Fueling MASH: Metabolic Drivers and Inflammatory Crosstalk
Apr 12–15, 2026 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers:
Utpal B. Pajvani, Jennifer L. Estall, and Ariel E. Feldstein
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Apr 12–15, 2026 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Utpal B. Pajvani, Jennifer L. Estall, and Ariel E. Feldstein
Utpal B. Pajvani
Columbia University Medical Center
Jennifer L. Estall, PhD
Institut de Recherches Cliniques de Montréal
Ariel E. Feldstein, MD
Pfizer
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandSunday, April 12, 2026
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
British/Columbia Foyer
Welcome Mixer Sponsored by Lilly
6:00–8:00 PM
British/Columbia Foyer
Monday, April 13, 2026
Breakfast
7:30–8:30 AM
Vancouver Island Room
Welcome Remarks
8:30–8:40 AM
Columbia Ballroom
Keynote Address
8:40–10:00 AM
Columbia Ballroom
Linda G. Griffith, Massachusetts Institute of Technology
Humanizing Drug Discovery: Microphysiological Systems to Model MASH
Humanizing Drug Discovery: Microphysiological Systems to Model MASH
Rohit Loomba, University of California, San Diego, Salk Institute
Translational Update on MASH
Translational Update on MASH
Coffee Break
10:00–10:20 AM
British/Columbia Foyer
Award Recipient Acknowledgement
10:20–10:25 AM
Columbia Ballroom
Mechanisms of Hepatocyte Metabolic Dysfunction in Obesity
10:25–11:50 AM
Columbia Ballroom
Rotonya Carr, University of Washington
Unraveling the Role of Lipid Droplet Proteins in MASLD
Unraveling the Role of Lipid Droplet Proteins in MASLD
Mark A Herman, Baylor College of Medicine
Carbohydrate Metabolism and Steatosis, Intersection of Hepatokines and Metabolism
Carbohydrate Metabolism and Steatosis, Intersection of Hepatokines and Metabolism
Jennifer L Estall, Institut de Recherches Cliniques de Montréal
Understanding the Fasting Response in Hepatic Lipid Metabolism
Understanding the Fasting Response in Hepatic Lipid Metabolism
Poster Setup
11:50–1:00 PM
British/Columbia Ballroom
On Own for Lunch
11:50–5:00 PM
Poster Viewing
1:00–10:00 PM
British/Columbia Ballroom
Symposia Spotlight 1: Altered Metabolic Signals in MASH
2:30–4:30 PM
Columbia Ballroom
James M Eng †, IRCM
Obesogenic Diet and Loss of PGC-1α Increase Hepatic SerpinA3N Secretion through Induction of Oxidative Stress
Obesogenic Diet and Loss of PGC-1α Increase Hepatic SerpinA3N Secretion through Induction of Oxidative Stress
Helen M. Roche †, University College Dublin
Diet, Metabolism and Innate Immune Training: Systemic Inflammatory Responses Suggest Tolerance or Exhaustion in People with MASH, Compared to MAFLD
Diet, Metabolism and Innate Immune Training: Systemic Inflammatory Responses Suggest Tolerance or Exhaustion in People with MASH, Compared to MAFLD
Haressh Sajiir, NIH/NIDDK
Paired Fasted–Fed Multiomic Profiling of Human Livers Reveals Impaired Adaptive Hepatic Responses in MASH
Paired Fasted–Fed Multiomic Profiling of Human Livers Reveals Impaired Adaptive Hepatic Responses in MASH
Shijun Deng †, Harvard University
A Cholesterol-sensing NFE2L1-INSIG1 Checkpoint Controls VLDL Secretion and Attenuates MASH Progression
A Cholesterol-sensing NFE2L1-INSIG1 Checkpoint Controls VLDL Secretion and Attenuates MASH Progression
Christian Stoess †, University of California, San Diego
IL-18 Signaling Reflects Disease Severity in MASLD and Corresponds to Hepatic Inflammation in Humans
IL-18 Signaling Reflects Disease Severity in MASLD and Corresponds to Hepatic Inflammation in Humans
Rebecca A Haeusler †, Columbia University
Manganese Availability Determines Insulin Sensitivity By Enhancing Akt Activity
Manganese Availability Determines Insulin Sensitivity By Enhancing Akt Activity
Xing Zeng †, UT Southwestern medial center
