Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities

Mar 02–05, 2026 | Crowne Plaza Geneva, Geneva, Switzerland
Scientific Organizers: Karim-Jean Armache and Cigall Kadoch

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  On Demand
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Mar 02–05, 2026 | Crowne Plaza Geneva, Geneva, Switzerland

Scientific Organizers: Karim-Jean Armache and Cigall Kadoch

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Monday, March 2, 2026
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, March 3, 2026
Breakfast
7:30–8:30 AM
Poster Setup
8:00–8:30 AM
Poster Viewing
8:15–5:00 PM
Welcome and Keynote Address
8:30–9:30 AM
Joanna Wysocka, Stanford University
Epigenetic Regulators in Development and Disease
Chromatin Regulatory Mechanisms Governing Cell Fate in Health and Disease
9:30–11:45 AM
Robert J. Klose, University of Oxford
Understanding how CpG Island regulate Gene Expression
Anja Groth, University of Copenhagen
Maintaining Cell Fate through Replication
Karim-Jean Armache, New York University Grossman School of Medicine
Structure and Function of Epigenetic Complexes: Basic and Disease Mechanisms
Scott A. Armstrong, Dana-Farber Cancer Institute
Mechanisms of Menin Inhibitor Sensitivity and Resistance
Short Talk(s) Chosen from Abstracts
Coffee Break
10:00–10:20 AM
Lunch
11:45–12:45 PM
Posters
12:30–2:30 PM
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Therapeutic Opportunities Informed by Genetic Disruption of Chromatin Factors
5:00–7:00 PM
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School
Structure and Function of Chromatin Remodeling Complexes in Human Disease: From Basic Mechanisms to Therapeutic Opportunities
Nicolas H Thomä, EPFL Lausanne
Structural Basis of Transcription Factors and Protein Degradation
Isaac A. Klein, Dewpoint Therapeutics
Targeting Transcription via Condensate Disruption
Short Talk(s) Chosen from Abstracts
On Own for Dinner
7:00–8:00 PM
Wednesday, March 4, 2026
Breakfast
7:30–8:30 AM
Poster Setup
8:00–8:30 AM
Poster Viewing
8:15–5:00 PM
Novel Target Identification and Chemical Approaches
8:30–11:30 AM
Tom W. Muir, Princeton University
New Chemical Approaches to Reveal and Understand Chromatin Mechanisms
Ho Man Chan, AstraZeneca
Targeting Methyltransferases and Other Epigenetic Factors with Small Molecules
Alessio Ciulli, University of Dundee, School of Life Sciences
New Approaches Toward Chemical Degradation of Chromatin Machinery
Steven F Bellon, Foghorn Therapeutics
Pharmacologic Disruption of Chromatin Regulatory Factors
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
Lunch
11:30–12:30 PM
Posters
12:30–2:30 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Mechanisms and Vulnerabilities Conferred by DNA Methylation
5:00–7:00 PM
Yael David, Memorial Sloan Kettering Cancer Center
Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Noncanonical Chromatin Species
Chao Lu, Columbia University
At the Crossroads of Histone Modifications and DNA Methylation in Cancer
Alla Sigova, CAMP4 Therapeutics
RNA Amplifier Therapeutics Targeting Regulatory RNAs to Upregulate Disease-Associated genes
Short Talk(s) Chosen from Abstracts
On Own for Dinner
7:00–8:00 PM
Thursday, March 5, 2026
Breakfast
7:30–8:30 AM
Interplay between Chromatin Regulation and Transcription Dynamics in Human Disease
8:30–11:30 AM
Emily Bernstein, Mount Sinai School of Medicine
Histone Variants and Their Functions in Cancer
Ali Shilatifard, Northwestern University
Transcriptional Elongation and its Control of Oncogenic Mechanisms
Danny F Reinberg, University of Miami
Opportunities in Cancer
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
Lunch
11:30–12:30 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Chromatin Regulatory Machinery in Human Health and Disease
5:00–6:45 PM
Effie Apostolou, Weill Cornell Medical College
Epigenetic Mechanisms of Post-Mitotic Transcriptional Activation
Nada Jabado, McGill University Health Centre
Epigenetics of Pediatric Brain Cancers
Yadira M Soto-Feliciano, Massachusetts Institute of Technology
Chromatin Scaffold Proteins in Development and Disease
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
On Own for Dinner
7:00–8:00 PM
Friday, March 6, 2026
Departure
12:00–11:59 PM

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