Single Cell Biology: Unique Cells to Tissue Ecosystems
May 11–14, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Jose Ordovas-Montanes, Chrysothemis Brown, Karin Pelka and Jeffrey Moffitt
In Person
On Demand
May 11–14, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Jose Ordovas-Montanes, Chrysothemis Brown, Karin Pelka and Jeffrey Moffitt
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandSunday, May 11, 2025
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Macdonald Foyer
Welcome Mixer
6:00–8:00 PM
Macdonald Foyer
Monday, May 12, 2025
Breakfast
7:00–8:00 AM
Woodlands Terrace
Poster Setup
7:30–8:00 AM
Macdonald EF
Poster Viewing
7:30–5:00 PM
Macdonald EF
Welcome and Keynote Session (Joint)
8:00–9:45 AM
Macdonald ABCD
* Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School
Session Chair
Session Chair
* Quinton Smith, University of California, Irvine
Session Chair
Session Chair
Matthew F Krummel, University of California, San Francisco
Tissue Archetypes Across Space and Time
Tissue Archetypes Across Space and Time
Gordana Vunjak-Novakovic, Columbia University
Organs-on-Chip Models for Studying Human Pathophysiology
Organs-on-Chip Models for Studying Human Pathophysiology
Coffee Break
9:45–10:15 AM
Macdonald Foyer
Award Recipient Acknowledgement
10:15–10:20 AM
Macdonald ABCD
High-Throughput Approaches to Model Cells and Tissues (Joint)
10:20–11:30 AM
Macdonald ABCD
* Chrysothemis Brown, Sloan Kettering Institute
Session Chair
Session Chair
* Quinton Smith, University of California, Irvine
Session Chair
Session Chair
Dana Pe'er, Memorial Sloan Kettering Cancer Center
Plasticity in the Tissue Context
Plasticity in the Tissue Context
Peter Winter, Broad Institute
Defining, Modeling, and Targeting Cell States in Cancer
Defining, Modeling, and Targeting Cell States in Cancer
Lunch
11:30–12:30 PM
Woodlands Terrace
Poster Session 1
12:00–2:30 PM
Macdonald EF
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Macdonald AB
Han Chen, Gladstone Institutes
Multi-Task Learning for Context-Specific Representations of Cell States
Multi-Task Learning for Context-Specific Representations of Cell States
* Samantha Riesenfeld, University of Chicago
Modeling Cell-State Transitions in the Tissue Niche
Modeling Cell-State Transitions in the Tissue Niche
Jian Ma, Carnegie Mellon University
Multiscale Delineation of Cellular Interactions in Tissues
Multiscale Delineation of Cellular Interactions in Tissues
Yakir Reshef, Brigham and Women's Hospital
Powerful and Accurate Case-Control Analysis of Spatially Resolved Molecular Data
Powerful and Accurate Case-Control Analysis of Spatially Resolved Molecular Data
Jagadish Sankaran, Genome Institute of Singapore
Multimodal Inference of Morphogenomic Phenotypes Using Morphology and Expression Data Optimal Clustering (MEDOC)
Multimodal Inference of Morphogenomic Phenotypes Using Morphology and Expression Data Optimal Clustering (MEDOC)
Weiruo Zhang, Stanford University
MONTAGE: A Computational Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities
MONTAGE: A Computational Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities
Jana T Winterstein, German Cancer Research Center (DKFZ)
Unveiling Phenotypic Plasticity in Melanoma: a Novel Computational Approach to Quantify Transcriptional Heterogeneity
Unveiling Phenotypic Plasticity in Melanoma: a Novel Computational Approach to Quantify Transcriptional Heterogeneity
Christian Reardon-Lochbaum, Boston Children's Hospital
Single Cell Spatial Transcriptomics in Mouse Bone Marrow Reveals Age Dependent Cellular Structures
