B Cells: Multifaceted Functions and Dysfunctions

Feb 23–26, 2025 | Fairmont Monte Carlo, Monte Carlo, Monaco
Scientific Organizers: Rita Carsetti, Ali H. Ellebedy, and Hedda Wardemann

  In Person
  On Demand
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Feb 23–26, 2025 | Fairmont Monte Carlo, Monte Carlo, Monaco

Scientific Organizers: Rita Carsetti, Ali H. Ellebedy, and Hedda Wardemann

Supported by:

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, February 23, 2025
Registration  
4:00–8:00 PM
 Galerie Cristal
Welcome Mixer  
6:00–8:00 PM
 Galerie Cristal
Monday, February 24, 2025
Breakfast  
7:30–8:30 AM
 Individual Hotel
Poster Setup  
8:00–8:30 AM
 Salle d'Or 2
Poster Viewing  
8:15–5:00 PM
 Salle d'Or 2
Welcome and Keynote Address  
8:30–9:30 AM
 Salle d'Or 1
* Rita Carsetti, Bambino Gesù Children Hospital
Session Chair
Antonio Lanzavecchia, Vir Biotechnology, Inc.
Learning How to Design New Vaccines from Memory B Cells
Deploying B-Cell Responses to Protect Against Pathogens  
9:30–11:45 AM
 Salle d'Or 1
* Hedda Wardemann, German Cancer Research Center
Session Chair
* Jo Spencer, King's College London
Session Chair
Ali H. Ellebedy, Washington University School of Medicine
Persistence of Germinal Center Reactions after mRNA Vaccination in Humans
Carola G. Vinuesa, Francis Crick Institute
A B Cell Trilemma
Paula M Cannon, University of Southern California, Keck School of Medicine
Genome Edited B Cells as Therapeutics Against Pathogens
Robert Abbott, University of Texas Medical Branch
Short Talk: Antigen Avidity Drives the Durability of the Vaccine Immune Response.
Coffee Break  
10:00–10:20 AM
 Galerie Cristal
Lunch  
11:45–12:45 PM
 Galerie Cristal
Women in Science Networking Event  
11:50–12:50 PM
 Galerie Cristal
* Hedda Wardemann, German Cancer Research Center
Session Chair
* S. Rameeza Allie, Penn State College of Medicine
Session Chair
* Kim Good-Jacobson, Monash University
Session Chair
* Ali H. Ellebedy, Washington University School of Medicine
Session Chair
Poster Session 1  
12:30–2:30 PM
 Salle d'Or 2
Symposia Spotlight 1: B Cell Function  
2:30–4:30 PM
 Salle d'Or 1
* Pia Dosenovic, Karolinska Institutet
Session Chair
* Jenna Guthmiller, University of Colorado SOM
Session Chair
David R Glass, Fred Hutchinson Cancer Center
Bridging The Identity And Function Of Human Plasma Cells
Katharina Lahl, University of Calgary
Maternal Immunity Protects Offspring from Enteric Viral Infection Without Negatively Affecting Humoral Immune Memory
Michael Farzan, Boston Children's Hospital; Harvard Medical School
In Vivo Affinity Maturation of Mouse B Cells Engineered to Express Human Antibodies and Biologics
Joshua F.E. Koenig, McMaster University
Type 2-Polarized Memory B Cells Hold Ige Memory Against Allergens and Helmiths Independently of Igg1 Expression
Ragan Pitner, Seattle Children's Research Institute
Regulating Humoral And Cellular Immunity With Non-Differentiating Engineered Regulatory B Cells
Roxane Biersteker, Leiden University Medical Center
Modulation Of Igg Oligomerization By Variable Domain Glycans: A Novel Mechanism To Regulate Complement Activation
Jaime L Chao, University of Washington
B Cell Response Heterogeneity Is Spatially Encoded Across The Lymphatic Chain
Mohammed Zghaebi, Medical University of Vienna
Aiming at Conserved Ige Lineages: A Novel Approach to Target Allergic Cascades in Birch Pollen Allergy. Submitter
Coffee Available  
