Fibrosis: Inflammation, Drivers, and Therapeutic Resolution
Dec 08–11, 2024 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Valerie Horsley, Michael T. Longaker, and Thomas A Wynn
In Person
On Demand
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Dec 08–11, 2024 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Valerie Horsley, Michael T. Longaker, and Thomas A Wynn
Valerie Horsley
Michael T. Longaker
Thomas A Wynn
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandSunday, December 8, 2024
Booking Function
Registration
4:00–8:00 PM
Macdonald Foyer
Welcome Mixer
6:00–8:00 PM
Macdonald Foyer
Monday, December 9, 2024
Breakfast
7:00–8:00 AM
MacDonald CDEF
Welcome and Keynote Address
8:00–9:00 AM
Macdonald AB
* Valerie Horsley, Yale University
Session Chair
Session Chair
Neil C. Henderson, Institute of Regeneration and Repair, University of Edinburgh
State of the Art Technologies to Study Organ Fibrosis
State of the Art Technologies to Study Organ Fibrosis
Fibroblast Heterogeneity and Fibrosis
9:00–11:30 AM
Macdonald AB
* David Brenner, Sanford Burnham Prebys
Session Chair
Session Chair
* Jeff Biernaskie, University of Calgary
Session Chair
Session Chair
Darlene Dixon, NIEHS, National Institutes of Health
Mechanisms of Uterine Fibroids
Mechanisms of Uterine Fibroids
Florian Rieder, Cleveland Clinic
Fibroblast-Driven Mechanisms in Intestinal Fibrosis
Fibroblast-Driven Mechanisms in Intestinal Fibrosis
Rafael Kramann, RWTH Aachen University
Dissecting Mechanisms of Kidney and Heart Fibrosis Using Single Cell and Spatial Genomics
Dissecting Mechanisms of Kidney and Heart Fibrosis Using Single Cell and Spatial Genomics
Tianhe Sun, Genentech, Inc.
Targeting TGF-beta 3 for Fibrotic Diseases
Targeting TGF-beta 3 for Fibrotic Diseases
Coffee Break
9:30–9:50 AM
Macdonald Foyer
Jessica Langer, Helmsley Trust Introduction
9:50–9:55 AM
Macdonald AB
Poster Setup
11:30–1:00 PM
MacDonald CDEF
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
MacDonald CDEF
Symposia Spotlight 1: Beyond the Multiome: Integrating -Omics and AI in Fibrosis Models
2:30–4:30 PM
Macdonald AB
* Shruti Naik, Icahn School of Medicine at Mount Sinai
Session Chair
Session Chair
* Rafael Kramann, RWTH Aachen University
Session Chair
Session Chair
Rico Chandra Ardy, Sloan Kettering Institute
Comprehensive Transcription Factor Perturbations Recapitulate Fibroblast Transcriptional States
Comprehensive Transcription Factor Perturbations Recapitulate Fibroblast Transcriptional States
Ross Fitzsimmons, University of Calgary
Multi-Omic Analysis of a Fibrosis-Prone Tendon in a Clinically Relevant Large Mammalian Model
Multi-Omic Analysis of a Fibrosis-Prone Tendon in a Clinically Relevant Large Mammalian Model
Jingyi Xia, University of Michigan Ann Arbor
A 3D Image Atlas Chronicling Cellular and Structural Dynamics Following Lung Injury Identifies the Aberrant Expansion of Nonfunctional Endothelial Cells
A 3D Image Atlas Chronicling Cellular and Structural Dynamics Following Lung Injury Identifies the Aberrant Expansion of Nonfunctional Endothelial Cells
Ari Glasner, Technion
Conserved Transcriptional Connectivity of Regulatory T Cells in the Tumor Microenvironment as Well as Injury Induced Lung Fibrosis Informs New Combination Therapy Strategies
Conserved Transcriptional Connectivity of Regulatory T Cells in the Tumor Microenvironment as Well as Injury Induced Lung Fibrosis Informs New Combination Therapy Strategies
Lesley A. Hill, University of British Columbia
Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and Their Impact on Liver Regeneration, Fibrosis and Resolution
Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and Their Impact on Liver Regeneration, Fibrosis and Resolution
Michal Polonsky, Caltech
Fibroblasts Act as Key Spatial Determinants Following Acute Kidney Injury
Fibroblasts Act as Key Spatial Determinants Following Acute Kidney Injury
Yvon Woappi, Columbia University
Delineating the Complexity of Mammalian Skin Wound Healing at Organ-Scale
Delineating the Complexity of Mammalian Skin Wound Healing at Organ-Scale
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Mechanobiology in Regulation of Fibrosis
5:00–7:00 PM
Macdonald AB
* Sabine Eming, University of Cologne
Session Chair
Session Chair
* Kara Spiller, Drexel University
Session Chair
Session Chair
Michael T. Longaker, Stanford School of Medicine
Mechanical Signaling in Skin Fibrosis and Repair
Mechanical Signaling in Skin Fibrosis and Repair
Daniel Tschumperlin, Mayo Clinic
Mechanical Regulation of Lung Fibrosis Development
Mechanical Regulation of Lung Fibrosis Development
Jennifer Elisseeff, Johns Hopkins University
T Cells and Senescence in Fibrosis
T Cells and Senescence in Fibrosis
Rachel Biggs, MUSC
Short Talk: Evidence for Persistent Fibrosis in Heart Failure with a Reduced Ejection Fraction Linked to Phenotypic Differences in Human Cardiac Fibroblast Populations
Short Talk: Evidence for Persistent Fibrosis in Heart Failure with a Reduced Ejection Fraction Linked to Phenotypic Differences in Human Cardiac Fibroblast Populations
Aya Nassereddine, Yale University
Short Talk: A Mechanosensitive Pathway Drives Epigenetic and Transcriptional Fibrotic Responses
Short Talk: A Mechanosensitive Pathway Drives Epigenetic and Transcriptional Fibrotic Responses
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CDEF
Women in Science Networking Event
7:05–8:05 PM
MacDonald CDEF
* Shruti Naik, Icahn School of Medicine at Mount Sinai
Session Chair
Session Chair
* Carla V. Rothlin, Yale University
Session Chair
Session Chair
* Valerie Horsley, Yale University
Session Chair
Session Chair
Poster Session #1
7:30–10:00 PM
MacDonald CDEF
Tuesday, December 10, 2024
Breakfast
7:00–8:00 AM
MacDonald CDEF
Inflammatory Drivers of Fibrosis
8:00–11:00 AM
Macdonald AB
* Jennifer Elisseeff, Johns Hopkins University
Session Chair
Session Chair
* Florian Rieder, Cleveland Clinic
Session Chair
Session Chair
Thomas A Wynn, Pfizer
Type 2 Immunity and Macrophages in the Pathogenesis of Fibrosis
Type 2 Immunity and Macrophages in the Pathogenesis of Fibrosis
Shruti Naik, Icahn School of Medicine at Mount Sinai
Inflammatory Memory in Skin Regeneration
Inflammatory Memory in Skin Regeneration
Jeff Biernaskie, University of Calgary
Fibroblast Dynamics during Regenerative versus Fibrotic Skin Repair
Fibroblast Dynamics during Regenerative versus Fibrotic Skin Repair
Vinicio de Jesus Perez, Stanford University
Targeting Hyaluronan in Pulmonary Hypertension Associated with Lung Fibrosis: Insights from the SATURN Study
Targeting Hyaluronan in Pulmonary Hypertension Associated with Lung Fibrosis: Insights from the SATURN Study
Anthony Chang, UCSF
Short Talk: Defining a Stromal Niche for Type 2-Like Regulatory T Cells
Short Talk: Defining a Stromal Niche for Type 2-Like Regulatory T Cells
Asma Farhat, Medical University of Vienna/CeMM
Short Talk: An Ageing Bone Marrow Exacerbates Lung Fibrosis Via a Dysregulated Regulatory T Cell Axis, Fueling Profibrotic Macrophage Persistence.
Short Talk: An Ageing Bone Marrow Exacerbates Lung Fibrosis Via a Dysregulated Regulatory T Cell Axis, Fueling Profibrotic Macrophage Persistence.