Single Cell Spatial Transcriptomics in Mouse Bone Marrow Reveals Age Dependent Cellular Structures
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Biologically-Motivated Analytical Methods to Deconstruct Tissues
5:00–7:00 PM
Macdonald AB
Holger Heyn, CNAG-CRG
The Power of a Million Cells
The Power of a Million Cells
* Ricardo Ramirez, European Bioinformatics Institute
Knowledge-Based Computational Approaches to Dissect Multi-Cellular Programs from Single-Cell and Spatial Data
Knowledge-Based Computational Approaches to Dissect Multi-Cellular Programs from Single-Cell and Spatial Data
Peter V. Kharchenko
Downstream Impact of Segmentation Errors in Spatial Analysis
Downstream Impact of Segmentation Errors in Spatial Analysis
Aki Minoda, Radboud University
Mukin Mouse Ageing Atlas: How Microbiota affects Ageing
Mukin Mouse Ageing Atlas: How Microbiota affects Ageing
On Own for Dinner
7:00–8:00 PM
Tuesday, May 13, 2025
Breakfast
7:00–8:00 AM
Woodlands Terrace
Learning from Human and Animal Variation
8:00–11:00 AM
Macdonald AB
Monique van der Wijst, University Medical Center Groningen, UMCG
Lessons Learned from the Single-Cell eQTL Consortium
Lessons Learned from the Single-Cell eQTL Consortium
Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School
Charting Inflammatory Disease Trajectories in Human Barrier Tissues
Charting Inflammatory Disease Trajectories in Human Barrier Tissues
Karin Pelka, Gladstone Institutes and University of California, San Francisco
Spatially Organized Multicellular Immune Hubs
Spatially Organized Multicellular Immune Hubs
Paul G. Thomas, St. Jude Children's Research Hospital
Genetic and Infectious Drivers of Human Immune Variation
Genetic and Infectious Drivers of Human Immune Variation
* Sara Viragova, UCSF
Examining The Role Of Memory In Intestinal Regeneration
Examining The Role Of Memory In Intestinal Regeneration
Manu Setty, Fred Hutchinson Cancer Center
Short Talk: Desynchronization Between Gene Expression And Chromatin Reveals Mechanisms Driving Cell State Change
Short Talk: Desynchronization Between Gene Expression And Chromatin Reveals Mechanisms Driving Cell State Change
Coffee Break
9:00–9:20 AM
Macdonald Foyer
Poster Setup
11:00–1:00 PM
Macdonald EF
On Own for Lunch
11:00–3:00 PM
Poster Viewing
1:00–10:00 PM
Macdonald EF
Career Roundtable (Joint)
1:30–2:45 PM
MacDonald CD
Oscar J. Abilez, Stanford University
Senior Scientist-Stanford & Co-Founder-Bullseye Biotechnologies
Senior Scientist-Stanford & Co-Founder-Bullseye Biotechnologies
Giuliana Rossi, Roche Institute of Human Biology
Senior Scientist
Senior Scientist
Lei Tang, Nature Methods
Senior Editor
Senior Editor
Advances in Single Cell Biology and Organoids for Precision Medicine (Joint)
3:00–4:30 PM
Macdonald AB
* Quinton Smith, University of California, Irvine
Session Chair
Session Chair
* Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School
Session Chair
Session Chair
Oshiomah Oyageshio, University of California Davis
Remote Presentation: Integrating Single Cell Multiomics and Ancestry to Investigate TB susceptibility
Remote Presentation: Integrating Single Cell Multiomics and Ancestry to Investigate TB susceptibility
Joshua De Sousa Casal, Boston Children's Hospital
Early Life Development of The Pediatric Duodenum Across Distinct Geographical Environments
Early Life Development of The Pediatric Duodenum Across Distinct Geographical Environments
Kaitriana Colling, University of Iowa
Lead Compound Identification Using Live-Cell Imaging of Patient-Derived Endometrial Cancer Organoids
Lead Compound Identification Using Live-Cell Imaging of Patient-Derived Endometrial Cancer Organoids
