Positive Strand RNA Viruses: Interdisciplinary Advances in Virology, Pathogenesis, Immunology, and Technology Development
Oct 21–24, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers:
Kizzmekia S. Corbett-Helaire, William B. Klimstra, and Jolanda M. Smit
In Person
On Demand
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Oct 21–24, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Kizzmekia S. Corbett-Helaire, William B. Klimstra, and Jolanda M. Smit
Kizzmekia S. Corbett-Helaire
William B. Klimstra
Jolanda M. Smit
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandBooking Function
Monday, October 21, 2024
Scholarship
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
INEC Foyer
Welcome Mixer
6:00–8:00 PM
INEC Foyer
Tuesday, October 22, 2024
Breakfast
7:00–8:00 AM
Individual Hotel
Welcome and Keynote Address
8:00–9:00 AM
INEC Main Auditorium
* William B. Klimstra, University of Pittsburgh
* Jolanda M. Smit, University of Groningen
Ted C. Pierson, NIAID, National Institutes of Health
Zika Virus Vaccine Development: Seeking a General Solution to Flavivirus Vaccine Design
Zika Virus Vaccine Development: Seeking a General Solution to Flavivirus Vaccine Design
On the Surface: Viral Attachment and Entry
9:00–11:15 AM
INEC Main Auditorium
* William B. Klimstra, University of Pittsburgh
Session Chair
Session Chair
* Jolanda M. Smit, University of Groningen
Early Events in Arbovirus Infection
Early Events in Arbovirus Infection
Vidya Mangala Prasad, Indian Institute of Science
Structural Insights into Broadly Neutralizing Antibodies Against Dengue Virus
Structural Insights into Broadly Neutralizing Antibodies Against Dengue Virus
Jonathan Abraham, Harvard University
How Equine Encephalitic Alphaviruses Interact with Cellular Receptors
How Equine Encephalitic Alphaviruses Interact with Cellular Receptors
Shan-Lu Liu, Ohio State University
Short Talk: IFN-Inducible Phospholipid Scramblase 1 (PLSCR1) Differentially Modulates Viral Entry
Short Talk: IFN-Inducible Phospholipid Scramblase 1 (PLSCR1) Differentially Modulates Viral Entry
Coffee Break
9:30–9:50 AM
INEC Foyer
Poster Setup
11:15–1:00 PM
INEC Foyer
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
INEC Foyer
Symposia Spotlight 1: Novel Approaches to Virus Research
2:30–4:30 PM
INEC Main Auditorium
* Bogdan Dragnea, Indiana University
Session Chair
Session Chair
* James E. Crowe, Jr., Vanderbilt University Medical Center
Session Chair
Session Chair
Ramya Boddepalli, Indian Institute of Science Bengaluru
Integrative Mathematical Model to Elucidate the Role of Interferon-Stimulated-Genes (Isgs) in the Innate Immune Response During Positive-Sense RNA Virus Infection
Integrative Mathematical Model to Elucidate the Role of Interferon-Stimulated-Genes (Isgs) in the Innate Immune Response During Positive-Sense RNA Virus Infection
Jonathan Burnie, Harvard T.H. Chan School of Public Health
Assessing Coronavirus Spike Epitope Accessibility on Native Virions Using Flow Virometry
Assessing Coronavirus Spike Epitope Accessibility on Native Virions Using Flow Virometry
Anastazia Jablunovsky, Penn State University
Investigating the Host Interactome and Intracellular Dynamics Of Zika Virus Genomic RNA Using a Fluorogenic Aptamer-Tag
Investigating the Host Interactome and Intracellular Dynamics Of Zika Virus Genomic RNA Using a Fluorogenic Aptamer-Tag
Patrick T Dolan, NIH-NIAID
Linking Viral Genotype to Host Cell Phenotype Using Single-Cell RNA Sequencing
Linking Viral Genotype to Host Cell Phenotype Using Single-Cell RNA Sequencing
Anna K Overby, Umeå University
Whole Brain Imaging Reveals That Both the Type I IFN System and the Structural Proteins Shape Tropism of Tick-Borne Flavivirus Within the Brain.
Whole Brain Imaging Reveals That Both the Type I IFN System and the Structural Proteins Shape Tropism of Tick-Borne Flavivirus Within the Brain.
