Organelle quality control, nutrient regulation, and signaling all converge at the lysosome. In particular, macroautophagy is a process by which a double membrane structure engulfs cytoplasmic material for lysosomal degradation. This meeting will bring together leaders and innovative thinkers within the broad fields of autophagy and endolysosomes to disentangle the complex mechanisms of lysosome-mediated quality control, nutrient regulation, and cell signaling. The meeting will highlight new discoveries surrounding endolysosomes and their intersections with autophagosomes.

Over the last two decades it has become increasingly clear that lysosomes and autophagic machinery play an important role in many disease processes including infection, cancer, metabolism and neurodegeneration. This meeting will emphasize the fundamental mechanisms of lysosome trafficking, signaling, and autophagy while also highlighting the impact of these discoveries on human health. We will include leaders from academia and industry while also featuring diverse speakers across career-stage and international representation. Abstracts will be chosen that showcase novel late-breaking discoveries and early-stage scientists in the field. The sessions will be designed to bring together experts from around the world and foster discussion and collaborations; ultimately to broaden our understanding of the diverse roles played by the autophagy machinery in health and disease.