Reimagining Diabetes: From Molecular Mechanisms to Transformative Therapies
Feb 01–04, 2027 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Anna Krook, Jennifer Green, and David Moller
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Feb 01–04, 2027 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Anna Krook, Jennifer Green, and David Moller
Anna Krook, PhD
Karolinska Institutet
Anna Krook, PhD, is a Professor at Karolinska Institute whose research focuses on skeletal muscle metabolism, insulin resistance and exercise-regulated signaling, including epigenetic and non-coding RNA mechanisms. She has led multi-disciplinary programs that link human physiology with mechanistic studies, contributing to targets and biomarkers in type 2 diabetes.
Jennifer Green, MD
Duke University
Jennifer Green, MD, is a clinician-scientist at Duke University specializing in diabetes care and clinical trials, with a focus on understanding potential cardiovascular and renal complications resulting from diabetes treatments.
David Moller, MD
Third Rock Ventures
David E. Moller, MD is a Venture Partner at Third Rock Ventures where focuses on next generation therapies for metabolic disease. He has over 30 years of experience in academia and biopharma, resulting in discoveries and translational studies that have advanced understanding of pathophysiology in metabolic disease, clinical proof-of-concept for novel mechanisms and first-in-class approved therapies for diabetes-obesity that have enhanced the standard of care for patients.
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandMonday, February 1, 2027
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
1:00–6:00 PM
Longs Peak Foyer
Welcome Remarks
3:00–3:10 PM
Grays Peak
Keynote Address
3:10–4:00 PM
Grays Peak
Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute
The Expanding Benefits of GLP-1 Medicines-is Weight Loss Always Critical
The Expanding Benefits of GLP-1 Medicines-is Weight Loss Always Critical
Fine Tuning our Understanding of Genetic Causes for Metabolic Disease
4:00–6:00 PM
Grays Peak
Ruth J Loos, University of Copenhagen
Identification of Genes and Genetic Loci Contributing to the Risk of Obesity and Related Traits
Identification of Genes and Genetic Loci Contributing to the Risk of Obesity and Related Traits
Melina Claussnitzer, Broad Institute, Harvard Medical School and Massachusetts General Hospital
Moving from Variant to Function to Tractable Therapeutic Hypotheses
Moving from Variant to Function to Tractable Therapeutic Hypotheses
Bart O Roep, LUMC
Genetic beta-Cell Protection Modulating Type 1 Diabetes
Genetic beta-Cell Protection Modulating Type 1 Diabetes
Short Talk(s) Chosen from Abstracts
Welcome Reception with Heavy Apps
6:00–8:00 PM
Longs Peak Foyer
Tuesday, February 2, 2027
Breakfast
7:00–8:00 AM
Longs Peak
Breakthrough Opportunities for Type 1 Diabetes and Preservation of Pancreatic B-Cell Mass-Function
8:00–11:00 AM
Grays Peak
Matthias Hebrok, Technical University Munich and Helmholtz Center Munich
Advances toward Realizing the Goal of Stem Cell-Derived Islet Replacement Therapies
Advances toward Realizing the Goal of Stem Cell-Derived Islet Replacement Therapies
Andrew F. Stewart, Mount Sinai School of Medicine
Novel Approaches for Pancreatic Beta Cell Regeneration
Novel Approaches for Pancreatic Beta Cell Regeneration
Kevan C. Herold, Yale University
Clinical Trial Advances to Decode Beta Cell Resilience in Type 1 Diabetes: Cellular Pathways that Prevent Immune Destruction
Clinical Trial Advances to Decode Beta Cell Resilience in Type 1 Diabetes: Cellular Pathways that Prevent Immune Destruction
Lucy S. K. Walker, University College London
T Cell Dysregulation Type 1 Diabetes
T Cell Dysregulation Type 1 Diabetes
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
Panel Discussion 1: What are Current Issues in Trial Design Diabetes-Obesity Clinical Trials
11:10–12:10 PM
Grays Peak
* Manu Chakravarthy, Roche
Poster Setup
12:10–1:00 PM
Longs Peak
On Own for Lunch
12:10–2:30 PM
Poster Viewing
1:00–10:00 PM
Longs Peak
Symposia Spotlight 1: Basic Aspects of Diabetes Pathophysiology
2:30–4:30 PM
Grays Peak
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
New Mechanisms with Clinical Results
5:00–7:00 PM
Grays Peak
David Moller, Third Rock Ventures
Overview of Emerging Clinical Trial Results - Impact and Implications
Overview of Emerging Clinical Trial Results - Impact and Implications
David Kendall, Zealand Pharma
Amylin Biology-Rationale and Clinical Results
Amylin Biology-Rationale and Clinical Results
Scott Harris, Altimmune Inc.