Aarthi Narayanan, George Mason University
Optimizing a Machine Learning Strategy Towards the Development of an Artificial Intelligence Platform to Understand Host Drivers of Endothelial Damage in (Re)Emerging Viral Infections
Optimizing a Machine Learning Strategy Towards the Development of an Artificial Intelligence Platform to Understand Host Drivers of Endothelial Damage in (Re)Emerging Viral Infections
Natasha Wyndham Hanners, University of Texas Southwestern Medical Center
Shiftless-Mediated Control of Zika Virus Neuropathogenesis
Shiftless-Mediated Control of Zika Virus Neuropathogenesis
Frank van Kuppeveld, Utrecht University
Live Cell Single-Molecule Imaging to Study the Role of Enterovirus 2A Protease in the Early Phases of Viral RNA Translation and Replication
Live Cell Single-Molecule Imaging to Study the Role of Enterovirus 2A Protease in the Early Phases of Viral RNA Translation and Replication
Coffee Available
4:30–5:00 PM
INEC Foyer
Below the Surface: Mechanisms of Viral Replication, Assembly, and Pathogenesis
5:00–7:00 PM
INEC Main Auditorium
* Ana Fernandez-Sesma, Icahn School of Medicine at Mount Sinai
Session Chair
Session Chair
Stephanie Karst, University of Florida
Remote Presenter: Maternal Metabolism Determines Heightened Neonatal Susceptibility to Norovirus Disease
Remote Presenter: Maternal Metabolism Determines Heightened Neonatal Susceptibility to Norovirus Disease
Margaret Kielian, Albert Einstein College of Medicine
Mechanisms of RNA Virus Entry and Transmission
Mechanisms of RNA Virus Entry and Transmission
Jan E. Carette, Stanford University
Genetic Screens Identify Host Proteins Required for Emerging Picornaviruses
Genetic Screens Identify Host Proteins Required for Emerging Picornaviruses
Andrii Slonchak, University of Queensland
Short Talk: Zika Virus Noncoding RNA (Sfrna) Interacts With Viral Protein NS5 To Inhibit Antiviral Response and Promote Viral Replication and Pathogenesis
Short Talk: Zika Virus Noncoding RNA (Sfrna) Interacts With Viral Protein NS5 To Inhibit Antiviral Response and Promote Viral Replication and Pathogenesis
Chun-Chieh (Jack) Hsu, Rutgers University
Short Talk: SARS-Cov-2 NSP14 Induces N7-Methylguanosine Modifications in Host and Viral RNA
Short Talk: SARS-Cov-2 NSP14 Induces N7-Methylguanosine Modifications in Host and Viral RNA
Cocktail Hour Sponsored by Michelson Philanthropies
7:00–8:00 PM
INEC Foyer
Dinner
7:05–8:05 PM
INEC Foyer
Women in Science Networking Event
7:10–8:10 PM
INEC Foyer
* Margaret Kielian, Albert Einstein College of Medicine
Session Chair
Session Chair
* Aarthi Narayanan, George Mason University
Session Chair
Session Chair
* Jolanda M. Smit, University of Groningen
Session Chair
Session Chair
Poster Session 1
7:45–10:00 PM
INEC Foyer
Wednesday, October 23, 2024
Breakfast
7:00–8:00 AM
Individual Hotel
Host Responses to RNA Virus Infection
8:00–11:00 AM
INEC Main Auditorium
* Stacey Lynne Schultz-Cherry, St. Jude Children's Research Hospital
Session Chair
Session Chair
* Julie M Fox, NIAID/NIH
Session Chair
Session Chair
Matthew D. Daugherty, University of California, San Diego
Tripping the Wire: Innate Immune Sensing of Viral Protease Activity Through Effector-Triggered Immunity
Tripping the Wire: Innate Immune Sensing of Viral Protease Activity Through Effector-Triggered Immunity
Suresh Mahalingam, Griffith University
Host Responses and Pathogenesis of Acute and Chronic Chikungunya Infection
Host Responses and Pathogenesis of Acute and Chronic Chikungunya Infection
Ana Fernandez-Sesma, Icahn School of Medicine at Mount Sinai
Innate Immune Modulation by Arboviruses
Innate Immune Modulation by Arboviruses
Katherine C Barnett, University of North Carolina at Chapel Hill
Short Talk: Cell Death, Damage, and Inflammation in SARS-Cov-2 Infection
Short Talk: Cell Death, Damage, and Inflammation in SARS-Cov-2 Infection
Tulika Singh, University of California, Berkeley
Short Talk: Striking Differences in Pediatric Dengue Virus B Cell And Antibody Imprinting Based on Prior Flavivirus Infection
Short Talk: Striking Differences in Pediatric Dengue Virus B Cell And Antibody Imprinting Based on Prior Flavivirus Infection
Megan M Dunagan, National Institutes of Health
Short Talk: Activating FcγRs on Monocytes are Necessary for Optimal Mayaro Virus Clearance and Disease Resolution
Short Talk: Activating FcγRs on Monocytes are Necessary for Optimal Mayaro Virus Clearance and Disease Resolution
Coffee Break
9:00–9:20 AM
INEC Foyer
Poster Setup
11:00–1:00 PM
INEC Foyer
On Own for Lunch
11:00–1:30 PM
Poster Viewing
1:00–10:00 PM
INEC Foyer
Academia vs. Industry vs Government: Navigating Your Next Career Stage
1:30–3:00 PM
INEC Main Auditorium
Ted C. Pierson, NIAID, National Institutes of Health
Director, Vaccine Research Center
Director, Vaccine Research Center
Crystal W Burke, US Army Medical Research Institute for Infectious Diseases
Branch Chief, Viral Pathogenesis
Branch Chief, Viral Pathogenesis
Chris Bahl, AI Proteins, Inc.