Hyung-Sik Kim, Pusan National University
TGFβ2-Driven Iron Dysregulation and Ferroptosis in Salivary Glands Trigger Hyposalivation Under Postmenopausal Conditions
TGFβ2-Driven Iron Dysregulation and Ferroptosis in Salivary Glands Trigger Hyposalivation Under Postmenopausal Conditions
Gat Rauner, Tufts University School of Medicine
Next-Generation Breast Organoids as a Platform for Studying Human Lactation and Breast Tissue Regeneration
Next-Generation Breast Organoids as a Platform for Studying Human Lactation and Breast Tissue Regeneration
Coffee Available
4:30–5:00 PM
Macdonald Foyer
New Biology of Cell Types, Subsets, States and Clones
5:00–6:30 PM
Macdonald AB
Andrew RJ Lawson, Wellcome Sanger Institute
Somatic Mutations in Health and Disease
Somatic Mutations in Health and Disease
Chrysothemis Brown, Sloan Kettering Institute
Novel Antigen Presenting Cells in Early Life Immune Tolerance
Novel Antigen Presenting Cells in Early Life Immune Tolerance
Karan R Kathuria, Stanford University
Short Talk: Synapse-Seq of Human Immune Cell Interactions Reveals Cytotoxic T Cell Suppression of Autoantibody Production
Short Talk: Synapse-Seq of Human Immune Cell Interactions Reveals Cytotoxic T Cell Suppression of Autoantibody Production
* Veronika Niederlova, Institute of Molecular Genetics
Manipulating Effector and Memory Fates in CD8+ T cells: a Novel Tpam Transitional State and the Role of TGF-B
Manipulating Effector and Memory Fates in CD8+ T cells: a Novel Tpam Transitional State and the Role of TGF-B
Social Hour with Lite Bites
7:00–8:00 PM
Woodlands Terrace
Poster Session 2
7:30–10:00 PM
Macdonald EF
Wednesday, May 14, 2025
Breakfast
7:00–8:00 AM
Woodlands Terrace
From Community-Engaged Research to Drug Discovery
8:00–11:15 AM
Macdonald AB
Andreas Moor, ETH
Remote Presentation: Systematic Perturbation of Cellular Interactions in the Tumor Microenvironment
Remote Presentation: Systematic Perturbation of Cellular Interactions in the Tumor Microenvironment
* Sara Suliman, University of California, San Francisco
Community-Based Single-Cell Research
Community-Based Single-Cell Research
Tommaso Biancalani, Genentech
Foundation Models for Target Identifications
Foundation Models for Target Identifications
Daniel B. Burkhardt, NVIDIA
Accelerating the Development of Virtual Cells
Accelerating the Development of Virtual Cells
Miranda Orr, Washington University in St Louis, MO
Short Talk: Highest-Plex Single-Cell Spatial Whole Transcriptome and 1000+ Proteome Identify a New Cell Type and Neural State in Alzheimer’s Disease Brains
Short Talk: Highest-Plex Single-Cell Spatial Whole Transcriptome and 1000+ Proteome Identify a New Cell Type and Neural State in Alzheimer’s Disease Brains
Hamish W King, Walter and Eliza Hall Institute
Short Talk: Pooled Single-cell CRISPR Screening In Primary Human B Cells Discovers Gene Targets And Pathways Of Non-Coding Autoimmune Risk Loci
Short Talk: Pooled Single-cell CRISPR Screening In Primary Human B Cells Discovers Gene Targets And Pathways Of Non-Coding Autoimmune Risk Loci
Joan Camunas-Soler, University Of Gothenburg
Short Talk: High-Resolution Spatial Transcriptomics And Functional Imaging Reveal Cellular Heterogeneity In The Human Pancreas
Short Talk: High-Resolution Spatial Transcriptomics And Functional Imaging Reveal Cellular Heterogeneity In The Human Pancreas
Coffee Break
9:00–9:20 AM
Macdonald Foyer
People's Choice Poster Award Announcement
9:20–9:25 AM
Macdonald AB
On Own for Lunch
11:15–2:30 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Macdonald AB
