Joint with: Stromal Immunology in Health and Disease
Fibrosis: Cross Organ Pathology and Pathways to Clinical Development
Feb 02–05, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Florian Rieder, Tatiana Kisseleva, and Marco Prunotto
In Person
On Demand
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Feb 02–05, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Florian Rieder, Tatiana Kisseleva, and Marco Prunotto
Florian Rieder, MD
Cleveland Clinic
Tatiana Kisseleva, MD, PhD
University of California, San Diego
Marco Prunotto, PhD
Medicxi
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMonday, February 2, 2026
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Van Horne Foyer
Welcome Mixer
6:00–8:00 PM
Van Horne Foyer
Tuesday, February 3, 2026
Breakfast
7:00–8:00 AM
President's Hall
Welcome Remarks (Joint)
8:00–8:10 AM
Van Horne A/B
Keynote Address (Joint)
8:10–9:00 AM
Van Horne A/B
* Anne Fletcher, Monash University
Session Chair
Session Chair
* Florian Rieder, Cleveland Clinic
Session Chair
Session Chair
Thomas A Wynn, Pfizer
Anti-Fibrotic Therapy: Thinking outside the TGF-beta box
Anti-Fibrotic Therapy: Thinking outside the TGF-beta box
From Fibroblasts to Fibrosis, and Back Again (Joint)
9:00–11:30 AM
Van Horne A/B
* Yuval Rinkevich, Chinese Institutes for Medical Research, Beijing, China
Session Chair
Session Chair
* Tatiana Kisseleva, University of California, San Diego
Session Chair
Session Chair
Boris Hinz, St. Michael's Hospital and University of Toronto
Mechanically Induced Chromatin Remodelling Stabilizes Myofibroblast Activation Through Enhanced DNA Methylation
Mechanically Induced Chromatin Remodelling Stabilizes Myofibroblast Activation Through Enhanced DNA Methylation
Sheila A. Stewart, Washington University School of Medicine
Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy
Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy
Michael B. Brenner, Harvard Medical School
Identifying Pathways for Targeting Fibroblasts in Inflammatory and Fibrotic Diseases
Identifying Pathways for Targeting Fibroblasts in Inflammatory and Fibrotic Diseases
Gisli Jenkins, Imperial College London
Short Talk: DEMISTIFIing Multi-Organ Fibrosis
Short Talk: DEMISTIFIing Multi-Organ Fibrosis
Angela Riedel, University of Würzburg
Short Talk: A TLR4-Dependent Fibroblast-Monocyte Axis in Tumor-Draining Lymph Nodes Contributes to Metastasis in Triple-Negative Breast Cancer
Short Talk: A TLR4-Dependent Fibroblast-Monocyte Axis in Tumor-Draining Lymph Nodes Contributes to Metastasis in Triple-Negative Breast Cancer
Coffee Break
9:30–9:50 AM
Van Horne Foyer
Award Recipient Acknowledgement
9:50–9:55 AM
Van Horne A/B
Jessica Langer, Helmsley Trust Introduction
11:30–11:35 AM
Van Horne A/B
Poster Setup
11:35–1:00 PM
Van Horne C
On Own for Lunch
11:35–2:30 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Symposia Spotlight 1
2:30–4:30 PM
Van Horne A
* Robert Barrett, Cedars-Sinai Medical Center
Session Chair
Session Chair
* Detlef B Schuppan, Univ Medical Center
Session Chair
Session Chair
Khristian Bauer-Rowe Ramos, Sandford University School of Medicine
Creeping Fat Adipocytes Can Transdifferentiate Into Pro-Fibrotic CTHRC1+ Fibroblasts in Intestinal Fibrosis
Creeping Fat Adipocytes Can Transdifferentiate Into Pro-Fibrotic CTHRC1+ Fibroblasts in Intestinal Fibrosis
Chenxiao Liu, Ruijin Hospital, Shanghai jiaotong University School of Medicine
Spatiotemporal Decoding Reveals Pro-Fibrotic Niche Transitions in Intestinal Fibrosis of Crohn’s Disease
Spatiotemporal Decoding Reveals Pro-Fibrotic Niche Transitions in Intestinal Fibrosis of Crohn’s Disease
Eric Nelius, University of Zurich
HIF Signaling and Type 2 Innate Lymphoid Cell Effector Functions in the Lung: A Tale of Inflammation versus Regeneration
HIF Signaling and Type 2 Innate Lymphoid Cell Effector Functions in the Lung: A Tale of Inflammation versus Regeneration
Irina Ferapontova, University of Zurich
Combined Ribosome Profiling and Immunopeptidomics of IPF Patient Fibroblasts
Combined Ribosome Profiling and Immunopeptidomics of IPF Patient Fibroblasts
Valerie Horsley, Yale University
Nuclear Mechanosensing Regulates Fibrosis Via Epigenetic Induction of Fibrotic Gene Expression
Nuclear Mechanosensing Regulates Fibrosis Via Epigenetic Induction of Fibrotic Gene Expression
Allen Wang, University of California, San Diego
Single Cell Multiomics Reveals Drivers of Metabolic Dysfunction-Associated Steatohepatitis
Single Cell Multiomics Reveals Drivers of Metabolic Dysfunction-Associated Steatohepatitis
Souradipta Ganguly, Sanford Burnham Prebys Medical Discovery Institute
Mechanistic Understanding of MASLD-Associated Cardiac Dysfunction and its Reversibility
Mechanistic Understanding of MASLD-Associated Cardiac Dysfunction and its Reversibility
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Mechanisms of the Extracellular Matrix Environment Driving Disease
5:00–7:00 PM
Van Horne A
* Gisli Jenkins, Imperial College London
Session Chair
Session Chair
* Boris Hinz, St. Michael's Hospital and University of Toronto
Session Chair
Session Chair
Rachel Lennon, University of Manchester
The Matrisome in Disease Pathology
The Matrisome in Disease Pathology
Natalie J. Torok, Stanford University
Viscoelasticity Promoting Cancer Progression
Viscoelasticity Promoting Cancer Progression
Detlef B Schuppan, Univ Medical Center
Targeting the ECM to Treat Liver Fibrosis and Liver Cancer
Targeting the ECM to Treat Liver Fibrosis and Liver Cancer
Peleg Hasson, Technion - Israel Institute of Technology
Short Talk: Inhibiting Enzyme-Mediated Fibronectin Fibrillogenesis – A Novel Mechanism For Fibrosis Inhibition
Short Talk: Inhibiting Enzyme-Mediated Fibronectin Fibrillogenesis – A Novel Mechanism For Fibrosis Inhibition
Kate Hitpass Romero, The University of Auckland
Short Talk: Age-Related Meningeal Extracellular Matrix Remodeling Compromises CNS Lymphatic Function;
Short Talk: Age-Related Meningeal Extracellular Matrix Remodeling Compromises CNS Lymphatic Function;
Social Hour with Dinner
7:00–8:00 PM
President's Hall
Poster Session 1
7:30–10:00 PM
Van Horne C
Wednesday, February 4, 2026
Breakfast
7:00–8:00 AM
President's Hall
Fibroblast Heterogenity across Organs: A Critical Basis for Discovery and Therapy Translation
8:00–10:30 AM
Van Horne A
* Thomas A Wynn, Pfizer
Session Chair
Session Chair
* Tatiana Kisseleva, University of California, San Diego
Session Chair
Session Chair
Suzanne Devkota, Cedars-Sinai Medical Center
Microbiome Influence on Adipose Tissue Fibrosis
Microbiome Influence on Adipose Tissue Fibrosis
Stefanie Dimmeler, Institute of Cardiovascular Regeneration
Persistent Fibroblast Activation in the Hypertrophic Human Heart
Persistent Fibroblast Activation in the Hypertrophic Human Heart
Matthew Buechler, University of Toronto
Leveraging Cross Tissue Fibroblast Heterogeneity in the Skin Microenvironment
Leveraging Cross Tissue Fibroblast Heterogeneity in the Skin Microenvironment
Dean Sheppard, University of California, San Francisco
Therapeutic Targeting of the Fibrotic Niche
Therapeutic Targeting of the Fibrotic Niche
