Single-Cell Biology: Tissue Genomics, Technologies and Disease
Jan 21–24, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers:
Jason Buenrostro, Lacramioara Bintu, and Fei Chen
In Person
On Demand
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Jan 21–24, 2024 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Jason Buenrostro, Lacramioara Bintu, and Fei Chen
Jason Buenrostro
Lacramioara Bintu
Fei Chen
Available Formats:
Supported by the Directors' Fund
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMerchandise Options
Registration Options
Booking Function
Fundraising
Sunday, January 21, 2024
Arrival and Registration
4:00–8:00 PM
British Columbia Foyer
Welcome Mixer
6:00–8:00 PM
British Columbia Foyer
Monday, January 22, 2024
Breakfast
7:00–8:00 AM
Columbia Ballroom
Welcome and Keynote Address
8:00–9:00 AM
British Ballroom
Ido Amit, Weizmann Institute
Single-Cell Discovery of Disease-Associated Cell States
Single-Cell Discovery of Disease-Associated Cell States
Genomic Regulators of Cellular Circuitry
9:00–11:15 AM
British Ballroom
Lacramioara Bintu, Stanford University
The Control of Gene Regulation at Single-Cell Resolution
The Control of Gene Regulation at Single-Cell Resolution
David R. Kelley, Calico Life Sciences
Sequence-Based Deep Learning of Single-Cell Genomics
Sequence-Based Deep Learning of Single-Cell Genomics
Michael Lorenzini, Salk Institute
Short Talk: Short Talk: Direct Readout of Genome Perturbations and Transcription Outcomes by Single-Cell Edit Capture
Short Talk: Short Talk: Direct Readout of Genome Perturbations and Transcription Outcomes by Single-Cell Edit Capture
Fabian Müller, Saarland University
Short Talk: Short Talk: Dissecting the Epigenome Dynamics of Human Immune Cells Upon Pathogen Exposure at Single-Cell Resolution
Short Talk: Short Talk: Dissecting the Epigenome Dynamics of Human Immune Cells Upon Pathogen Exposure at Single-Cell Resolution
Siddharth S. Dey, University of California, Santa Barbara
Short Talk: Short Talk: Combinatorial Quantification of 5mC and 5hmC at Individual CpG Dyads and the Transcriptome in Single Cells Reveals Modulators of DNA Methylation Maintenance Fidelity in Early Mouse Development
Short Talk: Short Talk: Combinatorial Quantification of 5mC and 5hmC at Individual CpG Dyads and the Transcriptome in Single Cells Reveals Modulators of DNA Methylation Maintenance Fidelity in Early Mouse Development
Coffee Break
9:30–9:50 AM
British Columbia Foyer
On Own for Lunch
11:15–1:00 PM
Poster Setup
11:15–1:00 PM
Columbia Ballroom
Poster Viewing
1:00–10:00 PM
Columbia Ballroom
Career Roundtable
3:00–4:30 PM
British Ballroom
Hongkui Zeng, Allen Institute for Brain Science
Executive Vice President, Director
Executive Vice President, Director
Ana Gabriela Cristancho, Children's Hospital of Philadelphia
Assistant Professor
Assistant Professor
Grace Zheng, Arsenal Biosciences
Senior Director of Computational Biology and Machine Learning
Senior Director of Computational Biology and Machine Learning
Gonçalo Castelo-Branco, Karolinska Institutet
Professor
Professor
Coffee Available
4:30–5:00 PM
British Columbia Foyer
Multi-omic Approaches to Study Gene Regulation
5:00–7:00 PM
British Ballroom
Jason Buenrostro, Harvard University
Single-Cell Epigenomics
Single-Cell Epigenomics
Peter Smibert, 10x Genomics
An Ecosystem of Complementary Technologies for Analyzing Fresh and Archived Single Cells and Tissues
An Ecosystem of Complementary Technologies for Analyzing Fresh and Archived Single Cells and Tissues
Gonçalo Castelo-Branco, Karolinska Institutet
Multi-Omic Dynamics of Oligodendroglia in Development and Disease
Multi-Omic Dynamics of Oligodendroglia in Development and Disease
Mattia Zaghi, Karolinska Institutet
Short Talk: Short Talk: Multi-nano Cut&Tag-RNA,a Novel Approach to Map Transcriptomic and Multiple Epigenetic Modalities from Single Cells
Short Talk: Short Talk: Multi-nano Cut&Tag-RNA,a Novel Approach to Map Transcriptomic and Multiple Epigenetic Modalities from Single Cells
Siran Li, Cold Spring Harbor Laboratory
Short Talk: Short Talk: Associating Cancer and Stromal Genomes with Transcriptomes by High-Throughput Single-Nucleus Multiomic Sequencing
