Epigenetics in Development and Disease
March 30–April 02, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Karen Adelman and Kristian Helin
In Person
On Demand
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March 30–April 02, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Karen Adelman and Kristian Helin
Karen Adelman
Kristian Helin
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMerchandise Options
Registration Options
Sunday, March 30, 2025
Fundraising
Booking Function
Registration
4:00–8:00 PM
Riverview Lounge
Welcome Mixer
6:00–8:00 PM
Riverview Lounge
Monday, March 31, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Welcome and Keynote Address (Joint)
8:00–9:00 AM
Cascade Ballroom
* Karen Adelman, Harvard Medical School
Session Chair
Session Chair
Patrick Cramer, Max Planck Institute for Multidisciplinary Sciences
Chromatin and Transcription
Chromatin and Transcription
Mechanisms of Gene Control and Epigenetic Regulation (Joint)
9:00–11:30 AM
Cascade Ballroom
* Seychelle Vos, Massachusetts Institute of Technology
Session Chair
Session Chair
Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research
Controlling CpG islands
Controlling CpG islands
François Fuks, University of Brussels
RNA Modifications in Health and Disease
RNA Modifications in Health and Disease
Lacramioara Bintu, Stanford University
High-Throughput Measurements of Activation and Repression Domains from Human Proteins
High-Throughput Measurements of Activation and Repression Domains from Human Proteins
Havva Ortabozkoyun, University of Miami / HHMI
Short Talk: Members of an Array of Zinc Finger Proteins Specify Distinct Hox Chromatin Boundaries
Short Talk: Members of an Array of Zinc Finger Proteins Specify Distinct Hox Chromatin Boundaries
Coffee Break
9:30–9:50 AM
Riverview Lounge
Award Recipient Acknowledgement
9:50–9:55 AM
Cascade Ballroom
Poster Setup
11:30–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Symposia Spotlight 1: Epigenetics and Cancer
2:30–4:30 PM
Cascade Ballroom
* Kristian Helin, The Institute of Cancer Research
Session Chair
Session Chair
Pablo R Freire, Dana-Farber Cancer Institute
Large AT-rich Promoter Flanks Control Menin/KMT2A Complex Localization at Key Developmental Genes
Large AT-rich Promoter Flanks Control Menin/KMT2A Complex Localization at Key Developmental Genes
Jun Ho Lee, Memorial Sloan Kettering Cancer Center
Joint TGF-β and RAS Transcriptional Program Supports Metastasis
Joint TGF-β and RAS Transcriptional Program Supports Metastasis
Tom A Milne, University of Oxford
Aberrant Enhancer Activation in KMT2A: AFF1 Leukemia
Aberrant Enhancer Activation in KMT2A: AFF1 Leukemia
Mara Steiger, Hasso Plattner Institute for Digital Engineering
Rapid Brain Tumor Classification from Sparse Epigenomic Data
Rapid Brain Tumor Classification from Sparse Epigenomic Data
Wazim Mohammed Ismail, Mayo Clinic
Single Cell Multiomics Reveal Divergent Effects of DNMT3A and TET2 Mutant Clonal Hematopoiesis in Inflammatory Response
Single Cell Multiomics Reveal Divergent Effects of DNMT3A and TET2 Mutant Clonal Hematopoiesis in Inflammatory Response
Hsiao P. J. Voon, Monash University
The Paediatric Glioma H3.3 K27M Mutation Disrupts Cell Differentiation by Interfering with Heterochromatin Formation at Pericentric Regions
The Paediatric Glioma H3.3 K27M Mutation Disrupts Cell Differentiation by Interfering with Heterochromatin Formation at Pericentric Regions
David Spencer, Washington University in St. Louis
Blocks of Sequence-Independent Allele-Specific DNA Methylation in Acute Myeloid Leukemia are Clonal Events that can Originate in Normal Hematopoietic Cells
Blocks of Sequence-Independent Allele-Specific DNA Methylation in Acute Myeloid Leukemia are Clonal Events that can Originate in Normal Hematopoietic Cells
Aaron D. Viny, Columbia University Irving Medical Center
FLI1 Accessible Stem Cell Programs Drive Leukemic Transformation
FLI1 Accessible Stem Cell Programs Drive Leukemic Transformation
Coffee Break with Hot Chocolate, Firepits & Mountain Views
4:30–5:00 PM
Conservatory Terrace
Histone Modifications: Cause or Cog in Gene Regulation?
