Joint with: Single Cell Biology: Unique Cells to Tissue Ecosystems
Organoids: Engineering Innovative Approaches for Basic and Translational Insight
May 11–14, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Quinton Smith, Matthias Lutolf and Kelly R. Stevens
In Person
On Demand
May 11–14, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Quinton Smith, Matthias Lutolf and Kelly R. Stevens
Available Formats:
Supported by:
In Person
On Demand
Available Formats: = In Person = On Demand
Sunday, May 11, 2025
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Macdonald Foyer
Welcome Mixer
6:00–8:00 PM
Macdonald Foyer
Monday, May 12, 2025
Breakfast
7:00–8:00 AM
Woodlands Terrace
Poster Setup
7:30–8:00 AM
Macdonald EF
Poster Viewing
7:30–7:00 PM
Macdonald EF
Welcome and Keynote Session (Joint)
8:00–9:30 AM
Macdonald ABCD
* Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School
Matthew F Krummel, University of California, San Francisco
Tissue Archetypes Across Space and Time
Tissue Archetypes Across Space and Time
Gordana V Vunjak-Novakovic, Columbia University
Organs-on-Chip Models for Studying Human Pathophysiology
Organs-on-Chip Models for Studying Human Pathophysiology
Coffee Break
9:30–9:50 AM
Macdonald Foyer
High-Throughput Approaches to Model Cells and Tissues (Joint)
9:50–11:30 AM
Macdonald ABCD
* Chrysothemis Brown, Sloan Kettering Institute
Dana Pe'er, Memorial Sloan Kettering Cancer Center
Plasticity in the Tissue Context
Plasticity in the Tissue Context
Peter Winter, Broad Institute
Defining, Modeling, and Targeting Cell States in Cancer
Defining, Modeling, and Targeting Cell States in Cancer
Lunch
11:30–12:30 PM
Woodlands Terrace
Poster Session 1
12:00–2:30 PM
Macdonald EF
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
MacDonald CD
Oscar J. Abilez, Stanford University
Perfusion Of Human Cardiac Vascularized Organoids
Perfusion Of Human Cardiac Vascularized Organoids
Meghan Capeling, Genentech
Dictionary Of Human Intestinal Organoid Responses to Secreted Niche Factors at Single Cell Resolution
Dictionary Of Human Intestinal Organoid Responses to Secreted Niche Factors at Single Cell Resolution
Alexander Kleger, Institute of Molecular Oncology and Stem Cell Biology, Ulm University
3D Bioprinting Leverages Mature Pancreatic Ductal Tube Formation and Advances Early-Stage Cancer Modelling
3D Bioprinting Leverages Mature Pancreatic Ductal Tube Formation and Advances Early-Stage Cancer Modelling
Jessica Klein, Genentech
The Differentiation State of Small Intestinal Organoid Models Influences Prediction of Drug-Induced Toxicity
The Differentiation State of Small Intestinal Organoid Models Influences Prediction of Drug-Induced Toxicity
Alison P. McGuigan, University of Toronto
Engineered Tumours Containing Patient Derived Pancreatic Organoids and Primary Macrophages To Dissect The Relative Impact Of Multiple Tumour Microenvironmental Signals on Tumour Cell Behaviour
Engineered Tumours Containing Patient Derived Pancreatic Organoids and Primary Macrophages To Dissect The Relative Impact Of Multiple Tumour Microenvironmental Signals on Tumour Cell Behaviour
M. Carmen Ortuño Costela, Berlin Institute of Health at Charité
Generation Of Hepatocyte Organoids From Primary Hepatocytes
Generation Of Hepatocyte Organoids From Primary Hepatocytes
Chris Yankaskas, Thermo Fisher Scientific
Derivation Of a Cohort Of Patient-Derived Cancer Organoids for Screening Immunotherapy Efficacy
Derivation Of a Cohort Of Patient-Derived Cancer Organoids for Screening Immunotherapy Efficacy
Tobias Raabe, University of Pennsylvania
Lipid Nanoparticles For Rapid Cell Type Specific Genome Editing Of A MASH Patient Liver Derived 3D Fibrosis Model
Lipid Nanoparticles For Rapid Cell Type Specific Genome Editing Of A MASH Patient Liver Derived 3D Fibrosis Model
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Controlling the Organoid Microenvironment
5:00–7:00 PM
MacDonald CD
Celeste M Nelson, Princeton University
Mechanical Drivers of Lung Development
Mechanical Drivers of Lung Development
Alex Hughes, University of Pennsylvania
Engaging the Design Cycle of Rhythmic Stem Cell Biology in Developing and Synthetic Kidney Tissues
Engaging the Design Cycle of Rhythmic Stem Cell Biology in Developing and Synthetic Kidney Tissues
Pilnam Kim, Korea Advanced Institute of Science and Technology
