The study of somatic mosaicism has provided new fundamental insights into human development, aging, and diverse diseases. Comprehensive analyses of somatic mosaicism has enabled tracing of lineagess from the fertilized egg to adult organs, and it has revealed novel aspects of mutational processes active across tissues. Furthermore, somatic mosaicism has been identified as consequential to human diseases with previously unknown etiology.

This meeting will serve as a forum for exchange of emerging research concepts and directions in the field of somatic mosaicism, and it will provide an opportunity for new investigators to be introduced to this exciting new field. The meeting will integrate diverse aspects of somatic mosaicism, from mechanisms to translational disease insights. Specifically, the program will cover:

1. the development of new sequencing and bioinformatic tools for accurately detecting somatic mosaicism;
2. the involvement of somatic mosaicism in human development and aging;
3. somatic mosaicism in disease biology, and modeling thereof;
4. efforts to translate research on somatic mosaicism to the  clinic.

This meeting will bring together scientists and clinicians from developmental and aging biology, bioinformatics, systems biology, molecular and genetic biology, medicine, and the pharmaceutical industry to collaboratively explore the intersection of these diverse fields and collectively advance our understanding of somatic mosaicism in health and disease.