Lipids in Cellular Function and Disease

Apr 06–09, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Valerie B. O'Donnell, Junken Aoki, and Vytas A. Bankaitis

  In Person
  On Demand
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Apr 06–09, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States

Scientific Organizers: Valerie B. O'Donnell, Junken Aoki, and Vytas A. Bankaitis

Supported by:

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, April 6, 2025
Workshop on Networking & Communication Skills for Early-Career Scientists  
4:00–6:00 PM
 Peaks 4-5
Registration  
4:00–8:00 PM
 Colorado Ballroom Foyer
Welcome Mixer  
6:00–8:00 PM
 Colorado Ballroom Foyer
Monday, April 7, 2025
Breakfast  
7:00–8:00 AM
 Summit Gallery
Welcome and Keynote Address  
8:00–9:00 AM
 Peaks 4 - 5
* Valerie B. O'Donnell, Cardiff University
* Junken Aoki, University of Tokyo
Marcus Conrad, Helmholtz Zentrum München
Role of Lipids in Driving Ferroptosis in Mitochondria
Organelle Stress and Ferroptosis in Health and Diseases  
9:00–11:15 AM
 Peaks 4 - 5
* L. A Cowart, Virginia Commonwealth University
Session Chair
Karen Reue, University of California, Los Angeles
Identification of Genes that Control Lipid Metabolism
Guillaume Thibault, Nanyang Technological University
Lipid Bilayer Stress-Induced Unfolded Protein Response in Aging
James A Olzmann, University of California, Berkeley
At The Intersection of Lipid Droplets and Ferroptosis
Cyrus Nikain, Memorial Sloan Kettering Cancer Center, New York
Short Talk: IFITM3 Regulates Ferroptosis Through Membrane Remodeling
Coffee Break  
9:30–9:50 AM
 Colorado Ballroom Foyer
Poster Setup  
11:15–1:00 PM
 Peaks 1 - 3
On Own for Lunch  
11:15–2:30 PM
Poster Viewing  
1:00–10:00 PM
 Peaks 1 - 3
LIPID MAPS/ILS Workshop  
2:30–4:30 PM
 Peaks 4 - 5
Kim Ekroos, Lipidomics Consulting Ltd.
Gerhard Liebisch, University of Regensburg
Matthew Conroy, Cardiff University
Dominik Kopczynski, University of Vienna
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Lipids in Metabolic Disease  
5:00–7:00 PM
 Peaks 4 - 5
* Valerie B. O'Donnell, Cardiff University
Session Chair
* Michael H. Gelb, University of Washington
Session Chair
Judith A. Simcox, University of Wisconsin - Madison
Regulation of Energy Expenditure by Plasma Lipid Signaling
Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center
Cholesterol Metabolism
L. A Cowart, Virginia Commonwealth University
Diversity of Structures and Roles of Atypical Sphingolipids
Mehdi Damaghi, Stony Brook University
Short Talk: Sphingolipids Metabolic Plasticity Defines Cancer Cell Fitness in Adaptation to Acidic Tumor Microenvironments
Robert Ahrends, University of Vienna
Short Talk: Critical Shifts In Lipid Metabolism Promote Megakaryocyte Differentiation And Proplatelet Formation
Social Hour with Lite Bites  
7:00–8:00 PM
 Peaks 1 - 3
Poster Session 1  
7:30–10:00 PM
 Peaks 1 - 3
Tuesday, April 8, 2025
Breakfast  
7:00–8:00 AM
 Summit Gallery
Role of Lipids in Organisms and Metabolic Disease  
8:00–11:00 AM
 Peaks 4 - 5
* Karen Reue, University of California, Los Angeles
Session Chair
* Judith A. Simcox, University of Wisconsin - Madison
Session Chair
Dominic Campopiano, University of Edinburgh
Remote Presentation: Novel Sphingolipids Generated by Bacteria
Michael H. Gelb, University of Washington
Mass Spectrometry-Based Expansion of Newborn Screening
