Neurodegeneration: Linking Cellular Pathways to Therapeutic Strategies
Jun 08–11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:
Michael Ward, Erika L Holzbaur, and Sarah DeVos
Livestream
In Person
On Demand
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Jun 08–11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Michael Ward, Erika L Holzbaur, and Sarah DeVos
Michael Ward
Erika L Holzbaur
Sarah DeVos
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandMerchandise Options
Registration Options
Sunday, June 8, 2025
Fundraising
Booking Function
Registration
4:00–8:00 PM
Grand Foyer
Welcome Mixer
6:00–8:00 PM
Grand Foyer
Monday, June 9, 2025
Breakfast
7:00–8:00 AM
Sea to Sky A
Welcome and Keynote Session (Joint)
8:00–9:30 AM
Sea to Sky B/C
* Dorothy Schafer, University of Massachusetts Chan Medical School
Catherine G. Dulac, Harvard University and HHMI
Neuronal Circuits of Sickness and Social Behavior
Neuronal Circuits of Sickness and Social Behavior
Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT
Development of Epigenetic Modifiers for Discovery Research and Neurodegenerative Disease Therapies
Development of Epigenetic Modifiers for Discovery Research and Neurodegenerative Disease Therapies
Coffee Break
9:30–9:50 AM
Grand Foyer
Cell Biology of Neuroinflammation Within Diseased Brain Circuits (Joint)
9:50–11:30 AM
Sea to Sky B/C
* Richard Daneman, University of California, San Diego
Session Chair
Session Chair
Veronique Miron, University of Toronto
Immune Regulation of Remyelination in Multiple Sclerosis
Immune Regulation of Remyelination in Multiple Sclerosis
Timothy Hammond, Sanofi
Therapeutic Targeting of Microglial Inflammatory Responses within Diseased Brain Circuits
Therapeutic Targeting of Microglial Inflammatory Responses within Diseased Brain Circuits
Aaron DiAntonio, Washington University in St. Louis
The SARM1 Axon Degeneration Pathway: Mechanistic Insights Drive Therapeutic Opportunities
The SARM1 Axon Degeneration Pathway: Mechanistic Insights Drive Therapeutic Opportunities
Poster Setup
11:15–1:00 PM
Sea to Sky A
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
Sea to Sky A
Symposia Spotlight 1: The Digital Era in Neurodegeneration and Neuroinflammation & Panel Discussion(Joint)
2:30–4:30 PM
Sea to Sky B/C
* Michael Ward, NIH
Session Chair
Session Chair
Max Salick, Insitro
Integrating iPSC-Based Models, Genomics, And Machine Learning To Uncover Neurological Disease Mechanisms And Therapeutic Targets
Integrating iPSC-Based Models, Genomics, And Machine Learning To Uncover Neurological Disease Mechanisms And Therapeutic Targets
Camille Januel, Chan Zuckerberg Biohub San Francisco
Global Organelle Profiling: Combining Stem Cell Models and Proteomics to Uncover Variant-Specific Disease Mechanism in Neurodegenerative Diseases
Global Organelle Profiling: Combining Stem Cell Models and Proteomics to Uncover Variant-Specific Disease Mechanism in Neurodegenerative Diseases
Heather Stark, Syncell
Optoproteomics: Unbiased Spatial Proteomics for Neurodegenerative Diseases
Optoproteomics: Unbiased Spatial Proteomics for Neurodegenerative Diseases
Carmen Sandoval-Espinosa, Genentech
Soma-seq: Intracellular CITE-seq in Frozen Human Brain Tissue Enables the Discovery of Proteinopathy-Associated Gene Expression Signatures
Soma-seq: Intracellular CITE-seq in Frozen Human Brain Tissue Enables the Discovery of Proteinopathy-Associated Gene Expression Signatures
Zinan Zhou, Boston Children's Hospital
Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders
Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders
Coffee Available
4:30–5:00 PM
Grand Foyer
Genetics and Genomics in Neurodegeneration
5:00–7:00 PM
Sea to Sky C
* Thomas L. Kukar, Emory University
Session Chair
Session Chair
Juliana Acosta-Uribe, University of California, Santa Barbara
Ancestral Diversity in Neurodegenerative Disease Genomics
Ancestral Diversity in Neurodegenerative Disease Genomics
Alison Goate, Icahn School of Medicine at Mount Sinai
Genetics and Genomics of Alzheimer’s Disease
Genetics and Genomics of Alzheimer’s Disease
Azad Bonni, F.Hoffmann La-Roche Ltd.
