Joint with: Membrane Dynamics, Repair and Disease
Autophagy: Mechanisms to Therapy

Feb 02–05, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Anne Simonsen, Sharon A. Tooze, and Dan Baird

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Feb 02–05, 2026 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Anne Simonsen, Sharon A. Tooze, and Dan Baird

Supported by:

***Meeting program subject to change.

Available Formats:     = Livestream   = In Person     = On Demand
Monday, February 2, 2026
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, February 3, 2026
Breakfast
7:00–8:00 AM
Welcome Remarks (Joint)
8:00–8:10 AM
Keynote Address (Joint)
8:10–9:00 AM
Erika L Holzbaur, University of Pennsylvania
Mitophagy and Lysophagy in Neurons
Intersections of Autophagy and Lysosomal Membrane Repair: Mechanisms and Implications (Joint)
9:00–11:15 AM
Sharon A. Tooze, Francis Crick Institute
Role of PI 4-Kinases in Autophagy and Membrane Repair
Oliver Florey, Babraham Institute
Conjugation of ATG8s to Single Membranes
Jayanta Debnath, University of California, San Francisco
Non-Canonical ATG8ylation and Secretion
Coffee Break
9:30–9:50 AM
Poster Setup
11:15–1:00 PM
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight 1 (Joint)
2:30–4:30 PM
Rupert Beale †, The Francis Crick Institute
Targeting of ATG8s to Different Compartments Mediated by V-ATPase V1H Recruitment of ATG16L1
Lizhen Cheng †, Ludwig-Maximilians-Universität München
Dissecting Canonical and Non-Canonical Autophagy Pathways in Microglia in Healthy and Disease States
Ruben D Elias †, Scripps Research
LLOMe Exposure Results in the Cathepsin C-Mediated Intralysosomal Generation of Membranolytic Amyloid Fibrils Alongside Promiscuous Dipeptide Ligation
Andreas Jenny †, Albert Einstein College of Medicine
The role of Lamp1 in the Non-Cell Autonomous Regulation of Endo-Lysosomal Acidification
Coffee Available
4:30–5:00 PM
Membrane Dynamics and Cargo Selection in Autophagy Initiation
5:00–7:00 PM
Maho Hamasaki, Osaka University
Mechanistic Insights into Membrane Dynamics in Macroautophagy
Zvulun Elazar, Weizmann Institute of Science
Autophagosome Morphogenesis
J. W Harper, Harvard Medical School
Autophagy Proteomics
Liang Ge †, Tsinghua University
Short Talk: Golgi PI4P Overload Triggers Piezo1-dependent Ca²⁺ Signaling to Initiate RIMMBA Formation
Social Hour with Dinner
7:00–8:00 PM
Poster Session 1
7:30–10:00 PM
Wednesday, February 4, 2026
Breakfast
7:00–8:00 AM
Keynote Address (Joint)
8:00–8:45 AM
Harald Stenmark, Oslo University Hospital
Integration of ESCRTs and ATG8 Conjugation in Membrane Repair
Lysosomal Membrane Repair: ESCRTs and Beyond (Joint)
8:45–11:00 AM
Phyllis Hanson, University of Michigan
Calcium and ESCRTs in Membrane Repair
James H. Hurley, University of California, Berkeley
ESCRTs as Suppressors of Amyloid Spread
Claudio Bussi, Nanyang Technological University
Biomolecular Condensates and Lysosome Repair
Coffee Break
9:00–9:20 AM
Poster Setup
11:00–1:00 PM
On Own for Lunch
11:00–3:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable (Joint)
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Selective Autophagy Pathways: Regulation, Function, and Disease Relevance
5:00–7:00 PM
Lifeng Pan, Shanghai Institute of Organic Chemistry, CAS
Mechanistic Insights into Selective Autophagy of Glycogen in Mammals
Ivan Dikic, Goethe University Medical School
ER-Phagy and Novel Pathways for Ubiquitination
Ai Yamamoto, Columbia University
Autophagy in Neurodegenerative Diseases
Yogaditya Chakrabarty †, California Institute of Technology
Short Talk: Hierarchical Stress Licensing of ER-Phagy: Chaperone Signaling and Autophagy-Initiation Control Define Organelle-Selective Turnover
Jonathan Friedman †, UT Southwestern Medical Center
Short Talk: Mitophagy Amplitude is Regulated By An Interplay Between Receptor Protection and Turnover
Social Hour with Dinner
7:00–8:00 PM
Poster Session 2
7:30–10:00 PM
Thursday, February 5, 2026
Breakfast
7:00–8:00 AM
Advancing Autophagy-Based Therapies: Novel Strategies and Innovations
8:00–11:00 AM
Anastasia G Henry, Denali Therapeutics
Pharmacological Targeting of Parkinson's Disease
Joseph D. Mancias, Dana-Farber Cancer Institute
Targeting Autophagy in Cancer
Dan Baird, Casma Tx
Pharmacological Tools to Study Autophagy and Treat Disease
Angela Cacace †, Arvinas Inc
Talk Title to be Announced
Emma Guilbaud †, Fox Chase Cancer Center
Short Talk: Targeting Mitophagy to Enhance the Immunostimulatory Effects of Radiation in Estrogen Receptor-Positive Breast Cancer
Nicholas T Hertz †, Montara Therapeutics, Inc.
Short Talk: BrainOnly Pharmacology Enables Brain-Specific mTOR Inhibition to Restore Autophagy in Neurological Disease
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2 (Joint)
2:30–4:30 PM
Zi Gao †, Scripps Research
TAX1BP1 Emerges as a Candidate Proteaphagy Receptor Through Global Protein Turnover Mapping
Chris Shoemaker †, Dartmouth College
Decoding and Predicting Autophagy Interactions at Scale
Stephanie Spada †, NIH/Oxford
TRIM5α Couples Membrane Targeting with Noncanonical Autophagy to Restrict Viral Infection
Simon Wilkinson †, University of Edinburgh
FAM134B Clustering and ER-phagy Driven by Multi-functional, Phase-separated Degradation Hubs
Coffee Available
4:30–5:00 PM
Mitochondrial Clearance Pathways
5:00–6:45 PM
Anne Simonsen, University of Oslo
Regulation of HIF1a Induced Mitophagy
Michael Lazarou, Monash University
Mitophagy's Impact on Cell Health
Chantell S Evans, Duke University School of Medicine
Mitochondrial Quality Control in Neurodegenerative Diseases
Hagai Abeliovich †, Hebrew University of Jerusalem
Short Talk: Regulation of the Atg32 Mitophagy Receptor By Signaling From Within The Mitochondrial Matrix
Meeting Wrap-Up: Outcomes and Future Directions
6:45–7:00 PM
Social Hour with Dinner
7:00–8:00 PM
Cash Bar
8:00–11:00 PM
Entertainment
8:00–11:00 PM
Friday, February 6, 2026
Departure
12:00–11:59 PM

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