Neural-Immune Interactions: A Systems-Wide Perspective on Whole Organism Physiology
Jun 08–11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:
Dorothy Schafer, Asya Rolls and Anne Schaefer
Livestream
In Person
On Demand
Jun 08–11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:
Dorothy Schafer, Asya Rolls and Anne Schaefer
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandMerchandise Options
Registration Options
Sunday, June 8, 2025
Fundraising
Booking Function
Registration
4:00–8:00 PM
Grand Foyer
Welcome Mixer
6:00–8:00 PM
Grand Foyer
Monday, June 9, 2025
Breakfast
7:00–8:00 AM
Sea to Sky A
Welcome and Keynote Session (Joint)
8:00–9:30 AM
Sea to Sky B/C
* Dorothy Schafer, University of Massachusetts Chan Medical School
Catherine G. Dulac, Harvard University and HHMI
Neuronal Circuits of Sickness and Social Behavior
Neuronal Circuits of Sickness and Social Behavior
Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT
Development of Epigenetic Modifiers for Discovery Research and Neurodegenerative Disease Therapies
Development of Epigenetic Modifiers for Discovery Research and Neurodegenerative Disease Therapies
Coffee Break
9:30–9:50 AM
Grand Foyer
Cell Biology of Neuroinflammation within Diseased Brain Circuits (Joint)
9:50–11:30 AM
Sea to Sky B/C
* Richard Daneman, University of California, San Diego
Session Chair
Session Chair
Veronique Miron, University of Toronto
Accumulation of dysfunctional oligodendrocytes in human cognitive decline with aging
Accumulation of dysfunctional oligodendrocytes in human cognitive decline with aging
Timothy Hammond, Sanofi
Therapeutic Targeting of Microglial Inflammatory Responses within Diseased Brain Circuits
Therapeutic Targeting of Microglial Inflammatory Responses within Diseased Brain Circuits
Aaron DiAntonio, Washington University in St. Louis
The SARM1 Axon Degeneration Pathway: Mechanistic Insights Drive Therapeutic Opportunities
The SARM1 Axon Degeneration Pathway: Mechanistic Insights Drive Therapeutic Opportunities
Poster Setup
11:15–1:00 PM
Sea to Sky A
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
Sea to Sky A
Symposia Spotlight 1: The Digital Era in Neurodegeneration and Neuroinflammation & Panel Discussion(Joint)
2:30–4:30 PM
Sea to Sky B/C
* Michael Ward, NIH
Session Chair
Session Chair
Max Salick, Insitro
Integrating iPSC-Based Models, Genomics, And Machine Learning To Uncover Neurological Disease Mechanisms And Therapeutic Targets
Integrating iPSC-Based Models, Genomics, And Machine Learning To Uncover Neurological Disease Mechanisms And Therapeutic Targets
Camille Januel, Chan Zuckerberg Biohub San Francisco
Global Organelle Profiling: Combining Stem Cell Models and Proteomics to Uncover Variant-Specific Disease Mechanism in Neurodegenerative Diseases
Global Organelle Profiling: Combining Stem Cell Models and Proteomics to Uncover Variant-Specific Disease Mechanism in Neurodegenerative Diseases
Heather Stark, Syncell
Optoproteomics: Unbiased Spatial Proteomics for Neurodegenerative Diseases
Optoproteomics: Unbiased Spatial Proteomics for Neurodegenerative Diseases
Carmen Sandoval-Espinosa, Genentech
Soma-seq: Intracellular CITE-seq in Frozen Human Brain Tissue Enables the Discovery of Proteinopathy-Associated Gene Expression Signatures
Soma-seq: Intracellular CITE-seq in Frozen Human Brain Tissue Enables the Discovery of Proteinopathy-Associated Gene Expression Signatures
Zinan Zhou, Boston Children's Hospital
Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders
Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders
Coffee Available
4:30–5:00 PM
Grand Foyer
Neural-Immune Signaling Intrinsic to Brain Circuits
5:00–7:00 PM
Sea to Sky B
* Veronique Miron, University of Toronto
Session Chair
Session Chair
Anne Schaefer, Icahn School of Medicine at Mount Sinai, MPI Ageing
Alzheimer’s Disease Reveals Regulatory Microglia Potential
Alzheimer’s Disease Reveals Regulatory Microglia Potential
Ádám Dénes, Hungarian Academy of Sciences
Microglia Control Circuit Homeostasis and Pathological States
Microglia Control Circuit Homeostasis and Pathological States
Richard Daneman, University of California, San Diego
The Brain Vasculature: A Conduit between the Periphery and Control of Brain Circuits
The Brain Vasculature: A Conduit between the Periphery and Control of Brain Circuits
Baljit S. Khakh, David Geffen School of Medicine, UCLA
Astrocyte Control of Neural Circuits During Inflammation
