Systems and Engineering Immunology: Advancing Immunological Insights in Health and Disease
Apr 09–12, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
John Tsang, Shannon J Turley and Alex Marson
In Person
Apr 09–12, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
John Tsang, Shannon J Turley and Alex Marson
Available Formats:
Supported by the Directors' Fund
In Person
***Meeting program subject to change.
Available Formats: = In PersonMerchandise Options
Registration Options
Booking Function
Fundraising
Tuesday, April 9, 2024
Arrival and Registration
4:00–8:00 PM
Van Horne Foyer
Welcome Mixer
6:00–8:00 PM
Van Horne Foyer
Wednesday, April 10, 2024
Breakfast
7:00–8:00 AM
President's Hall
Systems Immunology: Signatures and Mechanisms
8:00–11:00 AM
Van Horne B
Mark M. Davis, Stanford University School of Medicine, Howard Hughes
Of Human, Mouse, and Organoid Immune Systems
Of Human, Mouse, and Organoid Immune Systems
John Tsang, Yale University School of Medicine
The Systems Immunology of Immune Set Points
The Systems Immunology of Immune Set Points
Aleksandra Walczak, École Normale Supérieure
Decoding Immune Repertoires
Decoding Immune Repertoires
Rachelly Normand, Massachusetts General Hospital
Short Talk: Short Talk: Modeling the Effect of Immune Cell Infiltration on Tissue Function Reveals Cellular Rewiring Driving Human Thyroid Autoimmunity
Short Talk: Short Talk: Modeling the Effect of Immune Cell Infiltration on Tissue Function Reveals Cellular Rewiring Driving Human Thyroid Autoimmunity
Guangbo Chen, Stanford University
Short Talk: Short Talk: Pre-Vaccination Type I Interferon Abundance is Rate-Limiting for Post-Vaccination Influenza Antibody Response Among Human Populations
Short Talk: Short Talk: Pre-Vaccination Type I Interferon Abundance is Rate-Limiting for Post-Vaccination Influenza Antibody Response Among Human Populations
Coffee Break
9:30–9:50 AM
Van Horne Foyer
Poster Setup
11:15–1:00 PM
Van Horne C
On Own for Lunch
11:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Workshop 1: Organoids and Model Systems for Systems and Engineering Immunology
2:30–4:30 PM
Van Horne B
Yuri Pritykin, Princeton University
Ultra-Long-Range and Interchromosomal Looping and Compartmentalization in Regulatory T Cell Genome
Ultra-Long-Range and Interchromosomal Looping and Compartmentalization in Regulatory T Cell Genome
Stefan Schattgen, St Jude Children's Research Hospital
MetaCoNGA: A Comprehensive Multi-Modal Index of Human T Cell Phenotype and Specificity
MetaCoNGA: A Comprehensive Multi-Modal Index of Human T Cell Phenotype and Specificity
Alma-Martina Cepika, Stanford School of Medicine
Integration of Systems Biology Analysis and CRISPR-based Functional Epigenomics Reveals the Key Transcriptional Regulators of Human Antigen-Inducible Tregs
Integration of Systems Biology Analysis and CRISPR-based Functional Epigenomics Reveals the Key Transcriptional Regulators of Human Antigen-Inducible Tregs
Ruby Lunde, Bristol Myers Squibb
Automated Analytical Pipeline for Cell Therapy Hypothesis Generation
Automated Analytical Pipeline for Cell Therapy Hypothesis Generation
Daniel P Caron, Columbia University Irving Medical Center
Multimodal Hierarchical Classification of CITE-Seq Data Enables Delineation of Tissue-Specific Signatures Shared Across Human Immune Cell Subsets
Multimodal Hierarchical Classification of CITE-Seq Data Enables Delineation of Tissue-Specific Signatures Shared Across Human Immune Cell Subsets
Aditya Murthy, Gilead Sciences
Decoding Regulators of Inflammatory Macrophage States Through Functional Genomics
Decoding Regulators of Inflammatory Macrophage States Through Functional Genomics
Jishnu Das, University of Pittsburgh
Sliding Window Interaction Grammar (SWING) - a Generalized Interaction Language Model for Decoding Biological Interactions
Sliding Window Interaction Grammar (SWING) - a Generalized Interaction Language Model for Decoding Biological Interactions
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Programming and Engineering Immune Cells: Understand to Build and Build to Understand
5:00–7:00 PM
Van Horne B
Alex Marson, Gladstone Institutes, University of California, San Francisco
Genomics Programming of Human T Cells
Genomics Programming of Human T Cells
Jenny McGovern, Quell Therapeutics
Regulatory T Cell Engineering
Regulatory T Cell Engineering
Mirco J Friedrich, MIT
Short Talk: Short Talk: Reprogramming T Cell Aging with a Transient mRNA Intervention