Co-Founder, CSO, and President
Co-Founder, CSO, and President
Zhiyun Wen, Merck Co., Inc.
Associate Principal Scientist
Associate Principal Scientist
Michael Letko, Washington State University
Assistant Professor
Assistant Professor
Vidya Mangala Prasad, Indian Institute of Science
Assistant Professor
Assistant Professor
Views from Journal Editors: Tips and Tricks
3:15–4:30 PM
INEC Main Auditorium
Nonia Pariente, PLOS Biology
*Session Chair, Editor-in-Chief
*Session Chair, Editor-in-Chief
Clare E. Thomas, Springer Nature
Senior Editor
Senior Editor
Christiana Fogg, Science Immunology
Senior Editor
Senior Editor
Coffee Available
4:30–5:00 PM
INEC Foyer
The Structure/Function Relationship
5:00–7:00 PM
INEC Main Auditorium
* Richard J. Kuhn, Purdue University
Session Chair
Session Chair
* Jonathan Abraham, Harvard University
Session Chair
Session Chair
Dahai Luo, Nanyang Technological University
Molecular Architecture of the CHIKV Replication Complex
Molecular Architecture of the CHIKV Replication Complex
James E. Crowe, Jr., Vanderbilt University Medical Center
Human Monoclonal Antibodies for Prevention or Treatment of Positive Strand RNA Viruses
Human Monoclonal Antibodies for Prevention or Treatment of Positive Strand RNA Viruses
Shee Mei Lok, Duke-NUS Medical School
Tomography Studies of the Dengue Fusion Process
Tomography Studies of the Dengue Fusion Process
Paige D Hall, Washington University in St. Louis
Short Talk: Cryo-EM Structure Of Mature Human Astrovirus In Complex With Neonatal Fc Receptor
Short Talk: Cryo-EM Structure Of Mature Human Astrovirus In Complex With Neonatal Fc Receptor
Matthew Sutton, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Short Talk: Potent Vaccine-Elicited Mabs: Structural Basis for Broad Protection Against Alphaviruses
Short Talk: Potent Vaccine-Elicited Mabs: Structural Basis for Broad Protection Against Alphaviruses
Social Hour
7:00–8:00 PM
INEC Foyer
Dinner Sponsored by Michelson Philanthropies
7:05–8:05 PM
INEC Foyer
Michelson Philanthropies Award Ceremony
7:30–8:15 PM
INEC Foyer
Poster Session 2
8:00–10:00 PM
INEC Foyer
Thursday, October 24, 2024
Breakfast
7:00–8:00 AM
Individual Hotel
Zoonosis, Viral Evolution, and Epidemiology
8:00–11:00 AM
INEC Main Auditorium
* Michael Letko, Washington State University
Session Chair
Session Chair
Chris Bahl, AI Proteins, Inc.