Coffee Break
9:00–9:20 AM
Macdonald Foyer
Poster Setup
11:00–1:00 PM
MacDonald CDEF
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
MacDonald CDEF
Career Roundtable
3:00–4:30 PM
Macdonald AB
Darlene Dixon, NIEHS, National Institutes of Health
Senior Investigator
Senior Investigator
Yvon Woappi, Columbia University
Assistant Professor
Assistant Professor
Min Lu, Morphic Therapeutic, a wholly owned subsidiary of Eli Lilly and Company
Executive Director, Head of Fibrosis
Executive Director, Head of Fibrosis
Audrey Sambeat, Boehringer-Ingelheim
Principal Scientist
Principal Scientist
Andreas Ramming, University of Erlangen-Nuremberg
Senior Physician & Professor
Senior Physician & Professor
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Macrophage-Fibroblast Interactions
5:00–7:00 PM
Macdonald AB
* Michael T. Longaker, Stanford School of Medicine
Session Chair
Session Chair
* M. Carrie Miceli, University of California, Los Angeles
Session Chair
Session Chair
Charlotte L. Scott, University of Ghent & VIB
Remote Presenter: Investigating Macrophage Functional Heterogeneity in the Fibrotic Liver
Remote Presenter: Investigating Macrophage Functional Heterogeneity in the Fibrotic Liver
Carla V. Rothlin, Yale University
Cell Death Mechanisms During Tissue Repair
Cell Death Mechanisms During Tissue Repair
Sabine Eming, University of Cologne
Metabolic Regulation of Macrophages in Skin Fibrosis
Metabolic Regulation of Macrophages in Skin Fibrosis
Shin-Huey Lin, National Tsing Hua University
Short Talk: Foxm1 Regulates Macrophage Polarization and Cytokine Secretion to Drive Renal Fibrosis After Acute Kidney Injury
Short Talk: Foxm1 Regulates Macrophage Polarization and Cytokine Secretion to Drive Renal Fibrosis After Acute Kidney Injury
Preethy Parthiban, University of Minnesota- Twin Cities
Short Talk: Macrophage-Derived CCL24 Promotes Fibrosis and Worsens Cardiac Dysfunction During Heart Failure
Short Talk: Macrophage-Derived CCL24 Promotes Fibrosis and Worsens Cardiac Dysfunction During Heart Failure
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CDEF
Poster Session #2
7:30–10:00 PM
MacDonald CDEF
Wednesday, December 11, 2024
Breakfast
7:00–8:00 AM
MacDonald CDEF
New Horizons: Resolving Fibrosis
8:00–11:00 AM
Macdonald AB
* Jeff Biernaskie, University of Calgary
Session Chair
Session Chair
Valerie Horsley, Yale University
Cellular and Molecular Crosstalk During Fibrosis Resolution
Cellular and Molecular Crosstalk During Fibrosis Resolution
Tatiana Kisseleva, University of California, San Diego
Portal Fibroblasts in Liver Fibrosis Resolution
Portal Fibroblasts in Liver Fibrosis Resolution
Michelle Griffin, Stanford University
Piezo Inhibition Prevents and Rescues Scarring by Targeting the Adipocyte To Fibroblast Transition
Piezo Inhibition Prevents and Rescues Scarring by Targeting the Adipocyte To Fibroblast Transition
Konrad Hoeft, RWTH Aachen University
Short Talk: ADAMTS12 Promotes Fibrosis by Restructuring Extracellular Matrix to Enable Activation and Migration of Injury-Responsive Fibroblasts
Short Talk: ADAMTS12 Promotes Fibrosis by Restructuring Extracellular Matrix to Enable Activation and Migration of Injury-Responsive Fibroblasts
Resat Cinar, NIAAA, National Institutes of Health
Short Talk: Targeting Fibrometabolism Via Glutamate Mediated Metabotropic Glutamate Receptor 5 (Mglur5) Signaling in Pulmonary Fibroblasts to Reverse Pulmonary Fibrosis: Prospective of Repositioning Basimglurant, a Negative Allosteric Modulator of Mglur5
Short Talk: Targeting Fibrometabolism Via Glutamate Mediated Metabotropic Glutamate Receptor 5 (Mglur5) Signaling in Pulmonary Fibroblasts to Reverse Pulmonary Fibrosis: Prospective of Repositioning Basimglurant, a Negative Allosteric Modulator of Mglur5
Hyun Young Kim, University of California San Diego
Short Talk: LARP6 Binding Modulates Mrna Translation in Human Liver Fibrosis
Short Talk: LARP6 Binding Modulates Mrna Translation in Human Liver Fibrosis
Coffee Break
9:00–9:20 AM
Macdonald Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Common Fibrosis Mechanisms: Lessons Across Tissues
2:30–4:30 PM
Macdonald AB
* Mehdi Maneshi, abbvie
Session Chair
Session Chair
* Lisa Ahne, Martin-Luther-University Halle-Wittenberg
Silencing Neat1 Alleviates Fibrosis in an in Vivo Model Of Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Silencing Neat1 Alleviates Fibrosis in an in Vivo Model Of Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Kara Spiller, Drexel University
Biomaterials-Based Engineering of Macrophages for Regenerative Medicine
Biomaterials-Based Engineering of Macrophages for Regenerative Medicine
Sritejasvinithi Karimikonda, Medical College of Wisconsin
Exploring the Role of Fibroblast Reg3 Proteins In Response to Intestinal Inflammation
Exploring the Role of Fibroblast Reg3 Proteins In Response to Intestinal Inflammation
M. Carrie Miceli, University of California, Los Angeles
Transcriptomics Reveals DMD Driven Cell Dynamics and Mechanisms of Fibroblast Inflammatory Tissue Priming in Human Dystrophic Muscle
Transcriptomics Reveals DMD Driven Cell Dynamics and Mechanisms of Fibroblast Inflammatory Tissue Priming in Human Dystrophic Muscle
Sruthi Purushothaman, University of British Columbia
The Nail Bed Orchestrates a Multicellular Response To Promote Mammalian Fingertip (Digit Tip) Regeneration Versus Fibrosis
The Nail Bed Orchestrates a Multicellular Response To Promote Mammalian Fingertip (Digit Tip) Regeneration Versus Fibrosis
Ryan M Friedman, University of Pennsylvania & Children's Hospital of Philadelphia
Inhibition of the MRTF-A/SRF Axis Alleviates Vocal Fold Scarring
Inhibition of the MRTF-A/SRF Axis Alleviates Vocal Fold Scarring
Anne-Katrine Z. Johansen, Cincinnati Children’s Hospital Medical Center
Down-Regulation of the Basic Helix-Loop-Helix Transcription Factor TCF21 is Necessary for the Development of Cardiac Fibrosis
Down-Regulation of the Basic Helix-Loop-Helix Transcription Factor TCF21 is Necessary for the Development of Cardiac Fibrosis
Astrid Hofman, University Hospital Zürich
Integrating Liver and Cardiac Microtissues in a Multi-Organ-on-a-Chip Model Reveales Liver-Mediated Modulation of Cardiac Fibrosis
Integrating Liver and Cardiac Microtissues in a Multi-Organ-on-a-Chip Model Reveales Liver-Mediated Modulation of Cardiac Fibrosis
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Clinical Innovations in Fibrosis
5:00–6:45 PM
Macdonald AB
* Thomas A Wynn, Pfizer
Session Chair
Session Chair
* Michael Underhill, University of British Columbia
Session Chair
Session Chair
Martin L. Decaris, Pliant Therapeutics
Translational Approaches used in the Development of Bexotegrast, a Dual αvβ6/αvβ1 Integrin Inhibitor, for IPF
Translational Approaches used in the Development of Bexotegrast, a Dual αvβ6/αvβ1 Integrin Inhibitor, for IPF
Haig Aghajanian, Capstan Therapeutics
In vivo Generated CAR T Cells Targeting Pathogenic Fibroblasts for the Treatment of Cardiac Fibrosis
In vivo Generated CAR T Cells Targeting Pathogenic Fibroblasts for the Treatment of Cardiac Fibrosis
Steve Ho, Pliant Therapeutics
Short Talk: Multi-Omic Approach Toward Identifying Pharmacodynamic Biomarkers in Fibrotic Human Liver Explants
Short Talk: Multi-Omic Approach Toward Identifying Pharmacodynamic Biomarkers in Fibrotic Human Liver Explants
Mehdi Maneshi, abbvie
Short Talk: Leveraging Recent Advances in Human Precision-Cut Tissue Slices: Improved Translational Models to Pursue a Cure for Fibrotic Diseases
Short Talk: Leveraging Recent Advances in Human Precision-Cut Tissue Slices: Improved Translational Models to Pursue a Cure for Fibrotic Diseases
Paul J. Yaworsky, Mediar Therapeutics
Short Talk: Anti-WISP1 (MTX-463) as a Novel Potential Therapy for Idiopathic Pulmonary Fibrosis
Short Talk: Anti-WISP1 (MTX-463) as a Novel Potential Therapy for Idiopathic Pulmonary Fibrosis
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Macdonald AB
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CDEF
Trivia
8:00–9:00 PM
Macdonald AB
Fundraising
Thursday, December 12, 2024
Departure
12:00–11:59 PM
Merchandise Options
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