Although emerging evidence points to the critical importance of the long non-coding transcriptome in human physiology and pathology, the clinical potential of long non-coding RNAs (lncRNAs) as therapeutic and prognostic targets remain largely unexplored. The increasing availability of high-throughput technologies and newly developed computational methodologies are rapidly making it possible to address this gap in our knowledge. However, optimal use of these new capabilities and recognition of their power in transforming the field of lncRNA research require the formation of new collaborative and training efforts. This conference specifically aims to: 1) Communicate the latest available technologies and developing methodologies for lncRNA functional genetics to the lncRNA community; 2) Bridge the already thriving lncRNA mechanistic and basic research to the clinical need for novel, effective diagnostic, prognostic and therapeutic targets; 3) Highlight and promote the emerging feasibility of performing lncRNA functional genetics; and 4) Stimulate the formation of new collaborative efforts that will accelerate the integration of the lncRNA research into the existing body of biological knowledge.