Short Talk: Short Talk: Associating Cancer and Stromal Genomes with Transcriptomes by High-Throughput Single-Nucleus Multiomic Sequencing
Social Hour with Lite Bites
7:00–8:00 PM
Columbia Ballroom
Poster Session 1
7:30–10:00 PM
Columbia Ballroom
Tuesday, January 23, 2024
Breakfast
7:00–8:00 AM
Columbia Ballroom
Tissue Organization and Interactions
8:00–11:00 AM
British Ballroom
Barbara Treutlein, ETH Zürich
Reconstructing Brain Development and Regeneration with Single-cell Technologies
Reconstructing Brain Development and Regeneration with Single-cell Technologies
Fei Chen, Broad Institute of MIT and Harvard
Tissue Genomics Tools for Probing Cellular Interactions
Tissue Genomics Tools for Probing Cellular Interactions
Hongkui Zeng, Allen Institute for Brain Science
Spatial and Cellular Organization of Mouse and Human Brain
Spatial and Cellular Organization of Mouse and Human Brain
Cassandra Burdziak, Memorial Sloan Kettering Cancer Center
The Environment-plasticity Axis in Tumor Progression
The Environment-plasticity Axis in Tumor Progression
Michal Polonsky, Caltech
Short Talk: Short Talk: Spatial Transcriptomics Defines Injury-Specific Microenvironments in the Adult Mouse Kidney and Novel Cellular Interactions in Regeneration and Disease
Short Talk: Short Talk: Spatial Transcriptomics Defines Injury-Specific Microenvironments in the Adult Mouse Kidney and Novel Cellular Interactions in Regeneration and Disease
Coffee Break
9:00–9:20 AM
British Columbia Foyer
On Own for Lunch
11:00–1:00 PM
Poster Setup
11:00–1:00 PM
Columbia Ballroom
Poster Viewing
1:00–10:00 PM
Columbia Ballroom
Workshop 1: Mapping Diseases
3:00–4:30 PM
British Ballroom
Samuel Cooper, Phenomic
Single-cell RNA Analysis at Scale Identifies a Conserved Wound Healing Axis in Health and Disease
Single-cell RNA Analysis at Scale Identifies a Conserved Wound Healing Axis in Health and Disease
Siyuan Wang, Yale University
A Genome-Wide Single-Cell 3D Genome Atlas of Lung Cancer Progression
A Genome-Wide Single-Cell 3D Genome Atlas of Lung Cancer Progression
Shreya Menon, University of California, San Francisco / Gladstone Institutes
Leveraging Single-cell Multi-omic Profiling to Investigate Non-coding Variants in Neurodegenerative Disease
Leveraging Single-cell Multi-omic Profiling to Investigate Non-coding Variants in Neurodegenerative Disease
Ana Gabriela Cristancho, Children's Hospital of Philadelphia
Single-nucleus Multi-omics Predicts Persistent Functional Deficits in Glutamatergic Neurons after Prenatal Hypoxic Brain Injury
Single-nucleus Multi-omics Predicts Persistent Functional Deficits in Glutamatergic Neurons after Prenatal Hypoxic Brain Injury
André F Rendeiro, CeMM Research Center for Molecular Medicine
Tissue-level Prediction of Biological Age and Pathology Incidence
Tissue-level Prediction of Biological Age and Pathology Incidence
Lochlan J. Fennell, Monash University
Traversing The Colorectal Transcriptomic Landscape Through Space, Time and Disease
Traversing The Colorectal Transcriptomic Landscape Through Space, Time and Disease
Coffee Available
4:30–5:00 PM
British Columbia Foyer
Development and Cellular Dynamics
5:00–7:00 PM
British Ballroom
Cole Trapnell, University of Washington
Creating Cellular Diversity During Development
Creating Cellular Diversity During Development
Samantha A. Morris, Washington University School of Medicine in St Louis
Lineage Tracing Cell Fates
Lineage Tracing Cell Fates
Martin Tran, Caltech
Short Talk: Short Talk: Lineage motifs as developmental modules for control of cell type proportions
Short Talk: Short Talk: Lineage motifs as developmental modules for control of cell type proportions
HaoSheng Sun, Howard Hughes Medical Institute, University of Alabama at Birmingham
Short Talk: Short Talk: Genetic Regulation of the Post-embryonic Post-mitotic Nervous System Maturation in Single Neuron Resolution
Short Talk: Short Talk: Genetic Regulation of the Post-embryonic Post-mitotic Nervous System Maturation in Single Neuron Resolution
Social Hour with Lite Bites
7:00–8:00 PM
Columbia Ballroom
Poster Session 2
7:30–10:00 PM
Columbia Ballroom
Wednesday, January 24, 2024
Breakfast
7:00–8:00 AM
Columbia Ballroom
Keynote Address
8:00–8:45 AM
British Ballroom
Emma K. Lundberg, Stanford University and Chan Zuckerberg Initiative
From Mapping to Modeling the Subcellular Proteome Architecture of Cells
From Mapping to Modeling the Subcellular Proteome Architecture of Cells
Single-Cell and Tissue Perturbation Technologies
8:45–11:15 AM
British Ballroom
Bogdan Bintu, University of California, San Diego
Spatial Transcriptomics Reveals the Activation of Quiescent Neurogenic Niches in the Aging Mammalian Brain
Spatial Transcriptomics Reveals the Activation of Quiescent Neurogenic Niches in the Aging Mammalian Brain
Martin Borch Jensen, Gordian Biotechnology
Pooled in vivo Testing of Therapeutics in the Environment you want them to Work
Pooled in vivo Testing of Therapeutics in the Environment you want them to Work
Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT
Genome-Wide Perturbations for Defining Principles of Biological Systems
Genome-Wide Perturbations for Defining Principles of Biological Systems
Grace Zheng, Arsenal Biosciences
Short Talk: Short Talk: Combinatorial High-throughput Genetic Screening of Regulators of T Cell Function to Improve Efficacy of Therapeutic Engineered T Cells
Short Talk: Short Talk: Combinatorial High-throughput Genetic Screening of Regulators of T Cell Function to Improve Efficacy of Therapeutic Engineered T Cells
Ceejay Lee, Liau Lab (Harvard University)
Short Talk: Short Talk: Massively Parallel Profiling of Androgen Receptor Protein-coding Variants with SCAnnEd
Short Talk: Short Talk: Massively Parallel Profiling of Androgen Receptor Protein-coding Variants with SCAnnEd
Coffee Break
9:00–9:20 AM
British Columbia Foyer
On Own for Lunch
11:15–1:00 PM
Workshop 2: Frontiers in Computation
2:30–4:30 PM
British Ballroom
Joshua Weinstein, University of Chicago
Volumetric Imaging of an Intact Organism by a Distributed Molecular Network
Volumetric Imaging of an Intact Organism by a Distributed Molecular Network
David Wen, Gladstone Institutes/University of California, San Francisco
A Comprehensive Map of Dosage Sensitivity Across Fetal Development
A Comprehensive Map of Dosage Sensitivity Across Fetal Development
Camilo Espinosa Bernal, Stanford University School of Medicine
Modeling Cell-type-specific Perturbations in Single-cell Omic Datasets with Attention
Modeling Cell-type-specific Perturbations in Single-cell Omic Datasets with Attention
Peiyao Zhao, Allen Institute
SPARROW: A Sequential Algorithm for Cell Type Inference and Microenvironment Delineation in Spatial Transcriptomics
SPARROW: A Sequential Algorithm for Cell Type Inference and Microenvironment Delineation in Spatial Transcriptomics
Salil Bhate, Broad Institute of MIT and Harvard
Deriving Genetic Codes for Tissues from First Principles
Deriving Genetic Codes for Tissues from First Principles
Sandeep Kambhampati, Harvard University
Connecting Spatial Organization of Tissues to Cell State and Function using Self-supervised Machine Learning
Connecting Spatial Organization of Tissues to Cell State and Function using Self-supervised Machine Learning
Coffee Available
4:30–5:00 PM
British Columbia Foyer
Aging and Disease Associated Cell States
5:00–6:15 PM
British Ballroom
Brian D. Brown, Mount Sinai School of Medicine
Single Cell Mapping of Myeloid Cell Targets of Cancer
Single Cell Mapping of Myeloid Cell Targets of Cancer
Wolf Reik, Altos Labs, Cambridge Institute of Science
Single Cell Multi-omics Landscape of Development and Ageing
Single Cell Multi-omics Landscape of Development and Ageing
Ailsa Jeffries, UMass Chan Medical School
Short Talk: Short Talk: The Bidirectional Relationship between the Aging Genome and Transcriptome in the Human Brain
Short Talk: Short Talk: The Bidirectional Relationship between the Aging Genome and Transcriptome in the Human Brain
Closing Keynote Address
6:15–7:00 PM
British Ballroom
Michael Elowitz, HHMI/California Institute of Technology
Cellular Circuitry and Dynamics
Cellular Circuitry and Dynamics
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
British Ballroom
Social Hour with Lite Bites
7:00–8:00 PM
The Roof
Cash Bar
8:00–9:00 PM
The Roof
Thursday, January 25, 2024
Departure
7:00–11:59 PM
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