March 30–April 02, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Karen Adelman and Kristian Helin

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Scientific Organizers: Karen Adelman and Kristian Helin
Karen Adelman
Kristian Helin
***Meeting program subject to change.
Available Formats: = In Person = On DemandMerchandise Options
Registration Options
Sunday, March 30, 2025
Fundraising
Booking Function
Monday, March 31, 2025
Session Chair
Chromatin and Transcription
Session Chair
Controlling CpG islands
RNA Modifications in Health and Disease
High-Throughput Measurements of Activation and Repression Domains from Human Proteins
Short Talk: Members of an Array of Zinc Finger Proteins Specify Distinct Hox Chromatin Boundaries
Session Chair
Large AT-rich Promoter Flanks Control Menin/KMT2A Complex Localization at Key Developmental Genes
Joint TGF-β and RAS Transcriptional Program Supports Metastasis
Aberrant Enhancer Activation in KMT2A: AFF1 Leukemia
Rapid Brain Tumor Classification from Sparse Epigenomic Data
Single Cell Multiomics Reveal Divergent Effects of DNMT3A and TET2 Mutant Clonal Hematopoiesis in Inflammatory Response
The Paediatric Glioma H3.3 K27M Mutation Disrupts Cell Differentiation by Interfering with Heterochromatin Formation at Pericentric Regions
Blocks of Sequence-Independent Allele-Specific DNA Methylation in Acute Myeloid Leukemia are Clonal Events that can Originate in Normal Hematopoietic Cells
FLI1 Accessible Stem Cell Programs Drive Leukemic Transformation
Session Chair
Dissecting the Role of Histone Modifications Using Histone Mutants
Catalytic-Independent Functions of CPB/P300
Functional Consequences of Histone Acetylation
Short Talk: Heterochromatin Form and Function during Vertebrate Development
Short Talk: Histone 4 Acetylation Regulates Developmental Plasticity of Predatory Nematodes
Tuesday, April 1, 2025
Session Chair
Polycomb Complexes in Development
Dynamic Changes in Chromatin and Transcription During Cell Differentiation
The Influence of Histone Modifications and Chromatin Domains on Biallelic Gene Expression
Functional Genomics to Study Transcription Factors and Chromatin Remodelers in Cancer
Short Talk: Bystander Chromatin Poising by Pioneer Factors Confers Aberrant Enhancer Activation in Congenital Disease
Short Talk: Dissecting the Cooperative, Context-dependent Rules of Transcription Factor Binding in Human Development
Group Leader
VP, Head of Biology
Assistant Professor
Assistant Professor
Senior Editor
Session Chair
Short Talk: Exposure to Childhood Maltreatment is Associated with Specific Epigenetic Patterns in Sperm
Short Talk: Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Malformations through Dysregulation of DNA Methylation
Short Talk: Genetic, Epigenomic, and Phenotypic Integration Reveals the Roles of Circulating Immune Cells and Patient Subgroups in Bipolar Disorder
Short Talk: CTCF is Required for Breast Tumour Initiation, but is Dispensable for Normal Mammary Gland Development
Session Chair
Metabolic Control of Chromatin Modifications
Mitochondrial Signaling to the Transcription Machinery
Metabolic Pathways Govern Cell Fate Decisions
Short Talk: Mitochondrial Stress Modulates Chromatin Accessibility and Cell Identity in Breast Cancer
Short Talk: Nuclear Specific Reductive Carboxylation of Alpha-ketoglutarate Fuels Histone Acetylation
Wednesday, April 2, 2025
Session Chair
Epigenetic Memory in Plants
Three Dimensional Genome Organization and Epigenetic Memory
The Structural Basis for de novo DNA Methylation in Chromatin
Short Talk: Allosteric Effectors of PRC2 Synergise to Restrict the Spread of Polycomb Domains
Short Talk: LncRNA-Mediated Heterochromatin Assembly
Short Talk: Advanced Multiomic Sequencing Technologies Reveal Complex Crosstalk between Chromatin Proteins and DNA Methylation in Development
Session Chair
HDAC3 Functions as a Speed-limit for Developmental Enhancers
Transgenic Mouse Models for Editing DNA Methylation in vivo
Chromatin Accessibility Noise is Amplified via p53 Repression to Promote Cell Plasticity for Immune Tolerance
The Role of Histone Ubiquitination in Plasticity and Neurodevelopmental Disease
Chromatin Recognition by the AAA+ ATPase Superfamily Protein ATAD2B
A Molecular Adapter that Mediates Disordered cBAF Interactions
Herpesviruses Mimic Zygotic Genome Activation to Promote Viral Replication
Rare Regions of Facultative Heterochromatin Define Domains of Cellular Constraint Underpinning Genomic Regulation of Cell Identity
Session Chair
Chromatin Regulation and Cancer
Session Chair
Epigenetics and Functional Intratumor Heterogeneity
Targeting Chromatin Modulators with Therapeutic Degraders
Targeting RNA Modifying Enzymes in the Treatment of Cancer
Thursday, April 3, 2025
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