5:00–7:00 PM
Cascade Ballroom
* Yang Shi, Ludwig Institute for Cancer Research, Oxford Branch
Session Chair
Session Chair
Kristian Helin, The Institute of Cancer Research
Dissecting the Role of Histone Modifications Using Histone Mutants
Dissecting the Role of Histone Modifications Using Histone Mutants
Nicola Iovino, Max Planck Institute of Immunobiology and Epigenetics
Catalytic-Independent Functions of CPB/P300
Catalytic-Independent Functions of CPB/P300
Shelley L Berger, University of Pennsylvania
Functional Consequences of Histone Acetylation
Functional Consequences of Histone Acetylation
Mark Pownall, UCSF
Short Talk: Heterochromatin Form and Function during Vertebrate Development
Short Talk: Heterochromatin Form and Function during Vertebrate Development
Michael S Werner, University of Utah
Short Talk: Histone 4 Acetylation Regulates Developmental Plasticity of Predatory Nematodes
Short Talk: Histone 4 Acetylation Regulates Developmental Plasticity of Predatory Nematodes
Social Hour with Lite Bites
7:00–8:00 PM
Alberta/New Brunswick
Poster Session 1
7:30–10:00 PM
Alberta/New Brunswick
Tuesday, April 1, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Epigenetics in Cellular Plasticity and Development
8:00–11:00 AM
Cascade Ballroom
* Giacomo Cavalli, Institute of Human Genetics
Session Chair
Session Chair
Luciano Di Croce, CRG - Center for Genomic Regulation
Polycomb Complexes in Development
Polycomb Complexes in Development
Karen Adelman, Harvard Medical School
Dynamic Changes in Chromatin and Transcription During Cell Differentiation
Dynamic Changes in Chromatin and Transcription During Cell Differentiation
Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics
The Influence of Histone Modifications and Chromatin Domains on Biallelic Gene Expression
The Influence of Histone Modifications and Chromatin Domains on Biallelic Gene Expression
Mark A. Dawson, Peter MacCallum Cancer Centre
Functional Genomics to Study Transcription Factors and Chromatin Remodelers in Cancer
Functional Genomics to Study Transcription Factors and Chromatin Remodelers in Cancer
Evgeny Kvon, University of California, Irvine
Short Talk: Bystander Chromatin Poising by Pioneer Factors Confers Aberrant Enhancer Activation in Congenital Disease
Short Talk: Bystander Chromatin Poising by Pioneer Factors Confers Aberrant Enhancer Activation in Congenital Disease
Selin Jessa, Stanford University
Short Talk: Dissecting the Cooperative, Context-dependent Rules of Transcription Factor Binding in Human Development
Short Talk: Dissecting the Cooperative, Context-dependent Rules of Transcription Factor Binding in Human Development
Coffee Break
9:00–9:20 AM
Riverview Lounge
Poster Setup
11:00–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:00–3:00 PM
Career Roundtable (Joint)
1:00–2:30 PM
Alhambra
Paola Scaffidi, European Institute of Oncology
Group Leader
Group Leader
Gromek Smolen, Foghorn Therapeutics
VP, Head of Biology
VP, Head of Biology
Evan J. Worden, Van Andel Institute
Assistant Professor
Assistant Professor
Michael S Werner, University of Utah
Assistant Professor
Assistant Professor
Ivanka D Kamenova, Nature Protocols
Senior Editor
Senior Editor
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Innate and Environmental Impacts on Epigenetic Regulation
3:00–4:15 PM
Cascade Ballroom
* Mark A. Dawson, Peter MacCallum Cancer Centre
Session Chair
Session Chair
