Joint with: Proximity Based Therapeutics
Targeted Protein Degradation

Jan 21–24, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: James E. Bradner, Eric S. Fischer, and Brenda A. Schulman

  In Person
  On Demand
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Jan 21–24, 2024 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: James E. Bradner, Eric S. Fischer, and Brenda A. Schulman

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, January 21, 2024
Arrival and Registration  
4:00–8:00 PM
 Longs Peak Foyer
Welcome Mixer  
6:00–8:00 PM
 Longs Peak Foyer
Monday, January 22, 2024
Breakfast  
7:00–8:00 AM
 Quandary Peaks
Welcome and Keynote Address (Joint)  
8:00–9:00 AM
 Grays/Longs Peak
Ning Zheng, University of Washington
Targeting Ubiquitin Ligases: From Hormones to Metabolites
Mechanisms of the Ubiquitin System (Joint)  
9:00–11:15 AM
 Grays/Longs Peak
Brenda A. Schulman, Max Planck Institute of Biochemistry
Structural Mechanisms of Dynamic Multiprotein E3 Ligases
Michael Rape, University of California, Berkeley
Novel Cullin-RING E3 Ligase Mechanisms Discovered through Deciphering Pathways Underlying Cellular Differentiation
Henry M. Colecraft, Columbia University
Developing Targeted Deubiquitination: Opportunities for Therapeutic Protein Stabilization
Jin Wang, Baylor College of Medicine
Short Talk: Short Talk: Unexpected Discoveries Through Developing BTK PROTACs
Ana Marcu, Genentech
Short Talk: Short Talk: Developing Discovery Proteomics Technologies to Elucidate HLA Neoantigen Presentation
Coffee Break  
9:30–9:50 AM
 Longs Peak Foyer
Poster Setup  
11:15–1:00 PM
 Quandary Peaks
On Own for Lunch  
11:15–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Quandary Peaks
Workshop  
2:30–4:30 PM
 Longs Peak
Sebastian Kenny, University of Washington
De novo Design of Virus-Inspired 'Molecular Glues' to Efficiently Degrade Target Proteins
Hai-Tsang Huang, Broad Institute
Profiling E3 Substrate Ubiquitylation by Ubiquitin-specific Proximity Labeling
Justin Reitsma, AbbVie, Inc.
Degrader Speedometer: Quantitative Measurement of Degrader Rate of Targeted Protein Degradation
Jessie Kroonen, UMC Utrecht
Surface Removal and Lysosomal Degradation of PD-L1 using SureTACTM Technology
Hui Myeong Wang, Postech
Encoded Display of Chemical Libraries on Nanoparticles for Rapid Discovery of Potent Protein Ligands
Shourya S. Roy Burman, Dana-Farber Cancer Institute
Continuous Evolution of Compact Protein Degradation Tags Regulated by Selective Cereblon Molecular Glues
Lori Emert-Sedlak, University of Pittsburgh School of Medicine
Targeted Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication
Juliane Elisabeth Müller, Julius Maximilians Universität Würzburg
Targeted Protein Degradation Reveals a Scaffolding Function of Aurora-A Kinase
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Chemical Biology of Protein Degradation  
5:00–7:00 PM
 Longs Peak
Alessio Ciulli, University of Dundee, School of Life Sciences
How PROTAC Degraders Work and Why the Ternary Complex Matters
Nathanael Gray, Stanford University
Transcription Factor Chemical Induced Proximity – Reprogramming Cellular Function
James E. Bradner, Novartis
The Chemical Biology of Targeted Protein Degradation
Ashley Julio, UCLA
Short Talk: Short Talk: Pervasive Aggregation and Degradation of Host and Viral Proteins in Response to Cysteine-Reactive Electrophilic Compounds
Brian B. Liau, Harvard University
Short Talk: Short Talk: Chemical Facsimile of KBTBD4 Cancer Mutations Promotes Corepressor Degradation
Social Hour with Lite Bites  
7:00–8:00 PM
 Quandary Peaks
Poster Session 1  
7:30–10:00 PM
 Quandary Peaks
Tuesday, January 23, 2024
Breakfast  
7:00–8:00 AM
 Quandary Peaks
Strategies and Targets for Therapeutics in the Ubiquitin Proteasome System  
8:00–11:00 AM
