Immunometabolism: From Mechanisms to Pathways to Therapies

Mar 18–21, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Luke A. J. O'Neill, Evanna Mills, and Erika L. Pearce

  In Person
  On Demand
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Mar 18–21, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland

Scientific Organizers: Luke A. J. O'Neill, Evanna Mills, and Erika L. Pearce

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Monday, March 18, 2024
Arrival and Registration  
4:00–8:00 PM
 INEC Foyer
Welcome Mixer  
6:00–8:00 PM
 INEC Foyer
Tuesday, March 19, 2024
Breakfast  
7:00–8:00 AM
 Individual Hotel
Welcome and Keynote Address  
8:00–9:00 AM
 INEC Main Auditorium
Lydia Lynch, Harvard Medical School
Metabolism, Fat, and Cancer
New Approaches to Study Immunometabolism  
9:00–11:15 AM
 INEC Main Auditorium
Theodore Alexandrov, European Molecular Biology Laboratory
Spatial Single Cell Metabolomics
Rafael Jose Arguello, CIML
From Single Cell Metabolism, ER-Stress and Epigenetics to Prediction of Responses in Cancer Patients
Florent Ginhoux, Singapore Immunology Network
Macrophage-Mediated Tissue Metabolic Reprogramming During Development
David K. Finlay, Trinity Biomedical Sciences Institute
Short Talk: Short Talk: Using Biorthogonal (CLICK) Chemistry to Measure Nutrient Uptake Flux in Single Immune Cells
Coffee Break  
9:30–9:50 AM
 INEC Foyer
Poster Setup  
11:15–1:00 PM
 INEC Foyer
On Own for Lunch  
11:15–5:00 PM
Poster Viewing  
1:00–10:00 PM
 INEC Foyer
Career Roundtable  
3:30–4:30 PM
 INEC Main Auditorium
Alice Prince, Columbia University
Physician Scientist/Professor
Frank Dorsey, Eli Lilly and Company
Associate Vice President
Theodore Alexandrov, European Molecular Biology Laboratory
Team Leader / Head of MCF / MMPU Faculty
Coffee Available  
4:30–5:00 PM
 INEC Foyer
Mito-Nuclear Communication by Mitochondrial Metabolites  
5:00–7:00 PM
 INEC Main Auditorium
Tiffany Horng, ShanghaiTech University
Mitochondrial Metabolism and Macrophage Function
Claudio J. Villanueva, University of California, Los Angeles
Transcriptional Mechanisms that Regulate Adipocyte Development and Biology
Murad R. Mamedov, UCSF / Gladstone
Short Talk: Short Talk: CRISPR Screens Reveal AMPK-Dependent Metabolic Regulation of Cancer Cell Killing by γδ T Cells
Luisa Maria Mateus Abreu, European Molecular Biology Laboratory
Short Talk: Short Talk: High-Throughput Single-Cell Metabolomics Reveals Distinct Metabolic States of Drug-Modulated Activated CD4+ T Cells
Dirk Brenner, Luxembourg Institute of Health
Short Talk: Short Talk: Beyond Ubiquitination: Ubc13 in the Core of Mitochondrial Regulation and Innate Immunity
Eloïse Marques, University of Cambridge, MRC Mitochondrial Biology Unit
Short Talk: Short Talk: Assessing the Impact of a Heteroplasmic mt-tRNA Mutation on Inflammatory Macrophage Function
Social Hour with Lite Bites  
7:00–8:00 PM
 INEC Foyer
Poster Session 1  
7:30–10:00 PM
 INEC Foyer
Wednesday, March 20, 2024
Breakfast  
7:00–8:00 AM
 Individual Hotel
Immunometabolism: A Microbe’s View  
8:00–11:00 AM
 INEC Main Auditorium
Janelle S. Ayres, The Salk Institute for Biological Studies
Iron Metabolism in Host/Pathogen Interactions
Alice Prince, Columbia University
Airway Metabolites Promote Persistent Infection
Kathrin Renner, University Hospital Regensburg
Metabolic Imbalance and COVID19
Katherine L. Cook, Wake Forest University School of Medicine
Short Talk: Short Talk: Diet-Microbe Interactions Modulate Immune Checkpoint Blockade Response in Triple-Negative Breast Cancer
Johan Garaude, ImmunoConcEpT, INSERM ERL1303
Short Talk: Short Talk: Sensing of Microbial Viability Orchestrates the Metabolic Recycling of Engulfed Bacteria in Macrophages
Fran Prenen, Rega Institute for Medical Research
Short Talk: Short Talk: JAK/STAT Inhibition Restores Disease Tolerance in Malaria-Infected Glucocorticoid Receptor Knockout Mice by Preventing Lethal Hypoglycemia
