Autoimmunity & Autoinflammation: Translating Basic Mechanisms into Novel Therapeutic Approaches

Jan 19–22, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Virginia Pascual, Raphaela Theresia Goldbach-Mansky, Veit Hornung, and Richard M. Siegel

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  On Demand
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Jan 19–22, 2026 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Virginia Pascual, Raphaela Theresia Goldbach-Mansky, Veit Hornung, and Richard M. Siegel

Supported by:

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Monday, January 19, 2026
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, January 20, 2026
Breakfast
7:00–8:00 AM
Welcome and Keynote Address
8:00–9:00 AM
Jenny P.Y. Ting, University of North Carolina at Chapel Hill
A 360° View of the Inflammasome: Mechanisms of Activation, Cell Death, and Diseases
Autoimmunity and Autoinflammation: The Nucleic Acid Sensing Perspective
9:00–11:15 AM
Veit Hornung, Ludwig-Maximilians-University Munich
Recognition of Non-Self RNA by the Innate Immune System
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
cGAS-STING in Aging-Related Inflammation and Neurodegeneration
Michael Crackower, Ventus Therapeutics
Novel Therapies to Target cGAS-STING
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
Poster Setup
11:15–1:00 PM
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Inflammasomes: From Basic Mechanisms to Autoinflammatory Diseases
5:00–7:00 PM
Franklin Zhong, NTU LKC School of Medicine
The NLRP1 Inflammasome
Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health
Novel Mechanisms in Autoinflammatory Diseases
Nick Clarke, NodThera
An Update on Inflammasome Targeting
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, January 21, 2026
Breakfast
7:00–8:00 AM
Innate Immune Cell Dysregulation in Autoimmune and AutoInflammatory Diseases
8:00–11:00 AM
Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences
The Intersection of Epigenetics and Metabolism in Trained Immunity
Virginia Pascual, Cornell University
Innate Immunity Dysregulation in Human Lupus
Brian Kim, Mount Sinai
Interorgan Neuroimmune Circuits
Kate L. Jeffrey, Moderna
mRNA: A New Era in Immune Therapeutics
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Poster Setup
11:00–1:00 PM
On Own for Lunch
11:00–3:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
1:30–2:45 PM
Panel Discussion 1: Optimizing Interactions with Biotech and Pharma
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Adaptive Immune Cell Dysregulation in Autoimmune and Autoinflammatory Diseases
5:00–7:00 PM
Francisco J. Quintana, Brigham and Women's Hospital / Harvard Medical School & Broad Institute
Disease-Associated Astrocyte Epigenetic Memory Promotes CNS Pathology
Carola G. Vinuesa, Francis Crick Institute
Preclinical Models of Human Monogenic Autoimmunity
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Thursday, January 22, 2026
Breakfast
7:00–8:00 AM
Stromal Cells in Autoinflammation and Autoimmunity: From Basic Mechanisms to Precision Medicine
8:00–11:00 AM
Speaker to be Announced
Michael B. Brenner, Harvard Medical School
Adipocyte and Fibroblast Dysfunction in Inflammatory Diseases
Ken H. Cadwell, University of Pennsylvania
Mechanisms of Intestinal Tissue Resilience to Immune-Mediated Damage
Kara Lassen, Roche
Patient Stratification Towards Precision Medicine in IBD
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–2:30 PM
Panel Discussion 2: Venture Capital and Identifying Promising Startups
2:30–4:30 PM
Coffee Available
4:30–5:00 PM
Novel Disease Insights and Therapies: Lessons from Tissue Profiling
5:00–6:45 PM
Tobias Lanz, Stanford University
Roadmap for Understanding Mechanisms on how Epstein-Barr Virus Triggers Multiple Sclerosis and for Developing Therapeutic Approaches
Shruti Naik, Icahn School of Medicine at Mount Sinai
Spatial Transcriptomics to Stratify Psoriatic Disease Severity
Richard M. Siegel, Novartis Biomedical Research
Novel Approaches to Tissue B Cell Depletion in Autoimmune Diseases
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Social Hour with Dinner
7:00–8:00 PM
Cash Bar
8:00–11:00 PM
Entertainment
8:00–11:00 PM
Friday, January 23, 2026
Departure
12:00–11:59 PM

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