 Longs Peak
Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center
Proteostatic Control of the Cholesterol Biosynthetic Pathway
Raymond J. Deshaies, Amgen, Inc.
Cutting-Edge Developments in Targeted Protein Degradation
Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research
Mechanisms of Transcriptional Regulation by E3 Ligases and Harnessing for Targeted Protein Degradation
Tanja Mittag, St. Jude Children's Research Hospital
Malleable Higher-Order Structures in Substrate Receptor SPOP Function and Pathophysiology
Liron Bar-Peled, Massachusetts General Hospital/Harvard Medical School
Short Talk: Short Talk: DrugMap: A Quantitative Pan-Cancer Analysis of Cysteine Ligandability
Coffee Break  
9:00–9:20 AM
 Longs Peak Foyer
Poster Setup  
11:00–1:00 PM
 Quandary Peaks
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Quandary Peaks
Women in TPD & IP Networking Social - Open to All!
1:30–2:30 PM
 Castle Peak 1-2
Career Roundtable (Joint)  
3:00–4:30 PM
 Longs Peak
Michelle R. Arkin, University of California, San Francisco
Professor & Chair, Codirector, Small Molecule Discovery Center (SMDC)
Helen Walden, University of Glasgow
Professor of Structural Biology, Head of School (Molecular Biosciences)
Ramon J. Whitson, Novartis
Principal Scientist II
Byram Hirsch Ozer, National Cancer Institute
Assistant Research Physician
Heather Bisbee, Cell Press
Associate Scientific Editor, Molecular Cell
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Novel Opportunities in the Ubiquitin System  
5:00–7:00 PM
 Longs Peak
Sara Buhrlage, Dana-Farber Cancer Institute
Harnessing DUBs for Protein Stability Therapeutics
Helen Walden, University of Glasgow
Targeting USP1-UAF1 in DNA Repair
Ivan Dikic, Goethe University Medical School
Novel Ubiquitin Modifications Deployed by Pathogenic Bacteria
Zacharias Thiel, Novartis Biomedical Research
Short Talk: Short Talk: Identification of New Entry Points for Autophagy-Mediated Targeted Protein and Organelle Degradation using an Induced-Proximity Screen
Social Hour with Lite Bites  
7:00–8:00 PM
 Quandary Peaks
Poster Session 2  
7:30–10:00 PM
 Quandary Peaks
Wednesday, January 24, 2024
Breakfast  
7:00–8:00 AM
 Quandary Peaks
Methodologies and Technologies for the Investigation of Protein Degradation  
8:00–11:00 AM
 Longs Peak
Marta Cortes-Cros, Novartis Institutes for BioMedical Research
Degraders by Design vs. Serendipity: What have we Learned?
Yifat Merbl, Weizmann Institute of Science
Proteasome Profiling : Global Views of Degradation
Xin Zhou, Dana-Farber Cancer Institute
TransTAC
Angela Cacace, Arvinas Inc
Oral PROTAC® Degrader Molecules Selectively Clear Pathologic Proteins Underlying Neurodegenerative Diseases
Weicheng Li, UCSF
Short Talk: Short Talk: Intracellular Ubiquitination of a Synthetic Small Molecule Inhibits the UPS
Coffee Break  
9:00–9:20 AM
 Longs Peak Foyer
On Own for Lunch  
11:00–5:00 PM
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Development and Discovery of Molecular Glues (Joint)  
5:00–6:45 PM
 Grays/Longs Peak
Eric S. Fischer, Dana-Farber Cancer Institute
New Mechanism for Protein Degradation Therapeutics
Mary E. Matyskiela, Neomorph Inc.
Expanding the Target Space of Molecular Glue Degraders
Keriann Marie Backus, David Geffen School of Medicine at UCLA
Global Proteome Rewiring by Fragment Electrophiles
Michael A. Erb, The Scripps Research Institute
Short Talk: Short Talk: Systematic Remodeling of Protein-Ligand Surfaces for Prospective Molecular Glue Discovery
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Grays/Longs Peak
Social Hour with Lite Bites  
7:00–8:00 PM
 Quandary Peaks
Trivia  
8:00–9:00 PM
 Longs Peak
Cash Bar  
8:00–9:00 PM
 Quandary Peaks
Thursday, January 25, 2024
Departure  
8:00–8:00 AM

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