Integrative Structural Biology: Bridging Fields, Techniques, and Scales
September 28–October 01, 2026 | Village at Breckenridge, Breckenridge, CO, United States
Scientific Organizers:
Alex de Marco, Giulia Palermo, and Niccolò Banterle
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In Person
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September 28–October 01, 2026 | Village at Breckenridge, Breckenridge, CO, United States
Scientific Organizers: Alex de Marco, Giulia Palermo, and Niccolò Banterle
Alex de Marco, PhD
New York Structural Biology Center
Alex de Marco, Ph.D., is Director of the Simons Electron Microscopy Center (SEMC) at the New York Structural Biology Center, where he leads one of the world's largest cryo-electron microscopy facilities. His research focuses on method and technology development for cryo-electron tomography, correlative microscopy, and sample preparation, with contributions including the PIE-scope, OpenFIBSEM, and nanocrate technology. He completed his doctoral training at EMBL Heidelberg and has held appointments at Monash University and Columbia University, in addition to directing two NIH national centers for cryo-EM access, training, and in-situ tomographic ultramicroscopy.
Giulia Palermo, PhD
University of California Riverside
Giulia Palermo, Ph.D., is a Professor of Bioengineering and Chemistry at the University of California, Riverside. A computational biophysicist, her lab is best known for pioneering computational studies of the CRISPR-Cas9 system, applying cutting-edge computer simulations and artificial intelligence to unravel the mechanisms of genome editing and advance innovative tools that are transforming the life sciences. She is the recipient of numerous prestigious honors, including the NSF CAREER Award, the Sloan Research Fellowship in Chemistry, and the Camille Dreyfus Teacher-Scholar Award, reflecting her exceptional contributions to both research and education.
Niccolò Banterle, PhD
European Molecular Biology Laboratory
Niccolò Banterle, Ph.D., is a group leader in the Cell Biology and Biophysics unit at the European Molecular Biology Laboratory (EMBL). His research focuses on deciphering the structural design principles of centrioles — subcellular organelles critical to cell division, motility, and signalling — and understanding how their ultrastructure governs cellular function. By combining CRISPR-based gene editing with cutting-edge imaging approaches, including super-resolution microscopy, high-speed atomic force microscopy, and live cell imaging, his lab investigates centriole architecture across multiple scales to bridge molecular structure and physiological function.
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandMonday, September 28, 2026
Fundraising
Registration
4:00–8:00 PM
Atrium Lobby
Welcome Mixer
6:00–8:00 PM
Forest Ballroom and Lounge
Tuesday, September 29, 2026
Breakfast
7:00–8:00 AM
Forest Ballroom and Lounge
Welcome Remarks
8:00–8:10 AM
Elevation Ballroom
Keynote Address
8:10–9:00 AM
Elevation Ballroom
James S Fraser, University of California, San Francisco
Statistical Structural Biology
Statistical Structural Biology
Integrating Multiscale Microscopy
9:00–11:15 AM
Elevation Ballroom
Alex de Marco, New York Structural Biology Center
Visual Proteomics, from Data to Virtual Cells
Visual Proteomics, from Data to Virtual Cells
Lindsey Young, University of California, San Diego
Expanding the Toolkit for Structural Cell Biology
Expanding the Toolkit for Structural Cell Biology
Agnieszka Obarska-Kosinska, Max Planck Institute of Biophysics
Structural Modeling of Nuclear Pore Complexes
Structural Modeling of Nuclear Pore Complexes
William Conway †, Flatiron Institute
Short Talk: Multiscale, Local Self-Organization of the Human Metaphase Mitotic Spindle
Short Talk: Multiscale, Local Self-Organization of the Human Metaphase Mitotic Spindle
Coffee Break
9:30–9:50 AM
Elevation Foyer
Meet the Editors
11:25–12:25 PM
Elevation Ballroom
Katarzyna M. Marcinkiewicz, Nature Communications
Poster Setup
12:25–1:00 PM
Atrium Lobby
On Own for Lunch
12:25–5:00 PM
Poster Viewing
1:00–10:00 PM
Atrium Lobby
Symposia Spotlight: Machines, Membranes, and Molecular Recognition
2:30–4:30 PM
Elevation Ballroom
Md Ashaduzzaman †, UC Davis
Short Talk: Mechanism of Heterotrimeric Kinesin-2 Autoinhibition and Cargo-mediated Activation
Short Talk: Mechanism of Heterotrimeric Kinesin-2 Autoinhibition and Cargo-mediated Activation