Slater Clay, Harvard T.H. Chan School of Public Health
Short Talk: Short Talk:Acetoacetate Regulates Anti-Tumor Immunity
Coffee Break  
9:00–9:20 AM
 INEC Foyer
Poster Setup  
11:00–1:00 PM
 INEC Foyer
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 INEC Foyer
Workshop  
3:00–4:30 PM
 INEC Main Auditorium
Laura Atehortua, CCHMC
Apolipoprotein E-Containing HDL Enhances Survival of Memory Regulatory T Lymphocytes by Regulating Lipid Metabolism and Mitochondrial Fitness
Laura R Dwyer, UCSF
Decoding the Role of CD38 and Metabolic Pathways on the Heightened Treg Potential of Human Neonatal CD4+ T Cells
Amy Lorraine Seufert, Portland State University
Palmitic Acid Mediates Innate Immune Memory via Ceramide Metabolism in Vitro and in Vivo
Alva Casey, University of Cambridge
Elucidating the Mechanism of Mitochondrial Superoxide Production in Pro-Inflammatory Macrophages
Beatrice Angi, University of Padova
Cell-Specific Deletion of Kv1.3 Potassium Channel Modulates Regulatory T Cell-Dependent Pro-Tumor Activity in Vivo
Jackie Bader, Vanderbilt University Medical Center
PD-1 Directly Suppresses Macrophage Metabolism in an Obesity-Cancer Connection to Restrain Anti-Tumor Immunity
Alaa Madi, German Cancer Research Center, DKFZ
Triacylglycerol Synthesis Camouflages Sexual Dimorphism in Antitumor Immunity
Coffee Available  
4:30–5:00 PM
 INEC Foyer
Macrophage Metabolism: Emerging Metabolites  
5:00–7:00 PM
 INEC Main Auditorium
Karsten Hiller, Technische Universität Braunschweig
Mesaconate and Itaconate in Macrophage Function
Dan Ye, Shanghai Medical College, Fudan University
Itaconate in Host Defense and inflammation
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute
Anti-Inflammatory Potential of Targeting Immunometabolism in Inflammation and Coagulopathies
Evanna Mills, Dana-Farber Cancer Institute
Metabolite Signaling in Macrophages as a Regulator of Thermogenesis
Jean-Philippe Auger, University Hospital Erlangen & University of Erlangen-Nuremberg
Short Talk: Short Talk: Mitochondrial Rewiring Essentially Contributes to the Anti-Inflammatory Effects of Glucocorticoids
Social Hour with Lite Bites  
7:00–8:00 PM
 INEC Foyer
Poster Session 2  
7:30–10:00 PM
 INEC Foyer
Thursday, March 21, 2024
Breakfast  
7:00–8:00 AM
 Individual Hotel
Metabolite Signaling in the Tumor Microenvironment: Friend and Foe  
8:00–11:00 AM
 INEC Main Auditorium
Erika L. Pearce, Johns Hopkins University
Macrophage Tissue Residency
Speaker to be to be Announced
Talk Title to be Announced
Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences
Exercise Mediated Extracellular Vesicles Influence Tumor Progression
Frank Dorsey, Eli Lilly and Company
Immunometabolism: Targeting Metabolic Nodes that Regulate Immunity
Roddy O'Connor, University of Pennsylvania
Short Talk: Short Talk: Arginine Links 1-Carbon Metabolism to Histone Methylation in CAR T Cells with Enhanced Metabolic Fitness
Coffee Break  
9:00–9:20 AM
 INEC Foyer
Poster Setup  
11:00–1:00 PM
 INEC Foyer
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 INEC Foyer
Coffee Available  
4:30–5:00 PM
 INEC Foyer
Immunometabolism: Translational Potential  
5:00–6:45 PM
 INEC Main Auditorium
Jonathan D. Powell, Calico Life Sciences
Targeting Metabolism in Aging
Mariana J. Kaplan, NIAMS, National Institutes of Health
Metabolism and Autoimmunity
Edward Driggers, General Metabolics
Metabolic Control of Autoimmunity and Inflammatory Disease
Chutao Chen, TWINCORE, Centre for Experimental and Clinical Infection Research
Short Talk: Short Talk: Development of Citraconate Derivatives as Novel ACOD1 Inhibitors
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 INEC Main Auditorium
Social Hour with Lite Bites  
7:00–8:00 PM
 INEC Foyer
Poster Session 3  
7:30–10:00 PM
 INEC Foyer
Friday, March 22, 2024
Departure  
7:00–11:59 PM

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