Joint with: Epigenetics in Development and Disease
Interplay of Chromatin Architecture and Transcription Regulation
March 30–April 02, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Seychelle Vos, John T. Lis, and Luca Giorgetti
In Person
On Demand
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March 30–April 02, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Seychelle Vos, John T. Lis, and Luca Giorgetti
Seychelle Vos
John T. Lis
Luca Giorgetti
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMerchandise Options
Registration Options
Sunday, March 30, 2025
Fundraising
Booking Function
Registration
4:00–8:00 PM
Riverview Lounge
Welcome Mixer
6:00–8:00 PM
Riverview Lounge
Monday, March 31, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Welcome and Keynote Address (Joint)
8:00–9:00 AM
Cascade Ballroom
* Karen Adelman, Harvard Medical School
Session Chair
Session Chair
Patrick Cramer, Max Planck Institute for Multidisciplinary Sciences
Chromatin and Transcription
Chromatin and Transcription
Mechanisms of Gene Control and Epigenetic Regulation (Joint)
9:00–11:30 AM
Cascade Ballroom
* Seychelle Vos, Massachusetts Institute of Technology
Session Chair
Session Chair
Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research
Controlling CpG islands
Controlling CpG islands
François Fuks, University of Brussels
RNA Modifications in Health and Disease
RNA Modifications in Health and Disease
Lacramioara Bintu, Stanford University
High-Throughput Measurements of Activation and Repression Domains from Human Proteins
High-Throughput Measurements of Activation and Repression Domains from Human Proteins
Havva Ortabozkoyun, University of Miami / HHMI
Short Talk: Members of an Array of Zinc Finger Proteins Specify Distinct Hox Chromatin Boundaries
Short Talk: Members of an Array of Zinc Finger Proteins Specify Distinct Hox Chromatin Boundaries
Coffee Break
9:30–9:50 AM
Riverview Lounge
Award Recipient Acknowledgement
9:50–9:55 AM
Cascade Ballroom
Poster Setup
11:30–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Symposia Spotlight 1: Research presentations selected from abstract submissions
2:30–4:30 PM
Alhambra
* Luca Giorgetti, Friedrich Miescher Institute for Biomedical Research
Session Chair
Session Chair
Julia Schaepe, Stanford University
Thermodynamic Principles Link in vitro Transcription Factor Affinities to Single-molecule Chromatin States in Cells
Thermodynamic Principles Link in vitro Transcription Factor Affinities to Single-molecule Chromatin States in Cells
Allison James, Harvard Medical School
Structural Basis of Human CHD1 Nucleosome Recruitment and Pausing
Structural Basis of Human CHD1 Nucleosome Recruitment and Pausing
Blaine Bartholomew, MD Anderson Cancer Center
SWI/SNF Regulates Nuclear Condensates in an eRNA Dependent Manner
SWI/SNF Regulates Nuclear Condensates in an eRNA Dependent Manner
Zachary A Drum, University of North Carolina at Chapel Hill
Mechanisms of Phase-separation Driven Chromatin Looping in Acute Myeloid Leukemia
Mechanisms of Phase-separation Driven Chromatin Looping in Acute Myeloid Leukemia
James Kentro, Brown University
Conserved Transcription Factors Coordinate Synaptic Gene Expression Through Repression
Conserved Transcription Factors Coordinate Synaptic Gene Expression Through Repression
Daniel Ibrahim, Berlin Institute of Health
Enhancer-promoter Specificity Mediated by the Promoter-proximal Region
Enhancer-promoter Specificity Mediated by the Promoter-proximal Region
Wen Yan, Pfizer
Identification Of A Selective And Orally Bioavailable BPTF PROTAC With Anti-Tumor Activity In SWI/SNF Mutant Lung Cancer
Identification Of A Selective And Orally Bioavailable BPTF PROTAC With Anti-Tumor Activity In SWI/SNF Mutant Lung Cancer
Coffee Break with Hot Chocolate, Firepits & Mountain Views
4:30–5:00 PM
Conservatory Terrace
Enhancer-Promoter Communication
5:00–6:45 PM
Alhambra
* Lacramioara Bintu, Stanford University
Session Chair
Session Chair
Thomas G Graham, University of California, Berkeley
Single-molecule Live Imaging of Transcriptional Regulatory Complex Interactions using Proximity-assisted Photoactivation (PAPA)
Single-molecule Live Imaging of Transcriptional Regulatory Complex Interactions using Proximity-assisted Photoactivation (PAPA)