Short Talk: Short Talk: Reprogramming T Cell Aging with a Transient mRNA Intervention
Yiming Yin, Boston Children's Hospital
Short Talk: Short Talk: Affinity Maturation of CRISPR-Engineered B-Cell Receptors in vivo
Short Talk: Short Talk: Affinity Maturation of CRISPR-Engineered B-Cell Receptors in vivo
Nicholas Kalogriopoulos, Stanford University
Short Talk: Short Talk: Programmable Synthetic GPCRs for Customized Antigen-dependent Control of Cell Behaviors
Short Talk: Short Talk: Programmable Synthetic GPCRs for Customized Antigen-dependent Control of Cell Behaviors
Alissa Danford, UC Berkeley
Short Talk: Short Talk: Depletion of Intratumoral Tregs Enhances Tumor Immunity Locally and Systemically Against Disseminated Metastatic Cancer
Short Talk: Short Talk: Depletion of Intratumoral Tregs Enhances Tumor Immunity Locally and Systemically Against Disseminated Metastatic Cancer
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Poster Session 1
7:30–10:00 PM
Van Horne C
Thursday, April 11, 2024
Breakfast
7:00–8:00 AM
President's Hall
Immunoreceptors: Specificities, Interactions, and Engineering
8:00–11:00 AM
Van Horne B
Frederick A. Matsen IV, Fred Hutchinson Cancer Research Center
Deconvolving Mutation and Selection in Antibody Evolution using Neural Networks Trained on Large-Scale Repertoire Data
Deconvolving Mutation and Selection in Antibody Evolution using Neural Networks Trained on Large-Scale Repertoire Data
Armita Nourmohammad, University of Washington
Leaning the Shape of the Immune and Protein Universe
Leaning the Shape of the Immune and Protein Universe
Stephanie A. Gaglione, Massachusetts Institute of Technology
Viruses for High-throughput Antigen Discovery
Viruses for High-throughput Antigen Discovery
Mark Coles, University of Oxford
Short Talk: Short Talk: Combining Mechanistic Modelling with Machine Learning to Predict Human T Cell Epitopes and Vaccine Immune Responses in Ancestrally Diverse Populations
Short Talk: Short Talk: Combining Mechanistic Modelling with Machine Learning to Predict Human T Cell Epitopes and Vaccine Immune Responses in Ancestrally Diverse Populations
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Poster Setup
11:00–1:00 PM
Van Horne C
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Career Roundtable (Joint)
3:00–4:30 PM
Van Horne B
Sarah Teichmann, Wellcome Sanger Institute
Head of Cellular Genetics and Senior Group Leader, Co-Founder and Principal Leader of Human Cell Atlas
Head of Cellular Genetics and Senior Group Leader, Co-Founder and Principal Leader of Human Cell Atlas
Kara Lassen, Roche
VP and Global Head, Immunology Therapeutic Area
VP and Global Head, Immunology Therapeutic Area
Bryan D. Bryson, Massachusetts Institute of Technology
Associate Professor
Associate Professor
Jonathan Sockolosky, Curie.Bio
Senior Director, CSO Partner Team
Senior Director, CSO Partner Team
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Immunoengineering and Drug Development
5:00–7:00 PM
Van Horne B
Christoph Bock, CeMM & Medical University of Vienna
Immune Cell Engineering and “Structural Immunity'
Immune Cell Engineering and “Structural Immunity'
Caleb Perez, MIT
Mapping Diverse CAR Signaling Inputs to Transcriptional and Functional Outcomes via Library-Based Single-Cell Omics Assays
Mapping Diverse CAR Signaling Inputs to Transcriptional and Functional Outcomes via Library-Based Single-Cell Omics Assays
Kate Griffin, University of Michigan
Short Talk: Short Talk: Nanoparticles Reprogram Circulating Immune Cells to Alter the Metastatic Niche and Reduce Metastatic Burden in Murine Triple Negative Breast Cancer
Short Talk: Short Talk: Nanoparticles Reprogram Circulating Immune Cells to Alter the Metastatic Niche and Reduce Metastatic Burden in Murine Triple Negative Breast Cancer
Nathaniel Robichaud, Nomic Bio
Short Talk: Short Talk: High-Throughput Protein Profiling Captures Variability Across Donors, Cellular Environments, and Perturbations - Implications for Systems and Engineering Immunology
Short Talk: Short Talk: High-Throughput Protein Profiling Captures Variability Across Donors, Cellular Environments, and Perturbations - Implications for Systems and Engineering Immunology
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Poster Session 2
7:30–10:00 PM
Van Horne C
Friday, April 12, 2024
Breakfast
7:00–8:00 AM
President's Hall
The Emerging, Unexpected and New Frontiers (Joint)
8:00–11:00 AM
Van Horne A
Sarah Teichmann, Wellcome Sanger Institute
What's Next in Human Cell Atlasing?
