About This Meeting:

Targeted Protein Degradation and other Induced-Proximity Modalities are now established concepts for fundamental academic chemical biology and are revolutionizing therapeutic discovery. At the heart of this field is the chemical remodeling and rewiring of proteins to control biomolecular interactions. As the field advances from foundational discovery toward clinical application, opportunities remain to understand the mechanistic principles, technologies, and translational pathways that will shape the next generation of induced proximity therapeutics. 

This Keystone Symposia conference on Induced Proximity and Targeted Protein Degradation: Emerging Technologies and Therapeutic Applications will provide an opportunity to showcase the latest mechanistic insights and progress in the clinic of advanced systems, highlight emerging innovations in the field, and foster interactions to catalyze the exchange of new ideas for disease targeting strategies. The program will emphasize anticipated frontiers in 2027 that will come to bear in the clinic, in the form of new E3 ligases and induced proximity modalities, with focus on the discovery chemistry and biology that underpins these innovations, and will look towards the future using emerging next-generation technologies such as artificial intelligence. 

The meeting will bring together recognized leaders with new scientists, spanning leaders from the lab to the clinic and providing fresh perspectives and new systems. Joint programming with Autophagy in Health and Disease: From Mechanisms to Therapeutics will expand the scope of induced proximity applications across cellular processes and therapeutic targets. 

This meeting positions itself as a unique forum to inspire new ideas and opportunities for collaborations to deliver the next wave of breakthroughs for TPD and induced proximity, connecting fundamental chemical biology discoveries with translational pathways and clinical application.

In the video below, Drs. Alessio Ciulli, PhD (University of Dundee) and William Forrester, PhD (Novartis) talk about what to expect from this meeting and why you should attend:

Additionally, check out the speaker highlights: