Induced Proximity and Targeted Protein Degradation: Emerging Technologies and Therapeutic Applications

Jan 01–04, 2027 | Location to be Determined
Scientific Organizers: Christina Woo, William Forrester, and Alessio Ciulli

  In Person
  On Demand
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Jan 01–04, 2027 | Location to be Determined

Scientific Organizers: Christina Woo, William Forrester, and Alessio Ciulli

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Friday, January 1, 2027
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Saturday, January 2, 2027
Breakfast
7:00–8:00 AM
Welcome and Keynote Address
8:00–9:00 AM
Craig M. Crews †, Yale University
Regulated Induced Proximity Targeting Chimeras—RIPTACs—A Heterobifunctional Small Molecule Strategy for Cancer Selective Therapies: Cell Chemical Biology
Clinic to First Approval, TPD Medicinal Chemistry to in vivo
9:00–11:15 AM
Angela Cacace †, Arvinas Inc
Neurodegenerative Targets in TPD
Juliet Williams †, Kymera Therapeutics
Solving Big Problems with Small Molecule Degraders
William Forrester, Novartis
The Novartis Targeted Protein Degradation Platform
Gwenn Hansen †, Nurix Therapeutics
Clinical Development of Nurix’s Degrader Drugs
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
Meet the Editors
11:15–12:15 PM
Poster Setup
11:15–1:00 PM
On Own for Lunch
12:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Induced Proximity Modalities to Treat Human Disease
5:00–7:00 PM
Lauren V Albrecht †, University of California Irvine
Methyl Arginine TACs
Steven Banik †, Stanford University
Shuttle Proteins
Mikko Taipale †, University of Toronto
Pervasive Mislocalization of Pathogenic Coding Variants Underlying Human Disorders: Cell
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Sunday, January 3, 2027
Breakfast
7:00–8:00 AM
New Frontiers for E3 Ligases in TPD
8:00–11:00 AM
Nicolas H Thomä †, EPFL Lausanne
Haven't Got a Glue: Protein Surface Variation for the Design of Molecular Glue Degraders
Lindsey Ingerman James †, University of North Carolina at Chapel Hill
E3 Ligase and Degrader Discovery
Jacob E. Corn †, ETH Zürich
C-Terminal Amides Mark Proteins for Degradation via SCF–FBXO31
Christina Woo, Harvard University
Probing Cereblon Allosterically
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Panel Discussion: How to Start a Company
11:00–12:00 PM
Poster Setup
11:00–1:00 PM
On Own for Lunch
12:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Discovery Chemistry for Novel Induced Proximity Modalities
5:00–7:00 PM
Alessio Ciulli, University of Dundee, School of Life Sciences
Trivalent TAC Chemistry
Nir London †, Weizmann Institute of Science
A Pharmacological Modality to Sequester Homomeric Proteins
Ekaterina Vinogradova †, Rockefeller University
Chemical Immunology and Proteomics for Small Molecule Degraders
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Monday, January 4, 2027
Breakfast
7:00–8:00 AM
Antibody and Biologic Degraders from the Lab to the Clinic
8:00–11:00 AM
Laura L. Kiessling †, Massachusetts Institute of Technology
Cell Surface Induced Proximity Engineering
Hui-Kuan Lin †, Duke University
Degrader Delivery through CD36
John Flygare †, Eli Lilly
Delving into Novel Design and Development to Strive for Next-Generation ADCs Providing Long-Term Benefit to Patients
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Glues at the AI and ML Interface
5:00–6:30 PM
Bruno Emanuel Correia †, École Polytechnique Fédérale de Lausanne
PP Interface
Victor Guallar †, Barcelona Supercomputing Center and Nostrum Biodiscovery
Adventures in CADD
Daphne Koller †, insitro
AI-Driven Drug Discovery
Short Talk(s) Chosen from Abstracts
Closing Keynote Address
6:30–7:15 PM
David Baker †, University of Washington
Future of PPIs
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:15–7:30 PM
Social Hour with Dinner
7:30–8:30 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:30–11:00 PM
Tuesday, January 5, 2027
Departure
12:00–11:59 PM

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