Astrocyte Control of Neural Circuits During Inflammation
Social Hour with Lite Bites
7:00–8:00 PM
Sea to Sky A
Poster Session 1
7:30–10:00 PM
Sea to Sky A
Tuesday, June 10, 2025
Breakfast
7:00–8:00 AM
Sea to Sky A
Mechanisms of Aging in Neuroinflammation and Neurodegeneration (Joint)
8:00–11:00 AM
Sea to Sky B/C
* John Fryer, Translational Genomics Research Institute
Session Chair
Session Chair
Robin Franklin, Altos Labs
The Impact of Aging on Remyelination Potential in the Inflamed Brain
The Impact of Aging on Remyelination Potential in the Inflamed Brain
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
Role of cGAS/Sting in Neurodegenerative Diseases
Role of cGAS/Sting in Neurodegenerative Diseases
Judith Frydman, Stanford University
Age-Related Translational and Ribosomal Dysfunction and its Contribution to Neurodegeneration
Age-Related Translational and Ribosomal Dysfunction and its Contribution to Neurodegeneration
Oliver Hahn, Calico Life Sciences LLC
Short Talk: Decoding Regional Drivers of Microglia Aging via Heterochronic Myeloid Cell Replacement
Short Talk: Decoding Regional Drivers of Microglia Aging via Heterochronic Myeloid Cell Replacement
Ian Guldner, Stanford University
Short Talk: Synaptic Proteins with Age-Related Proteostasis Aberrations Accumulate in Microglia
Short Talk: Synaptic Proteins with Age-Related Proteostasis Aberrations Accumulate in Microglia
Vanessa Martin, University of California, San Diego
Short Talk: Enhancer Deletion of a Microglial-Specific AD BIN1 Risk Variant Alters Lysosomal Phenotype and DAM Response in Ipsc-Derived Microglia
Short Talk: Enhancer Deletion of a Microglial-Specific AD BIN1 Risk Variant Alters Lysosomal Phenotype and DAM Response in Ipsc-Derived Microglia
Wei Jing Chong, Nanyang Technological University
Short Talk: Targeting Cellular Metabolism to Modulate Microglial Function in Health and Disease
Short Talk: Targeting Cellular Metabolism to Modulate Microglial Function in Health and Disease
Coffee Break
9:00–9:20 AM
Grand Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Sea to Sky B/C
Poster Setup
11:00–1:00 PM
Sea to Sky A
On Own for Lunch
11:00–3:30 PM
Poster Viewing
1:00–10:00 PM
Sea to Sky A
Career Roundtable (Joint)
2:15–3:15 PM
Sea to Sky B
Maayan Levy, Stanford University
Assistant Professor
Assistant Professor
Alessandro Ori, Genentech Inc.
Senior Principal Scientist
Senior Principal Scientist
Dirk Landgraf, SV Health Investors
Principal, Dementia Discovery Fund
Principal, Dementia Discovery Fund
Heather B Wood, Springer Nature
Senior Editor
Senior Editor
Meet the Editors (Joint)
3:30–4:30 PM
Sea to Sky B
Ted Dobie, Cell Press
*Session Chair, Scientific Editor, Neuron
*Session Chair, Scientific Editor, Neuron
Shari Wiseman, Nature Neuroscience
Chief Editor
Chief Editor
Lucie Van Emmenis, The Rockefeller University Press - The Journal of Experimental Medicine
Senior Scientific Editor
Senior Scientific Editor
Eric Sawey, Genes & Development
Executive Editor, CSHL Press
Executive Editor, CSHL Press
Taylor Hart, PLOS
Associate Editor
Associate Editor
Coffee Available
4:30–5:00 PM
Grand Foyer
Neural Circuit Control of Immunity
5:00–7:00 PM
Sea to Sky B
* Timothy Hammond, Sanofi
Session Chair
Session Chair
Asya Rolls, Tel Aviv University
Immunoception- Neuronal Representation of Immune Processes to Modulate Behavior
Immunoception- Neuronal Representation of Immune Processes to Modulate Behavior
Erica K Sloan, Monash University
Stress-Induced Regulation of Immune System Function
Stress-Induced Regulation of Immune System Function
Isaac Chiu, Harvard Medical School
Neural Control of the Peripheral Immune Response
Neural Control of the Peripheral Immune Response
Michelle Swarovski, University of Utah
Short Talk: Uncovering the Role of Circumventricular Organs During Infection
Short Talk: Uncovering the Role of Circumventricular Organs During Infection
Social Hour with Lite Bites
7:00–8:00 PM
Sea to Sky A
Poster Session 2
7:30–10:00 PM
Sea to Sky A
Wednesday, June 11, 2025
Breakfast
7:00–8:00 AM
Sea to Sky A
Neural-Immune Regulation of Peripheral Organ Homeostasis
8:00–11:00 AM
Sea to Sky B
* Jonathan Kipnis, Washington University School of Medicine
Session Chair
Session Chair
Jens C. Brüning, Max Planck Institute for Metabolism Research
Neural Control of Age-Related Metabolic Dysfunction
Neural Control of Age-Related Metabolic Dysfunction
Wenfei Han, Max Planck Institute for Biological Cybernetics
