Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities
Mar 02–05, 2026 | Crowne Plaza Geneva, Geneva, Switzerland
Scientific Organizers:
Karim-Jean Armache and Cigall Kadoch
In Person
On Demand
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Mar 02–05, 2026 | Crowne Plaza Geneva, Geneva, Switzerland
Scientific Organizers: Karim-Jean Armache and Cigall Kadoch
Karim-Jean Armache, PhD
New York University Grossman School of Medicine
Cigall Kadoch, PhD
Dana-Farber Cancer Institute, Harvard Medical School
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMonday, March 2, 2026
Fundraising
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Merchandise Options
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Registration
4:00–8:00 PM
Foyer International
Welcome Mixer
6:00–8:00 PM
Foyer International
Tuesday, March 3, 2026
Breakfast
7:00–8:00 AM
Individual Hotel
Poster Setup
7:30–8:00 AM
Zurich Ballroom
Poster Viewing
7:45–5:00 PM
Zurich Ballroom
Welcome Remarks
8:00–8:10 AM
New York Ballroom
Keynote Address
8:10–9:00 AM
New York Ballroom
* Karim-Jean Armache, New York University Grossman School of Medicine
Session Chair
Session Chair
Joanna Wysocka, Stanford University
Epigenetic Regulators in Development and Disease
Epigenetic Regulators in Development and Disease
Chromatin Regulatory Mechanisms Governing Cell Fate in Health and Disease
9:00–11:30 AM
New York Ballroom
* Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School
Session Chair
Session Chair
Robert J. Klose, University of Oxford
Understanding how CpG Island regulate Gene Expression
Understanding how CpG Island regulate Gene Expression
Anja Groth, University of Copenhagen
Maintaining Cell Fate through Replication
Maintaining Cell Fate through Replication
Karim-Jean Armache, New York University Grossman School of Medicine
Structure and Function of Epigenetic Complexes: Basic and Disease Mechanisms
Structure and Function of Epigenetic Complexes: Basic and Disease Mechanisms
Scott A. Armstrong, Dana-Farber Cancer Institute
Mechanisms of Menin Inhibitor Sensitivity and Resistance
Mechanisms of Menin Inhibitor Sensitivity and Resistance
Beat Fierz, EPFL
Short Talk: Choreography of Epigenetic Control Captured on the Molecular Level
Short Talk: Choreography of Epigenetic Control Captured on the Molecular Level
Coffee Break
9:30–9:50 AM
Foyer International
Lunch
11:30–12:30 PM
Europe Ballroom
Poster Session 1
12:00–2:00 PM
Zurich Ballroom
Symposia Spotlight 1
2:00–4:00 PM
New York Ballroom
* Anja Groth, University of Copenhagen
Session Chair
Session Chair
James K. Nuñez, University of California, Berkeley
Short Talk: DNA Methylation Interplays With RNA M6a Factors To Establish Heritable Epigenetic Silencing In Human Cells
Short Talk: DNA Methylation Interplays With RNA M6a Factors To Establish Heritable Epigenetic Silencing In Human Cells
Jean-Paul Armache, Penn State University
Short Talk: Structure-function and Chromatin Biology
Short Talk: Structure-function and Chromatin Biology
Diego Pasini, European Institute of Oncology
Short Talk: Control of Transcriptional Identity by the Polycomb Repressive Machinery
Short Talk: Control of Transcriptional Identity by the Polycomb Repressive Machinery
Robert L Yauch, Genentech, Inc.
