Joint with: Proximity Based Biology and Therapeutics
The Ubiquitin Family in Biology and Disease

Feb 23–26, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Michael Rape, Christopher D. Lima, and Bekky Feltham

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Feb 23–26, 2026 | Fairmont Banff Springs, Banff, AB, Canada

Scientific Organizers: Michael Rape, Christopher D. Lima, and Bekky Feltham

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:     = Livestream   = In Person     = On Demand
Monday, February 23, 2026
Registration
4:00–8:00 PM
 Van Horne Foyer
Welcome Mixer
6:00–8:00 PM
 Van Horne Foyer
Tuesday, February 24, 2026
Breakfast
7:00–8:00 AM
 President's Hall
Welcome Remarks
8:00–8:10 AM
 Van Horne B
Keynote Address
8:10–9:00 AM
 Van Horne B
Nicolas H Thomä, EPFL Lausanne
Ubiquitin Signaling in Transcription and DNA Repair
Ubiquitin System – A Global View
9:00–11:15 AM
 Van Horne B
Brenda A Schulman, Max Planck Institute of Biochemistry
Molecular Machines of Ubiquitylation
Eric J. Bennett, University of California, San Diego
Leveraging Plasticity within the Ubiquitin System
Michele Pagano, New York University School of Medicine
Talk Title to be Announced
Predrag Jevtic †, UC Berkeley
Short Talk: Dynamics of Gene Repression in Development and Disease
Coffee Break
9:30–9:50 AM
 Van Horne Foyer
Award Recipient Acknowledgement
9:50–9:55 AM
 Van Horne B
Poster Setup
11:15–1:00 PM
 Van Horne C
On Own for Lunch
11:15–5:00 PM
Meet the Editors
11:15–12:15 PM
 Van Horne B
Poster Viewing
1:00–10:00 PM
 Van Horne C
Symposia Spotlight
2:30–4:30 PM
 Van Horne B
Shannon Buckley †, Huntsman Cancer Institue
Targeting the Ubiquitin E3 Ligase FBXO21 Reveals a New Approach to Modulate Aberrant PI3K Signaling in Cancer
Emma C Fink †, Dana Farber Cancer Institute
CRL5(LRRC58) Controls Cysteine Catabolism by Cyst(e)ine-regulated Degradation of CDO1
Peter Hsu †, Genentech
Template-mediated Multivalent Scaffolding of the SCF(FBXO42) E3 Ligase Regulates PP2A Degradation
Hani Zaher †, Washington University in St. Louis
eIF4E Links Transcription and Translation
Elijah Mena †, UT Southwestern
Proteasomal Surveillance of Exposed Cysteines
Hai Rao †, Southern University of Science and Technology
Tryptophan-sensing Ubiquitin Ligases Regulate Tryptophan Metabolism and Tumor Immune Suppression via IDO1 Modulation
Jennifer Kong †, University of Washington
Ubiquitin Signaling at the Plasma Membrane: Adapter-mediated Control of Receptor Abundance
Robert Piper †, University of Iowa
K48-Ubiquitin-Dependent Proteases Cut-Up Post-ER Proteins
Coffee Available
4:30–5:00 PM
 Van Horne Foyer
SUMO: The First Ubiquitin-Like Molecule
5:00–7:00 PM
 Van Horne B
Christopher D. Lima, Memorial Sloan Kettering Cancer Center
SUMOylation Mechanisms
Yifat Merbl, Weizmann Institute of Science
SUMO in the Immune Response
Stefan Müller †, Goethe-University Frankfurt
Short Talk: SUMO Signaling Rewires HSF1-dependent Gene Expression Programs
Nima Mosammaparast †, Washington University in St. Louis
Short Talk: Stalling of a Late Activated Spliceosome Recruits the ASC-1 Complex to Initiate Ubiquitin-dependent Spliceosomal Disassembly
Social Hour with Dinner
7:00–8:00 PM
 President's Hall
Poster Session 1
7:30–10:00 PM
 Van Horne C
Wednesday, February 25, 2026
Breakfast
7:00–8:00 AM
 President's Hall
Quality Control Ubiquitylation in Development and Disease
8:00–11:00 AM
 Van Horne B