Harnessing Glucagon Agonism to Amplify Efficacy
Harnessing Glucagon Agonism to Amplify Efficacy
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Longs Peak
Poster Session 1
7:30–10:00 PM
Longs Peak
Wednesday, February 3, 2027
Breakfast
7:00–8:00 AM
Longs Peak
Addressing Shortcomings and Expanding Use of Incretin-Based Therapies
8:00–11:00 AM
Grays Peak
Philip Larsen, Antag Therapeutics
Residual Challenges: Weight Regain, Sarcopenia, Long-Term Weight Maintenance
Residual Challenges: Weight Regain, Sarcopenia, Long-Term Weight Maintenance
Brian Finan, Eli Lilly
Incretin based Tri Agonists
Incretin based Tri Agonists
Murielle Veniat †, Amgen Inc.
Talk Title to be Announced
Talk Title to be Announced
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
Award Recipient Acknowledgement
9:20–9:25 PM
Grays Peak
Meet the Editors
11:10–12:10 PM
Grays Peak
Poster Setup
12:10–1:00 PM
Longs Peak
On Own for Lunch
12:10–2:15 PM
Poster Viewing
1:00–10:00 PM
Longs Peak
Career Roundtable
2:15–3:15 PM
Grays Peak
Panel: Health Equity
3:30–4:30 PM
Grays Peak
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Disease Biology and Novel Therapeutic Targets
5:00–7:00 PM
Grays Peak
Anna Krook, Karolinska Institutet
Skeletal Muscle as a Player in Pathobiology and a Therapeutic Target Organ
Skeletal Muscle as a Player in Pathobiology and a Therapeutic Target Organ
Philipp E. Scherer, University of Texas Southwestern Medical Center
Novel Adipose Biology and Targets
Novel Adipose Biology and Targets
Judith A. Simcox, University of Wisconsin - Madison
Molecular and Cellular Regulation of Thermogenesis
Molecular and Cellular Regulation of Thermogenesis
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Longs Peak
Poster Session 2
7:30–10:00 PM
Longs Peak
Thursday, February 4, 2027
Breakfast
7:00–8:00 AM
Longs Peak
New Approaches Aimed at Modulating Energy Balance
8:00–11:00 AM
Grays Peak
Randy J. Seeley, University of Michigan
Neural Pathways Regulating Food Intake and Energy Balance
Neural Pathways Regulating Food Intake and Energy Balance
Katrin J. Svensson, Stanford University
Novel Peptides that Regulate Feeding and Obesity
Novel Peptides that Regulate Feeding and Obesity
Eleftheria Maratos-Flier, Harvard Medical School and Alnylam
FGF21: What have we Learned from Mice and Human Trials?
FGF21: What have we Learned from Mice and Human Trials?
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Novel Therapeutic Opportunities
2:00–4:00 PM
Grays Peak
Short Talks Chosen from Abstracts
Coffee Available
4:00–4:30 PM
Longs Peak Foyer
Clinical Technology Innovations & Devices
4:30–6:15 PM
Grays Peak
Jose C. Florez, Massachusetts General Hospital
Use of Big Data to Advance Precision Medicine in the Clinic
Use of Big Data to Advance Precision Medicine in the Clinic
Emmanuel Opara, Wake Forest Institute for Regenerative Medicine
Re-Engineering the Bioartificial Pancreas
Re-Engineering the Bioartificial Pancreas
Aaron Kowalski, Juvenile Diabetes Research Foundation International
Technology Advances for Optimizing Care in Insulin-Requiring Patients
Technology Advances for Optimizing Care in Insulin-Requiring Patients
Short Talk(s) Chosen from Abstracts
Panel Discussion 2: What Does the Future Hold for Strategies to Predict, Prevent, and Treat Diabetes Mellitus
6:25–6:55 PM
Grays Peak
* Jennifer Green, Duke University
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:55–7:10 PM
Grays Peak
Social Hour with Dinner
7:10–8:10 PM
Longs Peak
Entertainment
8:00–9:00 PM
Cash Bar
8:10–9:00 PM
Friday, February 5, 2027
Departure
12:00–11:59 PM
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