Response
Short Talk: Short Talk: High Resolution 3D Spatial-Temporal Mapping of Influenza A Virus Infection and Innate Immune Signaling in Whole Lung Organs Reveals the Early Spatial Interplay of Viral Spread and Host Response
Julia Bayer, University of Bern
Short Talk: Short Talk: Spatial Transcriptomics Reveals Interaction of Mesothelial Cells with Injury-Derived Osteopontin in Serosal Scarring
Short Talk: Short Talk: Spatial Transcriptomics Reveals Interaction of Mesothelial Cells with Injury-Derived Osteopontin in Serosal Scarring
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Poster Setup
11:00–1:00 PM
Van Horne C
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Career Roundtable (Joint)
3:00–4:30 PM
Van Horne B
Sarah Teichmann, Wellcome Sanger Institute
Head of Cellular Genetics and Senior Group Leader, Co-Founder and Principal Leader of Human Cell Atlas
Head of Cellular Genetics and Senior Group Leader, Co-Founder and Principal Leader of Human Cell Atlas
Kara Lassen, Roche
VP and Global Head, Immunology Therapeutic Area
VP and Global Head, Immunology Therapeutic Area
Bryan D. Bryson, Massachusetts Institute of Technology
Associate Professor
Associate Professor
Jonathan Sockolosky, Curie.Bio
Senior Director, CSO Partner Team
Senior Director, CSO Partner Team
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Innate Immune Protectors and Drivers of Disease
5:00–7:00 PM
Van Horne A
Yasmine Belkaid, Pasteur Institut
Remote Presentation: Microbial Control of Tissue Threshold of Activation
Remote Presentation: Microbial Control of Tissue Threshold of Activation
Bryan D. Bryson, Massachusetts Institute of Technology
Unraveling TB Granuloma Phagocyte Heterogeneity
Unraveling TB Granuloma Phagocyte Heterogeneity
Kara Lassen, Roche
Fibroblasts in Chronic Inflammatory Diseases
Fibroblasts in Chronic Inflammatory Diseases
Hernandez Moura Moura Silva, Massachusetts Institute of Technology
Short Talk: Short Talk: Decoding Immune Mediated Circuits Supporting Tissue Physiology
Short Talk: Short Talk: Decoding Immune Mediated Circuits Supporting Tissue Physiology
Disha Sood, Sanofi
Short Talk: Short Talk: Astrocyte Sensitivity to Nucleic Acid Agonism Contributes to Neurodegeneration in iPSC-Derived Tri-Culture Models of Amyotrophic Lateral Sclerosis
Short Talk: Short Talk: Astrocyte Sensitivity to Nucleic Acid Agonism Contributes to Neurodegeneration in iPSC-Derived Tri-Culture Models of Amyotrophic Lateral Sclerosis
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Poster Session 2
7:30–10:00 PM
Van Horne C
Friday, April 12, 2024
Breakfast
7:00–8:00 AM
President's Hall
The Emerging, Unexpected and New Frontiers (Joint)
8:00–11:00 AM
Van Horne A
Sarah Teichmann, Wellcome Sanger Institute
Cell Atlas Mapping of the Immune System Across Organs
Cell Atlas Mapping of the Immune System Across Organs
Graham Heimberg, Genentech, Inc.
SCimilarity Queries Reveal Connections across Macrophage Populations
SCimilarity Queries Reveal Connections across Macrophage Populations
Nicolas Chevrier, University of Chicago
Decoding the Body Language of Immunity
Decoding the Body Language of Immunity
Subhajit Poddar, University of Pennsylvania
Short Talk: Short Talk: STING Modulates Golgi pH, Cargo Sorting, and Secretion Through ArfGAP2
Short Talk: Short Talk: STING Modulates Golgi pH, Cargo Sorting, and Secretion Through ArfGAP2
Toufic Mayassi, Broad Institute
Short Talk: Short Talk: Molecular Cartography Reveals Robust, Adaptable, and Resilient Intestinal Networks
Short Talk: Short Talk: Molecular Cartography Reveals Robust, Adaptable, and Resilient Intestinal Networks
Shubham Tripathi, Yale School of Medicine
Short Talk: Short Talk: Role of a Cellular Circuit Involving IFN-γ / IL-15 Positive Feedback in Establishing Antigen-Non-Specific Immune Memory
Short Talk: Short Talk: Role of a Cellular Circuit Involving IFN-γ / IL-15 Positive Feedback in Establishing Antigen-Non-Specific Immune Memory
Tomer Milo, Weizmann Institute of Science
Short Talk: Short Talk: A Paradox of Foreign-Specific Regulatory T Cells and a Proposed Resolution by a Lymph Node Microdomain Theory
Short Talk: Short Talk: A Paradox of Foreign-Specific Regulatory T Cells and a Proposed Resolution by a Lymph Node Microdomain Theory
Coffee Break
9:00–9:20 AM
Van Horne Foyer
On Own for Lunch
11:00–5:00 PM
Workshop 2: Single Cell to Tissue-Level Immunity
2:30–4:30 PM
Van Horne A
Ayshwarya Subramanian, Cornell University
Immune Checkpoint Molecule Tim-3 Regulates Microglial Function and the Development of Alzheimer’s Disease Pathology
Immune Checkpoint Molecule Tim-3 Regulates Microglial Function and the Development of Alzheimer’s Disease Pathology
Tasuku Nishimura, Kumamoto University
Non-Canonical Type I Interferons are Induced by Cholesterol Restriction and Prime RIG-I-Mediated Antiviral Innate Immune Responses
Non-Canonical Type I Interferons are Induced by Cholesterol Restriction and Prime RIG-I-Mediated Antiviral Innate Immune Responses
Rio Sugimura, HKU
Cancer and Vascular Immune Assembloids Model the Oncofoetal Niche in the Solid Tumor Microenvironment
Cancer and Vascular Immune Assembloids Model the Oncofoetal Niche in the Solid Tumor Microenvironment
Stephanie Hajjar, Boston Children's Hospital
Exploring the Role of GPR65-Mediated pH Sensing in Tuning Systemic and Local Immune Responses
Exploring the Role of GPR65-Mediated pH Sensing in Tuning Systemic and Local Immune Responses
Kiara Wiggins, UC Irvine
TLR4’S Impact on Pcos Outcomes in Letrozole-induced Mouse Model
TLR4’S Impact on Pcos Outcomes in Letrozole-induced Mouse Model
Siyan Cao, Washington University in St. Louis
Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets
Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets
Victoria Schuster, Oregon Health and Sciences University
Multi-Antigen Management by Dendritic Cells Within the Melanoma Microenvironment
Multi-Antigen Management by Dendritic Cells Within the Melanoma Microenvironment
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Therapeutics - Leveraging and Avoiding Innate Immunity
5:00–6:45 PM
Van Horne A
Joseph R. Arron, Sonoma Biotherapeutics
Engineered Treg Therapies for Inflammatory Disorders
Engineered Treg Therapies for Inflammatory Disorders
Martin Oft, Synthekine
Talk Title to be Announced
Talk Title to be Announced
Eicke Latz, University of Bonn
Drugging Innate Immunity
Drugging Innate Immunity
Lingyin Li, Stanford University and Arc Institute
Short Talk: Short Talk: Chemical Biology of Extracellular cGAMP Signaling in Health and Disease
Short Talk: Short Talk: Chemical Biology of Extracellular cGAMP Signaling in Health and Disease
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Van Horne A
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Trivia!
8:00–9:00 PM
Van Horne A
Cash Bar
8:00–9:00 PM
President's Hall
Saturday, April 13, 2024
Departure
7:00–11:59 PM
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