Walter J Chazin, Vanderbilt University
Short Talk: Capturing Active Nucleotide Excision Repair Machinery As It Assembles, Scans and Verifies Lesions
Short Talk: Capturing Active Nucleotide Excision Repair Machinery As It Assembles, Scans and Verifies Lesions
Kitaik Lee †, St. Jude Children's Research Hospital
Short Talk: In Situ Photo-Crosslinking and Cryo-EM Reveal a Transient PSMD5/S5b Chaperone State of the Proteasome
Short Talk: In Situ Photo-Crosslinking and Cryo-EM Reveal a Transient PSMD5/S5b Chaperone State of the Proteasome
Zhicheng Cui †, University of Colorado Anschutz Medical Campus
Short Talk: Structural Basis of PI3P Recognition and Membrane Remodeling by the DFCP1 Oligomer during Autophagy Initiation
Short Talk: Structural Basis of PI3P Recognition and Membrane Remodeling by the DFCP1 Oligomer during Autophagy Initiation
Alys A Peisley †, University of Michigan
Short Talk: Cryo-EM Structures of Kir7.1 Reveal the Molecular Mechanisms of Gating and ML418 Blockade
Short Talk: Cryo-EM Structures of Kir7.1 Reveal the Molecular Mechanisms of Gating and ML418 Blockade
Harsh Bansia †, New York University
Short Talk: Structural Basis for NGF/TrkA Blockade by Analgesic Antibodies
Short Talk: Structural Basis for NGF/TrkA Blockade by Analgesic Antibodies
Alesandro Civljak †, Icahn School of Medicine at Mount Sinai
Short Talk: Cryo-EM Reveals a Structural Mechanism of Polyvalent Engagement of the Peanut Allergen Ara h 2 by a Class of Pathogenic IgE Antibodies
Short Talk: Cryo-EM Reveals a Structural Mechanism of Polyvalent Engagement of the Peanut Allergen Ara h 2 by a Class of Pathogenic IgE Antibodies
Diego Suchenski Loustaunau †, Yale University
Short Talk: PORECAST: Deep Learning Segmentation of Nuclear Pore Complexes and Nuclei to Map Local Nuclear Envelope Tension in Cells and Tissues
Short Talk: PORECAST: Deep Learning Segmentation of Nuclear Pore Complexes and Nuclei to Map Local Nuclear Envelope Tension in Cells and Tissues
Coffee Available
4:30–5:00 PM
Elevation Foyer
Integrating Data Generation and Computational Approaches
5:00–7:00 PM
Elevation Ballroom
Kevin H Gardner, CUNY Advanced Science Research Center
Lighting the Way: Integrative Structural Biology Studies of Photosensors in Action
Lighting the Way: Integrative Structural Biology Studies of Photosensors in Action
Alisha Jones, New York University
Integrative Structural and Computational Biology for RNA Discovery
Integrative Structural and Computational Biology for RNA Discovery
Pilar Cossio, Flatiron Institute
Inferring Probability Distributions of RNAs using Cryo-EM Images
Inferring Probability Distributions of RNAs using Cryo-EM Images
Christopher JF Cameron †, New York Structural Biology Center
Short Talk: Real-Time Movie Triage for Early Quality Control in Cryo-EM
Short Talk: Real-Time Movie Triage for Early Quality Control in Cryo-EM
Abhilash Sahoo, Simons Foundation
Short Talk: A Physics-Based Framework for Predicting and Controlling Preferred Orientation in Cryo-EM
Short Talk: A Physics-Based Framework for Predicting and Controlling Preferred Orientation in Cryo-EM
Social Hour with Dinner
7:00–8:00 PM
Forest Ballroom and Lounge
Poster Session 1
7:30–10:00 PM
Atrium Lobby
Wednesday, September 30, 2026
Breakfast
7:00–8:00 AM
Forest Ballroom and Lounge
Computational Approaches and Data Integration
8:00–11:00 AM
Elevation Ballroom
Karissa Y. Sanbonmatsu, Los Alamos National Laboratory
Multiscale Modeling of Biological Systems: Integrating Structural and Dynamic Information
Multiscale Modeling of Biological Systems: Integrating Structural and Dynamic Information
Giulia Palermo, University of California Riverside
Advancing Gene Editing through Computational Models and Deep Learning
Advancing Gene Editing through Computational Models and Deep Learning
Uriel Morzan, Universidad de Buenos Aires
Unsupervised Learning Approaches in Molecular Dynamics towards Understanding Allostery and Protein Regulation
Unsupervised Learning Approaches in Molecular Dynamics towards Understanding Allostery and Protein Regulation
Ivaylo I. Ivanov †, Columbia University
Short Talk: Molecular Model of TFIIH Recruitment to the Transcription-coupled Repair Machinery
Short Talk: Molecular Model of TFIIH Recruitment to the Transcription-coupled Repair Machinery
Piotr Chyzy †, University of Warsaw
Short Talk: Catching a Riboswitch in the Act: Multidimensional Simulations of Aminoglycoside Recognition
Short Talk: Catching a Riboswitch in the Act: Multidimensional Simulations of Aminoglycoside Recognition
