Reimagining Diabetes: From Molecular Mechanisms to Transformative Therapies

January 31–February 04, 2027 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Anna Krook, Jennifer Green, and David Moller

  In Person
  On Demand
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January 31–February 04, 2027 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Anna Krook, Jennifer Green, and David Moller

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, January 31, 2027
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Monday, February 1, 2027
Welcome Remarks
4:00–4:10 PM
Keynote Address
4:10–5:00 PM
Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute
The Expanding Benefits of GLP-1 Medicines-is Weight Loss Always Critical
Fine Tuning our Understanding of Genetic Causes for Metabolic Disease
5:00–7:00 PM
Ruth J Loos, University of Copenhagen
Identification of Genes and Genetic Loci Contributing to the Risk of Obesity and Related Traits
Melina Claussnitzer, Broad Institute, Harvard Medical School and Massachusetts General Hospital
Moving from Variant to Function to Tractable Therapeutic Hypotheses
Bart O. Roep, Leiden University Medical Center
Genetic beta-Cell Protection Modulating Type 1 Diabetes
Short Talk(s) Chosen from Abstracts
Tuesday, February 2, 2027
Breakfast
7:00–8:00 AM
New Mechanisms with Clinical Results
8:00–11:00 AM
David Moller, Third Rock Ventures
Overview of Emerging Clinical Trial Results - Impact and Implications
David Kendall, Zealand Pharma
Amylin Biology-Rationale and Clinical Results
Scott Harris, Altimmune Inc.
Harnessing Glucagon Agonism to Amplify Efficacy
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Panel Discussion 1: Lessons from Diabetes-Obesity Clinical Trials
11:00–12:00 PM
Poster Setup
11:00–1:00 PM
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Breakthrough Opportunities for Type 1 Diabetes and Preservation of Pancreatic B-Cell Mass-Function
5:00–7:00 PM
Matthias Hebrok, Technical University Munich and Helmholtz Center Munich
Advances toward Realizing the Goal of Stem Cell-Derived Islet Replacement Therapies
Andrew F. Stewart, Mount Sinai School of Medicine
Novel Approaches for Pancreatic Beta Cell Regeneration
Kevan C. Herold, Yale University
Clinical Trial Advances to Decode Beta Cell Resilience in Type 1 Diabetes: Cellular Pathways that Prevent Immune Destruction
Lucy S. K. Walker †, University College London
T Cell Dysregulation Type 1 Diabetes
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, February 3, 2027
Breakfast
7:00–8:00 AM
Disease Biology and Novel Therapeutic Targets
8:00–11:00 AM
Anna Krook, Karolinska Institutet
Skeletal Muscle as a Player in Pathobiology and a Therapeutic Target Organ
Philipp E. Scherer, University of Texas Southwestern Medical Center
Novel Adipose Biology and Targets
Judith A. Simcox, University of Wisconsin - Madison
Molecular and Cellular Regulation of Thermogenesis
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Panel Discussion 2: Global Perspectives in Diabetes Drug Development and Access to Care
11:00–12:00 PM
Poster Setup
12:00–1:00 PM
On Own for Lunch
12:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Addressing Shortcomings and Expanding Use of Incretin-Based Therapies
5:00–7:00 PM
Philip Larsen, Sixpeaks Bio AG
Residual Challenges: Weight Regain, Sarcopenia, Long-Term Weight Maintenance
Rotonya Carr, University of Washington
Treating Metabolic Dysfunction-Associated Steatotic Liver Disease
Brian Finan, Eli Lilly
Incretin based Tri Agonists
Lotte Bjerre Knudsen, Novo Nordisk A/S
GLP-1 and Beyond: Clinical Drug-Specific Mechanisms in Diabetes, Obesity, Cardiovascular, Kidney, Liver and Brain Diseases
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Thursday, February 4, 2027
Breakfast
7:00–8:00 AM
New Approaches Aimed at Modulating Energy Balance
8:00–11:00 AM
Randy J. Seeley, University of Michigan
Neural Pathways Regulating Food Intake and Energy Balance
Katrin J. Svensson, Stanford University
Novel Peptides that Regulate Feeding and Obesity
Eleftheria Maratos-Flier, Harvard Medical School and Alnylam
FGF21: What have we Learned from Mice and Human Trials?
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
12:00–5:00 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:30 PM
Clinical Technology Innovations & Devices
5:00–6:45 PM
Jose C. Florez †, Massachusetts General Hospital
What’s Next in the Field Diabetes and Metabolism Research
Emmanuel Opara, Wake Forest Institute for Regenerative Medicine
Re-Engineering the Bioartificial Pancreas
Aaron Kowalski †, Juvenile Diabetes Research Foundation International
Technology Advances for Optimizing Care in Insulin-Requiring Patients
Short Talk(s) Chosen from Abstracts
Panel Discussion 3: What Does the Future Hold for Strategies to Predict, Prevent, and Treat Diabetes Mellitus
6:45–7:15 PM
* Jennifer Green, Duke University
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:15–7:30 PM
Social Hour with Dinner
7:30–8:00 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Friday, February 5, 2027
Departure
12:00–11:59 PM

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