Edward A Dennis, University of California, San Diego
Specificity of Lipid Enzymes in Cellular Function and Metabolic Disease
Yarden Ariav, Weizmann Institute of Science
Short Talk: Elevating cGMP Levels Through PDE5A Inhibition Restricts Cancer Metastasis By Impeding NPC1-Mediated Cholesterol Trafficking
Eugene Koo, University of Texas Southwestern Medical Center
Short Talk: Bacterial Lipopolysaccharide Stimulates Long Chain Fatty Acid Uptake in The Small Intestine
Josie Daldegan Rezende, University of Maryland, Baltimore
Short Talk: Correlation Of Hepatoxicity Markers And Sphingolipid Enzymatic Activity To Sphingolipid Structure And Abundance
Xiaoman Liu, The Broad Institute of MIT and Harvard
Short Talk: Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking Akap11, a Risk Gene for Schizophrenia and Bipolar Disorder
Coffee Break  
9:00–9:20 AM
 Colorado Ballroom Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
 Peaks 4 - 5
Poster Setup  
11:00–1:00 PM
 Peaks 1 - 3
On Own for Lunch  
11:00–3:00 PM
Poster Viewing  
1:00–10:00 PM
 Peaks 1 - 3
Career Roundtable  
1:30–2:30 PM
 Peaks 4 - 5
Judith A. Simcox, University of Wisconsin - Madison
Assistant Professor
Robert Ahrends, University of Vienna
Professor
Camille M Konopnicki, Korro Bio
Principal Scientist
Intersections between Lipid Metabolism and Ferroptosis  
3:00–4:30 PM
 Peaks 4 - 5
* Ginger L. Milne, Vanderbilt University Medical Center
Session Chair
* Marcus Conrad, Helmholtz Zentrum München
Session Chair
Daniela Costa, Cardiff University
Platelet-Derived Enzymatically Oxidized Phospholipids Link Coagulopathies To Systemic Inflammation In Thromboembolic Disease
Javier Garcia-Bermudez, University of Texas Southwestern Medical Center
Dissecting The Roles Of Lipid Uptake In Tumors
Justine Mucinski, AdventHealth
Effects of 24 months of calorie restriction on circulating ceramides and associated sphingolipids in healthy adults
Michele R Plewes, University of Nebraska Medical Center
Dysregulated Lipid Metabolism and SREBP1/2 Signaling Contribute to Granulosa Cell Dysfunction and Impaired Ovarian Response
Sri Ramya Donepudi, University of Pittsburgh
Investigating The Role Of Epoxyeicosatrienoic Acids In Allergic Asthma: Sex Differences And The Effect Of Seh Inhibitor On Lung Function In Females And Males
Ke Shan, Duke Univeristy
TMEM16F as a Regulator of Ferroptosis in Astrocytes and Trophoblasts: Implications for Neurodegeneration and Placental Biology
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Phospholipid Metabolism in Physiology and Disease  
5:00–7:00 PM
 Peaks 4 - 5
* Alan R Brash, Vanderbilt University School of Medicine
Session Chair
* Guillaume Thibault, Nanyang Technological University
Session Chair
Timothy T Hla, Boston Children's Hospital/Harvard Medical School
Endothelial Protective Property of S1P as a Therapeutic Strategy in Diseases of Multiple Organ Systems
Junken Aoki, University of Tokyo
An Emerging Role of PAQR Family Members as Phospholipid Remodeling PLA2
William L. Holland, University of Utah
Genetics of Hyperceramidemia
Gerhard Liebisch, University of Regensburg
Lipidomics Reveals Novel Insights into Platelet Activation in Patients with Antiphospholipid Syndrome
Social Hour with Lite Bites  
7:00–8:00 PM
 Peaks 1 - 3
Poster Session 2  
7:30–10:00 PM
 Peaks 1 - 3
Wednesday, April 9, 2025
Breakfast  
7:00–8:00 AM
 Summit Gallery
Lipids and Regulation of Cellular Homeostasis  