Jo Iversen, University of Copenhagen
Short Talk: Exposure to Childhood Maltreatment is Associated with Specific Epigenetic Patterns in Sperm
Short Talk: Exposure to Childhood Maltreatment is Associated with Specific Epigenetic Patterns in Sperm
Kian Koh, Baylor College of Medicine
Short Talk: Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Malformations through Dysregulation of DNA Methylation
Short Talk: Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Malformations through Dysregulation of DNA Methylation
Lei Hou, Boston University School of Medicine
Short Talk: Genetic, Epigenomic, and Phenotypic Integration Reveals the Roles of Circulating Immune Cells and Patient Subgroups in Bipolar Disorder
Short Talk: Genetic, Epigenomic, and Phenotypic Integration Reveals the Roles of Circulating Immune Cells and Patient Subgroups in Bipolar Disorder
Audrey Houle, McGill University
Short Talk: CTCF is Required for Breast Tumour Initiation, but is Dispensable for Normal Mammary Gland Development
Short Talk: CTCF is Required for Breast Tumour Initiation, but is Dispensable for Normal Mammary Gland Development
Coffee Available
4:30–5:00 PM
Riverview Lounge
Epigenetics and Metabolism
5:00–7:00 PM
Cascade Ballroom
* Shelley L Berger, University of Pennsylvania
Session Chair
Session Chair
Kathryn E. Wellen, University of Pennsylvania
Metabolic Control of Chromatin Modifications
Metabolic Control of Chromatin Modifications
Navdeep S Chandel, Northwestern University
Mitochondrial Signaling to the Transcription Machinery
Mitochondrial Signaling to the Transcription Machinery
Lydia Finley, Memorial Sloan Kettering Cancer Center
Metabolic Pathways Govern Cell Fate Decisions
Metabolic Pathways Govern Cell Fate Decisions
Gabriel Alzial, IRIC, Université de Montréal
Short Talk: Mitochondrial Stress Modulates Chromatin Accessibility and Cell Identity in Breast Cancer
Short Talk: Mitochondrial Stress Modulates Chromatin Accessibility and Cell Identity in Breast Cancer
Subhamoy Dasgupta, Roswell Park Comprehensive Cancer Center
Short Talk: Nuclear Specific Reductive Carboxylation of Alpha-ketoglutarate Fuels Histone Acetylation
Short Talk: Nuclear Specific Reductive Carboxylation of Alpha-ketoglutarate Fuels Histone Acetylation
Social Hour with Lite Bites
7:00–8:00 PM
Alberta/New Brunswick
Poster Session 2
7:30–10:00 PM
Alberta/New Brunswick
Wednesday, April 2, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
DNA Methylation and Epigenetic Inheritance
8:00–11:00 AM
Cascade Ballroom
* François Fuks, University of Brussels
Session Chair
Session Chair
Robert A. Martienssen, Cold Spring Harbor Laboratory
Epigenetic Memory in Plants
Epigenetic Memory in Plants
Giacomo Cavalli, Institute of Human Genetics
Three Dimensional Genome Organization and Epigenetic Memory
Three Dimensional Genome Organization and Epigenetic Memory
Evan J. Worden, Van Andel Institute
The Structural Basis for de novo DNA Methylation in Chromatin
The Structural Basis for de novo DNA Methylation in Chromatin
Samuel C Agius, Monash University
Short Talk: Allosteric Effectors of PRC2 Synergise to Restrict the Spread of Polycomb Domains
Short Talk: Allosteric Effectors of PRC2 Synergise to Restrict the Spread of Polycomb Domains
Jasbeer S Khanduja, Massachusetts General Hospital
Short Talk: LncRNA-Mediated Heterochromatin Assembly
Short Talk: LncRNA-Mediated Heterochromatin Assembly
Ellen Weinzapfel, EpiCypher, Inc.
