Biomolecular Condensates: Mechanisms and Therapeutic Opportunities

Sep 06–09, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mingjie Zhang and Jin Zhang

  In Person
  On Demand
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Sep 06–09, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States

Scientific Organizers: Mingjie Zhang and Jin Zhang

Supported by:

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Friday, September 6, 2024
Registration  
4:00–8:00 PM
 Colorado Ballroom Foyer
Welcome Mixer  
6:00–8:00 PM
 Colorado Ballroom Foyer
Saturday, September 7, 2024
Breakfast  
7:00–8:00 AM
 Summit Gallery
Welcome and Keynote Address  
8:00–9:00 AM
 Peaks 4 & 5
* Jin Zhang, University of California, San Diego
Session Chair
Michael K. Rosen, University of Texas Southwestern Medical Center
Phase Separation in Biological Systems
Mechanisms of Phase Separation  
9:00–11:15 AM
 Peaks 4 & 5
* Hao Wu, Harvard Medical School, Boston Children's Hospital
Session Chair
Jin Zhang, University of California, San Diego
Phase Separation in Protein Kinase Signaling
Tanja Mittag, St. Jude Children's Research Hospital
The Role of Emergent Condensate Properties in Transcription
Simon Alberti, Biotechnology Center of the TU Dresden
Phase Separation and Cell Stress Signaling
Anthony K. L. Leung, Johns Hopkins University/Leung Lab
Short Talk: Scope and Mechanism of Poly(ADP-ribose)-mediated Protein Condensation
Coffee Break  
9:30–9:50 AM
 Colorado Ballroom Foyer
Poster Setup  
11:15–1:00 PM
 Peaks 1 - 3
On Own for Lunch  
11:15–2:30 PM
Poster Viewing  
1:00–10:00 PM
 Foyer / Peaks 1 - 3
Symposia Spotlight 1: Hot off the Press: Talks Selected from Abstracts  
2:30–4:30 PM
 Peaks 4 & 5
* Joshua Riback, Baylor College of Medicine
Session Chair
Saki Takayanagi, Johns Hopkins University
Development of a Molecular Tool iDoG to Explore the Physiological Roles of Biomolecular Condensates
Kevin Rhine, UC San Diego
Neuronal Aging Leads to Chronic Activation of the Stress Response
Daniel M Shapiro, Duke University
Synthetic Biomolecular Condensates Enhance Translation from a Target mRNA in Living Cells
Melanie Allram, University of Veterinary Medicine Vienna
The Role of lncRNAs in Biomolecular Condensation of Leukemia Fusion Oncoproteins
Benjamin R. Sabari, University of Texas Southwestern Medical Center
Gain-of-Function RNA Polymerase II Partitioning is a Shared Feature of Diverse Oncogenic Fusions
David Kuster, Max Planck Institute of Molecular Cell Biology
Biomolecular Condensates as Crucibles of Protein Aggregation
Huabin Zhou,  University of Texas Southwestern Medical Center
Structures of Biomolecular Condensates by Cryo-ET
Huaiying Zhang, Carnegie Mellon University
TERRA-LSD1 Phase Separation Promotes R-Loop Formation for Telomere Maintenance in ALT Cancer Cells
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Biological Condensates in Genomic Organization and Transcriptional Regulation  
5:00–7:00 PM
 Peaks 4 & 5
* Lindsay Case, Massachusetts Institute of Technology
Session Chair
Dirk Görlich, Max Planck Institute for Multidisciplinary Sciences
Passage of HIV Capsids through the FG Phase of Nuclear Pores
Pilong Li, Tsinghua University
Miscibility and Immiscibility of Condensates Control Chromatin Organization and Transcription
Marina Feric, Pennsylvania State University
Structure-Function Relationships in Mitochondrial Transcriptional Condensates
Kirstin Meyer, UCSF
Short Talk: YAP Signal Integration Through Transcriptional Condensates
Jonathan Henninger, Carnegie Mellon University
Short Talk: RNA in the Regulation of Transcriptional Condensates
Social Hour with Lite Bites  
7:00–8:00 PM
 Peaks 1 - 3
Poster Session  
7:30–10:00 PM
 Peaks 1 - 3
Sunday, September 8, 2024
Breakfast  
7:00–8:00 AM
 Summit Gallery
Biological Condensates in Cell Signaling
8:00–11:15 AM
 Peaks 4 & 5
* Mingjie Zhang, Southern University of Science and Technology
Phase Separation in Synapses
Sua Myong, Boston Children's Hospital
Size Regulation of FUS Condensates
Yi Lin, Tsinghua University
Phase Separation and Circadian Rhythm
Lindsay Case, Massachusetts Institute of Technology
Phase Separation in Integrin Signaling
Monica Sharma, Genentech
Short Talk: PD-1 Regulates the Formation of Protein Condensates in T-Cell Receptor Signaling
Maria F Ullo, Massachusetts Institute of Technology
Short Talk: Tuning Epidermal Growth Factor Receptor (EGFR) Condensate Properties Through Adaptor Protein Valency and Competition