Interorganelle Competition for Linoleoyl Phospholipids Underlies Steatotic Liver Pathology
Interorganelle Competition for Linoleoyl Phospholipids Underlies Steatotic Liver Pathology
Wajahat Z Mehal †, Yale University
Regulation of Free Fatty Acid (FFA) Induced Hepatocyte Dysfunction by FGF21 Receptor Agonism
Regulation of Free Fatty Acid (FFA) Induced Hepatocyte Dysfunction by FGF21 Receptor Agonism
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Endocrine Regulators of Hepatocyte Metabolic Functions
5:00–7:00 PM
Columbia Ballroom
Magdalene K. Montgomery, University of Melbourne
Using Genome-Wide CRISPR Screens to Identify Novel Regulators of Hepatic Lipid Metabolism in MASH
Using Genome-Wide CRISPR Screens to Identify Novel Regulators of Hepatic Lipid Metabolism in MASH
Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL
Gut-Liver Axis
Gut-Liver Axis
Timothy P Rolph, Akero Therapeutics
Mechanisms Underlying Therapeutic Effects of FGF21 Analogs in Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Mechanisms Underlying Therapeutic Effects of FGF21 Analogs in Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Filip K. Knop, Gentofte Hospital, University of Copenhagen
Role of Glucagon and Incretins in MASH
Role of Glucagon and Incretins in MASH
Social Hour with Dinner
7:00–8:00 PM
Vancouver Island Room
Poster Session 1
7:30–10:00 PM
British/Columbia Ballroom
Tuesday, April 14, 2026
Breakfast
7:30–8:30 AM
Vancouver Island Room
Poster Setup
8:00–8:30 AM
British/Columbia Ballroom
Poster Viewing
8:15–5:00 PM
British/Columbia Ballroom
Intercellular and Interorgan Crosstalk in Development of Liver Disease
8:30–11:30 AM
Columbia Ballroom
Xingxing Kong, Fudan University
Adipose-Muscle-Liver Crosstalk
Adipose-Muscle-Liver Crosstalk
Ruchi Bansal, University Medical Center Groningen, The Netherlands
Single-Cell Phenomics and EV-Omics to Unravel Cellular and Organ Crosstalk in MASH and Liver Cancer
Single-Cell Phenomics and EV-Omics to Unravel Cellular and Organ Crosstalk in MASH and Liver Cancer
Ornella Barrandon, Cellarity
Revealing Novel MASH Biology at Single Cell Resolution
Revealing Novel MASH Biology at Single Cell Resolution
Jonathan B Steinman, Columbia University
Short Talk: Molecular Characterization of Periportal vs. Pericentral Pediatric MASH
Short Talk: Molecular Characterization of Periportal vs. Pericentral Pediatric MASH
Jed Friedman, University of Oklahoma
Short Talk: Maternal Western-style Diet Promotes Immune Tolerance and Liver Sinusoidal Endothelial Cell (LSEC) Dysfunction in Nonhuman Primate Juvenile Offspring Liver
Short Talk: Maternal Western-style Diet Promotes Immune Tolerance and Liver Sinusoidal Endothelial Cell (LSEC) Dysfunction in Nonhuman Primate Juvenile Offspring Liver
Dipayan Chaudhuri, University of Utah
Short Talk: A Maladaptive Antiviral Response Drives Liver Injury in MASH
Short Talk: A Maladaptive Antiviral Response Drives Liver Injury in MASH
Won-Il Choi, Jeonbuk National University Medical School
Short Talk: Peripheral Serotonin–HTR2A Signaling as a Therapeutic Target for MASLD
Short Talk: Peripheral Serotonin–HTR2A Signaling as a Therapeutic Target for MASLD
Coffee Break
9:30–9:50 AM
British/Columbia Foyer
Lunch
11:30–12:30 PM
Vancouver Island Room
Poster Session 2
12:00–2:30 PM
British/Columbia Ballroom
Career Roundtable
3:00–4:30 PM
British Ballroom
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Intrahepatic Determinants of Liver Inflammation and Fibrosis in MASH
5:00–7:00 PM
Columbia Ballroom
Utpal B. Pajvani, Columbia University Medical Center
Adipogenic Reprogramming of Hepatocytes as a Contributor to Fibrosis
Adipogenic Reprogramming of Hepatocytes as a Contributor to Fibrosis
Mathias F Heikenwälder, German Cancer Research Center, DKFZ
Fueling MASH: Metabolic Drivers and Inflammatory Crosstalk
