Jan 27–30, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Uttiya Basu, Sun Hur, and Noam Stern-Ginossar

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Scientific Organizers: Uttiya Basu, Sun Hur, and Noam Stern-Ginossar
Uttiya Basu
Sun Hur
Noam Stern-Ginossar
***Meeting program subject to change.
Available Formats: = In Person = On DemandMonday, January 27, 2025
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Tuesday, January 28, 2025
Session Chair
Cellular Regulation of Exogenous Rnas: from Viral Rnas to Mrna Therapeutics
Session Chair
Viral Pathogenesis and RNAs
Charting the Ribosomal Epitranscriptome
RNA Therapeutics to Modulate Tumor Immunity
Short Talk: An Anti-Retrotransposon Silencing Mechanism Promotes Antibody Diversification
Short Talk: T Cell-derived miR-721 as a Key Player in Inflammaging and Age-related Diseases
Impact of Adenosine mRNA Modifications on the Immune Function of Macrophages
Molecular Mechanisms of Transient Re-activation of the Inactive X Chromosome During Female Immune Cell Development
RNA Processing Mechanisms in B Cell Development
RNA Helicase Ddx1 Regulates Germinal Centre Selection and Affinity Maturation by Promoting Trna Ligase Activity
Regulation of B Cell Tolerance and Autoimmunity by MicroRNAs
Session Chair
lncRNA Mediated Regulation of Innate Immunity
Exuberant long noncoding RNA expression may regulate Igh locus function and V(D)J recombination on multiple levels
ADAR1 Haploinsufficiency and Viral RdRp dsRNA Synthesis Synergize to Dysregulate RNA Editing and Cause Multi-system Interferonopathy
High throughput and Targeted Approaches to Characterize lncRNAs in Macrophage Biology
Wednesday, January 29, 2025
Session Chair
New Players in the RNA Sensing Pathway
Cytoplasmic dsRNA Sensors
RNA/DNA Hybrids and Immune System Activators
Short Talk: GGNBP2 Regulates Self-sensing of Cellular Double-stranded RNA Following Loss of ADAR1
Short Talk: Small Extracellular Vesicles (sEV) Released by Cells Infected with the Cytoplasmic RNA Virus Rift Valley Fever Virus Protect against Viral Infection by Inducing RIG-I-dependent IFN-B Activation that Leads to Activation of Autophagy
Short Talk: 2’-O-Methyl-Guanosine 3-Base RNA Fragments Mediate Essential Natural TLR7/8 Antagonism
Short Talk: MDA5-Mediated Immune Response to Endogenous dsRNAs as Driver of Type 1 Diabetes
Principal Investigator
Professor
Principal Scientist
Assistant Professor
Session Chair
Pathogenic Noncoding RNA Processing in Immune and Neural Diseases
Use of Artificial Intelligence in Designing Immunogenic RNAs
m6A RNA Modification in Immune Cells
G4 RNAs in B Cells
Thursday, January 30, 2025
Session Chair
The Immune Impact of L1 Retrotransposons
How HUSH Directs RNA-Mediated Epigenetic Silencing
HUSH Complexes in L1 Silencing in Immune Cells
Structures of HUSH Domains | MDA5 Variants Trade Antiviral Activity for Autoimmune Protection
Short Talk: Extracellular Functions of Viral RNA Sensor MDA5 in Complex with Disease-associated Autoantibody
*Session Chair, Editor-in-Chief
Deputy Editor
Associate Editor, Reviews
Academic Editor, EMBO Press
Session Chair
Myelodysplastic Syndrome-Associated Spliceosome Mutations Weaken Host Defense by compromising myeloid cell function
Short Talk: MDA5 Employs ATP Hydrolysis to Condense Long Dsrna into a Stable Nucleoprotein Complex
A Long Noncoding RNA Genetic Risk Factor of Systemic Lupus Erythematosus
Complementary Transcriptomic Methods Provide Alternative Views of Messenger RNA Vaccine Distribution in the Murine Lymph Node
Long Noncoding RNA Regulation of Inflammation in Atherosclerosis
miRNA-Mediated Translational Activation and Repression During Early T Cell Activation in Jurkat Cells
Epitranscriptomic Regulation of Immune Response: The Role of MAPKAPK5AS1 lncRNA in IFN-γ Secretion and Autoimmune Disease Modulation
Neat1 and the Nuclear Paraspeckle Orchestrate the Early Innate Immune Response in Macrophages
Session Chair
RNA Regulation of Tumor Associated Macrophages
Targeting RNA Splicing in Cancer: From Synthetic Lethality to Immuno-Oncology
RNA Methylation and Control of Cellular Fate in the Blood
Friday, January 31, 2025
Fundraising
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