Dec 03–06, 2023 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Ivan Dikic and Cynthia Wolberger

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Scientific Organizers: Ivan Dikic and Cynthia Wolberger
Ivan Dikic
Cynthia Wolberger
***Meeting program subject to change.
Available Formats: = In Person = On DemandBooking Function
Fundraising
Sunday, December 3, 2023
Monday, December 4, 2023
Session Chair
Twists and Turns in Ubiquitin Conjugation Cascades
Session Chair
Session Chair
Ubiquitin Ligases and Stress Responses
Short Talk: Short Talk: Bacterial Mimicry of Eukaryotic HECT Ubiquitin Ligation
Proteasome Subunit Rpn13: Interactions, Activities and Therapeutic Opportunities
Short Talk: Short Talk: Structural Mechanism of the Ubiqutin Ligase HACE1
p62-Ubiquitin Condensates: Formation, Physiology and Autophagic Degradation
Associate Professor
Senior Investigator
Clinical Group Leader
Senior Scientist II
Session Chair
Session Chair
Is that RING Mutant Really Ligase-dead?
Short Talk: Short Talk: Exploring the Transitions Between Open and Closed States in E2~Ub Conjugates
Ribosome UFMylation in ER Homeostasis
Histone H2B Ubiquitination in Transcription Regulation
Tuesday, December 5, 2023
Session Chair
Session Chair
Capturing Conformational Transitions in the Ubiquitin Conjugation Cascade
Linear Ubiquitination in Regulation of Innate Immunity
Short Talk: Short Talk: A Global, Integrated View of the Ubiquitylation Site Occupancy and Dynamics
Mechanism and Evolutionary Origins of Alanine-tail C-degron Recognition by E3 Ligases Pirh2 and CRL2-KLHDC10
Ubiquitination and ER Remodeling
Short Talk: Short Talk: C-terminal Amides Mark Proteins for Degradation via SCF-FBXO31
Session Chair
Global Remodeling of the Proteome in Terminal Differentiation
Short Talk: Short Talk: The Midnolin-proteasome Pathway Catches Proteins for Ubiquitination-independent Degradation
Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Disease States
Short Talk: Short Talk: The Functional Proteome Landscape Reveals Adaptive Regulation of the Proteasome in Aging
Modulators of Ubiquilin Phase Separation: Implications for Protein Quality Control
Wednesday, December 6, 2023
Session Chair
Principles of Organelle Quality Control by Autophagy
Session Chair
Session Chair
E3 Ligase and DUB Imposed Restrictions on Mitophagy
Regulation of Mitophagy and Cellular Bioenergetics by Lipid-binding Proteins
Short Talk: Short Talk: The Function of ER-phagy Receptors is Regulated through Phosphorylation-dependent Ubiquitination Pathways
Short Talk: Short Talk: Hexokinase II Catalytic Activity Regulates Mitophagy
STING Activation of LC3 Lipidation and Linear (M1) Ubiquitination in Innate Immune Signaling
Session Chair
Session Chair
Probing a New Model of Ubiquilin Client Selection
Deciphering the Molecular Mechanism of HOIL-1, an Unconventional Ubiquitin Ligase
Antiviral Mechanism of the Non-canonical Ubiquitin Ligase ZNFX1
Regulation of PTEN by Ubiquitination
Decoding Ubiquitin Signals for Ciliary Trafficking
Ubiquitin Dynamics at the Center of Host-pathogen Interactions
Session Chair
Session Chair
Reimagining Druggability using Chemoproteomic Platforms
Chasing Molecular Glue Degraders
Short Talk: Short Talk: Innovative Approaches for Examining Ternary Complex Formation in TPD and Key Insights
SOCS2: A Recruitable E3 Ligase for TPD with Disease-specific Expression
Thursday, December 7, 2023
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