Fueling MASH: Metabolic Drivers and Inflammatory Crosstalk
Ariel E. Feldstein, Pfizer
Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis
Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis
Cynthia Lebeaupin, Pfizer
Myeloid Cells Contribute to Bystander CD8 T Cell Accumulation in Metabolic-associated Steatohepatitis and are Sufficient for Fibrosis
Myeloid Cells Contribute to Bystander CD8 T Cell Accumulation in Metabolic-associated Steatohepatitis and are Sufficient for Fibrosis
Xin (Tony) Tong †, University of Michigan Medical School
Short Talk: Hepatocyte TGF-β-OPR3 Signaling Axis Promotes Hepatic Stellate Cell Activation and Liver Fibrosis in Mice
Short Talk: Hepatocyte TGF-β-OPR3 Signaling Axis Promotes Hepatic Stellate Cell Activation and Liver Fibrosis in Mice
Patrice Mimche, Indiana University
Short Talk: EPHB2 Promotes Diet-induced MASH Liver Fibrosis
Short Talk: EPHB2 Promotes Diet-induced MASH Liver Fibrosis
On Own for Dinner
7:00–8:00 PM
Wednesday, April 15, 2026
Breakfast
7:30–8:30 AM
Vancouver Island Room
Mechanisms of Liver Regeneration and Progression to HCC
8:30–11:30 AM
Columbia Ballroom
Hao Zhu, University of Texas Southwestern Medical Center
Somatic Mutations in MASH Progression
Somatic Mutations in MASH Progression
Robert F. Schwabe, Columbia University
Regulation of Hepatocyte Metabolism by Hepatic Stellate Cells in MASH: Looking Beyond Fibrogenesis
Regulation of Hepatocyte Metabolism by Hepatic Stellate Cells in MASH: Looking Beyond Fibrogenesis
KyeongJin Kim, Inha University
Mechanisms of MASH-Induced HCC
Mechanisms of MASH-Induced HCC
Mathieu Ferron, Institut de Recherches Cliniques de Montréal
Short Talk: The Vitamin K Oxidoreductase VKORC1L1 Prevents Oxidative Stress in Hepatocytes and Protects Against MASLD and Hepatocellular Carcinoma
Short Talk: The Vitamin K Oxidoreductase VKORC1L1 Prevents Oxidative Stress in Hepatocytes and Protects Against MASLD and Hepatocellular Carcinoma
Yanting Wang †, University of California, San Diego
Short Talk: Prevention of the Insulin Receptor Isoform a Splicing Switch Remodels the Hepatic Innate Immune Niche to Restrain MASH-Driven Hepatocellular Carcinoma
Short Talk: Prevention of the Insulin Receptor Isoform a Splicing Switch Remodels the Hepatic Innate Immune Niche to Restrain MASH-Driven Hepatocellular Carcinoma
Junjie Yu, China Pharmaceutical University
Short Talk: Hepatocyte Tet1 integrates retinol signal to drive fibrogenesis in MASH
Short Talk: Hepatocyte Tet1 integrates retinol signal to drive fibrogenesis in MASH
Joel Haas †, INSERM UMR1011
Short Talk: Hepatic Dendritic Cells Display Persistent Metabolic Reprogramming Following MASH Resolution
Short Talk: Hepatic Dendritic Cells Display Persistent Metabolic Reprogramming Following MASH Resolution
Coffee Break
9:30–9:50 AM
British/Columbia Foyer
On Own for Lunch
11:30–5:00 PM
Panel: Perspectives: Personalized Medicine and Patient-Centered Strategies (joint)
1:00–2:00 PM
Columbia Ballroom
Symposia Spotlight 2: Inflammation and Fibrosis in the Obese Liver
2:30–4:30 PM
Columbia Ballroom
WonGun Choi, The Catholic University of Korea
The oxLDL–Pla2g7 Axis Drives LysoPC-Mediated Hepatic Inflammation and Fibrosis in MASH
The oxLDL–Pla2g7 Axis Drives LysoPC-Mediated Hepatic Inflammation and Fibrosis in MASH
Tabea K Bieler, Deutsches Krebsforschungszentrum Heidelberg
IL-17A–Mediated Skin–Liver Crosstalk Accelerates Steatosis and Inflammation in MASLD/MASH
IL-17A–Mediated Skin–Liver Crosstalk Accelerates Steatosis and Inflammation in MASLD/MASH
Alexandre Caron, Laval University
Loss of Hepatic ADRA1B Exacerbates Inflammation and Fibrosis in Diet-Induced MASLD
Loss of Hepatic ADRA1B Exacerbates Inflammation and Fibrosis in Diet-Induced MASLD
Chuhan Chung, Inipharm, Inc.