Challenges and Opportunities in Drug Discovery and Development for Neurological Disorders
Challenges and Opportunities in Drug Discovery and Development for Neurological Disorders
Lindsay Becker, Princeton University
Short Talk: Genome-Wide Mapping of Neuronal RNA Organization and Condensation
Short Talk: Genome-Wide Mapping of Neuronal RNA Organization and Condensation
Alessandro Ori, Genentech Inc.
Short Talk: Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder
Short Talk: Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder
Social Hour with Lite Bites
7:00–8:00 PM
Sea to Sky A
Poster Session 1
7:30–10:00 PM
Sea to Sky A
Tuesday, June 10, 2025
Breakfast
7:00–8:00 AM
Sea to Sky A
Mechanisms of Aging in Neuroinflammation and Neurodegeneration (Joint)
8:00–11:00 AM
Sea to Sky B/C
* John Fryer, Translational Genomics Research Institute
Session Chair
Session Chair
Robin Franklin, Altos Labs
The Impact of Aging on Remyelination Potential in the Diseased Brain
The Impact of Aging on Remyelination Potential in the Diseased Brain
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
Role of cGAS/Sting in Neurodegenerative Diseases
Role of cGAS/Sting in Neurodegenerative Diseases
Judith Frydman, Stanford University
Age-Related Translational and Ribosomal Dysfunction and its Contribution to Neurodegeneration
Age-Related Translational and Ribosomal Dysfunction and its Contribution to Neurodegeneration
Oliver Hahn, Calico Life Sciences LLC
Short Talk: Decoding Regional Drivers of Microglia Aging via Heterochronic Myeloid Cell Replacement
Short Talk: Decoding Regional Drivers of Microglia Aging via Heterochronic Myeloid Cell Replacement
Ian Guldner, Stanford University
Short Talk: Synaptic Proteins with Age-Related Proteostasis Aberrations Accumulate in Microglia
Short Talk: Synaptic Proteins with Age-Related Proteostasis Aberrations Accumulate in Microglia
Vanessa Martin, University of California, San Diego
Short Talk: Enhancer Deletion of a Microglial-Specific AD BIN1 Risk Variant Alters Lysosomal Phenotype and DAM Response in Ipsc-Derived Microglia
Short Talk: Enhancer Deletion of a Microglial-Specific AD BIN1 Risk Variant Alters Lysosomal Phenotype and DAM Response in Ipsc-Derived Microglia
Wei Jing Chong, Nanyang Technological University
Short Talk: Targeting Cellular Metabolism to Modulate Microglial Function in Health and Disease
Short Talk: Targeting Cellular Metabolism to Modulate Microglial Function in Health and Disease
Coffee Break
9:00–9:20 AM
Grand Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Sea to Sky B/C
Poster Setup
11:00–1:00 PM
Sea to Sky A
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Sea to Sky A
Career Roundtable (Joint)
2:15–3:15 PM
Sea to Sky B
Maayan Levy, Stanford University
Assistant Professor
Assistant Professor
Alessandro Ori, Genentech Inc.
Senior Principal Scientist
Senior Principal Scientist
Dirk Landgraf, SV Health Investors
Principal, Dementia Discovery Fund
Principal, Dementia Discovery Fund
Heather B Wood, Springer Nature
Senior Editor
Senior Editor
Meet the Editors (Joint)
3:30–4:30 PM
Sea to Sky B
Ted Dobie, Cell Press
*Session Chair, Scientific Editor, Neuron
*Session Chair, Scientific Editor, Neuron
Shari Wiseman, Nature Neuroscience
Chief Editor
Chief Editor
Lucie Van Emmenis, The Rockefeller University Press - The Journal of Experimental Medicine
Senior Scientific Editor
Senior Scientific Editor
Eric Sawey, Genes & Development
Executive Editor, CSHL Press
Executive Editor, CSHL Press
Taylor Hart, PLOS
Associate Editor
Associate Editor
Coffee Available
4:30–5:00 PM
Grand Foyer
Critical Cellular Pathways in Neurodegeneration
5:00–7:00 PM
Sea to Sky C
* Sandrine Da Cruz, VIB-KU Leuven
Session Chair
Session Chair
Erika L Holzbaur, University of Pennsylvania
Organelle Quality Control in Neuronal Homeostasis and Neurodegeneration.
