T Cells: From Basic Biology to Therapeutic Applications

Jan 11–14, 2027 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Andrea Schietinger, Daniel Campbell, and Ansuman Satpathy

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Jan 11–14, 2027 | Fairmont Banff Springs, Banff, AB, Canada

Scientific Organizers: Andrea Schietinger, Daniel Campbell, and Ansuman Satpathy

Supported by:

***Meeting program subject to change.

Available Formats:     = Livestream   = In Person     = On Demand
Monday, January 11, 2027
Registration  
4:00–8:00 PM
 Van Horne Foyer
Welcome Mixer  
6:00–8:00 PM
 Van Horne Foyer
Tuesday, January 12, 2027
Breakfast  
7:00–8:00 AM
 President's Hall
Welcome Remarks (Joint)      
8:00–8:10 AM
 Van Horne A/B
Keynote Address (Joint)      
8:10–9:00 AM
 Van Horne A/B
Catherine J Wu, Dana-Farber Cancer Institute
Personalizing Medicine through Cancer Vaccines
T Cells and Innate Allies: Partners in Vaccination (Joint)      
9:00–11:00 AM
 Van Horne A/B
Robert A. Seder, NIAID, National Institutes of Health
Vax-Innate
Peter C DeMuth, Elicio Therapeutics
Targeting mKRAS Immunotherapy to the Lymph Nodes to Promote Anti-Tumor Immunity
Gloryn Chia, National University of Singapore
Short Talk: Targeting an NK Cell Checkpoint to Overcome Immune Escape in MHC I Deficient Tumours
Cameron Sullivan, University of Colorado Anschutz
Short Talk: CD138+ B Cells Promote CD8 T Cell Responses to Vaccine Via IL-27
Coffee Break  
9:30–9:50 AM
 Van Horne Foyer
Award Recipient Acknowledgement      
9:50–9:55 AM
 Van Horne A/B
Jessica Langer, Helmsley Trust Introduction      
11:00–11:05 AM
 Van Horne A/B
Poster Setup  
11:00–1:00 PM
 Van Horne C
On Own for Lunch  
11:00–2:30 PM
Poster Viewing  
1:00–10:00 PM
 Van Horne C
Symposia Spotlight 1: T Cell Function and Differentiation: Connecting the Epigenome, Metabolome and Proteome      
2:30–4:30 PM
 Van Horne A
Omar B Abousaway, Washington University in St. Louis School of Medicine
Short Talk: CAR T Cell Mediated Depletion of cDC1s as a Potential Therapy for Autoimmunity and Graft Vs Host Disease
Kaitlyn Pirogovsky, Saint Louis University
Short Talk: Transcriptomic Conservation Defines Autoimmune Stem-Like T Cells and Uncovers Their Dependence on Apex1
Joshua Briggs, University of Manchester
Short Talk: Integrin αvβ8 Expression Marks a Transcriptionally Distinct Regulatory T-cell Population with Enhanced TGF-β Signaling
Christine Seeleitner, TU Munich
Short Talk: Cell–Intrinsic CARD11 Gain-of-Function Expression Triggers Lymphoproliferative Disease In Vivo
Gayathri Dileepan, The Ohio State University College of Medicine
Short Talk: Aiolos Promotes Lung-Resident CD8 T Cell Memory After Influenza a Virus Infection
Hakimeh Ebrahimi-Nik, Ohio State University Comprehensive Cancer Center
Short Talk: An Unrecognized Adaptor Protein, FHL2, Orchestrates CD8 T Cell Migration and Anti-Tumor Immunity
Michael Kilian, Brigham and Women's Hospital, Harvard Medical School
Short Talk: MHC Class II Dependent Dura Immune Cell Clusters Promote Effector T Cell Responses to Glioblastoma
Noah Pascual Maier †, Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford
Short Talk: Zeb2 Drives CD8+ T Cell Memory Inflation
Coffee Available  
4:30–5:00 PM
 Van Horne Foyer
T Cell Differentiation and Functions      
5:00–7:00 PM
 Van Horne A
E. John Wherry, University of Pennsylvania
T Cell Exhaustion
Andrea Schietinger, Memorial Sloan Kettering Cancer Center
T Cell Stemness and Differentiation in Autoimmunity and Cancer
Chrystal M. Paulos, Emory University School of Medicine
Th17-B Cell Cooperation for Adoptive T Cell Therapy
Zachary Earley, UCSF
Short Talk: GPCR-Gα13 Signaling Regulates Survival of Intestinal Intraepithelial CD8 Lymphocytes Through Migration to Cytokine-Rich Niches
Yusuke Takeuchi, Institute for Life and Medical Sciences, Kyoto University
Short Talk: Tissue-restricted Secondary TCR Engagement Drives the Phenotypic Transition from Tcf1+ stem-like to CD200+ Egr2hi Pathogenic Th17 Cells in Autoimmune Arthritis
Social Hour with Dinner  
7:00–8:00 PM
 President's Hall
Poster Session 1  
7:30–10:00 PM
 Van Horne C
Wednesday, January 13, 2027
Breakfast  
7:00–8:00 AM
 President's Hall
Functional Diversity in Tissues      
8:00–11:00 AM
 Van Horne A
Bruno Silva-Santos, University of Lisbon
γδ T Cells in Tissue Physiology and Surveillance
Caroline Sokol, Ragon Institute of Mass General Brigham, MIT, and Harvard
From Sensing to Response: Circuit Control of Tissue T Cells
Yasmine Belkaid, Institut Pasteur
Unconventional T Cells and Functions in Tissues
Daniel Campbell, Benaroya Research Institute
CD4 T Regulatory T Cells