* Nicholas F Kuhn, University of California, San Francisco
Identification of a Novel Fibroblast State and Associated Cellular Changes via Local In Vivo Gene Editing in Cancer
Identification of a Novel Fibroblast State and Associated Cellular Changes via Local In Vivo Gene Editing in Cancer
Hope Anderson, University of Chicago
Germline- And Non-Germline-Encoded Variation In The TCR Repertoire Impacts Gut-Resident γδ T Cell Activation And Function
Germline- And Non-Germline-Encoded Variation In The TCR Repertoire Impacts Gut-Resident γδ T Cell Activation And Function
Stefan Schattgen, St Jude Children's Research Hospital
A Multimodal Single-Cell Atlas Charts Phenotypic Landscapes Of T Cell Receptor Convergence
A Multimodal Single-Cell Atlas Charts Phenotypic Landscapes Of T Cell Receptor Convergence
Idan Milo, Weizmann Institute of Science
Immune Organization In Sentinel Lymph Nodes Of Melanoma Patients Is Prognostic Of Distant Metastases
Immune Organization In Sentinel Lymph Nodes Of Melanoma Patients Is Prognostic Of Distant Metastases
Robert Piscopio, University of California, Santa Barbara
Photolabile Oligonucleotides Combined with Topologically Imposed Light Gradients Enable Spatially Resolved Single-Cell Transcriptomics and Epigenomics
Photolabile Oligonucleotides Combined with Topologically Imposed Light Gradients Enable Spatially Resolved Single-Cell Transcriptomics and Epigenomics
Massimiliano Pagani, IFOM ETS - The AIRC Institute of Molecular Oncology
Single-Cell Enhancerome Profiling Identifies Key Transcriptional Regulators of Human Tumor-Infiltrating Treg Cells
Single-Cell Enhancerome Profiling Identifies Key Transcriptional Regulators of Human Tumor-Infiltrating Treg Cells
Prakrithi Pavithra, University of Queensland
SPanC-Lnc : Decoding the Spatial and Single Cell Landscape of Long Non-coding RNAs at a Pan-Cancer Level
SPanC-Lnc : Decoding the Spatial and Single Cell Landscape of Long Non-coding RNAs at a Pan-Cancer Level
Nate Hyams, Clemson University
Pericytes Promote Multiple Mechanisms of Cardiac Organoid Optimization for Cardiac Regeneration
Pericytes Promote Multiple Mechanisms of Cardiac Organoid Optimization for Cardiac Regeneration
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Ex Vivo and In Vivo Reconstruction of Tissues
5:00–6:45 PM
Macdonald AB
* Samuel Kazer, Boston Children's Hospital & Harvard Medical School
Session Chair
Session Chair
Alex K. Shalek, Massachusetts Institute of Technology
From Correlation to Causation: Improving Human Disease Representation in vitro for Functional Testing of in vivo-Derived Hypotheses
From Correlation to Causation: Improving Human Disease Representation in vitro for Functional Testing of in vivo-Derived Hypotheses
Chris Tape, University College London
Single-Cell Phenoscaping of Tumour Microenvironment Organoids
Single-Cell Phenoscaping of Tumour Microenvironment Organoids
Jeffrey Moffitt, Boston Children's Hospital
The Role of Spatial Organization in the Gut-Microbiome Interface in Gut Inflammation
The Role of Spatial Organization in the Gut-Microbiome Interface in Gut Inflammation
Lingting Shi, Columbia University
Short Talk: Multi-Omics Immune Profiling of Graft-Versus-Host Disease (GvHD) In Humans
Short Talk: Multi-Omics Immune Profiling of Graft-Versus-Host Disease (GvHD) In Humans
Meeting Wrap-Up: Outcomes and Future Directions and Survey (Organizers)
6:45–7:00 PM
Macdonald AB
Social Hour with Lite Bites
7:00–8:00 PM
Woodlands Terrace
Thursday, May 15, 2025
Departure
12:00–11:59 PM
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