Shivam Pandit †, The University of Tennessee, Knoxville
Short Talk: Integrative Simulation and Neutron Scattering Analysis of Sequence-Encoded Phase Separation in Plant IDPs
Short Talk: Integrative Simulation and Neutron Scattering Analysis of Sequence-Encoded Phase Separation in Plant IDPs
Coffee Break
9:00–9:20 AM
Elevation Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Elevation Ballroom
Poster Setup
11:00–1:00 PM
Atrium Lobby
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Atrium Lobby
Career Roundtable
3:00–4:30 PM
Elevation Ballroom
Coffee Available
4:30–5:00 PM
Elevation Foyer
Structural Dynamics
5:00–7:00 PM
Elevation Ballroom
Hashim M. Al-Hashimi, Columbia University
Predicting RNA Cellular Activity from Sequence via Conformational Ensembles
Predicting RNA Cellular Activity from Sequence via Conformational Ensembles
George Lisi, Brown University
Atomic Details at the Intersection of Allostery, Specificity, and Inhibition of CRISPR-Cas Systems
Atomic Details at the Intersection of Allostery, Specificity, and Inhibition of CRISPR-Cas Systems
Cesar de la Fuente, University of Pennsylvania
Accelerating Biological Discovery with AI
Accelerating Biological Discovery with AI
Jose Rodriguez, University of California, Los Angeles
Surveillance of Amyloid Structure and Function, from Atoms to Cells
Surveillance of Amyloid Structure and Function, from Atoms to Cells
Social Hour with Dinner
7:00–8:00 PM
Forest Ballroom and Lounge
Poster Session 2
7:30–10:00 PM
Atrium Lobby
Thursday, October 1, 2026
Breakfast
7:00–8:00 AM
Forest Ballroom and Lounge
Visualizing Correlative Datasets
8:00–11:00 AM
Elevation Ballroom
Niccolò Banterle, European Molecular Biology Laboratory
Structural Cell Biology at the Mesoscale
Structural Cell Biology at the Mesoscale
Fan Liu, Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Illuminating Drug-Target Interactions: Integrating Structural Biology and Advanced Proteomics
Illuminating Drug-Target Interactions: Integrating Structural Biology and Advanced Proteomics
Simon Scheuring, Weill Cornell Medicine
High-Speed Atomic Force Microscopy: Visualizing Biomolecular Structure-Dynamics in Real-Time
High-Speed Atomic Force Microscopy: Visualizing Biomolecular Structure-Dynamics in Real-Time
Jessie James L Malit, ETH Zurich
Short Talk: Uncovering the Cell Surface of Asgard Archaea
Short Talk: Uncovering the Cell Surface of Asgard Archaea
Maxim B Prigozhin, Harvard University
Short Talk: Dynamic and Multicolor Electron Microscopy
Short Talk: Dynamic and Multicolor Electron Microscopy
Vineeta Kaushik †, ICTER, IChf, Warsaw Poland
Short Talk: PDE6 Conformational Dynamics as a Molecular Driver of Light-Induced Photoreceptor Length Modulation
Short Talk: PDE6 Conformational Dynamics as a Molecular Driver of Light-Induced Photoreceptor Length Modulation
Rachael Kretsch †, Stanford University
Short Talk: High Throughput and In Situ Interrogation of Large ncRNA RNA Families
Short Talk: High Throughput and In Situ Interrogation of Large ncRNA RNA Families
Coffee Break
9:00–9:20 AM
Elevation Foyer
Panel Discussion: Funding Opportunities
11:10–12:10 PM
Elevation Ballroom
On Own for Lunch
12:10–5:00 PM
Coffee Available
4:30–5:00 PM
Elevation Foyer
Interpreting Correlative Datasets
5:00–6:45 PM
Elevation Ballroom
Janet Iwasa, University of Utah School of Medicine
New Tools for Animating Dynamic Molecular Models
New Tools for Animating Dynamic Molecular Models
Elizabeth Kellogg, St. Jude Children's Research Hospital
From Structure to Function: Integrative Approaches for Understanding Complex Biological Systems
From Structure to Function: Integrative Approaches for Understanding Complex Biological Systems
Peter Dahlberg, Stanford University
Integration of Advanced Optical Microscopy into FIB-Milling Platforms
Integration of Advanced Optical Microscopy into FIB-Milling Platforms
Jake Johnston †, Columbia University/NYSBC
Short Talk: DisTangle: A Deep Learning Tool for Cryo-ET Filament Semantic and Instance Segmentation
Short Talk: DisTangle: A Deep Learning Tool for Cryo-ET Filament Semantic and Instance Segmentation
Meeting Wrap-Up: Outcomes and Future Directions
6:45–7:00 PM
Elevation Ballroom
Social Hour with Dinner
7:00–8:00 PM
Forest Ballroom and Lounge
Cash Bar
8:00–9:00 PM
Forest Ballroom and Lounge
Entertainment
8:00–9:00 PM
Forest Ballroom and Lounge
Friday, October 2, 2026
Departure
12:00–11:59 PM
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