Joint with: Membrane Dynamics, Repair and Disease
Autophagy: Mechanisms to Therapy

Feb 02–05, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Anne Simonsen, Sharon A. Tooze, and Dan Baird

  Livestream
  In Person
  On Demand
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Feb 02–05, 2026 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Anne Simonsen, Sharon A. Tooze, and Dan Baird

Supported by:

***Meeting program subject to change.

Available Formats:     = Livestream   = In Person     = On Demand
Monday, February 2, 2026
Registration
4:00–8:00 PM
 Longs Peak Foyer
Welcome Mixer
6:00–8:00 PM
 Longs Peak Foyer
Tuesday, February 3, 2026
Breakfast
7:00–8:00 AM
 Quandary Peak
Welcome Remarks (Joint)
8:00–8:10 AM
 Longs/Grays Peaks
Keynote Address (Joint)
8:10–9:00 AM
 Longs/Grays Peaks
Erika L Holzbaur, University of Pennsylvania
Mitophagy and Lysophagy in Neurons
Intersections of Autophagy and Lysosomal Membrane Repair: Mechanisms and Implications (Joint)
9:00–11:15 AM
 Longs/Grays Peaks
Sharon A. Tooze, Francis Crick Institute
Role of PI 4-Kinases in Autophagy and Membrane Repair
Oliver Florey, Babraham Institute
Conjugation of ATG8s to Single Membranes
Jayanta Debnath, University of California, San Francisco
Non-Canonical ATG8ylation and Secretion
Coffee Break
9:30–9:50 AM
 Longs Peak Foyer
Poster Setup
11:15–1:00 PM
 Quandary Peak
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
 Quandary Peak
Symposia Spotlight 1 (Joint)
2:30–4:30 PM
 Longs/Grays Peaks
Rupert Beale, The Francis Crick Institute
Targeting of ATG8s to Different Compartments Mediated by V-ATPase V1H Recruitment of ATG16L1
Lizhen Cheng, Ludwig-Maximilians-Universität München
Dissecting Canonical and Non-Canonical Autophagy Pathways in Microglia in Healthy and Disease States
Ruben D Elias, Scripps Research
LLOMe Exposure Results in the Cathepsin C-Mediated Intralysosomal Generation of Membranolytic Amyloid Fibrils Alongside Promiscuous Dipeptide Ligation
Andreas Jenny, Albert Einstein College of Medicine
The Role of Lamp1 in the Non-Cell Autonomous Regulation of Endo-Lysosomal Acidification
Minghao Chen, UC Berkeley
Structure and Activation of the Human Autophagy-initiating ULK1C:PI3KC3-C1 Supercomplex
Michael G Hanna, Penn State University
Bridge-like Lipid transfer Protein 3A (BLTP3A) in the Response to Lysosome Damage
Ya-Cheng Liao, Columbia University Medical Center
ANXA11 Coordinates RNA Granules and mRNA Translation at Damaged Lysosomes
Jonathan X Meng, Gladstone Institutes
Metabolism-Dependent GARP Complex Protection of Neurons Against Alpha-Synuclein Toxicity
Coffee Available
4:30–5:00 PM
 Longs Peak Foyer
Membrane Dynamics and Cargo Selection in Autophagy Initiation
5:00–7:00 PM
 Longs Peak
Maho Hamasaki, Osaka University
Mechanistic Insights into Membrane Dynamics in Macroautophagy
Zvulun Elazar, Weizmann Institute of Science
Autophagosome Morphogenesis
J. Wade W Harper, Harvard Medical School
Charting Organelle Structural Interactomes with EndoMap and GolgiFold
Liang Ge, Tsinghua University
Short Talk: Golgi PI4P Overload Triggers Piezo1-dependent Ca²⁺ Signaling to Initiate RIMMBA Formation
Social Hour with Dinner
7:00–8:00 PM
 Quandary Peak
Poster Session 1
7:30–10:00 PM
 Quandary Peak
Wednesday, February 4, 2026
Breakfast
7:00–8:00 AM
 Quandary Peak
Keynote Address (Joint)
8:00–8:45 AM
 Longs/Grays Peaks
Harald Stenmark, Oslo University Hospital
An ER for Injured Lysosomes
Lysosomal Membrane Repair: ESCRTs and Beyond (Joint)
8:45–11:00 AM
 Longs/Grays Peaks
Phyllis Hanson, University of Michigan
Calcium and ESCRTs in Membrane Repair
James H. Hurley, University of California, Berkeley
ESCRTs as Suppressors of Amyloid Spread
Claudio Bussi, Nanyang Technological University
Biomolecular Condensates and Lysosome Repair
Coffee Break
