Joint with: Ubiquitin Biology and Disease
Autophagy and Disease

Dec 03–06, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Eric H. Baehrecke and Anastasia Henry

  In Person
  On Demand
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Dec 03–06, 2023 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Eric H. Baehrecke and Anastasia Henry

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, December 3, 2023
Arrival and Registration  
4:00–8:00 PM
 Shavano Foyer
Welcome Mixer  
6:00–8:00 PM
 Shavano Foyer
Monday, December 4, 2023
Breakfast  
7:00–8:00 AM
 Red Cloud/Crestone
Welcome and Keynote Address (Joint)  
8:00–9:00 AM
 Torreys/Shavano Peak
* Ivan Dikic, Goethe University Medical School
Session Chair
Brenda A. Schulman, Max Planck Institute of Biochemistry
Twists and Turns in Ubiquitin Conjugation Cascades
Ubiquitin in Regulation of Autophagy and Disease (Joint)  
9:00–11:30 AM
 Torreys/Shavano Peak
* Kylie J. Walters, NCI, National Institutes of Health
Session Chair
* Achim Werner, National Institutes of Health
Session Chair
Michael Rape, University of California, Berkeley
Ubiquitin Ligases and Stress Responses
Tyler Franklin, Oregon Health and Science University
Short Talk: Short Talk: Bacterial Mimicry of Eukaryotic HECT Ubiquitin Ligation
Kylie J. Walters, NCI, National Institutes of Health
Proteasome Subunit Rpn13: Interactions, Activities and Therapeutic Opportunities
Sonja Lorenz, Max Planck Institute for Multidisciplinary Sciences
Short Talk: Short Talk: Structural Mechanism of the Ubiqutin Ligase HACE1
Masaaki Komatsu, Juntendo University School of Medicine
p62-Ubiquitin Condensates: Formation, Physiology and Autophagic Degradation
Coffee Break  
9:30–9:50 AM
 Shavano Foyer
Poster Setup  
11:30–1:00 PM
 Red Cloud/Crestone
On Own for Lunch  
11:30–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Red Cloud/Crestone
Career Roundtable (Joint)  
3:00–4:30 PM
 Shavano Peak
Carlos Castañeda, Syracuse University
Associate Professor
Mary Lilly, National Institutes of Health
Senior Investigator
Rupert Beale, The Francis Crick Institute
Clinical Group Leader
Judith A. Ronau, AbbVie, Inc.
Senior Scientist II
Coffee Available  
4:30–5:00 PM
 Shavano Foyer
Biophysical and Novel Regulatory Mechanisms of Autophagy  
5:00–7:00 PM
 Shavano Peak
* Sharon A. Tooze, Francis Crick Institute
Session Chair
* Martin Graef, Cornell University
Session Chair
Hong Zhang, Chinese Academy of Sciences
Decoding of ER Ca2+ Transients to Trigger the Assembly of Autophagosome Formation Sites on the ER
Yang Wang, Chinese University of Hong Kong, Shenzhen
Short Talk: Short Talk: Structural Basis for Lipid Transfer by the ATG2A-ATG9A Complex
Mondira Kundu, St. Jude Children's Hospital
ULK/Atg1 and its Interacting Partners in the Regulation of Biomolecular Condensates: Relevance to Disease
Reuben J. Shaw, The Salk Institute for Biological Studies
Short Talk: Short Talk: AMPK and ULK1: Two Critical Kinases in Autophagy Initiation
James H. Hurley, University of California, Berkeley
The Molecular Acrobatics of Autophagy Initiation
Social Hour with Lite Bites  
7:00–8:00 PM
 Red Cloud/Crestone
Poster Session 1  
7:30–10:00 PM
 Red Cloud/Crestone
Tuesday, December 5, 2023
Breakfast  
7:00–8:00 AM
 Red Cloud/Crestone
Lysosomal Biology and Damage in Autophagy and Disease  
8:00–11:00 AM
 Shavano Peak
* Chris Shoemaker, Dartmouth College
Session Chair
* Anne Simonsen, University of Oslo
Session Chair
Anastasia Henry, Denali Therapeutics
Rab12 Regulates LRRK2 Activity and Recruitment to Damaged Lysosomes
Sharon A. Tooze, Francis Crick Institute
Maintenance of Lysosome Integrity by ATG9A Effectors and PI4P
Dan Baird, Casma Tx
Targeting Autophagy Initiation
Mary Lilly, National Institutes of Health
Short Talk: Short Talk: The GATOR2 Complex Maintains Lysosomal-autophagic Function by Inhibiting MiT/TFEs Protein Degradation
Vojo Deretic, University of New Mexico Health Sciences Center
Membrane Atg8ylation During Infection
Coffee Break  
9:10–9:30 AM
 Shavano Foyer
Poster Setup  
11:00–1:00 PM
 Red Cloud/Crestone
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Red Cloud/Crestone
Workshop  
2:30–4:30 PM
 Shavano Peak
* Mondira Kundu, St. Jude Children's Hospital
Session Chair
* Andreas Jenny, Albert Einstein College of Medicine
Session Chair
Louis R. Lapierre, Universite de Moncton
Location, Location, Location: Subcellular Protein Partitioning Modulates Proteostasis, Autophagy and Aging
Graham J Ray, MIT
The Substrates of Lysosomal RNA Degradation and the RNases that Degrade Them
Thabata L.A. Lopes Alberto Duque, University of New Mexico
Comparative Analysis of the Atg8ylation E3 Ligase ATG16L1 and a Candidate Alternative E3 Ligase ATG16L2 by Proximity Biotinylation Proteomics
Ta-Chiang Liu, Washington University School of Medicine
Macrophage LRRK2 Hyperactivity Impairs Autophagy and Induces Paneth Cell Dysfunction and Intestinal Inflammation
Guangyan Miao, UMASS Chan Medical School
Microglia are Key Executioners of Inflammation and Neuronal Cell Death Upon Mitochondrial Impairment in a Vps13D-deficient Mouse Model
Massiel C. Stolla, University of Washington
Atg4a Promotes Mitochondrial Clearance and Hemoglobin Production in vivo
Farzane Mirfakhar, Washington University in st louis
Cellular Cleanup Gone Awry: Tau Accumulates in Stem Cell Model of Tauopathy through Autophagy and Lysosomal Impairments
Rupert Beale, The Francis Crick Institute
Dissipation of Proton Gradients Leads to Recruitment of ATG16L1
Coffee Available  
4:30–5:00 PM
 Shavano Foyer
Autophagy, Organelle Contact and Disease  
5:00–7:00 PM
 Shavano Peak
* Herbert (Skip) W. Virgin, Washington University School of Medicine
Session Chair
Alexandra Stolz, Goethe University Frankfurt
Session Chair
Susan Ferro-Novick, University of California, San Diego
Autophagy Receptors Function at Distinct Endoplasmic Reticulum Domains
Mengying Cui, Osaka University
Short Talk: Short Talk: Identification of a Novel Target of TFEB Essential to Maintain Both Mitochondrial and Lysosomal Homeostasis, Preventing Cellular Senescence
Martin Graef, Cornell University
Autophagy Functions in Mitochondrial and Nuclear Genome Maintenance
Jose M Delgado, Dartmouth College
Short Talk: The ER Membrane Protein Complex Governs Lysosomal Turnover of a Mitochondrial Tail-anchored Protein, BNIP3, to Restrict Mitophagy
Eric H. Baehrecke, University of Massachusetts Medical School
Coordinated Selective Clearance of ER and Mitochondria
Social Hour with Lite Bites  
7:00–8:00 PM
 Red Cloud/Crestone
Poster Session 2  
7:30–10:00 PM
 Red Cloud/Crestone
Wednesday, December 6, 2023
Breakfast  
7:00–8:00 AM
 Red Cloud/Crestone
Keynote Address (Joint)  
8:00–8:45 AM
 Torreys/Shavano Peak
* Eric H. Baehrecke, University of Massachusetts Medical School
Session Chair
J. Wade Harper, Harvard Medical School
Principles of Organelle Quality Control by Autophagy
Autophagy, Ubiquitin, Organelle Clearance and Disease (Joint)  
8:45–11:15 AM
 Torreys/Shavano Peak
* Vojo Deretic, University of New Mexico Health Sciences Center
Session Chair
* Christina Towers, The Salk Institute for Biological Studies
Session Chair
Sylvie Urbé, University of Liverpool
E3 Ligase and DUB Imposed Restrictions on Mitophagy
Anne Simonsen, University of Oslo
Regulation of Mitophagy and Cellular Bioenergetics by Lipid-binding Proteins
Alexandra Stolz, Goethe University Frankfurt
Short Talk: The Function of ER-phagy Receptors is Regulated through Phosphorylation-dependent Ubiquitination Pathways
Philippa Rosewell, University of Dundee
Short Talk: Short Talk: Hexokinase II Catalytic Activity Regulates Mitophagy
Richard J. Youle, NINDS, National Institutes of Health
STING Activation of LC3 Lipidation and Linear (M1) Ubiquitination in Innate Immune Signaling
Coffee Break  
9:15–9:35 AM
 Shavano Foyer
On Own for Lunch  
11:15–5:00 PM
Coffee Available  
4:30–5:00 PM
 Shavano Foyer
Autophagy in Cancer and Inflammatory Disease  
5:00–6:45 PM
 Shavano Peak
* Anastasia Henry, Denali Therapeutics
Session Chair
* Dan Baird, Casma Tx
Session Chair
Eileen P. White, Rutgers Cancer Institute of New Jersey
Autophagy and Cancer
Aditya Murthy, Gilead Sciences
Short Talk: Short Talk: Suppression of Anti-tumor Immunity in Colorectal Cancer by the Autophagy Gene ATG16L1
Christina Towers, The Salk Institute for Biological Studies
Metabolic Adaptations to Autophagy Inhibition in Cancer
Herbert (Skip) W. Virgin, Washington University School of Medicine
Autophagy and Infection
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Shavano Peak
Social Hour with Lite Bites  
7:00–8:00 PM
 Red Cloud/Crestone
Trivia  
8:00–9:00 PM
 Shavano Peak
Cash Bar  
8:00–9:00 PM
 Red Cloud/Crestone
Thursday, December 7, 2023
Departure  
7:00–11:59 PM

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