Joint with: Autophagy: Mechanisms to Therapy
Membrane Dynamics, Repair and Disease

Feb 02–05, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: James H. Hurley, Phyllis Hanson, and Gilbert Di Paolo

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  In Person
  On Demand
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Feb 02–05, 2026 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: James H. Hurley, Phyllis Hanson, and Gilbert Di Paolo

Supported by:

***Meeting program subject to change.

Available Formats:     = Livestream   = In Person     = On Demand
Monday, February 2, 2026
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, February 3, 2026
Breakfast
7:00–8:00 AM
Welcome Remarks (Joint)
8:00–8:10 AM
Keynote Address (Joint)
8:10–9:00 AM
Erika L Holzbaur, University of Pennsylvania
Mitophagy and Lysophagy in Neurons
Intersections of Autophagy and Lysosomal Membrane Repair: Mechanisms and Implications (Joint)
9:00–11:15 AM
Sharon A. Tooze, Francis Crick Institute
Role of PI 4-Kinases in Autophagy and Membrane Repair
Oliver Florey, Babraham Institute
Conjugation of ATG8s to Single Membranes
Jayanta Debnath, University of California, San Francisco
Non-Canonical ATG8ylation and Secretion
Coffee Break
9:30–9:50 AM
Poster Setup
11:15–1:00 PM
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight 1 (Joint)
2:30–4:30 PM
Rupert Beale, The Francis Crick Institute
Targeting of ATG8s to Different Compartments Mediated by V-ATPase V1H Recruitment of ATG16L1
Lizhen Cheng, Ludwig-Maximilians-Universität München
Dissecting Canonical and Non-Canonical Autophagy Pathways in Microglia in Healthy and Disease States
Ruben D Elias, Scripps Research
LLOMe Exposure Results in the Cathepsin C-Mediated Intralysosomal Generation of Membranolytic Amyloid Fibrils Alongside Promiscuous Dipeptide Ligation
Andreas Jenny, Albert Einstein College of Medicine
The role of Lamp1 in the Non-Cell Autonomous Regulation of Endo-Lysosomal Acidification
Minghao Chen, UC Berkeley
Structure and Activation of the Human Autophagy-initiating ULK1C:PI3KC3-C1 Supercomplex
Michael G Hanna, Penn State Univeristy
Bridge-like Lipid transfer Protein 3A (BLTP3A) in the Response to Lysosome Damage
Ya-Cheng Liao, Columbia University Medical Center
ANXA11 Coordinates RNA Granules and mRNA Translation at Damaged Lysosomes
Jonathan X Meng, Gladstone Institutes
Metabolism-Dependent GARP Complex Protection of Neurons Against Alpha-Synuclein Toxicity
Coffee Available
4:30–5:00 PM
Mitochondria and Ferroptosis
5:00–7:00 PM
Ana J. García-Sáez, Max Planck Institute of Biophysics
Mitochondrial Membrane Dynamics in Cell Death
James A Olzmann, University of California, Berkeley
Ferroptosis, Lipotoxicity, and Organelle Homeostasis
Whitney Henry, Massachusetts Institute of Technology
Ferroptosis and Cancer
Lena Pernas †, University of California, Los Angeles and HHMI
Short Talk: Mitochondria Give Rise to Proto-organelles during Infection
Shilong Yang, Rutgers the State University of New Jersey
Short Talk: Membrane Phase Separation Drives NINJ1 In-Plane Assembly
Social Hour with Dinner
7:00–8:00 PM
Poster Session 1
7:30–10:00 PM
Wednesday, February 4, 2026
Breakfast
7:00–8:00 AM
Keynote Address (Joint)
8:00–8:45 AM
Harald Stenmark, Oslo University Hospital
An ER for Injured Lysosomes
Lysosomal Membrane Repair: ESCRTs and Beyond (Joint)
8:45–11:00 AM
Phyllis Hanson, University of Michigan
Calcium and ESCRTs in Membrane Repair
James H. Hurley, University of California, Berkeley
ESCRTs as Suppressors of Amyloid Spread