Neural Networks Controlling Peripheral Organ Function
Neural Networks Controlling Peripheral Organ Function
Ana Domingos, University of Oxford
Neuroimmune Control of Obesity
Neuroimmune Control of Obesity
Kartik Rajagopalan, UT Southwestern Medical Center
Short Talk: Leptin Signaling Maintains Autonomic Stability During Severe Influenza Infection in Mice
Short Talk: Leptin Signaling Maintains Autonomic Stability During Severe Influenza Infection in Mice
Jaewon Sim, Michigan State University
Short Talk: Monocyte-derived IL-10 Drives Sex Difference in Pain Duration
Short Talk: Monocyte-derived IL-10 Drives Sex Difference in Pain Duration
Caroline L Wee, A*STAR Institute of Molecular and Cell Biology
Short Talk: A Gut-Immune-Brain Circuit Links Diet-Induced Microbial Dysbiosis to Sleep Disruption
Short Talk: A Gut-Immune-Brain Circuit Links Diet-Induced Microbial Dysbiosis to Sleep Disruption
Coffee Break
9:00–9:20 AM
Grand Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Sea to Sky B
* Shelly Buffington, Baylor College of Medicine
Session Chair
Session Chair
Nannan Lu, Stanford University
Remote Presenter: Exploring the Interaction between Blood Plasma Proteins and Microglia: Insights into Brain-Peripheral Communication
Remote Presenter: Exploring the Interaction between Blood Plasma Proteins and Microglia: Insights into Brain-Peripheral Communication
Sravya Kurapati, University of Massachusetts Chan Medical School
Remote Presenter: Monocytes Mobilized by Enteric Neurons Remodel the Enteric Nervous System
Remote Presenter: Monocytes Mobilized by Enteric Neurons Remodel the Enteric Nervous System
Mitre Athaiya, University of Michigan
Remote Presenter: The Role of Macrophage Metabolic Reprogramming in Peripheral Nervous System Regeneration and Development of Neuropathic Pain
Remote Presenter: The Role of Macrophage Metabolic Reprogramming in Peripheral Nervous System Regeneration and Development of Neuropathic Pain
Irene Sanchez Martin, Cold Spring Harbor Laboratory
Remote Presenter: Maternal Immune Activation Reveals Male-Specific Sensitivity to Inflammation-Driven Deficits in Fetal Development
Remote Presenter: Maternal Immune Activation Reveals Male-Specific Sensitivity to Inflammation-Driven Deficits in Fetal Development
Annie Ciernia, University of British Columbia
Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Microglia Axis
Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Microglia Axis
Abi G Yates, Icahn School of Medicine at Mount Sinai
Astrocyte Precursor Cells Instruct Microglial Programming Via IL-3 For Neuronal Sculpting And Social Development
Astrocyte Precursor Cells Instruct Microglial Programming Via IL-3 For Neuronal Sculpting And Social Development
Ugur Akcan, Columbia University
The Transcription Factor RXRɑ, Regulates the Disease-Associated Gene Signatures of Myeloid Cells in Immune-Mediated OCD
The Transcription Factor RXRɑ, Regulates the Disease-Associated Gene Signatures of Myeloid Cells in Immune-Mediated OCD
Bradley J Cutler, The Ohio State University
Neuro-Immune Signaling Underlying Behavioral Fever in Larval Zebrafish
Neuro-Immune Signaling Underlying Behavioral Fever in Larval Zebrafish
Coffee Available
4:30–5:00 PM
Grand Foyer
Immune System Control of Behavior
5:00–6:45 PM
Sea to Sky B
* Isaac Chiu, Harvard Medical School
Session Chair
Session Chair
Dorothy Schafer, University of Massachusetts Chan Medical School
Neural-Immune Signaling Governing Microglia Function Within Brain Circuits
Neural-Immune Signaling Governing Microglia Function Within Brain Circuits
Maayan Levy, Stanford University
Understanding the Bi-Directional Communication Between the Gut and the Brain
Understanding the Bi-Directional Communication Between the Gut and the Brain
Jonathan Kipnis, Washington University School of Medicine
Immune Environment in Brain Borders Governing Circuit Function and Behavior
Immune Environment in Brain Borders Governing Circuit Function and Behavior
Shelly Buffington, Baylor College of Medicine
Short Talk: Protozoan Parasite Disrupts Intestinal Immunity in Pregnancy, Thalamocortical Activity in Offspring
Short Talk: Protozoan Parasite Disrupts Intestinal Immunity in Pregnancy, Thalamocortical Activity in Offspring
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Sea to Sky B
Social Hour with Lite Bites
7:00–8:00 PM
Sea to Sky A
Entertainment
8:00–9:00 PM
Sea to Sky C
Thursday, June 12, 2025
Departure
12:00–11:59 PM
Subscribe for Updates