Using AI to Predict SARS-CoV-2 Variant Evolution
Using AI to Predict SARS-CoV-2 Variant Evolution
Eva Harris, University of Califonia, Berkeley
Lessons from a Longitudinal Flavivirus Infection Cohort in Nicaragua: Immunological Underpinnngs of the Complex Interplay between Dengue and Zika Viruses
Lessons from a Longitudinal Flavivirus Infection Cohort in Nicaragua: Immunological Underpinnngs of the Complex Interplay between Dengue and Zika Viruses
Michael Letko, Washington State University
Functional Viromics of Beta-Coronavirus Entry
Functional Viromics of Beta-Coronavirus Entry
Dixitkumar Nanubhai Tandel, CSIR-Centre for Cellular and Molecular Biology
Short Talk: Evolutionary Tale of SARS-Cov-2 Variants from The Perspective of Host Innate Immune Response
Short Talk: Evolutionary Tale of SARS-Cov-2 Variants from The Perspective of Host Innate Immune Response
Coffee Break
9:00–9:20 AM
INEC Foyer
Poster Setup
11:00–1:00 PM
INEC Foyer
On Own for Lunch
11:00–2:30 PM
Poster Viewing
1:00–10:00 PM
INEC Foyer
Symposia Spotlight 2: Detecting and Preparing for Emerging Viral Threats
2:30–4:30 PM
INEC Main Auditorium
* Shan-Lu Liu, Ohio State University
Session Chair
Session Chair
Raul Y Sanchez-David, Blizard Institut, Queen Mary University London
Novel Strategy to Enhance Self-Amplifying mRNA's Technologies Activity in Mammalian Cells by Spatial Redistribution of the Vectors Double Stranded RNA
Novel Strategy to Enhance Self-Amplifying mRNA's Technologies Activity in Mammalian Cells by Spatial Redistribution of the Vectors Double Stranded RNA
Nicole Stark, Indiana University
The Interactive Effects of Wolbachia And Nop60B on Sindbis Virus Replication
The Interactive Effects of Wolbachia And Nop60B on Sindbis Virus Replication
Nicholas J Catanzaro, University of North Carolina at Chapel Hill
Species-Specific ACE2 Receptor Usage by The Merbecovirus HKU5: Divergence from MERS-Cov and Implications for Antiviral Strategies.
Species-Specific ACE2 Receptor Usage by The Merbecovirus HKU5: Divergence from MERS-Cov and Implications for Antiviral Strategies.
Paula Bueno Fernández, Spanish National Center for Biotechnology
Discovery of a Novel Coronaviral Molecular Target Through Characterization of Molecules with Pan-Coronavirus Antiviral Activity
Discovery of a Novel Coronaviral Molecular Target Through Characterization of Molecules with Pan-Coronavirus Antiviral Activity
Ségolène Gracias, Institut Pasteur
Investigating the Entry Mechanisms and Innate Immune Response of Bat Cells to BANAL-236 and Related Viruses
Investigating the Entry Mechanisms and Innate Immune Response of Bat Cells to BANAL-236 and Related Viruses
M. Alejandra Tortorici, University of Washington
Structural and Functional Characterization of the Emerging FCoV-23 Coronavirus
Structural and Functional Characterization of the Emerging FCoV-23 Coronavirus
Ji Min Lee, University of Washington
A Broadly Generalizable Stabilization Strategy for Sarbecovirus Fusion Machinery Vaccines
A Broadly Generalizable Stabilization Strategy for Sarbecovirus Fusion Machinery Vaccines
Coffee Available
4:30–5:00 PM
INEC Foyer
The Future of Vaccines, Antibodies, and Antivirals
5:00–6:45 PM
INEC Main Auditorium
* Mario Roederer, NIH
Session Chair
Session Chair
* Andres Merits, University of Tartu
Session Chair
Session Chair
Timothy P. Sheahan, University of North Carolina
Preparing for Tomorrow’s Pandemics Today Through the Development of Broadly Active Antivirals
Preparing for Tomorrow’s Pandemics Today Through the Development of Broadly Active Antivirals
William B. Klimstra, University of Pittsburgh
Informed Design of Live-Attenuated Alphavirus Vaccines
Informed Design of Live-Attenuated Alphavirus Vaccines
James Brett Case, Washington University School of Medicine
A Trivalent Mucosal Vaccine Encoding Phylogenetically Inferred Ancestral RBD Sequences Confers Pan-Sarbecovirus Protection in Mice
A Trivalent Mucosal Vaccine Encoding Phylogenetically Inferred Ancestral RBD Sequences Confers Pan-Sarbecovirus Protection in Mice
Christian K.O Dzuvor, Harvard University
Short Talk: Multivalent Endemic Immunodominant Domain (IDD) Nanoparticle Immunogens Induce Broadly Cross-reactive Anti-Coronavirus Responses
Short Talk: Multivalent Endemic Immunodominant Domain (IDD) Nanoparticle Immunogens Induce Broadly Cross-reactive Anti-Coronavirus Responses
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
INEC Main Auditorium
* William B. Klimstra, University of Pittsburgh
* Jolanda M. Smit, University of Groningen
Dinner and Surveys
7:00–8:00 PM
INEC Foyer
Poster Session 3
7:30–10:00 PM
INEC Foyer
Friday, October 25, 2024
Fundraising
Departure
12:00–11:59 PM
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