This Keystone HIV science symposium, jointly organized with Keystone Vaccines, will convene leading international scientists and innovators to address emerging technology and its application to the prevention and treatment of HIV.  From the basic science of immunogen and monoclonal antibody design, product delivery technologies and HIV remission strategies to breaking preclinical and clinical data, Keystone Crossroads 2027 will feature the most timely and relevant advancements in the fields of HIV vaccinology and HIV cure.  Participants will examine how new computational and delivery platform technologies can elevate the performance of infectious disease countermeasures.  The meeting will further highlight novel approaches to HIV cure and reservoir assessment.  Keystone Crossroads 2027 will represent science from where it is being conducted in resource constrained as well as research rich settings, and it will engage perspectives from across the landscape of infectious diseases countermeasure development, from the inventing scientist to the communities being served.  The symposium is organized to engender frank strategic discussion and facilitate new and renewed collaborations to address challenges and develop strategies to prevent and cure HIV amidst an evolving scientific landscape.