Organelle Quality Control in Neuronal Homeostasis and Neurodegeneration.
Juan S. Bonifacino, National Institutes of Health
Role of Lysosomes in the Axon in Health vs. Diseased Neurons
Role of Lysosomes in the Axon in Health vs. Diseased Neurons
Dario Alessi, University of Dundee
Mechanisms of LRRK2 Related Neurodegeneration
Mechanisms of LRRK2 Related Neurodegeneration
Amanda Bentley-DeSousa, Yale University
Short Talk: Integration of Innate Immunity and Lysosome Damage Signals in the Activation of LRRK2
Short Talk: Integration of Innate Immunity and Lysosome Damage Signals in the Activation of LRRK2
Suzanne R. Pfeffer, Stanford University
Short Talk: Parkinson’s-Linked Mutations Converge on a Neuroprotective Ciliogenesis Pathway in the Brain
Short Talk: Parkinson’s-Linked Mutations Converge on a Neuroprotective Ciliogenesis Pathway in the Brain
Social Hour with Lite Bites
7:00–8:00 PM
Sea to Sky A
Poster Session 2
7:30–10:00 PM
Sea to Sky A
Wednesday, June 11, 2025
Breakfast
7:00–8:00 AM
Sea to Sky A
Therapeutics based in Genetics and Cellular Pathways
8:00–11:00 AM
Sea to Sky C
* Soojin Kim, Genentech
Session Chair
Session Chair
Timothy A. Ryan, Weill Medical College of Cornell University
Dysregulation of Central Metabolism Pathways in Parkinson’s Disease and New Therapeutic Strategies
Dysregulation of Central Metabolism Pathways in Parkinson’s Disease and New Therapeutic Strategies
Sarah DeVos, Curie.Bio
Transporting Different Drug Modalities Across the BBB Using Transferrin Receptor
Transporting Different Drug Modalities Across the BBB Using Transferrin Receptor
Matthew Nolan, Massachusetts General Hospital
Short Talk: Inhibition of Geranylgeranylation Restores Stathmin-2 Expression in TDP-43 Deficient Cells and Promotes Neurite Outgrowth
Short Talk: Inhibition of Geranylgeranylation Restores Stathmin-2 Expression in TDP-43 Deficient Cells and Promotes Neurite Outgrowth
Timothy J Hines, The Jackson Laboratory
Short Talk: ATF4 Mediates Neuromuscular Deficits in CMT2D Mice
Short Talk: ATF4 Mediates Neuromuscular Deficits in CMT2D Mice
Tanya N Weerakkody, Denali Therapeutics
Short Talk: PILRA Regulates Microglial Immunometabolism to Reduce Disease Pathology as a Candidate Therapeutic Target for Alzheimer’s Disease
Short Talk: PILRA Regulates Microglial Immunometabolism to Reduce Disease Pathology as a Candidate Therapeutic Target for Alzheimer’s Disease
Rajeev Sivasankaran, Voyager Therapeutics
Short Talk: Intravenous Delivery of VY1706, a CNS Penetrant AAV Gene Therapy for Alzheimer’s Disease, Provides Broad Tau Lowering in Mouse Models of Tauoapathy and NHPs
Short Talk: Intravenous Delivery of VY1706, a CNS Penetrant AAV Gene Therapy for Alzheimer’s Disease, Provides Broad Tau Lowering in Mouse Models of Tauoapathy and NHPs
Leonard Petrucelli, Mayo Clinic Jacksonville
Short Talk: HDGFL2 Cryptic Peptide as a Biomarker for TDP-43 Proteinopathies
Short Talk: HDGFL2 Cryptic Peptide as a Biomarker for TDP-43 Proteinopathies
Alessandro Moro, VectorY BV
Short Talk: AAV-Mediated Therapy of an Intrabody Targeting TDP-43 for Amyotrophic Lateral Sclerosis
Short Talk: AAV-Mediated Therapy of an Intrabody Targeting TDP-43 for Amyotrophic Lateral Sclerosis
Coffee Break
9:00–9:20 AM
Grand Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Sea to Sky C
* Sarah DeVos, Curie.Bio
Session Chair