What's Next in Human Cell Atlasing?
Graham Heimberg, Genentech, Inc.
SCimilarity Queries Reveal Connections across Macrophage Populations
SCimilarity Queries Reveal Connections across Macrophage Populations
Nicolas Chevrier, University of Chicago
Decoding the Body Language of Immunity
Decoding the Body Language of Immunity
Subhajit Poddar, University of Pennsylvania
Short Talk: Short Talk: STING Modulates Golgi pH, Cargo Sorting, and Secretion Through ArfGAP2
Short Talk: Short Talk: STING Modulates Golgi pH, Cargo Sorting, and Secretion Through ArfGAP2
Toufic Mayassi, Broad Institute
Short Talk: Short Talk: Molecular Cartography Reveals Robust, Adaptable, and Resilient Intestinal Networks
Short Talk: Short Talk: Molecular Cartography Reveals Robust, Adaptable, and Resilient Intestinal Networks
Shubham Tripathi, Yale School of Medicine
Short Talk: Short Talk: Role of a Cellular Circuit Involving IFN-γ / IL-15 Positive Feedback in Establishing Antigen-Non-Specific Immune Memory
Short Talk: Short Talk: Role of a Cellular Circuit Involving IFN-γ / IL-15 Positive Feedback in Establishing Antigen-Non-Specific Immune Memory
Tomer Milo, Weizmann Institute of Science
Short Talk: Short Talk: A Paradox of Foreign-Specific Regulatory T Cells and a Proposed Resolution by a Lymph Node Microdomain Theory
Short Talk: Short Talk: A Paradox of Foreign-Specific Regulatory T Cells and a Proposed Resolution by a Lymph Node Microdomain Theory
Coffee Break
9:00–9:20 AM
Van Horne Foyer
On Own for Lunch
11:00–5:00 PM
Workshop 2: In vivo Systems Immunology and Engineering: Emerging Areas and Challenges
2:30–4:30 PM
Van Horne B
Antonella Prisco, National Research Council (Italy)
Modeling Variations in Antibody Response Longevity Among Individuals
Modeling Variations in Antibody Response Longevity Among Individuals
David R. Glass, Fred Hutchinson Cancer Center
Bridging the Identity and Function of Human Plasma Cell Subsets
Bridging the Identity and Function of Human Plasma Cell Subsets
Neil Tay, University of California, San Francisco
Tracking Cell-Cell Interactions Using Intercellular Barcode Transfer
Tracking Cell-Cell Interactions Using Intercellular Barcode Transfer
Nicole Rosin, University of Calgary
A Systems Biology Approach to Understanding Wound Healing
A Systems Biology Approach to Understanding Wound Healing
Katherine Susa, UCSF
A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation
A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation
Catera L Wilder, University of California, San Francisco
Dynamic Control of Signaling Networks: Uncovering Specificity in Interferon-Mediated Cellular Responses Through Coordinated Positive Feedback Loops
Dynamic Control of Signaling Networks: Uncovering Specificity in Interferon-Mediated Cellular Responses Through Coordinated Positive Feedback Loops
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Tissue Systems Immunology and Dynamics
5:00–6:45 PM
Van Horne B
Shannon J Turley, Genentech, Inc.
Evolution of Stromal Niches in Inflammation, Cancer and Immunotherapy
Evolution of Stromal Niches in Inflammation, Cancer and Immunotherapy
Karin Pelka, Gladstone Institutes and University of California, San Francisco
Spatially Organized Immune Hubs in Human Tumors
Spatially Organized Immune Hubs in Human Tumors
Gabriel D. Victora, Rockefeller University
Multicellular Dynamics in Germinal Center Responses
Multicellular Dynamics in Germinal Center Responses
Samuel Kazer, Boston Children's Hospital & Harvard Medical School
Short Talk: Short Talk: Primary Nasal Viral Infection Rewires the Tissue-Scale Memory Response
Short Talk: Short Talk: Primary Nasal Viral Infection Rewires the Tissue-Scale Memory Response
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Van Horne B
Social Hour with Lite Bites
7:00–8:00 PM
President's Hall
Trivia!
8:00–9:00 PM
Van Horne A
Cash Bar
8:00–9:00 PM
President's Hall
Saturday, April 13, 2024
Departure
7:00–11:59 PM
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