Microproteins, largely overlooked until the past decade, appear to play interesting and sometimes outsized roles in biological regulation across the tree of life. From peptides that are important for transcriptional regulation in plants to bacterial small proteins that regulate the function of multidrug efflux pumps to micropeptides that modulate muscle performance in mammals, we are just now discovering the wealth of biological properties of these small proteins. In this meeting, we will bring together experimental biologists, computational biologists, structural biologists, biochemists, microbiologists, physician scientists and technologists to share cutting edge insights in this emerging field of interest. This will be the very first meeting, to our knowledge, that is focused on microproteins - and the group of scientists who will be in attendance are unlikely to have an opportunity to meet in any other forum.