Sonya Neal, University of California, San Diego
ER-Associated Quality Control
Susan Shao, Harvard Medical School
Ribosome-Associated Quality Control
Michael Rape, University of California, Berkeley
Stress Response Silencing
David Komander, Walter and Eliza Hall Institute of Medical Research
Ubiquitin and Parkinson’s Disease
Lillie E Bell †, Research Institute of Molecular Pathology
Short Talk: Regulation of Cell Defence Factor RNF213 and its Targeting of Bacterial Pathogens
Ricardo Rajsbaum †, Rutgers University, New Jersey Medical School Cancer Center
Short Talk: The Role of Non-Covalent Ubiquitin Interactions in Virus-Induced Pathology
Coffee Break
9:00–9:20 AM
 Van Horne Foyer
Poster Setup
11:00–1:00 PM
 Van Horne C
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
 Van Horne C
Career Roundtable
3:00–4:30 PM
 Van Horne B
Coffee Available
4:30–5:00 PM
 Van Horne Foyer
New Insights into Ubiquitin-Like Proteins
5:00–7:00 PM
 Van Horne B
Yogesh Kulathu, University of Dundee
UFM1 in Ribosome Control
Eilika Weber-Ban, ETH Zürich
Pup Proteasome System and Mycobacterial Stress Responses
Reuven Wiener †, Hebrew University
Short Talk: E2 Enzymes Think Outside the HPN Box: New Insights into Ubiquitin-like Conjugation
Alexandra Whiteley †, University of Colorado, Boulder
Short Talk: A Model of Ubiquilin Function Relevant to Human Disease: UBQLN2, ALS, and the Virus-Like Protein PEG10
Xing Liu †, Purdue University
Short Talk: Regulation of Cullin-RING Ubiquitin Ligases by CAND Proteins
Hao Dong †, Walter and ELiza Hall Institute
Short Talk: Branching Out: Coordinated E3-Driven K29/K48 Ubiquitination Enables Efficient PROTAC-Induced Proteolysis
Social Hour with Dinner
7:00–8:00 PM
 President's Hall
Poster Session 2
7:30–10:00 PM
 Van Horne C
Thursday, February 26, 2026
Breakfast
7:00–8:00 AM
 President's Hall
Learning from the Clinic
8:00–11:00 AM
 Van Horne B
Gwenn M Hansen, Nurix Therapeutics
Learnings from BTK Degrader Trials in Brain
Ingrid E Wertz, Lyterian Therapeutics
Co-opting the Ubiquitin System for Therapeutic Benefit
Danette L Daniels †, Foghorn Therapeutics, Inc
Talk Title to be Announced
Stephen Hinshaw †, Stanford University
Talk title to be Announced
Madel Tutor †, AstraZeneca
Short Talk: Decoding Endogenous Cereblon Functions and PROTAC Impact in Prostate and Breast Cancer Cells
Daniela Rotin †, Hospital for Sick Children
Short Talk: Inactivating Mutations in NEDD4L Cause Liddle Syndrome with NDI and Deafness (LiNDID)
Coffee Break
9:00–9:20 AM
 Van Horne Foyer
On Own for Lunch
11:00–5:00 PM
Coffee Available
4:30–5:00 PM
 Van Horne Foyer
Ubiquitin at the Crossroads of Infection and Immunology
5:00–6:30 PM
 Van Horne B
Bekky Feltham, Walter and Eliza Hall Institute of Medical Research
Ubiquitin Biology in Inflammation
Aaron T Whiteley, University of Colorado Boulder
Ubiquitin Transferase-Like Proteins in Bacterial Phage Resistance
Ivan Dikic, Goethe University Medical School
Non-Conventional Ubiquitylation
Closing Keynote Address
6:30–7:15 PM
 Van Horne B
Vishva M. Dixit, Genentech, Inc.
Virulence Factors Mediate Ubiquitin-Dependent Immunomodulation
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:15–7:30 PM
 Van Horne B
Social Hour with Dinner
7:30–8:30 PM
 President's Hall
Entertainment
8:30–9:30 PM
Cash Bar
8:30–11:00 PM
Friday, February 27, 2026
Departure
12:00–11:59 PM

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