4:30–5:00 PM
 Galerie Cristal
B Cell Responses to Global Pathogens  
5:00–7:00 PM
 Salle d'Or 1
* Amy Chung, University of Melbourne
Session Chair
Hedda Wardemann, German Cancer Research Center
Humoral Immune Responses to Malaria Vaccines
Daniel Lingwood, Harvard Medical School
Expanding Exceptionally Broad Anti-flu Pathways from the Human B cell Repertoire
Patrick Madden, La Jolla Institute for Immunology
Short Talk: Priming And Shepherding Rare B Cell Precursors With Germline-Targeting And Boosting Immunizations In Non-Human Primates
Isabelle J Foo, The University of Melbourne
Short Talk: Historic 1994 Influenza Vaccine Cohorts Provide Key Insights into B Cell and Antibody Landscapes Toward Future Influenza Strains
On Own for Dinner  
7:00–8:00 PM
Tuesday, February 25, 2025
Breakfast  
7:30–8:30 AM
 Individual Hotel
Poster Setup  
8:00–8:30 AM
 Salle d'Or 2
Poster Viewing  
8:15–5:00 PM
 Salle d'Or 2
Longevity of B Cell Responses  
8:30–11:30 AM
 Salle d'Or 1
* Marcus R Clark, University of Chicago
Session Chair
* Michael Farzan, Boston Children's Hospital; Harvard Medical School
Session Chair
Pavel Tolar, University College London
Regulation of Normal and Oncogenic BCR Signaling by Immunoglobulin Class-switching
David M. Tarlinton, Monash University
Intrinsic and Extrinsic Regulators Setting Plasma Cell Lifespans
Tomohiro Kurosaki, Osaka University
Making Sense of Memory B Cell Heterogeneity
Adi Barzel, Tel Aviv University
In Vivo B Cell Engineering
Andrew J MacLean, The Rockefeller University
Short Talk: Affinity Maturation of Antibody Responses is Mediated by Differential Plasma Cell Proliferation
David R. Fooksman, Albert Einstein College of Medicine
Short Talk: Cd138 and April Regulate Pc Survival, Competition and Retention in the Bm Niche
Coffee Break  
9:30–9:50 AM
 Galerie Cristal
Lunch  
11:30–12:30 PM
 Galerie Cristal
Poster Session 2  
12:00–2:00 PM
 Salle d'Or 2
Career Roundtable  
2:15–3:45 PM
 Salle d'Or 1
F. Nina Papavasiliou, Deutsches Krebsforschungszentrum
Professor
David R. Fooksman, Albert Einstein College of Medicine
Associate Professor
Andre Limnander, Regeneron
Director, Immunology & Inflammation
Martina Trokter, LifeArc
Senior Scientist
Coffee Available  
3:45–4:15 PM
 Galerie Cristal
B Cell Responses at Mucosa Sites  
4:15–6:15 PM
 Salle d'Or 1
* Carla R. Nowosad, New York University
Session Chair
* Lisa A. Chakrabarti, Institut Pasteur
Session Chair
S. Rameeza Allie, Penn State College of Medicine
The Formation and Function of Lung-Resident Memory B Cells in Protection Against Viral Infections
Davide Angeletti, University of Gothenburg
Dynamics of Mucosal B Cell Responses to Influenza Virus Infection
Rita Carsetti, Bambino Gesù Children Hospital
Memory B Cells Turn Systemic Immunity into Local Protection
Emily Siniscalco, Yale University
Short Talk: Antigen-Selected Gut Iga is Generated from Igg1 Germinal Center B Cells Submitter
Anton Sholukh, Fred Hutch Cancer Center
Short Talk: Plasma Cells Establish Long-Term Residency and Secrete Virus-Specific Antibodies in Genital Skin Infected with Hsv-2
On Own for Dinner  
6:15–7:15 PM
Wednesday, February 26, 2025
Breakfast  
7:00–8:00 AM
 Individual Hotel
Poster Setup  
7:30–8:00 AM
 Salle d'Or 2
B Cells in Autoimmunity and Cancer  
8:00–11:00 AM
 Salle d'Or 1
* Roberta Pelanda, University of Colorado Anschutz Medical Campus
Session Chair
* Aaron J. Marshall, University of Manitoba
Session Chair