Pharmacologic Blockade of HSD17B13 is Dependent on the PNPLA3 Risk Variant
Pharmacologic Blockade of HSD17B13 is Dependent on the PNPLA3 Risk Variant
Reem Araji, NIH
Expression of Human HSD17B13 in Mice Recapitulates Endogenous Mouse Hsd17b13-Mediated Hepatic Fibrosis Under MASH-Inducing Conditions
Expression of Human HSD17B13 in Mice Recapitulates Endogenous Mouse Hsd17b13-Mediated Hepatic Fibrosis Under MASH-Inducing Conditions
Alexander Ledet, Albert Einstein College of Medicine
Attenuation of Protein Translation by Chaperone-Mediated Autophagy Protects Against Metabolic Dysfunction-Associated Steatohepatitis
Attenuation of Protein Translation by Chaperone-Mediated Autophagy Protects Against Metabolic Dysfunction-Associated Steatohepatitis
Wen-Wei Tsai †, Sagimet Biosciences
Reduction of Plasma Glycine- and Taurine-conjugated Bile Acids Correlated with Histological Improvements in Denifanstat-treated MASH Patients in Phase 2b FASCINATE-2 Trial
Reduction of Plasma Glycine- and Taurine-conjugated Bile Acids Correlated with Histological Improvements in Denifanstat-treated MASH Patients in Phase 2b FASCINATE-2 Trial
Francois Briand, Physiogenex
Withdrawal of Semaglutide Results in Weight Regain, Increased Alcohol Intake and Metabolic Disorders in a Diet-Induced Obese Hamster Model of Metald
Withdrawal of Semaglutide Results in Weight Regain, Increased Alcohol Intake and Metabolic Disorders in a Diet-Induced Obese Hamster Model of Metald
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Emerging Translational Approaches to MASH
5:00–6:45 PM
Columbia Ballroom
Simon J Cockell, University of Newcastle upon Tyne
Proteo-Transcriptomic Profiles in MASLD
Proteo-Transcriptomic Profiles in MASLD
Diana Julie Leeming, Nordic Bioscience
Circulating Markers of Extracellular Matrix for MASLD Risk Stratification and Prediction of Response to Therapy
Circulating Markers of Extracellular Matrix for MASLD Risk Stratification and Prediction of Response to Therapy
Katy Wack, PathAI
Bringing Precision to Pathologic Assessment for MASH: Clinical Validation of an AI-based Drug Development Tool
Bringing Precision to Pathologic Assessment for MASH: Clinical Validation of an AI-based Drug Development Tool
Patrice Rioux, Thiogenesis Therapeutics, Corp
Short Talk: TTI-0102 for MASH: Targeting Mitochondrial Dysfunction and Inflammatory Crosstalk in a Converging Cardiometabolic-Renal Syndrome
Short Talk: TTI-0102 for MASH: Targeting Mitochondrial Dysfunction and Inflammatory Crosstalk in a Converging Cardiometabolic-Renal Syndrome
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Columbia Ballroom
Social Hour with Dinner
7:00–8:00 PM
Vancouver Island Room
Cash Bar
8:00–11:00 PM
Entertainment
8:00–11:00 PM
Thursday, April 16, 2026
Departure
12:00–11:59 PM
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