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Panel Discussion 1: Fibroblast Heterogeneity Across Organs
10:30–11:00 AM
Van Horne A
* Thomas A Wynn, Pfizer
Panel Moderator
Panel Moderator
* Tatiana Kisseleva, University of California, San Diego
Panel Moderator
Panel Moderator
Matthew Buechler, University of Toronto
Suzanne Devkota, Cedars-Sinai Medical Center
Stefanie Dimmeler, Institute of Cardiovascular Regeneration
Dean Sheppard, University of California, San Francisco
Poster Setup
11:00–1:00 PM
Van Horne C
On Own for Lunch
11:00–3:30 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Career Roundtable (Joint)
3:30–4:30 PM
Van Horne B
Viviana Cremasco, Novartis Biomedical Research
Director
Director
Alice Denton, Imperial College London
Associate Professor
Associate Professor
Ilyssa Gordon, Cleveland Clinic
Professor of Pathology
Professor of Pathology
Souradipta Ganguly, Sanford Burnham Prebys Medical Discovery Institute
Staff Scientist
Staff Scientist
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Mechanisms that Drive the Progression and Regression of Fibrosis
5:00–7:00 PM
Van Horne A
* Valerie Horsley, Yale University
Session Chair
Session Chair
* Natalie J. Torok, Stanford University
Session Chair
Session Chair
Scott L Friedman, Icahn School of Medicine at Mount Sinai
Genetics linked with Fibrosis: Commonalities and Differences across Organs
Genetics linked with Fibrosis: Commonalities and Differences across Organs
Pilar Alcaide, University of Miami - Miller School of Medicine
The Crossroad of Cardiac Inflammation and Fibrosis: Cardiac fibroblasts-T Cell Interactions
The Crossroad of Cardiac Inflammation and Fibrosis: Cardiac fibroblasts-T Cell Interactions
Tatiana Kisseleva, University of California, San Diego
Mechanisms of Regression of Liver Fibrosis
Mechanisms of Regression of Liver Fibrosis
Blandine Baffert, University of Virginia
Short Talk: ELMO1 Efferocytosis Protects Against Nephrotoxic Injury And Counters Fibrosis
Short Talk: ELMO1 Efferocytosis Protects Against Nephrotoxic Injury And Counters Fibrosis
Lesley A. Hill, University of British Columbia
Short Talk: Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and their Impact on Liver Regeneration, Fibrosis and Resolution
Short Talk: Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and their Impact on Liver Regeneration, Fibrosis and Resolution
Social Hour with Dinner
7:00–8:00 PM
President's Hall
Poster Session 2
7:30–10:00 PM
Van Horne C
Thursday, February 5, 2026
Breakfast
7:00–8:00 AM
President's Hall
Drug Development Pathways for Fibrosis – From Mechanisms to Medicine
8:00–10:30 AM
Van Horne A
* Scott L Friedman, Icahn School of Medicine at Mount Sinai
Session Chair
Session Chair
* David A Brenner, Sanford Burnham Prebys
Preclinical Models of Fibrosis: Are we able to Predict Therapy Response
Preclinical Models of Fibrosis: Are we able to Predict Therapy Response
Marco Prunotto, Medicxi
Drug Development Pathways for Fibrotic Diseases: Lessons Learned
Drug Development Pathways for Fibrotic Diseases: Lessons Learned
Florian Rieder, Cleveland Clinic
From Mechanisms to Medicine in Intestinal Fibrosis
From Mechanisms to Medicine in Intestinal Fibrosis
William J Massey, Cleveland Clinic Research
Short Talk: Microbial Trimethylamine Exerts Pro-Fibrotic Properties in Inflammatory Bowel Diseases (IBD) and can be Targeted In Vivo to Prevent Intestinal Fibrosis.
Short Talk: Microbial Trimethylamine Exerts Pro-Fibrotic Properties in Inflammatory Bowel Diseases (IBD) and can be Targeted In Vivo to Prevent Intestinal Fibrosis.