Short Talk: Antibody-Mediated Delivery of SMARCA2/A4 Protein Degraders Affords Strong Anti-Tumor Efficacy in SMARCA4-Mutant NSCLC and Prostate Cancer Models
Short Talk: Antibody-Mediated Delivery of SMARCA2/A4 Protein Degraders Affords Strong Anti-Tumor Efficacy in SMARCA4-Mutant NSCLC and Prostate Cancer Models
Aliaksandra (Alex) Radzisheuskaya, The Institute of Cancer Research
Short Talk: Uncovering Critical Lysines in Mammalian Histone H3 with High-Throughput CRISPR Prime Editing
Short Talk: Uncovering Critical Lysines in Mammalian Histone H3 with High-Throughput CRISPR Prime Editing
Mo Chen, Tsinghua University
Short Talk: Spatiotemporal Control of SMARCA5 by a MAPK-RUNX1 Axis Distinguishes Mutant KRAS-Driven Pancreatic Malignancy From Tissue Regeneration
Short Talk: Spatiotemporal Control of SMARCA5 by a MAPK-RUNX1 Axis Distinguishes Mutant KRAS-Driven Pancreatic Malignancy From Tissue Regeneration
Serena Sanulli, Stanford University
Short Talk: Allosteric Regulation Of The Nucleosome Core Biases Cell State
Short Talk: Allosteric Regulation Of The Nucleosome Core Biases Cell State
Adrian P Bracken, Trinity College Dublin
Short Talk: The Abundant AEBP2 Long Isoform Restrains PRC2 to Direct H3K27me2 in Development and Cancer
Short Talk: The Abundant AEBP2 Long Isoform Restrains PRC2 to Direct H3K27me2 in Development and Cancer
Coffee Available
4:00–4:30 PM
Foyer International
Therapeutic Opportunities Informed by Genetic Disruption of Chromatin Factors
4:30–6:30 PM
New York Ballroom
* Aliaksandra (Alex) Radzisheuskaya, The Institute of Cancer Research
Session Chair
Session Chair
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School
Structure and Function of Chromatin Remodeling Complexes in Human Disease: From Basic Mechanisms to Therapeutic Opportunities
Structure and Function of Chromatin Remodeling Complexes in Human Disease: From Basic Mechanisms to Therapeutic Opportunities
Nicolas H Thomä, EPFL Lausanne
Structural Basis of Transcription Factors and Protein Degradation
Structural Basis of Transcription Factors and Protein Degradation
Isaac A. Klein, Dewpoint Therapeutics
Condensate Modulating Drugs: Targeting Gene Regulation Via Condensate Disruption
Condensate Modulating Drugs: Targeting Gene Regulation Via Condensate Disruption
François Fuks, University of Brussels
RNA Modifications in Health and Disease
RNA Modifications in Health and Disease
Tomasz Cierpicki, University of Michigan
Short Talk: Discovery of PRC1 Inhibitors with In Vivo Efficacy
Short Talk: Discovery of PRC1 Inhibitors with In Vivo Efficacy
On Own for Dinner
6:30–7:30 PM
Wednesday, March 4, 2026
Breakfast
7:00–8:00 AM
Individual Hotel
Poster Setup
7:30–8:00 AM
Zurich Ballroom
Poster Viewing
7:45–5:00 PM
Zurich Ballroom
Novel Target Identification and Chemical Approaches
8:00–11:00 AM
New York Ballroom
* François Fuks, University of Brussels
Session Chair
Session Chair
Tom W. Muir, Princeton University
New Chemical Approaches to Reveal and Understand Chromatin Mechanisms
New Chemical Approaches to Reveal and Understand Chromatin Mechanisms
Jelena Urosevic, AstraZeneca
Epigenetic Targeting in Oncology: Translating Mechanisms to Practice with MTAP-Selective PRMT5 Inhibition—The AZD3470 Story
Epigenetic Targeting in Oncology: Translating Mechanisms to Practice with MTAP-Selective PRMT5 Inhibition—The AZD3470 Story
Scott B Rothbart, Van Andel Institute
Revealing Novel Cancer Therapeutic Strategies Through Molecular Studies Of Chromatin Modification Crosstalk
Revealing Novel Cancer Therapeutic Strategies Through Molecular Studies Of Chromatin Modification Crosstalk
Steven F Bellon, Foghorn Therapeutics
Identification of First-In-Class Selective ARID1B Degraders
Identification of First-In-Class Selective ARID1B Degraders
Bryan Venters, EpiCypher, Inc.
Short Talk: Unraveling Chromatin Regulation With Fiber-seq: a Single-Molecule, Long-Read Assay That Simultaneously Measures Chromatin Architecture and DNA Methylation
Short Talk: Unraveling Chromatin Regulation With Fiber-seq: a Single-Molecule, Long-Read Assay That Simultaneously Measures Chromatin Architecture and DNA Methylation
Alejandro Correa Sáez, University of Dundee
Short Talk: Dual E3 Ligase Recruitment by Monovalent Degraders Enables Redundant and Tunable Degradation of SMARCA2/4b
Short Talk: Dual E3 Ligase Recruitment by Monovalent Degraders Enables Redundant and Tunable Degradation of SMARCA2/4b
Coffee Break
9:00–9:20 AM
Foyer International
Award Recipient Acknowledgement
9:20–9:25 AM
New York Ballroom
Lunch
11:00–12:00 PM
Europe Ballroom
Poster Session 2
11:30–1:45 PM
Zurich Ballroom
Career Roundtable
2:00–2:45 PM
New York Ballroom
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School
*Session Moderator
*Session Moderator
Karim-Jean Armache, New York University Grossman School of Medicine
*Session Moderator
*Session Moderator
Emily Bernstein, Mount Sinai School of Medicine
Professor
Professor
Nicolas H Thomä, EPFL Lausanne
Senior Group Leader
Senior Group Leader
Robert L Yauch, Genentech, Inc.