Session Chair
Sandrine Da Cruz, VIB-KU Leuven
Local Mechanisms of Axonal/Synaptic Maintenance and Demise in ALS/FTD
Local Mechanisms of Axonal/Synaptic Maintenance and Demise in ALS/FTD
Sarah E Heuer, Brigham and Women's Hospital
Dissecting Alzheimer’s Disease Genetic Risk Using Stem Cell Models: ABCA7 Deficiency Disrupts Lysosomal Function and Alters Inflammatory Responses in Microglia
Dissecting Alzheimer’s Disease Genetic Risk Using Stem Cell Models: ABCA7 Deficiency Disrupts Lysosomal Function and Alters Inflammatory Responses in Microglia
Amanda McQuade, UCSF
Transcriptional And Epigenetic Control Of Disease-Relevant Microglial Activation States
Transcriptional And Epigenetic Control Of Disease-Relevant Microglial Activation States
Jeffrey D. Rothstein, Johns Hopkins University
Whole Genome Screen-Based Identification and Examination of Novel Genes for Regulation of TDP-43 Import in Alzheimer’s Disease, Sporadic and C9orf72 ALS/FTD
Whole Genome Screen-Based Identification and Examination of Novel Genes for Regulation of TDP-43 Import in Alzheimer’s Disease, Sporadic and C9orf72 ALS/FTD
Daichi Shonai, Duke university
Discovery of Prodromal α-Synuclein Suppressors via Dopaminergic Neuron Proteomics and CRISPR Survival Screening
Discovery of Prodromal α-Synuclein Suppressors via Dopaminergic Neuron Proteomics and CRISPR Survival Screening
Martine Therrien, University of California Davis
Using Xenograft Model to Identify How Genetics Impact Microglial Response to Peripheral Inflammation
Using Xenograft Model to Identify How Genetics Impact Microglial Response to Peripheral Inflammation
Roi Meir, The Hebrew University of Jerusalem
Early Neuronal Reprogramming and Cell Cycle Re-entry Shape the Alzheimer’s Disease Cascade
Early Neuronal Reprogramming and Cell Cycle Re-entry Shape the Alzheimer’s Disease Cascade
Shannon L Macauley, University of Kentucky
Targeting Metabolic Inflexibility to Restore Slow Wave Sleep in Alzheimer’s Disease
Targeting Metabolic Inflexibility to Restore Slow Wave Sleep in Alzheimer’s Disease
Coffee Available
4:30–5:00 PM
Grand Foyer
Transformative New Technologies in Molecular and Cellular Neuroscience and Disease
5:00–6:45 PM
Sea to Sky C
* Carlo Condello, University of California, San Francisco
Session Chair
Session Chair
Roberto Zoncu, University of California, Berkeley
Decoding Cholesterol-mTORC1 Signaling in Organelle Homeostasis and Neurodegeneration
Decoding Cholesterol-mTORC1 Signaling in Organelle Homeostasis and Neurodegeneration
Andrew Bassett, Wellcome Sanger Institute
Massively Parallel Profiling of Neuronal and Glial Perturbation States
Massively Parallel Profiling of Neuronal and Glial Perturbation States
Michael Ward, NIH
Leveraging iPSC Models and ‘Omics to Study Neurodegeneration
Leveraging iPSC Models and ‘Omics to Study Neurodegeneration
Ophir Shalem, University of Pennsylvania
Short Talk: Towards Pooled Optical Profiling of Proteome Organization in Cell Lines and Neurons
Short Talk: Towards Pooled Optical Profiling of Proteome Organization in Cell Lines and Neurons
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Sea to Sky C
Social Hour with Lite Bites
7:00–8:00 PM
Sea to Sky A
Entertainment
8:00–9:00 PM
Sea to Sky C
Thursday, June 12, 2025
Departure
12:00–11:59 PM
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