9:00–9:20 AM
 Longs Peak Foyer
Poster Setup
11:00–1:00 PM
 Quandary Peak
On Own for Lunch
11:00–3:00 PM
Poster Viewing
1:00–10:00 PM
 Quandary Peak
Career Roundtable (Joint)
3:00–4:30 PM
 Longs Peak
Coffee Available
4:30–5:00 PM
 Longs Peak Foyer
Selective Autophagy Pathways: Regulation, Function, and Disease Relevance
5:00–7:00 PM
 Longs Peak
Lifeng Pan, Shanghai Institute of Organic Chemistry, CAS
Mechanistic Insights into Selective Autophagy of Glycogen in Mammals
Ivan Dikic, Goethe University Medical School
ER-Phagy and Novel Pathways for Ubiquitination
Ai Yamamoto, Columbia University
Autophagy in Neurodegenerative Diseases
Yogaditya Chakrabarty, California Institute of Technology
Short Talk: Hierarchical Stress Licensing of ER-Phagy: Chaperone Signaling and Autophagy-Initiation Control Define Organelle-Selective Turnover
Jonathan Friedman, UT Southwestern Medical Center
Short Talk: Mitophagy Amplitude is Regulated By An Interplay Between Receptor Protection and Turnover
Social Hour with Dinner
7:00–8:00 PM
 Quandary Peak
Poster Session 2
7:30–10:00 PM
 Quandary Peak
Thursday, February 5, 2026
Breakfast
7:00–8:00 AM
 Quandary Peak
Advancing Autophagy-Based Therapies: Novel Strategies and Innovations
8:00–11:00 AM
 Longs/Grays Peaks
Anastasia G Henry, Denali Therapeutics
Pharmacological Targeting of Parkinson's Disease
Joseph D. Mancias, Dana-Farber Cancer Institute
Targeting Autophagy in Cancer
Dan Baird, Casma Tx
Pharmacological Tools to Study Autophagy and Treat Disease
Angela Cacace, Arvinas Inc
Talk Title to be Announced
Emma Guilbaud, Fox Chase Cancer Center
Short Talk: Targeting Mitophagy to Enhance the Immunostimulatory Effects of Radiation in Estrogen Receptor-Positive Breast Cancer
Nicholas T Hertz, Montara Therapeutics, Inc.
Short Talk: BrainOnly Pharmacology Enables Brain-Specific mTOR Inhibition to Restore Autophagy in Neurological Disease
Coffee Break
9:00–9:20 AM
 Longs Peak Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2 (Joint)
2:30–4:30 PM
 Longs/Grays Peaks
Zi Gao, Scripps Research
TAX1BP1 Emerges as a Candidate Proteaphagy Receptor Through Global Protein Turnover Mapping
Chris Shoemaker, Dartmouth College
Decoding and Predicting Autophagy Interactions at Scale
Stephanie Spada, NIH/Oxford
TRIM5α Couples Membrane Targeting with Noncanonical Autophagy to Restrict Viral Infection
Simon Wilkinson, University of Edinburgh
FAM134B Clustering and ER-phagy Driven by Multi-functional, Phase-separated Degradation Hubs
Spencer Nelson, University of California, San Diego
Protein Ubiquitination and Phase Separation Regulate Membrane Scission in a Minimally Reconstructed HIV-1 Budding System
Berrak Ugur, Yale University
Exploring Targeting Mechanisms and Potential Function of VPS13B in Golgi Membrane Dynamics
Noah Weisleder, University of Kentucky
Modified Antibody Fusion Proteins with Tripartite Motif Family Protein 72 (TRIM72) Increase Plasma Membrane Repair to Treat Muscular Dystrophy Models
Coffee Available
4:30–5:00 PM
 Longs Peak Foyer
Mitochondrial Clearance Pathways
5:00–6:45 PM
 Longs Peak
Anne Simonsen, University of Oslo
Regulation of HIF1a Induced Mitophagy
Michael Lazarou, Monash University
Mitophagy's Impact on Cell Health
Chantell S Evans, Duke University School of Medicine
Mitochondrial Quality Control in Neurodegenerative Diseases
Hagai Abeliovich, Hebrew University of Jerusalem
Short Talk: Regulation of the Atg32 Mitophagy Receptor By Signaling From Within The Mitochondrial Matrix
Meeting Wrap-Up: Outcomes and Future Directions
6:45–7:00 PM
 Longs Peak
Social Hour with Dinner
7:00–8:00 PM
 Quandary Peak
Cash Bar
8:00–9:00 PM
 Quandary Peak
Entertainment
8:00–9:00 PM
 Longs Peak
Friday, February 6, 2026
Departure
12:00–11:59 PM

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