Executive Director
Executive Director
Jelena Urosevic, AstraZeneca
Associate Principal Scientist
Associate Principal Scientist
Panel Discussion: From Mechanisms to Drugs: Therapeutic Challenges and Opportunities Unique to Our Field
2:45–3:30 PM
New York Ballroom
Karim-Jean Armache, New York University Grossman School of Medicine
*Session Moderator
*Session Moderator
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School
*Session Moderator
*Session Moderator
Scott A. Armstrong, Dana-Farber Cancer Institute
Panelist
Panelist
Nada Jabado, McGill University Health Centre
Panelist
Panelist
Isaac A. Klein, Dewpoint Therapeutics
Panelist
Panelist
Steven F Bellon, Foghorn Therapeutics
Panelist
Panelist
Coffee Available
3:30–4:00 PM
Foyer International
Mechanisms and Vulnerabilities Conferred by DNA Methylation
4:00–6:00 PM
New York Ballroom
* Scott B Rothbart, Van Andel Institute
Session Chair
Session Chair
Yael David, Memorial Sloan Kettering Cancer Center
Targeting a New Metabolism-Epigenetic Axis Towards Improved CAR T Therapy
Targeting a New Metabolism-Epigenetic Axis Towards Improved CAR T Therapy
Chao Lu, Columbia University
Lineage-Specific Metabolic Regulation of Chromatin Contributes to Tumor Plasticity
Lineage-Specific Metabolic Regulation of Chromatin Contributes to Tumor Plasticity
Alla Sigova, CAMP4 Therapeutics
RNA Amplifier Therapeutics Targeting Regulatory RNAs to Upregulate Disease-Associated genes
RNA Amplifier Therapeutics Targeting Regulatory RNAs to Upregulate Disease-Associated genes
Emily Hodges, Vanderbilt University
Short Talk: Predicting Past, Present and Future Cell States with DNA Methylation
Short Talk: Predicting Past, Present and Future Cell States with DNA Methylation
Eneda Toska, Johns Hopkins University
Short Talk: Epigenetic Mechanisms of Therapy Resistance in Hormone Receptor–Positive Breast Cancer
Short Talk: Epigenetic Mechanisms of Therapy Resistance in Hormone Receptor–Positive Breast Cancer
On Own for Dinner
6:00–7:00 PM
Thursday, March 5, 2026
Breakfast
7:00–8:00 AM
Individual Hotel
Poster Setup
7:30–8:00 AM
Zurich Ballroom
Poster Viewing
7:45–5:00 PM
Zurich Ballroom
Interplay between Chromatin Regulation and Transcription Dynamics in Human Disease
8:00–11:00 AM
New York Ballroom
* Eneda Toska, Johns Hopkins University
Session Chair
Session Chair
Emily Bernstein, Mount Sinai School of Medicine
Mechanisms of Chromatin Remodeling Mutations in Cancer
Mechanisms of Chromatin Remodeling Mutations in Cancer
Ali Shilatifard, Northwestern University
The Long Road of Transcription: Elongation Control in Aging, Disease and Cancer
The Long Road of Transcription: Elongation Control in Aging, Disease and Cancer
Danny F Reinberg, University of Miami
Opportunities in Cancer
Opportunities in Cancer
Stefan Niekamp, Massachusetts General Hospital
Short Talk: Mutual Antagonism between PRC1 Condensates and SWI/SNF in Chromatin Regulation
Short Talk: Mutual Antagonism between PRC1 Condensates and SWI/SNF in Chromatin Regulation
Amanda Engstrom, Baylor College of Medicine
Short Talk: Dose-Dependent Molecular Consequences of MeCP2 Dysregulation in Neurological Disorders
Short Talk: Dose-Dependent Molecular Consequences of MeCP2 Dysregulation in Neurological Disorders
Chul-Hwan Lee, Seoul National University
Short Talk: EZH1 Orchestrates 3D Chromatin Architecture To Establish De Novo Heterochromatin And Safeguard Lineage Commitment
Short Talk: EZH1 Orchestrates 3D Chromatin Architecture To Establish De Novo Heterochromatin And Safeguard Lineage Commitment
Jane A. Skok, New York University School of Medicine