Jayendra Singh, Peter MacCallum Cancer Centre
Short Talk: Mitochondrial Respiration is a Critical Differentiation Checkpoint for Tissue- Resident Regulatory T Cells
Jonathan Jantsch, University of Cologne
Short Talk: T Cell-Driven Immunovascular Remodeling Reverses Tissue Hypoxia to License Myeloid Effector Function
Coffee Break  
9:00–9:20 AM
 Van Horne Foyer
Poster Setup  
11:00–1:00 PM
 Van Horne C
On Own for Lunch  
11:00–2:00 PM
Poster Viewing  
1:00–10:00 PM
 Van Horne C
Career Roundtable (Joint)  
2:00–3:00 PM
 Van Horne B
Debate: (Re-)defining Exhaustion and Dysfunction      
3:00–4:30 PM
 Van Horne A
E. John Wherry, University of Pennsylvania
Andrea Schietinger, Memorial Sloan Kettering Cancer Center
Ansuman Satpathy, Stanford University School of Medicine
Coffee Available  
4:30–5:00 PM
 Van Horne Foyer
Innate Signals in T Cells (Joint)      
5:00–7:00 PM
 Van Horne A/B
Eduardo Davila, University of Colorado
Rewiring T Cell Fate to Increase Anti-tumor Activity and Persistence While Reducing Exhaustion
Nicolas Manel, Institut Curie
Activation of Intracellular Innate Immune Sensors
Jelena Bezbradica Mirkovic, University of Oxford
Cytosolic Innate Sensing and Lytic Cell Death in Autoinflammation
Junko Sawada, Johns Hopkins All Children's Hospital
Short Talk: Tumor Heterogeneity Shapes Tertiary Lymphoid Structure Formation Following STING and LTβR Activation
Shirley Le †, The University of Melbourne
Short Talk: γδ T Cell-Derived Signals Initiate T Cell Immunity to Plasmodium
Social Hour with Dinner  
7:00–8:00 PM
 President's Hall
Poster Session 2  
7:30–10:00 PM
 Van Horne C
Thursday, January 14, 2027
Breakfast  
7:00–8:00 AM
 President's Hall
Genomics and Cell Engineering for Therapeutic Applications      
8:00–11:00 AM
 Van Horne A
Ansuman Satpathy, Stanford University School of Medicine
Immunogenomics
Justin Eyquem, University of California, San Francisco
In vivo T Cell Engineering
Paul Beavis, Peter MacCallum Cancer Centre
Novel T Cell Engineering for Treatment of Solid Tumors
Georg A Schett, Uniklinikum Erlangen
The Future of T Cell Engagers and CAR-T in Autoimmune and Inflammatory Diseases
Shivani Srivastava, Fred Hutchinson Cancer Center
Short Talk: A Recurrent Point Mutation in the Chimeric Antigen Receptor is Associated with Pathological CAR-T Cell Expansion and Toxicity
Christopher Waters, Genentech
Short Talk: Uncovering Regulators of T-cell Cytokine Secretion Via Optical Pooled Screening (OPS)
Coffee Break  
9:00–9:20 AM
 Van Horne Foyer
Poster Setup  
11:00–1:00 PM
 Van Horne C
On Own for Lunch  
11:00–2:30 PM
Poster Viewing  
1:00–10:00 PM
 Van Horne C
Symposia Spotlight 2: Next-Generation T Cell Engineering, Therapies, and Analytics      
2:30–4:30 PM
 Van Horne A
Keely Ji, Massachusetts General Hospital
Short Talk: Epigenome-Scale Screens Identify Drivers Of T Cell Fate Decisions In Cancer
Aneela Nomura, RIKEN
Short Talk: Runx3-R122C Boosts Anti-tumour Immunity Via Effector progenitor-exhausted Induction
Adi Nagler, DFCI
Short Talk: Spatial Colocalization Of Neoantigen-Expressing Tumor Cells And Cognate T Cells In Cancer
Christian P Otero †, Stanford University
Short Talk: Bidirectional Epigenetic Editing of FOXP3 Cis-Regulatory Elements Induces Stable Endogenous FOXP3 Activation in Conventional Human T Cells
Michael Harbell, University of Colorado, Anschutz
Short Talk: Variable Integration of Co-stimulation Dictate the Cellular Basis of Vaccine Efficacy
Grace Bugos, Fred Hutch Cancer Center
Short Talk: Structural Flexibility of γδ TCRs Expands Targetable Epitope Space For Chimeric T Cell Receptor Therapy
Kevin Bi †, Broad Institute
Short Talk: In Vivo Screening Reveals That HOXD8 Overexpression in CAR T Cells Enhances Stemness And Efficacy in Solid Tumors
Coffee Available  
4:30–5:00 PM
 Van Horne Foyer
Spatial Instruction of T Cell Function      
5:00–7:00 PM
 Van Horne A
Rong Fan, Yale School of Medicine
Decoding Tissue Immunity through Next-Gen Spatial Omics Technologies
Wolfgang Karl Kastenmueller, Institute of Systems Immunology, Max-Planck Research Group
Dynamic Orchestration of Cellular Networks in Tissues
Ananda W. Goldrath, University of California, San Diego
Tissue-Specific Spatial Cues Instructing T Cell Function
Carlo Bifulco, Providence Genomics
Decoding Tissue Microenvironments with Spatial Biology and AI
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)      
7:00–7:15 PM
 Van Horne A
Social Hour with Dinner  
7:15–8:15 PM
 President's Hall
Poster Session 3  
7:30–10:00 PM
 Van Horne C
Friday, January 15, 2027
Departure  
12:00–11:59 PM

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