Virginia Pascual, Cornell University
The B Helper T Cell Compartment in Human SLE
Georg A Schett, Uniklinikum Erlangen
Control of Autoimmune Diseases via CD19-Targeted CAR T Cells
F. Nina Papavasiliou, Deutsches Krebsforschungszentrum
ADAR1-Mediated Editing Promotes B Cell Lymphoma
Ziv Shulman, Weizmann Institute
Generation and Function of Tumor Reactive Antibodies
Nataliya Yeremenko, University of Nantes
Short Talk: Targeting Bob1: A Novel Strategy For Gc-Derived B Cell Diseases From Autoimmunity To Cancer
Naiara Juan-Larrea, Centro Nacional de Investigaciones Oncológicas (CNIO)
Short Talk: The B-Side Of Melanoma: Midkine Rewires B Cells to Support Tumor Growth and Immune Evasion
Poster Viewing  
8:15–5:00 PM
 Salle d'Or 2
Coffee Break  
9:00–9:20 AM
 Galerie Cristal
Panel Discussion: Data Sharing and Preprint Publication, Discussion Involving Journals Editors  
11:00–12:15 PM
 Salle d'Or 1
Hedda Wardemann, German Cancer Research Center
*Session Chair
Facundo D. Batista, Massachusetts Institute of Technology and Harvard University
Chief Editor, The EMBO Journal
Ursula Weiss, Nature
Senior Editor
Courtney Malo, Science Translational Medicine
Associate Editor
Kirsty Minton, Nature Publishing Group
Senior Editor
Lunch  
12:15–1:15 PM
 Galerie Cristal
Poster Session 3  
12:45–2:30 PM
 Salle d'Or 2
Symposia Spotlight 2: Single Cell Technologies  
2:30–4:30 PM
 Salle d'Or 1
* Gunilla B. Karlsson Hedestam, Karolinska Institutet
Session Chair
* Arash Grakoui, Emory University
Session Chair
Chiara Dionisi, King's College London
Analysis of Paired B Cell Epigenetic and Transcriptomic Features Reveals Aspects of Human B Cell Subset Development
Lisan H Kuijper, Sanquin Research
Clonal Relatedness Between B Cell Phenotypic Subsets: Using Multimodal Single-Cell Analysis of Antigen-Specific B Cells to Delineate Ef Vs Gc Response Evolution
Davide G. Franchina, Stanford University
Integration of Single Cell Mass Cytometry Imaging and Glyco-Imaging to Characterize B Cell Follicle Dynamics
Vitor R. C. Aguiar, Boston Children's Hospital
A Multiomics Resource of B Cell Activation Helps Decipher Disease Pathogenesis
Yiming Zhang, Massachusetts Institute of Technology
Investigating The Impact Of Vaccine Formulations On Humoral Immunity Via Integrated Single-Cell Multi-Omic Analysis
Gabriela Maciel da Silva, Universidade Federal do Rio de Janeiro
A Single-Cell Culture-Based Method For Comprehensive Analysis Of Memory B Cell Repertoire
Coffee Available  
4:30–4:45 PM
 Galerie Cristal
Regulation of B Cell Responses  
4:45–6:30 PM
 Salle d'Or 1
* Zia Rahman, Thomas Jefferson University
Session Chair
* Steven Kerfoot, University of Western Ontario
Session Chair
Facundo D. Batista, Massachusetts Institute of Technology and Harvard University
Antibody-Feedback Regulates B Cell Responses
Kim Good-Jacobson, Monash University
Molecular Control of Memory B Cell Differentiation
Almudena R. Ramiro, Centro Nacional de Investigaciones Cardiovasculares
The Antibody Immune Response in Atherosclerosis
Virginia G de Yébenes Mena, Universidad Complutense de Madrid
Short Talk: miR-28 Shapes Germinal Center Duration and Antibody Affinity in Viral Infection
Meeting Wrap-Up: Outcomes and Future Directions  
6:30–6:45 PM
 Salle d'Or 1
* Ali H. Ellebedy, Washington University School of Medicine
On Own for Dinner  
6:45–7:45 PM
Thursday, February 27, 2025
Departure  
12:00–11:59 PM

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