Stem Cell Models for Embryology

Feb 06–08, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Aryeh Warmflash and Magdalena D. Zernicka-Goetz

  In Person
  On Demand
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Feb 06–08, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States

Scientific Organizers: Aryeh Warmflash and Magdalena D. Zernicka-Goetz

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Tuesday, February 6, 2024
Arrival and Registration  
4:00–6:00 PM
 Kiln
Dinner  
6:00–7:00 PM
 Crocker Dining Room
Welcome Mixer and Registration  
7:00–8:00 PM
 Kiln
Wednesday, February 7, 2024
Breakfast  
7:30–8:30 AM
 Crocker Dining Room
Poster Setup  
8:00–8:30 AM
 Kiln
Welcome and Keynote Address  
8:30–9:30 AM
 Fred Farr Forum
* Aryeh Warmflash, Rice University
Session Chair
* Magdalena D. Zernicka-Goetz, University of Cambridge
Session Chair
Janet Rossant, The Gairdner Foundation
Stem Cells, Embryos and Embryo Models
Poster Viewing  
8:30–9:00 PM
 Kiln
Blastocysts and Blastoids  
9:30–12:00 PM
 Fred Farr Forum
* Mijo Simunovic, Columbia University
Session Chair
Nicolas Rivron, Institute of Molecular Biotechnology
Mouse and Human Blastoids
Jun Wu, University of Texas Southwestern Medical Center
Integrated Stem Cell based Embryo Models for Early Human Development
Ge Guo, University of Exeter
Lineage Segregation in Blastoids
Samuel Ojosnegros, IBEC
Short Talk: Short Talk: Mechanotransduction of Human and Mouse Embryo Implantation
Zukai Liu, Jackson Labortary / UConn Health
Short Talk: Short Talk: A Trophoblast Origin of Extra-embryonic Mesenchyme in Human Early Development
Coffee Break  
10:00–10:20 AM
 Fred Farr Forum
Lunch  
12:00–1:00 PM
 Crocker Dining Room
Workshop  
2:00–3:30 PM
 Fred Farr Forum
* Idse Heemskerk, University of Michigan
Session Chair
Harry McNamara, Princeton University
Recording Morphogen Signals Reveals Origins of Gastruloid Symmetry Breaking
Bohan Chen, University of Michigan
2D Gastruloids Develop Into Layered Structure With Spatially Patterned Mesoderm
Mijo Simunovic, Columbia University
Slingshot Through Time: A Stem Cell Approach to Modeling the First Cell Fate Decisions in Human Development
Luisa Rezende, Rice University
Role of Nodal Signaling Regulators in Nodal Dynamics and Cell Fate Decisions in a Stem Cell Model of Human Gastrulation
Blerta Stringa, Washington University in St. Louis
Exploring the Role of FGF17 in Human Gastrulation
Joshua Hislop, University of Pittsburgh School of Medicine
Modeling Post-Implantation Human Development to Yolk Sac Blood Emergence
Coffee Available  
3:30–4:00 PM
 Fred Farr Forum
Micropatterns and 2D Models  
4:00–6:00 PM
 Fred Farr Forum
* Mo Ebrahimkhani, University of Pittsburgh School of Medicine
Session Chair
Idse Heemskerk, University of Michigan
Germline Competence and BMP Signaling
Thorold Theunissen, Washington University in St. Louis
Regulation of Morphogenetic Cell Behaviors in Stem Cell Models of Human Gastrulation
Aryeh Warmflash, Rice University
Signaling Logic Underlying Germ Layer Differentiation
Mary Hynes, Stanford University
Short Talk: Short Talk: Distinct Roles for the Nanog 3’-Untranslated and Cognate Coding mRNA Components in Pluripotent Embryonic Stem Cell Patterning and Colony Formation
Gerrald Lodewijk, University of California Santa Cruz
Short Talk: Short Talk: Self-organization of Pluripotent Stem Cells Into Early Embryonic Developmental Patterns Through Minimal Epigenome Editing
Dinner  
6:00–7:00 PM
 Crocker Dining Room
Poster Session  
7:00–9:00 PM
 Kiln
Thursday, February 8, 2024
Breakfast  
7:30–8:30 AM
 Crocker Dining Room
Embryoids and 3D Models  
8:30–11:30 AM
 Fred Farr Forum
* Ge Guo, University of Exeter
Session Chair
Marta Shahbazi, MRC Laboratory of Molecular Biology
Remote Presentation: 3D Models of the Epiblast
Naomi Moris, Francis Crick Institute
Human Gastruloids
Magdalena D. Zernicka-Goetz, University of Cambridge
3D Whole Embryo Models
Kamyar Keshavarz Farajkhah, University of Pittsburgh School of Medicine
Short Talk: Short Talk: Building to Understand Multiorgan Function of Human Yolk Sac Tissue in vitro
Lizhong Liu, UT Southwestern
Short Talk: Short Talk: Stem-Cell-Based Modeling of Post-Implantation Human Development and Embryonic-Extraembryonic Interactions
Ikbal Choudhury, California Institute of Technology
Short Talk: Short Talk: Ex-Utero Human Embryo Implantation and Development in a 3D Vascular Niche
Coffee Break  
9:30–9:50 AM
 Fred Farr Forum
Presentation from CIRM  
11:30–12:00 PM
 Fred Farr Forum
Uta Grieshammer, CIRM
California Institute for Regenerative Medicine: Funding Programs and Resources
Lunch  
12:00–1:00 PM
 Crocker Dining Room
Group Walking Tour on History and Architecture of Asilomar State Park  
1:00–2:30 PM
 Social Hall
Ethics Talk and Panel Discussion  
3:00–4:00 PM
 Fred Farr Forum
Insoo Hyun, Museum of Science
Ethics of Stem Cell Models of Embryos
Jun Wu, University of Texas Southwestern Medical Center
Panelist
Nicolas Rivron, Institute of Molecular Biotechnology
Panelist
Magdalena D. Zernicka-Goetz, University of Cambridge
Panelist
Janet Rossant, The Gairdner Foundation
Panelist
Thorold Theunissen, Washington University in St. Louis
Panelist
Coffee Available  
4:00–4:30 PM
 Fred Farr Forum
Models of Neural Tube and Somitogenesis  
4:30–6:15 PM
 Fred Farr Forum
* Naomi Moris, Francis Crick Institute
Session Chair
Olivier Pourquie, Harvard Medical School and Brigham and Women’s Hospital
Mechanisms of Somitogenesis in vivo and in vitro
Cantas Alev, Kyoto University
Modeling Development and Disease in Axioloids
Randolph Scott Ashton, University of Wisconsin
RosetteArrays™: Quantitative Highthrough-put Assessment of Human Neurodevelopmental Risk
Matthew Lefebvre, University of California Santa Barbara
Short Talk: Short Talk: Developmental Biology in Human Organoids: Studying the Effect of PCP Loss on in vitro Neural Tube Morphogenesis
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:15–6:30 PM
 Fred Farr Forum
Dinner  
6:30–7:30 PM
 Crocker Dining Room
Bonfire with S'mores and Trivia  
7:30–9:00 PM
 Crocker Fire Pit
Friday, February 9, 2024
Breakfast  
7:30–9:00 AM
 Crocker Dining Room
Lunch  
12:00–1:00 PM
 Crocker Dining Room
Departure  
1:00–11:59 PM

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