Claudio Bussi, Nanyang Technological University
Biomolecular Condensates and Lysosome Repair
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–1:00 PM
Poster Setup
11:00–1:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable (Joint)
1:00–10:00 PM
Coffee Available
4:30–5:00 PM
Membrane Damage and Resilience
5:00–7:00 PM
Patrick Lusk, Yale University
Nuclear Membrane Rupture and Resilience
Vishva M. Dixit, Genentech, Inc.
Membrane Damage and Inflammation
Feng Shao, National Institute of Biological Sciences
Membrane Damage in Infection and Innate Immunity
Aakriti Jain, UT Southwestern Medical Center
Short Talk: LASER Senses Lysosomal Damage and Initiates ESCRT Assembly for Membrane Repair
Suhong Xu †, Zhejiang University
Short Talk: ESCRT-III Oligomerization Restores Membrane Tension to Facilitate Membrane Repair
Social Hour with Dinner
7:00–8:00 PM
Poster Session 2
7:30–10:00 PM
Thursday, February 5, 2026
Breakfast
7:00–8:00 AM
Membrane Homeostasis and Neurodegeneration
8:00–11:00 AM
Alyssa Coyne, Johns Hopkins University School of Medicine
Overactivation of ESCRT-III Nuclear Surveillance in Neurodegeneration: Mechanistic Insights and Therapeutic Targeting
Shawn Ferguson, Yale University
LRRK2-Dependent Responses to Lysosome Stress
Judith Frydman, Stanford University
ESCRTs and Proteostasis
Angela Cacace, Arvinas Inc
Targeting LRRK2
Utpal Das, University of California San Diego
Short Talk: Aβ Induces Endolysosomal Dysfunction by Prompting Hyperphosphorylation of RabGTPases, Disrupting Membrane Integrity
Patrick A. Lewis, Royal Veterinary College
Short Talk: A Role for GPNMB in Sensing and Responding to Lysosomal Stress
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2 (Joint)
2:30–4:30 PM
Zi Gao, Scripps Research
TAX1BP1 Emerges as a Candidate Proteaphagy Receptor Through Global Protein Turnover Mapping
Chris Shoemaker, Dartmouth College
Decoding and Predicting Autophagy Interactions at Scale
Stephanie Spada, NIH/Oxford
TRIM5α Couples Membrane Targeting with Noncanonical Autophagy to Restrict Viral Infection
Simon Wilkinson, University of Edinburgh
FAM134B Clustering and ER-phagy Driven by Multi-functional, Phase-separated Degradation Hubs
Spencer Nelson, University of California, San Diego
Protein Ubiquitination and Phase Separation Regulate Membrane Scission in a Minimally Reconstructed HIV-1 Budding System
Berrak Ugur †, Yale University
Exploring Targeting Mechanisms and Potential Function of VPS13B in Golgi Membrane Dynamics
Noah Weisleder, University of Kentucky
Modified Antibody Fusion Proteins with Tripartite Motif Family Protein 72 (TRIM72) Increase Plasma Membrane Repair to Treat Muscular Dystrophy Models
Coffee Available
4:30–5:00 PM
Lysosome Homeostasis and Lysosome-Directed Drug Discovery
5:00–6:45 PM
Haoxing Xu, Zhejiang University and University of Michigan
Molecular Physiology of Lysosomes
Hijai Regina Shin, University of Texas Southwestern Medical Center
Lysosome Cholesterol Signaling in Neuronal Health and Disease
Gilbert Di Paolo, Denali Therapeutics Inc.
Leveraging a Transferrin Receptor-Based Transport Vehicle for Lysosomal Enzyme/Protein Replacement Therapy in Neurodegenerative Diseases
Jay Xiaojun Tan, University of Pittsbrugh
Short Talk: Directional ER-to-Lysosome Lipid Transfer Mediates Lysosomal Vacuolation
Meeting Wrap-Up: Outcomes and Future Directions
6:45–7:00 PM
Social Hour with Dinner
7:00–8:00 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Friday, February 6, 2026
Departure
12:00–11:59 PM

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