Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities
Mar 02–05, 2026 | Crowne Plaza Geneva, Geneva, Switzerland
Scientific Organizers:
Karim-Jean Armache and Cigall Kadoch
×
-
Mar 02–05, 2026 | Crowne Plaza Geneva, Geneva, Switzerland
Scientific Organizers: Karim-Jean Armache and Cigall Kadoch
Karim-Jean Armache, PhD
New York University Grossman School of Medicine
Cigall Kadoch, PhD
Dana-Farber Cancer Institute, Harvard Medical School
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMonday, March 2, 2026
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, March 3, 2026
Breakfast
7:30–8:30 AM
Welcome Remarks
8:00–8:10 AM
Poster Setup
8:00–8:30 AM
Keynote Address
8:10–9:30 AM
Joanna Wysocka, Stanford University
Epigenetic Regulators in Development and Disease
Epigenetic Regulators in Development and Disease
Poster Viewing
8:15–5:00 PM
Chromatin Regulatory Mechanisms Governing Cell Fate in Health and Disease
9:30–12:00 PM
Robert J. Klose, University of Oxford
Understanding how CpG Island regulate Gene Expression
Understanding how CpG Island regulate Gene Expression
Anja Groth, University of Copenhagen
Maintaining Cell Fate through Replication
Maintaining Cell Fate through Replication
Karim-Jean Armache, New York University Grossman School of Medicine
Structure and Function of Epigenetic Complexes: Basic and Disease Mechanisms
Structure and Function of Epigenetic Complexes: Basic and Disease Mechanisms
Scott A. Armstrong, Dana-Farber Cancer Institute
Mechanisms of Menin Inhibitor Sensitivity and Resistance
Mechanisms of Menin Inhibitor Sensitivity and Resistance
Coffee Break
10:00–10:20 AM
Lunch
12:00–1:00 PM
Poster Session 1
12:30–2:30 PM
Symposia Spotlight 1
2:30–4:30 PM
James K. Nuñez, University of California, Berkeley
DNA Methylation Interplays With RNA M6a Factors To Establish Heritable Epigenetic Silencing In Human Cells
DNA Methylation Interplays With RNA M6a Factors To Establish Heritable Epigenetic Silencing In Human Cells
Jean-Paul Armache †, Penn State University
Structure-function and Chromatin Biology
Structure-function and Chromatin Biology
Diego Pasini, European Institute of Oncology
Control of Transcriptional Identity by the Polycomb Repressive Machinery
Control of Transcriptional Identity by the Polycomb Repressive Machinery
Robert L Yauch, Genentech, Inc.
Antibody-Mediated Delivery of SMARCA2/A4 Protein Degraders Affords Strong Anti-Tumor Efficacy in SMARCA4-Mutant NSCLC and Prostate Cancer Models
Antibody-Mediated Delivery of SMARCA2/A4 Protein Degraders Affords Strong Anti-Tumor Efficacy in SMARCA4-Mutant NSCLC and Prostate Cancer Models
Aliaksandra (Alex) Radzisheuskaya, The Institute of Cancer Research
Uncovering Critical Lysines in Mammalian Histone H3 with High-Throughput CRISPR Prime Editing
Uncovering Critical Lysines in Mammalian Histone H3 with High-Throughput CRISPR Prime Editing
Amanda Engstrom †, Baylor College of Medicine
Dose-Dependent Molecular Consequences of MeCP2 Dysregulation in Neurological Disorders
Dose-Dependent Molecular Consequences of MeCP2 Dysregulation in Neurological Disorders
Mo Chen, Tsinghua University
Spatiotemporal Control of SMARCA5 by a MAPK-RUNX1 Axis Distinguishes Mutant KRAS-Driven Pancreatic Malignancy From Tissue Regeneration
Spatiotemporal Control of SMARCA5 by a MAPK-RUNX1 Axis Distinguishes Mutant KRAS-Driven Pancreatic Malignancy From Tissue Regeneration
Adrian P Bracken, Trinity College Dublin
The Abundant AEBP2 Long Isoform Restrains PRC2 to Direct H3K27me2 in Development and Cancer
The Abundant AEBP2 Long Isoform Restrains PRC2 to Direct H3K27me2 in Development and Cancer
Coffee Available
4:30–5:00 PM
Therapeutic Opportunities Informed by Genetic Disruption of Chromatin Factors
5:00–7:00 PM
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School
Structure and Function of Chromatin Remodeling Complexes in Human Disease: From Basic Mechanisms to Therapeutic Opportunities
Structure and Function of Chromatin Remodeling Complexes in Human Disease: From Basic Mechanisms to Therapeutic Opportunities
Nicolas H Thomä, EPFL Lausanne