Neus Sanfeliu Cerdán, ICFO - The Institute of Photonic Sciences
Short Talk: Liquid-to-Solid Phase Transition of MEC-2 Condensates is Required for Mechanotransduction During Touch
Coffee Break  
9:30–9:50 AM
 Colorado Ballroom Foyer
Lunch  
11:30–12:30 PM
 Peaks 1 - 3
Women in Science Networking Event
11:30–12:30 PM
 Peaks 1 - 3
Poster Viewing  
11:30–6:00 PM
 Peaks 1 - 3
Panel Discussion: Challenges and Opportunities of Phase Separation in Biology  
12:45–2:15 PM
 Peaks 4 & 5
* Jin Zhang, University of California, San Diego
Panelist
Mingjie Zhang, Southern University of Science and Technology
Panelist
Michael K. Rosen, University of Texas Southwestern Medical Center
Panelist
Tanja Mittag, St. Jude Children's Research Hospital
Panelist
Lindsay Case, Massachusetts Institute of Technology
Panelist
Career Roundtable  
2:30–4:00 PM
 Peaks 4 & 5
Benjamin Wolozin, Aquinnah Pharmaceuticals and Boston University
Co-Founder & Chief Scientific Officer, Professor
Kandice Levental, University of Virginia
Associate Professor
Paul Lang, Sanofi
US Head In Vitro Biology, Integrated Drug Discovery
Yi Lin, Tsinghua University
Associate Professor
Coffee Available  
4:00–4:30 PM
 Colorado Ballroom Foyer
Interface Between Membraneless and Membrane Organelles  
4:30–6:15 PM
 Peaks 4 & 5
* Bo Huang, University of California, San Francisco
Session Chair
Sarah L. Veatch, University of Michigan
Phase Separation in Cell Signaling
Hong Zhang, Chinese Academy of Sciences
Phase Separation in Autophagy
Kandice Levental, University of Virginia
Phase Separation and Cell Signaling at Membrane Interface
Joo-Yeon Yoo, Postech
Short Talk: Membrane-Associated SCOTIN Condensates in the Regulation of Organelle Stress Response and Dynamics
On Own for Dinner  
6:15–7:00 PM
Monday, September 9, 2024
Breakfast  
7:00–8:00 AM
 Summit Gallery
Biomolecular Condensates: Disease Implications and Therapeutic Opportunities  
8:00–11:00 AM
 Peaks 4 & 5
* Pilong Li, Tsinghua University
Session Chair
Jidong Zhu, Etern Therapeutics
Harnessing Phase Separation for Drug Development
Diego A Vargas, Dewpoint Therapeutics
Discovery of Condensate Modifying Drugs Through AI-Powered Experimental Platform
Benjamin Wolozin, Aquinnah Pharmaceuticals and Boston University
Applying RNA Binding Proteins and Biological Condensates to Develop Therapeutic Pipelines for Amyotrophic Lateral Sclerosis and Alzheimer’s Disease
Dorothee Dormann, Johannes Gutenberg University Mainz
TDP-43 Phase Transitions in Neurodegenerative Diseases
Shannon Moreno, Whitehead Institute
Short Talk: Condensate Proteolethargy is a Pathogenic Mechanism in Chronic Disease
Eman Elshalia, University of Denver
Short Talk: G-Quadruplexes Modulate TDP-43 Aggregation In Vitro And In Vivo
Coffee Break  
9:00–9:20 AM
 Colorado Ballroom Foyer
On Own for Lunch  
11:00–3:30 PM
Symposia Spotlight 2: Young Investigator Forum  
3:30–4:30 PM
 Peaks 4 & 5
* Yi Lin, Tsinghua University
Session Chair
Zheng Shi, Rutgers University
Alpha-Synuclein Regulates the Material Properties of Synapsin Condensates in Live Cells
Runwen Yao, UT Southwestern Medical Center
Size-Dependent Functional Transitions in Actin Signaling Protein Condensates
Barak Raveh, The Hebrew University of Jerusalem
Combining Molecular and Whole-Cell Models to Reveal Design Features Underlying Nucleocytoplasmic Transport
Salman Banani, University of Chicago
Active RNA Synthesis Patterns Nuclear Condensates
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Methodologies for Phase Separation Research  
5:00–6:45 PM
 Peaks 4 & 5
* Jin Zhang, University of California, San Diego
Session Chair
Hao Wu, Harvard Medical School, Boston Children's Hospital
Inflammasomes: Condensates and Ordered Supramolecular Assemblies
Felipe Quiroz, Emory University and Georgia Institute of Technology
High-Fidelity Probing of Intracellular Phase Separation Dynamics
Xiaokun Shu, University of California, San Francisco
Oncoprotein Transcription Factor MYC Undergoes Phase Separation that Differentially Modulates the Transcriptome
Joshua Riback, Baylor College of Medicine
Short Talk: Physical-Chemical Probing Reveals a Networked Nucleolar Structure Funneling Ribosome Biogenesis
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Peaks 4 & 5
Social Hour with Lite Bites  
7:00–8:00 PM
 Peaks 1 - 3
Entertainment  
8:00–9:00 PM
 Peaks 4 & 5
Cash Bar  
8:00–9:30 PM
 Peaks 1 - 3
Tuesday, September 10, 2024
Departure  
12:00–11:59 PM

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