Short Talk: Replication-Coupled Cohesin Remodeling Reorganizes Nucleosome Phasing And Insulation
Short Talk: Replication-Coupled Cohesin Remodeling Reorganizes Nucleosome Phasing And Insulation
Joseph C Sudar, New York University Grossman School of Medicine
Short Talk: Epigenetics in Parasite Survival and Host Immune Evasion
Short Talk: Epigenetics in Parasite Survival and Host Immune Evasion
Coffee Break
9:00–9:20 AM
Foyer International
Lunch
11:00–12:15 PM
Europe Ballroom
Poster Session 3
12:00–2:30 PM
Zurich Ballroom
Symposia Spotlight 2
2:30–4:30 PM
New York Ballroom
* Chul-Hwan Lee, Seoul National University
Session Chair
Session Chair
Lu Wang, Northwestern University
Short Talk: Molecular Dissection of Gene Essentiality and Transcriptional Reprogramming in Cancer
Short Talk: Molecular Dissection of Gene Essentiality and Transcriptional Reprogramming in Cancer
Oliver Bell, Keck School of Medicine of USC
Short Talk: ZNF462 Haploinsufficiency Disrupts G9A/GLP-Mediated Gene Silencing To Drive Neurogenic Priming in Weiss-Kruszka Syndrome
Short Talk: ZNF462 Haploinsufficiency Disrupts G9A/GLP-Mediated Gene Silencing To Drive Neurogenic Priming in Weiss-Kruszka Syndrome
Alejandra Laguillo-Diego, Weill Cornell Medicine
Short Talk: KAT7 and KAT6A/B Dictate Cell Identity Decisions During M-to-G1
Short Talk: KAT7 and KAT6A/B Dictate Cell Identity Decisions During M-to-G1
Caroline Clarke, AstraZeneca
Short Talk: Distinct Specialisations of Cohesin-STAG1 and Cohesin-STAG2 Reshape 3D Genome Architecture and Gene–Protein Networks in Cancer
Short Talk: Distinct Specialisations of Cohesin-STAG1 and Cohesin-STAG2 Reshape 3D Genome Architecture and Gene–Protein Networks in Cancer
Yumeng Zhan, Max Planck Institute for Multidisciplinary Sciences
Short Talk: The +1 Nucleosome Functions in the Initiation-Elongation Transition of Pol II Transcription
Short Talk: The +1 Nucleosome Functions in the Initiation-Elongation Transition of Pol II Transcription
Eric M Conway, University College Dublin
Short Talk: Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin
Short Talk: Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin
Melanie Eckersley-Maslin, Peter MacCallum Cancer Centre
Short Talk: Hijacking Chromatin Regulators of Developmental Plasticity in Cancer
Short Talk: Hijacking Chromatin Regulators of Developmental Plasticity in Cancer
Coffee Available
4:30–5:00 PM
Foyer International
Chromatin Regulatory Machinery in Human Health and Disease
5:00–6:20 PM
New York Ballroom
* Chao Lu, Columbia University
Session Chair
Session Chair
Effie Apostolou, Weill Cornell Medical College
Epigenetic Mechanisms of Post-Mitotic Transcriptional Activation
Epigenetic Mechanisms of Post-Mitotic Transcriptional Activation
Nada Jabado, McGill University Health Centre
Epigenetics of Pediatric Brain Cancers
Epigenetics of Pediatric Brain Cancers
Lluis Morey, University of Miami Miller School of Medicine
Short Talk: Decoding the Role of PRC1 Missense Mutations in Neurodevelopmental Disorders
Short Talk: Decoding the Role of PRC1 Missense Mutations in Neurodevelopmental Disorders
Siddhant Jain, Dana-Farber Cancer Institute, Boston , Massachusetts, US
Short Talk: A SWI/SNF-Specific Ig-Like Domain, SWIFT, is a Transcription Factor Binding Platform
Short Talk: A SWI/SNF-Specific Ig-Like Domain, SWIFT, is a Transcription Factor Binding Platform
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:20–6:35 PM
New York Ballroom
On Own for Dinner
6:35–7:35 PM
Friday, March 6, 2026
Departure
12:00–11:59 PM
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