Structural Basis of Transcription Factors and Protein Degradation
Structural Basis of Transcription Factors and Protein Degradation
Isaac A. Klein, Dewpoint Therapeutics
Targeting Transcription via Condensate Disruption
Targeting Transcription via Condensate Disruption
Tomasz Cierpicki, University of Michigan
Short Talk: Discovery of PRC1 Inhibitors with In Vivo Efficacy
Short Talk: Discovery of PRC1 Inhibitors with In Vivo Efficacy
François Fuks †, University of Brussels
Short Talk: RNA Modifications in Health and Disease
Short Talk: RNA Modifications in Health and Disease
On Own for Dinner
7:00–8:00 PM
Wednesday, March 4, 2026
Breakfast
7:30–8:30 AM
Poster Setup
8:00–8:30 AM
Poster Viewing
8:15–5:00 PM
Novel Target Identification and Chemical Approaches
8:30–11:30 AM
Tom W. Muir, Princeton University
New Chemical Approaches to Reveal and Understand Chromatin Mechanisms
New Chemical Approaches to Reveal and Understand Chromatin Mechanisms
Jelena Urosevic †, AstraZeneca
Talk Title to be Announced
Talk Title to be Announced
Alessio Ciulli, University of Dundee, School of Life Sciences
New Approaches Toward Chemical Degradation of Chromatin Machinery
New Approaches Toward Chemical Degradation of Chromatin Machinery
Steven F Bellon, Foghorn Therapeutics
Pharmacologic Disruption of Chromatin Regulatory Factors
Pharmacologic Disruption of Chromatin Regulatory Factors
Scott B Rothbart, Van Andel Institute
Short Talk: Revealing Novel Cancer Therapeutic Strategies Through Molecular Studies Of Chromatin Modification Crosstalk
Short Talk: Revealing Novel Cancer Therapeutic Strategies Through Molecular Studies Of Chromatin Modification Crosstalk
Bryan Venters, EpiCypher, Inc.
Short Talk: Unraveling Chromatin Regulation With Fiber-seq: a Single-Molecule, Long-Read Assay That Simultaneously Measures Chromatin Architecture and DNA Methylation
Short Talk: Unraveling Chromatin Regulation With Fiber-seq: a Single-Molecule, Long-Read Assay That Simultaneously Measures Chromatin Architecture and DNA Methylation
Coffee Break
9:30–9:50 AM
Lunch
11:30–12:30 PM
Poster Session 2
12:30–2:30 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Mechanisms and Vulnerabilities Conferred by DNA Methylation
5:00–7:00 PM
Yael David, Memorial Sloan Kettering Cancer Center
Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Noncanonical Chromatin Species
Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Noncanonical Chromatin Species
Chao Lu, Columbia University
At the Crossroads of Histone Modifications and DNA Methylation in Cancer
At the Crossroads of Histone Modifications and DNA Methylation in Cancer
Alla Sigova, CAMP4 Therapeutics
RNA Amplifier Therapeutics Targeting Regulatory RNAs to Upregulate Disease-Associated genes
RNA Amplifier Therapeutics Targeting Regulatory RNAs to Upregulate Disease-Associated genes
Emily Hodges, Vanderbilt University
Short Talk: Predicting Past, Present and Future Cell States with DNA Methylation
Short Talk: Predicting Past, Present and Future Cell States with DNA Methylation
Eneda Toska, Johns Hopkins University
Short Talk: Epigenetic Mechanisms of Therapy Resistance in Hormone Receptor–Positive Breast Cancer
Short Talk: Epigenetic Mechanisms of Therapy Resistance in Hormone Receptor–Positive Breast Cancer
On Own for Dinner
7:00–8:00 PM
Thursday, March 5, 2026
Breakfast
7:30–8:30 AM
Interplay between Chromatin Regulation and Transcription Dynamics in Human Disease
8:30–11:30 AM
Emily Bernstein, Mount Sinai School of Medicine
Histone Variants and Their Functions in Cancer
Histone Variants and Their Functions in Cancer
Ali Shilatifard, Northwestern University
Transcriptional Elongation and its Control of Oncogenic Mechanisms
Transcriptional Elongation and its Control of Oncogenic Mechanisms
Danny F Reinberg, University of Miami
Opportunities in Cancer
Opportunities in Cancer
Serena Sanulli †, Stanford University
Short Talk: Allosteric Regulation Of The Nucleosome Core Biases Cell State
Short Talk: Allosteric Regulation Of The Nucleosome Core Biases Cell State
Stefan Niekamp, Massachusetts General Hospital
Short Talk: Mutual Antagonism between PRC1 Condensates and SWI/SNF in Chromatin Regulation
Short Talk: Mutual Antagonism between PRC1 Condensates and SWI/SNF in Chromatin Regulation
Chul-Hwan Lee †, Seoul National University
Short Talk: EZH1 Orchestrates 3D Chromatin Architecture To Establish De Novo Heterochromatin And Safeguard Lineage Commitment
Short Talk: EZH1 Orchestrates 3D Chromatin Architecture To Establish De Novo Heterochromatin And Safeguard Lineage Commitment
Jane A. Skok †, New York University School of Medicine
Short Talk: Replication-Coupled Cohesin Remodeling Reorganizes Nucleosome Phasing And Insulation
Short Talk: Replication-Coupled Cohesin Remodeling Reorganizes Nucleosome Phasing And Insulation
Joseph Sudar, New York University Grossman School of Medicine
Short Talk: Epigenetics in Parasite Survival and Host Immune Evasion
Short Talk: Epigenetics in Parasite Survival and Host Immune Evasion
Coffee Break
9:30–9:50 AM
Lunch
11:30–12:30 PM
Symposia Spotlight 2
2:30–4:30 PM
Noa Furth †, Weizmann Institute of Science
Recurrent Patterns of Epigenetic Heterogeneity in Luminal Breast Tumors with Implications for Liquid-biopsy-based Patient Monitoring
Recurrent Patterns of Epigenetic Heterogeneity in Luminal Breast Tumors with Implications for Liquid-biopsy-based Patient Monitoring
Lu Wang, Northwestern University
Molecular Dissection of Gene Essentiality and Transcriptional Reprogramming in Cancer
Molecular Dissection of Gene Essentiality and Transcriptional Reprogramming in Cancer
Oliver Bell, Keck School of Medicine of USC
KMT2A-AF9 hijacks CBX8-PRC1 to Drive Leukemic Stem Cell Self-Renewal, Defining a Synergistic Target To Overcome MENIN Resistance
KMT2A-AF9 hijacks CBX8-PRC1 to Drive Leukemic Stem Cell Self-Renewal, Defining a Synergistic Target To Overcome MENIN Resistance
Alejandra Laguillo-Diego, Weill Cornell Medicine
KAT7 and KAT6A/B Dictate Cell Identity Decisions During M-to-G1
KAT7 and KAT6A/B Dictate Cell Identity Decisions During M-to-G1
Caroline Clarke, AstraZeneca
Distinct Specialisations of Cohesin-STAG1 and Cohesin-STAG2 Reshape 3D Genome Architecture and Gene–Protein Networks in Cancer
Distinct Specialisations of Cohesin-STAG1 and Cohesin-STAG2 Reshape 3D Genome Architecture and Gene–Protein Networks in Cancer
Yumeng Zhan, Max Planck Institute for Multidisciplinary Sciences
The +1 Nucleosome Functions in Pol II Transcription Initiation
The +1 Nucleosome Functions in Pol II Transcription Initiation
Eric Conway, University College Dublin
Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin
Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin
Melanie Eckersley-Maslin, Peter MacCallum Cancer Centre
Hijacking Chromatin Regulators of Developmental Plasticity in Cancer
Hijacking Chromatin Regulators of Developmental Plasticity in Cancer
Coffee Available
4:30–5:00 PM
Chromatin Regulatory Machinery in Human Health and Disease
5:00–6:45 PM
Effie Apostolou, Weill Cornell Medical College
Epigenetic Mechanisms of Post-Mitotic Transcriptional Activation
Epigenetic Mechanisms of Post-Mitotic Transcriptional Activation
Nada Jabado, McGill University Health Centre
Epigenetics of Pediatric Brain Cancers
Epigenetics of Pediatric Brain Cancers
Yadira M Soto-Feliciano, Massachusetts Institute of Technology
Chromatin Scaffold Proteins in Development and Disease
Chromatin Scaffold Proteins in Development and Disease
Lluis Morey, University of Miami Miller School of Medicine
Short Talk: Decoding the Role of PRC1 Missense Mutations in Neurodevelopmental Disorders
Short Talk: Decoding the Role of PRC1 Missense Mutations in Neurodevelopmental Disorders
Siddhant Jain †, Dana-Farber Cancer Institute, Boston , Massachusetts, US
Short Talk: A SWI/SNF-Specific Ig-Like Domain, SWIFT, is a Transcription Factor Binding Platform
Short Talk: A SWI/SNF-Specific Ig-Like Domain, SWIFT, is a Transcription Factor Binding Platform
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
On Own for Dinner
7:00–8:00 PM
Friday, March 6, 2026
Departure
12:00–11:59 PM
Subscribe for Updates