Aukje Marieke Oudelaar, Max Planck Institute for Multidisciplinary Science
Regulation of Gene Expression in the 3D Genome
Regulation of Gene Expression in the 3D Genome
Luca Giorgetti, Friedrich Miescher Institute for Biomedical Research
Dynamics of Chromatin Loops and the Consequence on Transcription
Dynamics of Chromatin Loops and the Consequence on Transcription
Mervenaz Koska, Stanford University
Short Talk: Understanding the Mechanism of Promoter Competition
Short Talk: Understanding the Mechanism of Promoter Competition
Social Hour with Lite Bites
7:00–8:00 PM
Alberta/New Brunswick
Poster Session 1
7:30–10:00 PM
Alberta/New Brunswick
Tuesday, April 1, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Mechanisms of Chromatin Transcription
8:00–11:00 AM
Alhambra
* Xavier Darzacq, University of California, Berkeley
Session Chair
Session Chair
Yanhui Xu, Fudan University
Structural Basis of Transcription Initiation on Chromatin
Structural Basis of Transcription Initiation on Chromatin
Stephen Buratowski, Harvard Medical School
Single molecule microscopy reveals unexpected features of RNApII transcription
Single molecule microscopy reveals unexpected features of RNApII transcription
Karen Arndt, University of Pittsburgh
Chromatin and Transcription Elongation
Chromatin and Transcription Elongation
Carl Wu, Johns Hopkins University
The biogenesis and regulation of chromatin accessibility for dynamic transcription complexes
The biogenesis and regulation of chromatin accessibility for dynamic transcription complexes
Sarah Hainer, University of Pittsburgh
Short Talk: Widespread Impact of Nucleosome Remodelers on Transcription at Cis-regulatory Elements
Short Talk: Widespread Impact of Nucleosome Remodelers on Transcription at Cis-regulatory Elements
Michael J Guertin, UConn Health
Short Talk: Mechanisms of Direct cis Repression by a Transcriptional Activator
Short Talk: Mechanisms of Direct cis Repression by a Transcriptional Activator
Coffee Break
9:00–9:20 AM
Riverview Lounge
Poster Setup
11:00–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:00–5:00 PM
Career Roundtable (Joint)
1:00–2:30 PM
Alhambra
Paola Scaffidi, European Institute of Oncology
Group Leader
Group Leader
Gromek Smolen, Foghorn Therapeutics
VP, Head of Biology
VP, Head of Biology
Evan J. Worden, Van Andel Institute
Assistant Professor
Assistant Professor
Michael S Werner, University of Utah
Assistant Professor
Assistant Professor
Ivanka D Kamenova, Nature Protocols
Senior Editor
Senior Editor
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Coffee Available
4:30–5:00 PM
Riverview Lounge
Mechanisms and Dynamics of Genome Folding
5:00–7:00 PM
Alhambra
* Jennifer E. Phillips-Cremins, University of Pennsylvania
Session Chair
Session Chair
Tineke L Lenstra, Netherlands Cancer Institute
The Kinetics of Transcription Factor Target Search and Activation in Live Cells
The Kinetics of Transcription Factor Target Search and Activation in Live Cells
Xavier Darzacq, University of California, Berkeley
Quantifying the Molecular Transactions that Control Transcription in Live Cells
Quantifying the Molecular Transactions that Control Transcription in Live Cells
Jennifer E. Phillips-Cremins, University of Pennsylvania
Genome Looping and its Consequences on Transcription
Genome Looping and its Consequences on Transcription
Noura Maziak, Imperial College; LMS MRC
Short Talk: Extensive 3D Genome Reorganization Foreshadows Zygotic Genome Activation in Drosophila
Short Talk: Extensive 3D Genome Reorganization Foreshadows Zygotic Genome Activation in Drosophila
Erika Anderson, UCSF
Short Talk: Enhancers Regulate Transcription without Acting as Loading Sites for Extruding Cohesin
Short Talk: Enhancers Regulate Transcription without Acting as Loading Sites for Extruding Cohesin
Social Hour with Lite Bites
7:00–8:00 PM
Alberta/New Brunswick
Poster Session 2
7:30–10:00 PM
Alberta/New Brunswick
Wednesday, April 2, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Pausing Dynamics/Transcription Termination
8:00–11:00 AM
Alhambra
* Karen Arndt, University of Pittsburgh
Session Chair
Session Chair
Roberto Vazquez Nunez, Massachusetts Institute of Technology
Short Talk: Remote Presenter - GATO-Seq Uncovers RNA Polymerase II Promoter-Proximal Pausing Dynamics
