Joint with: The Ubiquitin Family in Biology and Disease
Proximity Based Biology and Therapeutics: Targeted Protein Degradation and Beyond
Feb 23–26, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Neil Bence, Cheryl Arrowsmith, and Amit Choudhary
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In Person
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Feb 23–26, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Neil Bence, Cheryl Arrowsmith, and Amit Choudhary
Neil Bence, PhD
Bristol Myers Squibb
Cheryl Arrowsmith, PhD
University of Toronto
Amit Choudhary, PhD
Harvard Medical School
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Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandMonday, February 23, 2026
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Van Horne Foyer
Welcome Mixer
6:00–8:00 PM
Van Horne Foyer
Tuesday, February 24, 2026
Breakfast
7:00–8:00 AM
President's Hall
Welcome Remarks
8:00–8:10 AM
Van Horne A
Keynote Address
8:10–9:00 AM
Van Horne A
Ning Zheng, University of Washington
Stuck on You: The Omnipresence of Molecular Glues
Stuck on You: The Omnipresence of Molecular Glues
Transformation of Drug Discovery and Induced Proximity through AI/ML
9:00–11:15 AM
Van Horne A
Nicholas F. Polizzi, Dana-Farber Cancer Institute
Designing Biosensors from Scratch Using Principles of Induced Proximity
Designing Biosensors from Scratch Using Principles of Induced Proximity
George M Burslem, University of Pennsylvania
Chemical Tools to Edit Protein Sequences and Post-Translational Modifications
Chemical Tools to Edit Protein Sequences and Post-Translational Modifications
Mikko Taipale, University of Toronto
Navigating the Proteome with Induced Proximity
Navigating the Proteome with Induced Proximity
Björn Schwalb †, NEOsphere Biotechnologies GmbH
Short Talk: AI/ML-based Prediction of Molecular Glue Degraders using Proteomics Profiles, Molecular Fingerprints and Co-folding Models
Short Talk: AI/ML-based Prediction of Molecular Glue Degraders using Proteomics Profiles, Molecular Fingerprints and Co-folding Models
Coffee Break
9:30–9:50 AM
Van Horne Foyer
Poster Setup
11:15–1:00 PM
Van Horne C
On Own for Lunch
11:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Symposia Spotlight: Emerging Technologies and Approaches in Proximity Induction
2:30–4:30 PM
Van Horne A
Hanna Budayeva †, Genentech, Inc.
Broadening the CRBN Molecular Glue Degrader Target Space Through Unbiased Proteomic Profiling
Broadening the CRBN Molecular Glue Degrader Target Space Through Unbiased Proteomic Profiling
Simon P Shen †, Harvard
A Novel Combinatorial Screening Platform Decodes the Chemical-Genetic Landscape of Molecular Glue-Neosubstrate Interactions
A Novel Combinatorial Screening Platform Decodes the Chemical-Genetic Landscape of Molecular Glue-Neosubstrate Interactions
Evan T Judd †, Novartis
Discovery of Pan-GATA Molecular Glues for Targeted Transcription Factor Degradation
Discovery of Pan-GATA Molecular Glues for Targeted Transcription Factor Degradation
Matthew Maitland †, University of Toronto
Deconstructing Degraders with New BioID-Based Tools
Deconstructing Degraders with New BioID-Based Tools
Karolina Krygier †, McMaster University
Covalent Stabilization of Ternary Complexes for Cell-Cell 'Induced Proximity”
Covalent Stabilization of Ternary Complexes for Cell-Cell 'Induced Proximity”
Skye Montoya †, Yale
Targeting Oncogenic Transcription Effectors: A RIPTAC for Dual BCL6-BRD4 Inhibition in Lymphoma
Targeting Oncogenic Transcription Effectors: A RIPTAC for Dual BCL6-BRD4 Inhibition in Lymphoma
Matthew Robers †, Promega Corporation
Dissecting Molecular Glue Cooperativity at Biomolecular Complexes in Cells with BRETTSA
Dissecting Molecular Glue Cooperativity at Biomolecular Complexes in Cells with BRETTSA
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Novel Induced Proximity based Approaches
5:00–7:00 PM
Van Horne A
Amit Choudhary, Harvard Medical School
Proximity-Inducing Molecules for Protein Editing
Proximity-Inducing Molecules for Protein Editing
Gerald R. Crabtree, Stanford University
Hijacking the Hijackers: TCIPs for Rewiring Oncogenic Circuits to Cell Death
Hijacking the Hijackers: TCIPs for Rewiring Oncogenic Circuits to Cell Death
Elena De Vita, Queen Mary University of London
Targeted Protein Dephosphorylation vial PHOSTACs
Targeted Protein Dephosphorylation vial PHOSTACs
Eric Bilotta †, The Scripps Research Institute
Short Talk: Rewiring DNA Repair with PARP-Based Chemical Inducers of Proximity
Short Talk: Rewiring DNA Repair with PARP-Based Chemical Inducers of Proximity
Social Hour with Dinner
7:00–8:00 PM
President's Hall
Poster Session 1
7:30–10:00 PM
Van Horne C
Wednesday, February 25, 2026
Breakfast
7:00–8:00 AM
President's Hall
Leveraging Novel Protein Degradation Machinery for Next Generation Protein Degraders
8:00–11:00 AM
Van Horne A
Cheryl Arrowsmith, University of Toronto
Increasing the Repertoire of Chemically Recruitable E3 Ligases for Targeted Protein Degradation
