Jan 19–22, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Virginia Pascual, Raphaela Theresia Goldbach-Mansky, Veit Hornung, and Richard M. Siegel

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Scientific Organizers: Virginia Pascual, Raphaela Theresia Goldbach-Mansky, Veit Hornung, and Richard M. Siegel
Virginia Pascual, MD
Cornell University
Raphaela Theresia Goldbach-Mansky, MD
NIAID, National Institutes of Health
Veit Hornung, MD
Ludwig-Maximilians-University Munich
Richard M. Siegel, PhD
Novartis Biomedical Research
***Meeting program subject to change.
Available Formats: = In Person = On DemandMonday, January 19, 2026
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Tuesday, January 20, 2026
A 360° View of the Inflammasome: Mechanisms of Activation, Cell Death, and Diseases
Recognition of Non-Self RNA by the Innate Immune System
cGAS-STING in Aging-Related Inflammation and Neurodegeneration
Novel Therapies to Target cGAS-STING
The NLRP1 Inflammasome
Novel Mechanisms in Autoinflammatory Diseases
An Update on Inflammasome Targeting
Wednesday, January 21, 2026
The Intersection of Epigenetics and Metabolism in Trained Immunity
Innate Immunity Dysregulation in Human Lupus
Interorgan Neuroimmune Circuits
mRNA: A New Era in Immune Therapeutics
Disease-Associated Astrocyte Epigenetic Memory Promotes CNS Pathology
Preclinical Models of Human Monogenic Autoimmunity
Thursday, January 22, 2026
Adipocyte and Fibroblast Dysfunction in Inflammatory Diseases
Mechanisms of Intestinal Tissue Resilience to Immune-Mediated Damage
Patient Stratification Towards Precision Medicine in IBD
Roadmap for Understanding Mechanisms on how Epstein-Barr Virus Triggers Multiple Sclerosis and for Developing Therapeutic Approaches
Spatial Transcriptomics to Stratify Psoriatic Disease Severity
Novel Approaches to Tissue B Cell Depletion in Autoimmune Diseases
Friday, January 23, 2026
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