ECM Control of Organoid Fate
ECM Control of Organoid Fate
Matthias Lutolf, Roche Institute of Human Biology and EPFL
Reconstructing Tumor–Immune Interactions with Organoids
Reconstructing Tumor–Immune Interactions with Organoids
On Own for Dinner
7:00–8:00 PM
Tuesday, May 13, 2025
Breakfast
7:00–8:00 AM
Woodlands Terrace
Reverse Engineering Embryogenesis
8:00–11:00 AM
MacDonald CD
Margherita Y Turco, Friedrich Miescher Institute
Placental Organoids
Placental Organoids
Jared Toettcher, Princeton University
Gastruloid Patterning
Gastruloid Patterning
Quinton Smith, University of California, Irvine
Microfluidic Models of Vascularization
Microfluidic Models of Vascularization
Xihe Liu, Johns Hopkins University
Short Talk: Gastrulation-Stage Cells Can Self-Organize and Pattern the Body Via Slit/Robo Signaling
Short Talk: Gastrulation-Stage Cells Can Self-Organize and Pattern the Body Via Slit/Robo Signaling
Giuliana Rossi, Roche Institute of Human Biology
Short Talk: Improved Human Gastruloids as Templates for Complex Organogenesis
Short Talk: Improved Human Gastruloids as Templates for Complex Organogenesis
Coffee Break
9:00–9:20 AM
Macdonald Foyer
Poster Setup
11:00–1:00 PM
Macdonald EF
On Own for Lunch
11:00–3:00 PM
Poster Viewing
1:00–10:00 PM
Macdonald EF
Career Roundtable (Joint)
1:30–2:45 PM
MacDonald CD
Advances in Single Cell Biology and Organoids for Precision Medicine (Joint)
3:00–4:30 PM
MacDonald CD
* Quinton Smith, University of California, Irvine
Session Chair
Session Chair
Oshiomah Oyageshio, University of California Davis
Integrating Single Cell Multiomics and Ancestry to Investigate TB susceptibility
Integrating Single Cell Multiomics and Ancestry to Investigate TB susceptibility
Joshua De Sousa Casal, Boston Children's Hospital
Early Life Development of The Pediatric Duodenum Across Distinct Geographical Environments
Early Life Development of The Pediatric Duodenum Across Distinct Geographical Environments
Kaitriana Colling, University of Iowa
Lead Compound Identification Using Live-Cell Imaging of Patient-Derived Endometrial Cancer Organoids
Lead Compound Identification Using Live-Cell Imaging of Patient-Derived Endometrial Cancer Organoids
Hyung-Sik Kim, Pusan National University
TGFβ2-Driven Iron Dysregulation and Ferroptosis in Salivary Glands Trigger Hyposalivation Under Postmenopausal Conditions
TGFβ2-Driven Iron Dysregulation and Ferroptosis in Salivary Glands Trigger Hyposalivation Under Postmenopausal Conditions
Gat Rauner, Tufts University School of Medicine
Next-Generation Breast Organoids as a Platform for Studying Human Lactation and Breast Tissue Regeneration
Next-Generation Breast Organoids as a Platform for Studying Human Lactation and Breast Tissue Regeneration
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Organoid Vascularization
5:00–7:00 PM
MacDonald CD
Kelly R. Stevens, University of Washington
Deploying 3D Printing to Vascularize Organoids
Deploying 3D Printing to Vascularize Organoids
Elizabeth Wayne, University of Washington
Monocytes and Macrophages Incorporated Lung Airway Organoids
Monocytes and Macrophages Incorporated Lung Airway Organoids
Britta Trappmann-Linkermann, TU Dortmund University
Vascularization of Organoids in Synthetic Extracellular Matrices
Vascularization of Organoids in Synthetic Extracellular Matrices
Clement Quintard, University of British Columbia
Short Talk: Engineering Organoids-On-Chip With Flow Dynamics To Model Organ-Specific Vascularization And Immune-Enhanced Cellular Cross-Talk In Cardiac Tissues
Short Talk: Engineering Organoids-On-Chip With Flow Dynamics To Model Organ-Specific Vascularization And Immune-Enhanced Cellular Cross-Talk In Cardiac Tissues
Mingxia Gu, UCLA
Short Talk: Reconstructing Organ-Specific Vasculature In iPSC-Derived Lung And Intestinal Organoids
Short Talk: Reconstructing Organ-Specific Vasculature In iPSC-Derived Lung And Intestinal Organoids
Social Hour with Lite Bites
7:00–8:00 PM
Woodlands Terrace
Poster Session 2
7:30–10:00 PM
Macdonald EF
Wednesday, May 14, 2025
Breakfast
7:00–8:00 AM
Woodlands Terrace
Programmable Organoids
8:00–11:00 AM
MacDonald CD
Anne Grapin-Botton, Max Planck Institute of Molecular Cell Biology and Genetics
High Content Screening in Human Pancreatic Organoids
High Content Screening in Human Pancreatic Organoids
Martin Fussenegger, ETH Zürich
Remote Control of Cellular Behavior
Remote Control of Cellular Behavior
Karmella Haynes, Emory University and Georgia Institute of Technology
Controlling Chromatin Epigenetics in 3D Breast Cancer Spheroids
Controlling Chromatin Epigenetics in 3D Breast Cancer Spheroids
Sachin N Davis, University of Pennsylvania
Short Talk: Engineering Optogenetic Control of Anisotropic Strain for Sculpting Epithelial Morphogenesis
Short Talk: Engineering Optogenetic Control of Anisotropic Strain for Sculpting Epithelial Morphogenesis
Louis S Prahl, University of Pennsylvania
Short Talk: Synthetic Control of Epithelial Morphogenesis by RET Receptor Tyrosine Kinase
Short Talk: Synthetic Control of Epithelial Morphogenesis by RET Receptor Tyrosine Kinase
Michael Blatchley, Syracuse University
Short Talk: Spatiotemporally Controlled Matrix Softening Facilitates Deterministic Crypt Formation In iPSC- Derived Intestinal Organoids
Short Talk: Spatiotemporally Controlled Matrix Softening Facilitates Deterministic Crypt Formation In iPSC- Derived Intestinal Organoids
Steven Caliari, University of Virginia
Short Talk: Spatiotemporal Control of Hydrogel Stress Relaxation for Creating Viscoelastic 3D Cell Culture Microenvironments
Short Talk: Spatiotemporal Control of Hydrogel Stress Relaxation for Creating Viscoelastic 3D Cell Culture Microenvironments
Coffee Break
9:00–9:20 AM
Macdonald Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
MacDonald CD
Marianna Kruithof-de Julio, Universität Bern
- Bladder Cancer-On-Chip: A 3D Model To Study Human Urothelial Tumors Under Physiological Stretch
- Bladder Cancer-On-Chip: A 3D Model To Study Human Urothelial Tumors Under Physiological Stretch
Madelyn Arzt, Cedars-Sinai Medical Center
Protein-Encapsulated Doxorubicin Reduces Cardiotoxicity In Hipsc-Cardiac Spheroids While Maintaining Anticancer Efficacy
Protein-Encapsulated Doxorubicin Reduces Cardiotoxicity In Hipsc-Cardiac Spheroids While Maintaining Anticancer Efficacy
Martin Stahl, STEMCELL Technologies
IntestiCult™ Plus Organoid Growth Medium Provides A Novel Means Of Establishing And Maintaining Physiologically-Relevant Intestinal Organoids
IntestiCult™ Plus Organoid Growth Medium Provides A Novel Means Of Establishing And Maintaining Physiologically-Relevant Intestinal Organoids
Samrawit Aforki, abbvie
Development of a Complex Human Skin Model to Investigate the Impact of Therapeutic Intervention on Vicious Cycle of Atopic Dermatitis
Development of a Complex Human Skin Model to Investigate the Impact of Therapeutic Intervention on Vicious Cycle of Atopic Dermatitis
Joram Mooiweer, University Medical Center Groningen
Advanced Intestine-On-Chip And Immuno-Organoid Models To Study Intestinal Diseases And Test Novel Treatments
Advanced Intestine-On-Chip And Immuno-Organoid Models To Study Intestinal Diseases And Test Novel Treatments
Jyoti Rao, Institute of Human Biology
Single Lumen Neuroepithelial Cyst-Derived Neural Organoids
Single Lumen Neuroepithelial Cyst-Derived Neural Organoids
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Physical Principles of Tissue Morphogenesis
5:00–6:45 PM
MacDonald CD
Katia Catherine Karalis, Regeneron Pharmaceuticals, Inc.
Talk Title to be Announced
Talk Title to be Announced
Xavier Trepat, Institute for Bioengineering of Catalonia
Integrative Tissue Dynamics and Cytoskeletal Mechanics
Integrative Tissue Dynamics and Cytoskeletal Mechanics
Austin J Graham, University of California, San Francisco
Living Materials Promote the Self-Organization of More Complex and Reproducible Organoid Models
Living Materials Promote the Self-Organization of More Complex and Reproducible Organoid Models
Martina Celotti, Hubrecht institute
Short Talk: Distinct Mutational Oncogenic Combinations, introduced by CRISPR in human basal airway Organoids, Drive the Emergence of Small Cell or Non-Small Cell Lung Cancer.
Short Talk: Distinct Mutational Oncogenic Combinations, introduced by CRISPR in human basal airway Organoids, Drive the Emergence of Small Cell or Non-Small Cell Lung Cancer.
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
MacDonald CD
Social Hour with Lite Bites
7:00–8:00 PM
Woodlands Terrace
Entertainment
8:00–11:00 PM
Macdonald AB
Cash Bar
8:00–11:00 PM
Thursday, May 15, 2025
Departure
12:00–11:59 PM
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