Short Talk: Advanced Multiomic Sequencing Technologies Reveal Complex Crosstalk between Chromatin Proteins and DNA Methylation in Development
Short Talk: Advanced Multiomic Sequencing Technologies Reveal Complex Crosstalk between Chromatin Proteins and DNA Methylation in Development
Coffee Break
9:00–9:20 AM
Riverview Lounge
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Epigenetics in Development
2:30–4:30 PM
Cascade Ballroom
* Karen Adelman, Harvard Medical School
Session Chair
Session Chair
Jan Zylicz, University of Copenhagen
HDAC3 Functions as a Speed-limit for Developmental Enhancers
HDAC3 Functions as a Speed-limit for Developmental Enhancers
Richard Pan, Columbia University
Transgenic Mouse Models for Editing DNA Methylation in vivo
Transgenic Mouse Models for Editing DNA Methylation in vivo
Andrew S Koh, University of Chicago
Chromatin Accessibility Noise is Amplified via p53 Repression to Promote Cell Plasticity for Immune Tolerance
Chromatin Accessibility Noise is Amplified via p53 Repression to Promote Cell Plasticity for Immune Tolerance
Alyssa Erickson, Washington University School of Medicine
The Role of Histone Ubiquitination in Plasticity and Neurodevelopmental Disease
The Role of Histone Ubiquitination in Plasticity and Neurodevelopmental Disease
Kiera Malone, University of Vermont
Chromatin Recognition by the AAA+ ATPase Superfamily Protein ATAD2B
Chromatin Recognition by the AAA+ ATPase Superfamily Protein ATAD2B
H. Courtney Hodges, Baylor College of Medicine
A Molecular Adapter that Mediates Disordered cBAF Interactions
A Molecular Adapter that Mediates Disordered cBAF Interactions
Eva Neugebauer, University Medical Center Freiburg
Herpesviruses Mimic Zygotic Genome Activation to Promote Viral Replication
Herpesviruses Mimic Zygotic Genome Activation to Promote Viral Replication
Nathan Palpant, University of Queensland
Rare Regions of Facultative Heterochromatin Define Domains of Cellular Constraint Underpinning Genomic Regulation of Cell Identity
Rare Regions of Facultative Heterochromatin Define Domains of Cellular Constraint Underpinning Genomic Regulation of Cell Identity
Coffee Available
4:30–5:00 PM
Riverview Lounge
Keynote Address (Joint)
5:00–5:45 PM
Cascade Ballroom
* Seychelle Vos, Massachusetts Institute of Technology
Session Chair
Session Chair
Yang Shi, Ludwig Institute for Cancer Research, Oxford Branch
Chromatin Regulation and Cancer
Chromatin Regulation and Cancer
Transcription and Epigenetics in Disease (Joint)
5:45–7:15 PM
Cascade Ballroom
* Kristian Helin, The Institute of Cancer Research
Session Chair
Session Chair
Paola Scaffidi, European Institute of Oncology
Epigenetics and Functional Intratumor Heterogeneity
Epigenetics and Functional Intratumor Heterogeneity
Gromek Smolen, Foghorn Therapeutics
Targeting Chromatin Modulators with Therapeutic Degraders
Targeting Chromatin Modulators with Therapeutic Degraders
Tony Kouzarides, Gurdon Institute, University of Cambridge
Targeting RNA Modifying Enzymes in the Treatment of Cancer
Targeting RNA Modifying Enzymes in the Treatment of Cancer
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint)
7:15–7:30 PM
Cascade Ballroom
Social Hour with Lite Bites
7:30–8:30 PM
Alberta/New Brunswick
Thursday, April 3, 2025
Departure
12:00–11:59 PM
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