Short Talk: Remote Presenter - GATO-Seq Uncovers RNA Polymerase II Promoter-Proximal Pausing Dynamics
John T. Lis, Cornell University
The Regulatory Interplay of Enhancers, Facilitators, and Promoters – A Case Study in a Native Chromatin Context
The Regulatory Interplay of Enhancers, Facilitators, and Promoters – A Case Study in a Native Chromatin Context
Seychelle Vos, Massachusetts Institute of Technology
Pausing and Release into Productive Elongation
Pausing and Release into Productive Elongation
Lidia Vasilieva, University of Oxford
Kinases, Phosphatases and their Role in Transcription Termination
Kinases, Phosphatases and their Role in Transcription Termination
Benjamin R Sabari, University of Texas Southwestern Medical Center
Short Talk: Gain-of-function RNA Polymerase II Partitioning is a Shared Feature of Diverse Oncogenic Fusions
Short Talk: Gain-of-function RNA Polymerase II Partitioning is a Shared Feature of Diverse Oncogenic Fusions
William Lai, Cornell University
Short Talk: High-resolution Mapping of the Pol II and Pol III Regulatory Complexes under Transcriptional Perturbation
Short Talk: High-resolution Mapping of the Pol II and Pol III Regulatory Complexes under Transcriptional Perturbation
Katerina Kraft, Stanford
Short Talk: Enhancer Activation from Transposable Elements in Extrachromosomal DNA
Short Talk: Enhancer Activation from Transposable Elements in Extrachromosomal DNA
Coffee Break
9:15–9:35 AM
Riverview Lounge
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Research presentations selected from abstract submissions
2:30–4:15 PM
Alhambra
* John T. Lis, Cornell University
Session Chair
Session Chair
Kalon J Overholt, MIT
High-resolution Footprints in Chromatin Architecture Enable Discovery of Transcription Factor Nano-assemblies
High-resolution Footprints in Chromatin Architecture Enable Discovery of Transcription Factor Nano-assemblies
Michael Quezada, Harvard Medical School
High-throughput Characterization of Interactions between Transcription Factors and Intrinsically Disordered Regions with Optical Pooled Screening
High-throughput Characterization of Interactions between Transcription Factors and Intrinsically Disordered Regions with Optical Pooled Screening
David Gross, Louisiana State University Health Sciences Center
Identification of Regulators that Drive Dynamic, Heat Shock-Induced Genome Restructuring
Identification of Regulators that Drive Dynamic, Heat Shock-Induced Genome Restructuring
Katherine Fleck, University of Connecticut
Novel Gene Evolution and 3D Chromatin Organization
Novel Gene Evolution and 3D Chromatin Organization
Matt Franklin, Stanford University
Human Satellite 3 DNA Encodes Megabase-scale Transcription Factor Binding Platforms
Human Satellite 3 DNA Encodes Megabase-scale Transcription Factor Binding Platforms
Djem Kissiov, University of California, Berkeley
Decoupling Transcriptional Memory from Chromatin Structure through Analysis of Single Chromatin Fibers
Decoupling Transcriptional Memory from Chromatin Structure through Analysis of Single Chromatin Fibers
Coffee Available
4:30–5:00 PM
Riverview Lounge
Keynote Address (Joint)
5:00–5:45 PM
Cascade Ballroom
* Seychelle Vos, Massachusetts Institute of Technology
Session Chair
Session Chair
Yang Shi, Ludwig Institute for Cancer Research, Oxford Branch
Chromatin Regulation and Cancer
Chromatin Regulation and Cancer
Transcription and Epigenetics in Disease (Joint)
5:45–7:15 PM
Cascade Ballroom
* Kristian Helin, The Institute of Cancer Research
Session Chair
Session Chair
Paola Scaffidi, European Institute of Oncology
Epigenetics and Functional Intratumor Heterogeneity
Epigenetics and Functional Intratumor Heterogeneity
Gromek Smolen, Foghorn Therapeutics
Targeting Chromatin Modulators with Therapeutic Degraders
Targeting Chromatin Modulators with Therapeutic Degraders
Tony Kouzarides, Gurdon Institute, University of Cambridge
Targeting RNA Modifying Enzymes in the Treatment of Cancer
Targeting RNA Modifying Enzymes in the Treatment of Cancer
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint)
7:15–7:30 PM
Cascade Ballroom
Social Hour with Lite Bites
7:30–8:30 PM
Alberta/New Brunswick
Thursday, April 3, 2025
Departure
12:00–11:59 PM
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