Apr 27–30, 2025 | Daejeon Convention Center, Daejeon, South Korea
Scientific Organizers:
Sharon B. Cantor, Alberto Ciccia, Vincenzo Costanzo, and Kyungjae Myung

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Scientific Organizers: Sharon B. Cantor, Alberto Ciccia, Vincenzo Costanzo, and Kyungjae Myung
Sharon B. Cantor
Alberto Ciccia
Vincenzo Costanzo
Kyungjae Myung
***Meeting program subject to change.
Available Formats: = In Person = On DemandMerchandise Options
Registration Options
Sunday, April 27, 2025
Fundraising
Booking Function
Monday, April 28, 2025
Session Chair
Mind the Gap: How Ubiquitylation Controls Postreplicative Gap Formation and Repair in Response to DNA Replication Stress
Session Chair
Session Chair
Causes and Consequences of DNA Replication Gaps
Factors Modulating Gap Formation and Repair
Mediating Replication ssDNA Gap Prevention and Repair Through the Lenses of BRCA2
Gap-Induced Fragility at DNA Structures Revealed in a Yeast Model
Session Chair
Session Chair
FANCM Minimizes Single-Strand Gap Formation and Promotes PARP Inhibitor Resistance by Counteracting 53BP1
BRCA2 at the Helm: Orchestrating Telomere G4 Dynamicity and its Impact in Ovarian Cancer
Alteration of RPA Binding Modes on Single-Stranded DNA by NSMF Potentiates RPA Phosphorylation by ATR Kinase
SLFN11 Enhances Chemotherapeutic Sensitivity by Binding to Multiple Types of Single-Stranded DNA Gaps
RNF4 and USP7 Coordinate Spatial Regulation of SLX4 Stability within the PML Nuclear Bodies
Mechanisms of ssDNA Gap Resection in BRCA1-Proficient and -Deficient Cells
The 9-1-1 Complex Protects ssDNA gaps in BRCA2-Deficient Cancer Cells To Preserve Cell Viability
APOBEC3A, not APOBEC3B, Drives Deaminase-Associated Mutagenesis In Single-Stranded DNA Gaps in Human Gastric Epithelium
Session Chair
Session Chair
How the Gap Model Redefines Chemotherapy Response
Tolerance to Stress vs. Immune Induction
Causes and Consequences of the Choice between Template Switching, Traslesion DNA Synthesis and Repriming
Short Talk: MRE11 Nuclease Activity Controls Senescence by Coordinating Replication Stress And Interferon Signaling
Short Talk: The Role of Translesion Synthesis (TLS) Polymerases in Temozolomide Resistance
Tuesday, April 29, 2025
Session Chair
Structure of the RAD52 double-ring at stalled replication forks, restriction of fork reversal and prevention of replication gaps
A BRCA Replication Fork Protecteome in Inflammation and Disease
Local & Spatial Chromatin Reorganization under Replication Stress
Central Role of Repriming by PRIMPOL in the Response To Replication Stress Induced By Low Doses of Genotoxic Agents
Short Talk: A Non-Proteolytic Release Mechanism for HMCES-DNA-Protein Crosslinks
Short Talk: Dissecting the Mechanism of Repriming during DNA Damage Response Using Single-Molecule Imaging
Professor
Section Head
Senior Editor
Session Chair
Session Chair
Dependency of ALT-Positive Cancer Cells on the SMARCAL1 DNA Translocase
Pol Theta and the Response to Replication Stress
A Genetic Delineation of Template Switching Bypass and its Role in Spontaneous Mutagenesis
Short Talk: DNA-PK Counteracts Toxic Single-Strand Breaks Accumulation and Promotes PARP Inhibitor Resistance
Short Talk: DNA Helicase HELQ Facilitates Fork Reversal in Response to Leading Strand Gaps
Wednesday, April 30, 2025
Session Chair
Session Chair
The Role of Nucleophagy in DNA Repair and Genome Stability
Untangling DNA Breakage at Centromeres
POLtheta Processes ssDNA Gaps and Promotes Replication Fork Progression in BRCA1-Deficient Cells
Mechanisms for Rna-Mediated Genome Instability
Short Talk: SLX complex Promotes Okazaki Fragment Maturation in FEN1 Deficient Cells
Short Talk: BRCA1 and BRCA2-Mediated Maturation of Nascent DNA Strands During DNA Replication
Session Chair
Session Chair
Enhanced Precision Targeting of Cancer Cells Using the CRISPR/Cas9 System and Lipid Nanoparticles
Efficient and precise targeting of cancer cells using multiplexed CRISPR/Cas9-nickase
Moonlighting Nuclear Function of The Actin-Binding Factor Profilin-1 In ssDNA Gap Formation
Fork Reversal Prevents TRAIP-Mediated POLE1 Degradation Under Conditions of ROS
The Role of ssDNA Gap Expansion in ATR Checkpoint Activation and Synthetic Lethality in BRCA1-defcient Cells
Chemical Inhibition of RPA Gap Protection Sensitizes BRCA1-deficient Cancers to PARP Inhibition
Artificial Intelligence-based High-resolution Analysis of DNA Replication Dynamics on Extrachromosomal DNA
MEN1 Loss Confers Resistance to Replication Stress-Inducing Drugs
Session Chair
Session Chair
Trabectedin - Targeting Tumors through Transcription-Coupled Nucleotide Excision Repair Induced DNA Gaps
p53 Gain of Function working together with PARP1 for Cancer Persistent Repair at Gaps
Translation of DNA Damage Including Gap for Cancer Therapy
Thursday, May 1, 2025
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