Over the past decade, research has revealed that disrupted chromatin and gene regulation play central roles in diseases ranging from cancer to immune and neurodevelopmental disorders. While these discoveries have driven new therapeutic strategies, translation has been slow due to limited understanding of how epigenetic factors connect to gene expression and cellular function. 

This meeting will bring together academic and industry experts to bridge that gap, focusing on disease-related chromatin and gene regulatory mechanisms. Key topics include catalytic vs. non-catalytic functions of chromatin modifiers, structured and disordered regions, and the interplay of chromatin factors with broader cellular networks. By linking large-scale genetic and chromatin profiling and proteomics efforts with biochemical, biophysical, structural, and sequence-based functional studies, the program aims to deepen mechanistic insight and inspire new therapeutic approaches. 

By convening a diverse, interdisciplinary community, this meeting will foster collaboration, spark novel discussions, and accelerate translation of epigenetic research into innovative treatments. 

In the video below, Dr. Karim-Jean Armache from New York University Grossman School of Medicine and Dr. Cigall Kadoch from Dana-Farber Cancer Institute, Harvard Medical School, talk about what to expect from this meeting and why you should attend:

Additionally, check out some speaker highlights: