Dec 08–11, 2024 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Valerie Horsley, Michael T. Longaker, and Thomas A Wynn

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Scientific Organizers: Valerie Horsley, Michael T. Longaker, and Thomas A Wynn
Valerie Horsley
Michael T. Longaker
Thomas A Wynn
***Meeting program subject to change.
Available Formats: = In Person = On DemandSunday, December 8, 2024
Booking Function
Monday, December 9, 2024
Session Chair
State of the Art Technologies to Study Organ Fibrosis
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Session Chair
Mechanisms of Uterine Fibroids
Fibroblast-Driven Mechanisms in Intestinal Fibrosis
Dissecting Mechanisms of Kidney and Heart Fibrosis Using Single Cell and Spatial Genomics
Targeting TGF-beta 3 for Fibrotic Diseases
Session Chair
Session Chair
Comprehensive Transcription Factor Perturbations Recapitulate Fibroblast Transcriptional States
Multi-Omic Analysis of a Fibrosis-Prone Tendon in a Clinically Relevant Large Mammalian Model
A 3D Image Atlas Chronicling Cellular and Structural Dynamics Following Lung Injury Identifies the Aberrant Expansion of Nonfunctional Endothelial Cells
Conserved Transcriptional Connectivity of Regulatory T Cells in the Tumor Microenvironment as Well as Injury Induced Lung Fibrosis Informs New Combination Therapy Strategies
Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and Their Impact on Liver Regeneration, Fibrosis and Resolution
Fibroblasts Act as Key Spatial Determinants Following Acute Kidney Injury
Delineating the Complexity of Mammalian Skin Wound Healing at Organ-Scale
Session Chair
Session Chair
Mechanical Signaling in Skin Fibrosis and Repair
Mechanical Regulation of Lung Fibrosis Development
T Cells and Senescence in Fibrosis
Short Talk: Evidence for Persistent Fibrosis in Heart Failure with a Reduced Ejection Fraction Linked to Phenotypic Differences in Human Cardiac Fibroblast Populations
Short Talk: A Mechanosensitive Pathway Drives Epigenetic and Transcriptional Fibrotic Responses
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Session Chair
Session Chair
Tuesday, December 10, 2024
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Session Chair
Type 2 Immunity and Macrophages in the Pathogenesis of Fibrosis
Inflammatory Memory in Skin Regeneration
Fibroblast Dynamics during Regenerative versus Fibrotic Skin Repair
Targeting Hyaluronan in Pulmonary Hypertension Associated with Lung Fibrosis: Insights from the SATURN Study
Short Talk: Defining a Stromal Niche for Type 2-Like Regulatory T Cells
Short Talk: An Ageing Bone Marrow Exacerbates Lung Fibrosis Via a Dysregulated Regulatory T Cell Axis, Fueling Profibrotic Macrophage Persistence.
Senior Investigator
Assistant Professor
Executive Director, Head of Fibrosis
Principal Scientist
Senior Physician & Professor
Session Chair
Session Chair
Remote Presenter: Investigating Macrophage Functional Heterogeneity in the Fibrotic Liver
Cell Death Mechanisms During Tissue Repair
Metabolic Regulation of Macrophages in Skin Fibrosis
Short Talk: Foxm1 Regulates Macrophage Polarization and Cytokine Secretion to Drive Renal Fibrosis After Acute Kidney Injury
Short Talk: Macrophage-Derived CCL24 Promotes Fibrosis and Worsens Cardiac Dysfunction During Heart Failure
Wednesday, December 11, 2024
Session Chair
Cellular and Molecular Crosstalk During Fibrosis Resolution
Portal Fibroblasts in Liver Fibrosis Resolution
Piezo Inhibition Prevents and Rescues Scarring by Targeting the Adipocyte To Fibroblast Transition
Short Talk: ADAMTS12 Promotes Fibrosis by Restructuring Extracellular Matrix to Enable Activation and Migration of Injury-Responsive Fibroblasts
Short Talk: Targeting Fibrometabolism Via Glutamate Mediated Metabotropic Glutamate Receptor 5 (Mglur5) Signaling in Pulmonary Fibroblasts to Reverse Pulmonary Fibrosis: Prospective of Repositioning Basimglurant, a Negative Allosteric Modulator of Mglur5
Short Talk: LARP6 Binding Modulates Mrna Translation in Human Liver Fibrosis
Session Chair
Silencing Neat1 Alleviates Fibrosis in an in Vivo Model Of Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Biomaterials-Based Engineering of Macrophages for Regenerative Medicine
Exploring the Role of Fibroblast Reg3 Proteins In Response to Intestinal Inflammation
Transcriptomics Reveals DMD Driven Cell Dynamics and Mechanisms of Fibroblast Inflammatory Tissue Priming in Human Dystrophic Muscle
The Nail Bed Orchestrates a Multicellular Response To Promote Mammalian Fingertip (Digit Tip) Regeneration Versus Fibrosis
Inhibition of the MRTF-A/SRF Axis Alleviates Vocal Fold Scarring
Down-Regulation of the Basic Helix-Loop-Helix Transcription Factor TCF21 is Necessary for the Development of Cardiac Fibrosis
Integrating Liver and Cardiac Microtissues in a Multi-Organ-on-a-Chip Model Reveales Liver-Mediated Modulation of Cardiac Fibrosis
Session Chair
Session Chair
Translational Approaches used in the Development of Bexotegrast, a Dual αvβ6/αvβ1 Integrin Inhibitor, for IPF
In vivo Generated CAR T Cells Targeting Pathogenic Fibroblasts for the Treatment of Cardiac Fibrosis
Short Talk: Multi-Omic Approach Toward Identifying Pharmacodynamic Biomarkers in Fibrotic Human Liver Explants
Short Talk: Leveraging Recent Advances in Human Precision-Cut Tissue Slices: Improved Translational Models to Pursue a Cure for Fibrotic Diseases
Short Talk: Anti-WISP1 (MTX-463) as a Novel Potential Therapy for Idiopathic Pulmonary Fibrosis
Fundraising
Thursday, December 12, 2024
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