Joint with: Autophagy and Disease
Ubiquitin Biology and Disease

Dec 03–06, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ivan Dikic and Cynthia Wolberger

  In Person
  On Demand
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Dec 03–06, 2023 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Ivan Dikic and Cynthia Wolberger

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, December 3, 2023
Arrival and Registration  
4:00–8:00 PM
 Shavano Foyer
Welcome Mixer  
6:00–8:00 PM
 Shavano Foyer
Monday, December 4, 2023
Breakfast  
7:00–8:00 AM
 Red Cloud/Crestone
Welcome and Keynote Address (Joint)  
8:00–9:00 AM
 Torreys/Shavano Peak
* Ivan Dikic, Goethe University Medical School
Session Chair
Brenda A. Schulman, Max Planck Institute of Biochemistry
Twists and Turns in Ubiquitin Conjugation Cascades
Ubiquitin in Regulation of Autophagy and Disease (Joint)  
9:00–11:30 AM
 Torreys/Shavano Peak
* Kylie J. Walters, NCI, National Institutes of Health
Session Chair
* Achim Werner, National Institutes of Health
Session Chair
Michael Rape, University of California, Berkeley
Ubiquitin Ligases and Stress Responses
Tyler Franklin, Oregon Health and Science University
Short Talk: Short Talk: Bacterial Mimicry of Eukaryotic HECT Ubiquitin Ligation
Kylie J. Walters, NCI, National Institutes of Health
Proteasome Subunit Rpn13: Interactions, Activities and Therapeutic Opportunities
Sonja Lorenz, Max Planck Institute for Multidisciplinary Sciences
Short Talk: Short Talk: Structural Mechanism of the Ubiqutin Ligase HACE1
Masaaki Komatsu, Juntendo University School of Medicine
p62-Ubiquitin Condensates: Formation, Physiology and Autophagic Degradation
Coffee Break  
9:30–9:50 AM
 Shavano Foyer
Poster Setup  
11:30–1:00 PM
 Red Cloud/Crestone
On Own for Lunch  
11:30–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Red Cloud/Crestone
Career Roundtable (Joint)  
3:00–4:30 PM
 Shavano Peak
Carlos Castañeda, Syracuse University
Associate Professor
Mary Lilly, National Institutes of Health
Senior Investigator
Rupert Beale, The Francis Crick Institute
Clinical Group Leader
Judith A. Ronau, AbbVie, Inc.
Senior Scientist II
Coffee Available  
4:30–5:00 PM
 Shavano Foyer
Expanding Mechanisms of Ub Conjugation and Deconjugation  
5:00–7:00 PM
 Torreys Peak
* Fumiyo Ikeda, Osaka University
Session Chair
* Yogesh Kulathu, University of Dundee
Session Chair
Rachel Klevit, University of Washington
Is that RING Mutant Really Ligase-dead?
Ian J. Fucci, National Cancer Institute
Short Talk: Short Talk: Exploring the Transitions Between Open and Closed States in E2~Ub Conjugates
Yogesh Kulathu, University of Dundee
Ribosome UFMylation in ER Homeostasis
Cynthia Wolberger, Johns Hopkins University School of Medicine
Histone H2B Ubiquitination in Transcription Regulation
Social Hour with Lite Bites  
7:00–8:00 PM
 Red Cloud/Crestone
Poster Session 1  
7:30–10:00 PM
 Red Cloud/Crestone
Tuesday, December 5, 2023
Breakfast  
7:00–8:00 AM
 Red Cloud/Crestone
Dynamics and Specificity of the Ubiquitin System  
8:00–11:00 AM
 Torreys Peak
* Sonja Lorenz, Max Planck Institute for Multidisciplinary Sciences
Session Chair
* Claudio A. P. Joazeiro, University of Heidelberg
Session Chair
Christopher D. Lima, Memorial Sloan Kettering Cancer Center
Capturing Conformational Transitions in the Ubiquitin Conjugation Cascade
Fumiyo Ikeda, Osaka University
Linear Ubiquitination in Regulation of Innate Immunity
Gabriela Prus, University of Copenhagen
Short Talk: Short Talk: A Global, Integrated View of the Ubiquitylation Site Occupancy and Dynamics
Claudio A. P. Joazeiro, University of Heidelberg
Mechanism and Evolutionary Origins of Alanine-tail C-degron Recognition by E3 Ligases Pirh2 and CRL2-KLHDC10
Ivan Dikic, Goethe University Medical School
Ubiquitination and ER Remodeling
Jacob E. Corn, ETH Zürich
Short Talk: Short Talk: C-terminal Amides Mark Proteins for Degradation via SCF-FBXO31
Coffee Break  
9:00–9:20 AM
 Shavano Foyer
Poster Setup  
11:00–1:00 PM
 Red Cloud/Crestone
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Red Cloud/Crestone
Coffee Available  
4:30–5:00 PM
 Shavano Foyer
Ubiquitin in Disease Mechanisms  
5:00–7:00 PM
 Torreys Peak
* Carlos Castañeda, Syracuse University
Session Chair
Daniel J. Finley, Harvard University
Global Remodeling of the Proteome in Terminal Differentiation
Xin Gu, Harvard Medical School
Short Talk: Short Talk: The Midnolin-proteasome Pathway Catches Proteins for Ubiquitination-independent Degradation
Achim Werner, National Institutes of Health
Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Disease States
Xiaojing Sui, Northwestern University
Short Talk: Short Talk: The Functional Proteome Landscape Reveals Adaptive Regulation of the Proteasome in Aging
Carlos Castañeda, Syracuse University
Modulators of Ubiquilin Phase Separation: Implications for Protein Quality Control
Social Hour with Lite Bites  
7:00–8:00 PM
 Red Cloud/Crestone
Poster Session 2  
7:30–10:00 PM
 Red Cloud/Crestone
Wednesday, December 6, 2023
Breakfast  
7:00–8:00 AM
 Red Cloud/Crestone
Keynote Address (Joint)  
8:00–8:45 AM
 Torreys/Shavano Peak
* Eric H. Baehrecke, University of Massachusetts Medical School
Session Chair
J. Wade Harper, Harvard Medical School
Principles of Organelle Quality Control by Autophagy
Autophagy, Ubiquitin, Organelle Clearance and Disease (Joint)  
8:45–11:15 AM
 Torreys/Shavano Peak
* Christina Towers, The Salk Institute for Biological Studies
Session Chair
* Vojo Deretic, University of New Mexico Health Sciences Center
Session Chair
Sylvie Urbé, University of Liverpool
E3 Ligase and DUB Imposed Restrictions on Mitophagy
Anne Simonsen, University of Oslo
Regulation of Mitophagy and Cellular Bioenergetics by Lipid-binding Proteins
Alexandra Stolz, Goethe University Frankfurt
Short Talk: Short Talk: The Function of ER-phagy Receptors is Regulated through Phosphorylation-dependent Ubiquitination Pathways
Philippa Rosewell, University of Dundee
Short Talk: Short Talk: Hexokinase II Catalytic Activity Regulates Mitophagy
Richard J. Youle, NINDS, National Institutes of Health
STING Activation of LC3 Lipidation and Linear (M1) Ubiquitination in Innate Immune Signaling
Coffee Break  
9:15–9:35 AM
 Shavano Foyer
On Own for Lunch  
11:15–5:00 PM
Workshop: Emerging Views on Structural, Molecular and Functional Aspects of Ub System  
2:30–4:30 PM
 Torreys Peak
* Alexandra Whiteley, University of Colorado, Boulder
Session Chair
* Sven M Lange, Harvard Medical School
Session Chair
Alexandra Whiteley, University of Colorado, Boulder
Probing a New Model of Ubiquilin Client Selection
Xiangyi (Susie) Wang, The Walter and Eliza Hall Institute of Medical Research (WEHI)
Deciphering the Molecular Mechanism of HOIL-1, an Unconventional Ubiquitin Ligase
Daniel Grabarczyk, Research Institute of Molecular Pathology
Antiviral Mechanism of the Non-canonical Ubiquitin Ligase ZNFX1
Reina Iwase, Harvard University
Regulation of PTEN by Ubiquitination
Sven M Lange, Harvard Medical School
Decoding Ubiquitin Signals for Ciliary Trafficking
Ranabir Das, National Centre for Biological Sciences
Ubiquitin Dynamics at the Center of Host-pathogen Interactions
Coffee Available
4:30–5:00 PM
 Shavano Foyer
Emerging Therapeutics Employing the Ubiquitin System
5:00–6:45 PM
 Torreys Peak
* Michael Rape, University of California, Berkeley
Session Chair
* Judith A. Ronau, AbbVie, Inc.
Session Chair
Daniel K. Nomura, University of California, Berkeley
Reimagining Druggability using Chemoproteomic Platforms
Cristina Mayor-Ruiz, IRB Barcelona
Chasing Molecular Glue Degraders
Judith A. Ronau, AbbVie, Inc.
Short Talk: Short Talk: Innovative Approaches for Examining Ternary Complex Formation in TPD and Key Insights
Benika Pinch, Novartis Institutes for BioMedical Research
SOCS2: A Recruitable E3 Ligase for TPD with Disease-specific Expression
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Torreys Peak
Social Hour with Lite Bites  
7:00–8:00 PM
 Red Cloud/Crestone
Trivia  
8:00–9:00 PM
 Shavano Peak
Cash Bar  
8:00–9:00 PM
 Red Cloud/Crestone
Thursday, December 7, 2023
Departure  
7:00–11:59 PM

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