8:00–11:00 AM
 Peaks 4 - 5
* Junken Aoki, University of Tokyo
Session Chair
Takeshi Harayama, Institute of Molecular and Cellular Pharmacology
Manipulating Cellular Lipidome to Discover Novel Regulatory Mechanisms of Lipid Composition
Meng C. Wang, HHMI/Janelia Research Campus
Lysosome Lipid Signaling in Neurons Regulates Longevity
Stacy L Gelhaus, University of Pittsburgh
Electrophilic Fatty Acid Regulation of Cellular Metabolism Mediates Inflammation Resolution
Kasparas Petkevicius, University of Cambridge
CLN8 is an acyltransferase catalyzing a key step in bis(monoacylglycero)phosphate biosynthesis
Maia Kinnebrew, Stanford University
Short Talk: ACC1 Links Lipid Droplet Metabolism to Cellular Cholesterol Homeostasis
Johannes Morstein, UCSF
Short Talk: Direct Targeting of Protein-Membrane Interactions
Gregory Wyant, MGH/HMS
Short Talk: Plasmalogen Control of Peroxisome Degradation Confers Ischemic Protection
Coffee Break  
9:00–9:20 AM
 Colorado Ballroom Foyer
People's Choice Poster Award Announcement
11:00–11:10 AM
 Peaks 4 - 5
On Own for Lunch  
11:10–2:30 PM
Symposia Spotlight: Research Presentations Selected from Abstract Submissions  
2:30–4:30 PM
 Peaks 4 - 5
* Stacy L Gelhaus, University of Pittsburgh
Session Chair
* William L. Holland, University of Utah
Session Chair
Alan R Brash, Vanderbilt University School of Medicine
Structural Basis Of Covalent Binding Of Acylceramides In Formation Of The Skin Permeability Barrier
Alessandra Ferrari, University of California, Berkeley
Nonvesicular Trafficking In Enterocytes Facilitates The Uptake Of Diet-Derived Cholesterol
Anna Hains, University of Manchester
Ceramides Mediate the Resolution of Psoriasis-Like Skin Inflammation
Takese T McKenzie, MD Anderson Cancer Center
Loss Of Lipocalin Prostaglandin D2 Synthase Impairs Myelin Debris Clearance And Microglial Activation During Demyelination
Ginger L. Milne, Vanderbilt University Medical Center
Metabolism Of Oxidized Lipid Mediators By UDP-Glucuronosyltransferases (Ugts): Implications For In Vivo Quantification
Brendan Prideaux, University of Texas Medical Branch
Spatial Lipidomic Analysis of Inflammatory Pathways in Pulmonary Tuberculosis
Bin Zheng, Cedars-Sinai Medical Center
DHODH Modulates Immune Evasion of Cancer Cells Via CDP-Choline Dependent Regulation of Phospholipid Metabolism
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Bioactive Lipids in Inflammatory Disease  
5:00–6:30 PM
 Peaks 4 - 5
* James A Olzmann, University of California, Berkeley
Session Chair
Valerie B. O'Donnell, Cardiff University
The SARS-CoV2 Envelope Responds to Host Lipid Metabolism through Changing its Coat
Scott A. Summers, University of Utah
Remodeling the Ceramide Backbone to Treat Cardiorenal Metabolic Disease
Mei Yee Koh, University of Utah
Short Talk: HAF Promotes Lipid Dysregulation and Progression from MASH to MASH-HCC
Marta Overchuk, University of North Carolina at Chapel Hill
Short Talk: Concurrent Induction of Ferroptosis- and Apoptosis-like Lipid Signatures in Ovarian Cancer Cells with Photodynamic Therapy
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:30–6:45 PM
 Peaks 4 - 5
Social Hour with Lite Bites  
6:45–8:00 PM
 Peaks 1 - 3
Entertainment  
7:30–9:00 PM
 Peaks 4 - 5
Cash Bar  
8:00–9:00 PM
 Peaks 1 - 3
Thursday, April 10, 2025
Departure  
12:00–11:59 PM

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