Increasing the Repertoire of Chemically Recruitable E3 Ligases for Targeted Protein Degradation
Gwenn M Hansen, Nurix Therapeutics
Enabling Novel Ligases for Targeted Protein Degradation through DEL based Approaches
Enabling Novel Ligases for Targeted Protein Degradation through DEL based Approaches
Daniel K Nomura, University of California, Berkeley
Enabling Novel Ligases
Enabling Novel Ligases
Simon Glerup †, Aarhus University
Short Talk: Reshaping the Progranulin/Sortilin Interaction for Targeted Degradation of Extracellular Proteins
Short Talk: Reshaping the Progranulin/Sortilin Interaction for Targeted Degradation of Extracellular Proteins
Gina Gotthardt †, Goethe University Frankfurt
Short Talk: Targeted Degradation of E3 Ligase Functions in Acute Myeloid Leukemia
Short Talk: Targeted Degradation of E3 Ligase Functions in Acute Myeloid Leukemia
Lucie Wolf †, University of Toronto
Short Talk: Proteome-scale Induced Proximity Screens Reveal Kinase-dependent Targeted Protein Degradation of Oncogenic Beta-catenin
Short Talk: Proteome-scale Induced Proximity Screens Reveal Kinase-dependent Targeted Protein Degradation of Oncogenic Beta-catenin
Louise Modis †, Amphista Therapeutics
Short Talk: Expanding Targeted Glue Applications for Clinical Use by Recruiting Novel E3 Ligases
Short Talk: Expanding Targeted Glue Applications for Clinical Use by Recruiting Novel E3 Ligases
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Van Horne A
Poster Setup
11:00–1:00 PM
Van Horne C
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Career Roundtable (Joint)
3:00–4:30 PM
Van Horne B
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Induced Proximity to Modulate Protein Complexes
5:00–7:00 PM
Van Horne A
Katherine Kayser-Bricker, Halda Therapeutics
Regulated Induced Proximity Targeting Chimeras (RIPTACs)
Regulated Induced Proximity Targeting Chimeras (RIPTACs)
Michelle R. Arkin, University of California, San Francisco
Utilization of Stabilizers of Protein-Protein Interactions
Utilization of Stabilizers of Protein-Protein Interactions
Jian Jin, Icahn School of Medicine at Mount Sinai
New Approaches to Target Undruggable Proteins
New Approaches to Target Undruggable Proteins
Asad Taherbhoy, Foghorn Therapeutics
Novel Strategies of Targeting the Transcriptional Machinery for Degradation
Novel Strategies of Targeting the Transcriptional Machinery for Degradation
Social Hour with Dinner
7:00–8:00 PM
President's Hall
Poster Session 2
7:30–10:00 PM
Van Horne C
Thursday, February 26, 2026
Breakfast
7:00–8:00 AM
President's Hall
Clinical Progress in Induced Proximity Approaches
8:00–11:00 AM
Van Horne A
Neil Bence, Bristol Myers Squibb
BMS Protein Degrader from Discovery to Clinical Development
BMS Protein Degrader from Discovery to Clinical Development
Paula O’Connor, Nurix Therapeutics
Advancing Novel Degraders to the Clinic (BTK and Beyond)
Advancing Novel Degraders to the Clinic (BTK and Beyond)
Michael Feldman, Kymera Therapeutics
KT-621: First STAT6-Targeted Medicine in Clinical Development
KT-621: First STAT6-Targeted Medicine in Clinical Development
Sheryl Gough, Arvinas Inc
The PROTAC Mode of Action Makes Therapeutic Targeting of BCL6 Possible
The PROTAC Mode of Action Makes Therapeutic Targeting of BCL6 Possible
Soraya Carrancio †, BMS
Short Talk: CK1α Degradation Unlocks p53 Activation and Pathway Rewiring in HR-MDS and AML: Translational and Clinical Evidence for BMS-986397
Short Talk: CK1α Degradation Unlocks p53 Activation and Pathway Rewiring in HR-MDS and AML: Translational and Clinical Evidence for BMS-986397
Coffee Break
9:00–9:20 AM
Van Horne Foyer
On Own for Lunch
11:00–5:00 PM
Panel Discussion: Driving Innovation: From Concept to Company, how to Start a Company around a New Idea
2:30–4:30 PM
Van Horne A
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Enabling Discovery and Development of Novel Induced Proximity Molecules and Glues
5:00–6:45 PM
Van Horne A
Georg E. Winter, CeMM Research Center for Molecular Medicine
Novel Glue Discovery via Isogenic Morphological Profiling
Novel Glue Discovery via Isogenic Morphological Profiling
Alessio Ciulli, University of Dundee, School of Life Sciences
Expanding the Target Space of Protein Degraders
Expanding the Target Space of Protein Degraders
Lauren V Albrecht, University of California Irvine
MrTAC: Proximity Induced Methylation and Lysosomal Degradation
MrTAC: Proximity Induced Methylation and Lysosomal Degradation
Takamitsu Hattori †, University Health Network
Short Talk: Creating Cancer-Specific Neoantigens with Covalent Inhibitors and Targeting Them with Bispecific T-cell Engagers
Short Talk: Creating Cancer-Specific Neoantigens with Covalent Inhibitors and Targeting Them with Bispecific T-cell Engagers
Meeting Wrap-Up: Outcomes and Future Directions
6:45–7:00 PM
Van Horne A
Social Hour with Dinner
7:00–8:00 PM
President's Hall
Entertainment
8:30–9:30 PM
President's Hall
Friday, February 27, 2026
Departure
12:00–11:59 PM
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