Sadatsugu Sakane, University of California San Diego
Short Talk: Ablation of Activated Hepatic Stellate Cells (Ahscs) Impairs Liver Regeneration in Mouse Model of Toxic Fibrosis
Short Talk: Ablation of Activated Hepatic Stellate Cells (Ahscs) Impairs Liver Regeneration in Mouse Model of Toxic Fibrosis
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Panel Discussion 2: Preclinical Evaluation and Clinical Development in Fibrotic Diseases
10:30–11:00 AM
Van Horne A
* Scott L Friedman, Icahn School of Medicine at Mount Sinai
Panel Moderator
Panel Moderator
* David A Brenner, Sanford Burnham Prebys
Panel Moderator
Panel Moderator
Marco Prunotto, Medicxi
Florian Rieder, Cleveland Clinic
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2
2:30–4:30 PM
Van Horne A
* Rachel Lennon, University of Manchester
Session Chair
Session Chair
* William J Massey, Cleveland Clinic Research
Session Chair
Session Chair
Na Li, Shanghai University of Medicine and Health Sciences
Targeting Cholesterol Biosynthesis (DHCR7) and PPAR Signaling to Reverse Fibrosis and Inflammation Across MetALD/MASH Models
Targeting Cholesterol Biosynthesis (DHCR7) and PPAR Signaling to Reverse Fibrosis and Inflammation Across MetALD/MASH Models
Lorena Rosas, The Ohio State University
BAX Activation by BTSA1.2 Drives Senolysis of CTHRC1-positive Fibroblasts to Alleviate Pulmonary Fibrosis
BAX Activation by BTSA1.2 Drives Senolysis of CTHRC1-positive Fibroblasts to Alleviate Pulmonary Fibrosis
Michael Jeffrey Podolsky, Weill Cornell Medical College
SEL1L Regulates Lung Collagen Homeostasis
SEL1L Regulates Lung Collagen Homeostasis
Mallar Bhattacharya, University of California, San Francisco
Arginase 1-Dependent Myeloid–Fibroblast Metabolic Coupling Drives Collagen Synthesis in Lung
Arginase 1-Dependent Myeloid–Fibroblast Metabolic Coupling Drives Collagen Synthesis in Lung
Rafael Contreras, University of Alabama at Birmingham
Centromeric and Mitochondrial DNA Instability as Upstream Triggers of cGAS-STING-Mediated Fibrosis in Systemic Sclerosis
Centromeric and Mitochondrial DNA Instability as Upstream Triggers of cGAS-STING-Mediated Fibrosis in Systemic Sclerosis
Geoffrey Teixeira, Alentis Therapeutics
Claudin-1: A Cross-Organ Driver of Barrier Dysfunction with Disease-Modifying, Pan-Organ Antifibrotic Potential
Claudin-1: A Cross-Organ Driver of Barrier Dysfunction with Disease-Modifying, Pan-Organ Antifibrotic Potential
Wolfgang Merkt, University of Heidelberg
NK Cell Immunotherapy Reverses Lung Fibrosis by Eliminating Senescent Fibroblasts
NK Cell Immunotherapy Reverses Lung Fibrosis by Eliminating Senescent Fibroblasts
Wolfgang Jarolimek, Syntara Ltd
Lysyl Oxidase Inhibitors in Fibrotic Diseases: A Two-Pronged Therapeutic Approach Targeting Collagen Cross-Linking and Cell Signalling
Lysyl Oxidase Inhibitors in Fibrotic Diseases: A Two-Pronged Therapeutic Approach Targeting Collagen Cross-Linking and Cell Signalling
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Therapeutic Modulation of Stromal Cell Function (Joint)
5:00–6:45 PM
Van Horne A/B
* Marco Prunotto, Medicxi
Session Chair
Session Chair
* Michael B. Brenner, Harvard Medical School
Session Chair
Session Chair
Viviana Cremasco, Novartis Biomedical Research
TGFβ Neutralization and Tumor Stroma Modulation: From Bench to Bedside
TGFβ Neutralization and Tumor Stroma Modulation: From Bench to Bedside
Yuval Rinkevich, Chinese Institutes for Medical Research, Beijing, China
Regenerative Medicine and Tissue Repair
Regenerative Medicine and Tissue Repair
Burkhard Ludewig, Kantonsspital St. Gallen
Immunomodulation of Myocardial Fibrosis
Immunomodulation of Myocardial Fibrosis
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint)
6:45–7:00 PM
Van Horne A/B
* Sanjiv A. Luther, University of Lausanne
* Florian Rieder, Cleveland Clinic
Social Hour with Dinner
7:00–8:00 PM
President's Hall
Entertainment
8:00–9:00 PM
President's Hall
Cash Bar
8:00–9:00 PM
President's Hall
Friday, February 6, 2026
Departure
12:00–11:59 PM
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