Neurodevelopmental Disorders: Mechanisms and Therapeutics

Jan 19–22, 2027 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Tomasz Nowakowski, Xin Jin, Stephan Sanders, and Zhaolan (Joe) Zhou

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Jan 19–22, 2027 | Beaver Run Conference Center, Breckenridge, CO, United States

Scientific Organizers: Tomasz Nowakowski, Xin Jin, Stephan Sanders, and Zhaolan (Joe) Zhou

Supported by:  

***Meeting program subject to change.

Available Formats:     = Livestream   = In Person     = On Demand
Tuesday, January 19, 2027
Registration
4:00–8:00 PM
 Colorado Ballroom Foyer
Welcome Mixer
6:00–8:00 PM
 Colorado Ballroom Foyer
Wednesday, January 20, 2027
Breakfast
7:00–8:00 AM
 Summit Gallery
Welcome Remarks
8:00–8:10 AM
 Breckenridge Ballroom
Keynote Address
8:10–9:00 AM
 Breckenridge Ballroom
Huda Y. Zoghbi, Baylor College of Medicine
A Journey in Rett Syndrome: From Basic Science Discovery of Causal Gene to Therapies of Patients
Decoding Variant Effects: From Population Genomics to Functional Consequences
9:00–11:15 AM
 Breckenridge Ballroom
Hyejung Won, University of North Carolina, Chapel Hill
Experimental Validation of Common Variants of Neurodevelopmental Disorders
Xin Jin, Scripps Research Institute
Massively Parallel Dissection of Gene to Phenotype Relationships Using Perturb-seq
Thomas Bourgeron, Institut Pasteur
The Genetic Orchestra of Autism: From Medicine to Neurodiversity
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
 Breckenridge Ballroom Foyer
Award Recipient Acknowledgement
9:50–9:55 AM
 Breckenridge Ballroom
Meet the Editors
11:25–12:25 PM
 Breckenridge Ballroom
Poster Setup
12:25–1:00 PM
 Colorado Ballroom Peak 1-3
On Own for Lunch
12:25–2:30 PM
Poster Viewing
1:00–10:00 PM
 Colorado Ballroom Peak 1-3
Symposia Spotlight 1: Emerging Technologies in the Study of Neurodevelopmental Disorders
2:30–4:30 PM
 Breckenridge Ballroom
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Breckenridge Ballroom Foyer
Molecular Mechanisms Linking Gene Dysregulation to Protein Function and Cellular Phenotypes
5:00–7:00 PM
 Breckenridge Ballroom
Yukiko Gotoh, University of Tokyo
Genetic and Epigenetic Mechanisms of Cortical Development
Willow Coyote-Maestas, University of California, San Francisco
Deep Mutational Scanning Approaches to Correlate Structure and Function of Proteins
Sila Ultanir, Francis Crick Institute
Kinase Signaling in Neurodevelopmental Disorders
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
 Summit Gallery
Poster Session 1
7:30–10:00 PM
 Colorado Ballroom Peak 1-3
Thursday, January 21, 2027
Breakfast
7:00–8:00 AM
 Summit Gallery
Circuit Dynamics Shaping Developmental Outcomes
8:00–11:00 AM
 Breckenridge Ballroom
Gabrielle Pouchelon, Cold Spring Harbor Laboratory
Transient Connectivity and Circuit Reprogramming in Cortical Development
Guillermina López Bendito, Instituto de Neurociencias
Spontaneous Activity–Gene Program Interplay in Circuits Development: Implications for Neurodevelopmental Disorders
Liqun Luo, Stanford University
Wiring Specificity of Neural Circuits
Weizhe Hong, UCLA Los Angeles
The Neuroscience of Prosocial Behavior: From Helping and Cooperation to Social AI
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
 Breckenridge Ballroom Foyer
Panel Discussion 1: What to Translate? When to Translate? How to Translate?
11:10–12:10 PM
 Breckenridge Ballroom
Poster Setup
12:10–1:00 PM
 Colorado Ballroom Peak 1-3
On Own for Lunch
12:10–3:00 PM
Poster Viewing
1:00–10:00 PM
 Colorado Ballroom Peak 1-3
Career Roundtable (Joint)
3:00–4:30 PM
 Colorado Ballroom Peak 4-5
Coffee Available
4:30–5:00 PM
 Breckenridge Ballroom Foyer
Experimental Models for Interrogating Human Specific Neurodevelopmental Mechanisms
5:00–7:00 PM
 Breckenridge Ballroom
Tomasz Nowakowski, University of California, San Francisco
Establishing Tools for Human Neuroscience
Pierre Vanderhaeghen, KU Leuven
Interrogating Human Specific and Neurodevelopmental Risk Genes using Chimeric Models
Paola Arlotta, Harvard University
Brain Organoids to Study Neurodevelopmental Disorders
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
 Summit Gallery
Poster Session 2
7:30–10:00 PM
 Colorado Ballroom Peak 1-3
Friday, January 22, 2027
Breakfast
7:00–8:00 AM
 Summit Gallery
Environment and Experience
8:00–11:00 AM
 Breckenridge Ballroom
Zhaolan (Joe) Zhou, University of Pennsylvania
Epigenetic Dissection of Mechanisms underlying Neurodevelopmental Disorders
Kristen J. Brennand, Yale School of Medicine
Insights into Gene-Environment Interactions in Neurodevelopmental Disorders
Gloria Choi, Massachusetts Institute of Technology
Cytokine Regulation of Brain and Behavior
Anca M. Pasca, Stanford University
Neonatal Hypoxia and Pediatric Risk Factors
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
 Breckenridge Ballroom Foyer
Panel Discussion 2: Grand Challenges in NDDs
11:10–12:10 PM
 Breckenridge Ballroom
On Own for Lunch
12:10–2:30 PM
Symposia Spotlight 2
2:30–4:30 PM
 Breckenridge Ballroom
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Breckenridge Ballroom Foyer
From Genetic Targets to Therapeutic Strategies
5:00–6:15 PM
 Breckenridge Ballroom
Stephan Sanders, University of Oxford
Gene Targeting Strategies for Autism and Neurodevelopmental Disorders
Joe Gleeson, University of California, San Diego
Lessons from Neurodevelopmental Disease
Short Talk(s) Chosen from Abstracts
Closing Keynote Address
6:15–7:05 PM
 Breckenridge Ballroom
Allyson Berent,  Foundation for Angelman Syndrome Therapeutics/AS2Bio
The Parents’ Journey through Drug Development: Making the IMPOSSIBLE POSSIBLE-The Angelman Syndrome Story
Meeting Wrap-Up: Outcomes and Future Directions
7:05–7:15 PM
 Breckenridge Ballroom
Social Hour with Dinner
7:15–8:15 PM
 Summit Gallery
Entertainment
8:00–9:00 PM
Cash Bar
8:00–9:00 PM
Saturday, January 23, 2027
Departure
12:00–11:59 PM

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