Feb 01–04, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Wendell A. Lim, Ashley K. Koegel, and Robbie G. Majzner
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Scientific Organizers: Wendell A. Lim, Ashley K. Koegel, and Robbie G. Majzner
Wendell A. Lim, PhD
University of California, San Francisco
Ashley K. Koegel, MD
Bristol Myers Squibb
Robbie G. Majzner, MD
Dana Farber Cancer Institute
***Meeting program subject to change.
Available Formats: = In Person = On DemandSunday, February 1, 2026
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Monday, February 2, 2026
Systems Medicine: Cell Therapies as Agents to Rewire the Physiological Circuits of Disease
Engineered Probiotic Bacteria for Cancer Immunotherapy
Skin Microbiota to Manipulate Immune Responses
Microglia Replacement
Short Talk: Engineering N-lactoyl Phenylalanine Producing Bacteria for the Treatment of Obesity
Reconstructing native immune enhancer logic into synthetic genetic circuits for Context-Resolved Immune Therapy
Tuning CAR-T Cells by Targeting Cancer-Associated Glycan in Pancreatic Cancer
Sensitive Bispecific Synthetic Chimeric T cell Receptors for Cancer Therapy
TCR-like Synthetic Chimeric T Cell Receptors (ChTCRs) Targeting Solid Tumors are More Sensitive to Low Antigen, but are Subject to Greater Negative Regulation than CAR-Ts at Supraphysiologic Antigen Levels
Targeting the Bone Marrow Microenvironment with CART Cell Therapy to Overcome Resistance in Multiple Myeloma
Fratricide by Design: Selective T Cell Elimination in Cancer Therapy
Engineered Signal Cascades for Synthetic Multicellular Immune Networks
Cell Therapies for Lupus
Autoimmune Cell Therapies
CAR Tregs
Short Talk: Discriminating Friend from Foe in Autoimmunity: A Tandem NOT Gate Cell Therapy Discriminates Pathogenic Versus Non-Pathogenic Lymphocytes
Short Talk: Reprogramming Neuroinflammation: Data-Guided Development of a PD-1 CAR T Platform for Multiple Sclerosis
Tuesday, February 3, 2026
Cells as Integrators of Complex Functions
Potency Enhancement Strategies for Cell Therapies
In vivo Immune Engineering Paves the Way Towards a New Therapeutic Modality
Biomolecular Circuits as Medicine
Short Talk: Cell Autonomous Control of CAR Signaling and Receptor Shedding via ADAM17 Mediated Proteolysis
Short Talk: Engineering Cell Autonomous IL-2 Circuits to Understand and Control T Cell Responses
in vivo Engineering using iGPS Technology
Cancer Cell Therapy
Peptide Centric CARs
Short Talk: Stromal-directed Synthetic Circuits Protect against on Target Off Tumor Toxicity and Effectively Treat Pancreatic Adenocarcinoma with CAR T Cell Therapy
Short Talk: EphA3-targeted Chimeric Antigen Receptor T Cells are Effective in Glioma and Generate Curative Memory T Cell Responses
Short Talk: Site Saturation Mutagenesis of ZAP70 Enables Rational CAR-T Cell Optimization
Wednesday, February 4, 2026
GD2-Targeted CAR T Cell Therapies for Solid Cancers
GART Lessons Learned Guiding Next Gen Cell Therapies
Cell Therapies for Glioblastoma and Beyond
GPC3-CAR T Cells for Patients with Solid Tumors
Short Talk: Preliminary Results from a Phase 1 Study of Autologous Anti-EGFRvIII SynNotch Receptor-Induced Anti-EphA2/Il-13Rα2 CAR (E-SYNC) T-Cells in Adult Participants with EGFRvIII+ Glioblastoma
Optimizing Progenitor Dynamics Enables Efficient CD4 and CD8 T Cell Production from Human Pluripotent Stem Cells
Immune Synapse Disruption and Reduction of MHC Expression by Base Editing Protects Allogeneic CAR T Cells from Immune Rejection
Robust Immune Evasion Technology Enables Durable Persistence of Allogeneic Engineered Regulatory T Cells
In Vivo CAR-T cell Engineering with the PACK-IT Platform Generates Il9-Receptor Expressing CAR-T cells with Potent Anti-Tumor Efficacy
Programming Tissue-Sensing T Cells to Deliver Therapies to the Brain
Precision Epigenome Engineering to Improve T Cell Therapy
A Novel CRISPR Screening Approach Identifies Targets for Reversal of Human CAR T Cell Exhaustion
A Continuous Landscape of Signaling Encodes a Corresponding Landscape of CAR T Cell Phenotype
Cell Therapy for Neurodegenerative Disease
Peripheral Nerve Regeneration
Utilizing Synthetic Embryo Models for Enhanced Stem Cell Differentiation
Short Talk: AI-Guided Cell Fate Programming Trained by Systematic TFome™-Wide Screening
Thursday, February 5, 2026
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